臺灣博碩士論文加值系統

在現今的社會，隨著醫療科技的不斷發展，近幾年興起的生物活性玻璃也逐漸受到重。而將生物活性玻璃進行改質，在合成過程中加入不同性質的界面活性劑做為造孔劑使用，可增加生物活性玻璃之比表面積，藉以增加生物活性玻璃與生物體液接觸面積，加速氫氧基磷灰石層生成。藉此增進生物活性玻璃的礦化能力幫助骨質生成及與骨周圍組織生長，以提高軟組織與骨質的癒合能力，為本研究的主要動機；因兩性界面活性劑P123的添加，可有效助於生物活性玻璃的表面礦化能力及擁有接近骨生成鈣磷比理想值1.67，且可加速MG-63成骨細胞的生長，達到快速傷口癒合及高生物相容性的效果。

In today’s society, with the continuous development of medical technology, bioactive glass that has emerged in recent years has gradually attracted concern in medical circles. In the process of synthesis, the modification of bioactive glass by adding surfactants with different properties surfactant as pore-forming agents, can increase the specific surface area of bioactive glass and improve the contact area between bioactive glass and body fluid, thereby accelerating the formation of hydroxyapatite layer. The main motivation of this study is to enhance mineralization ability of bioactive glass to help bone formation and tissue growth around the bone, thereby improving the healing ability of soft tissue and bone. Due to the addition of hydrophilic surfactant P123, it can effectively promote the surface mineralization ability of bioactive glass and have an ideal value of 1.67 for bone-forming calcium and phosphorus, and accelerate the growth of MG-63 osteoblasts for rapid wound healing. And high biocompatibility effects.

誌謝
摘要
Abstract
目錄
圖表目錄
第一章 緒論
1.1 前言
1.2 研究動機
第二章 文獻回顧
2.1生物活性玻璃介紹
2.1.1 生物活性玻璃發展史
2.1.2 氫氧基磷灰石
2.2 生物活性玻璃製備法
2.2.1 溶膠凝膠法
2.3 界面活性劑
2.3.1 兩性界面活性劑
2.3.2 親水性界面活性劑
2.3.3 親油性界面活性劑
2.4 靜電噴霧法 (Electrospray)
第三章 實驗方法與步驟
3.1 實驗流程
3.2 生物活性玻璃製程
3.2.1 生物活性玻璃粉末製備
3.2.2 界面活性劑之生物活性玻璃粉末製備
3.2.3 靜電噴霧生物活性玻璃於發泡鈦基板上
3.2.4 靜電噴霧P123於發泡鈦基板上
3.3 生物活性玻璃分析測試
3.3.1 掃描式電子顯微鏡 (SEM)
3.3.2 能量散射光譜儀 (EDS)
3.3.3 X光繞射分析儀（XRD）
3.3.4 比表面積分析 (BET)
3.3.5 傅立葉轉換紅外線光譜儀 (FTIR)
3.3.6 細胞存活率分析 (CCK-8 assay)
第四章 結果與討論
4.1 生物活性玻粉體之特性分析
4.1.1 生物活性玻璃樣品BG粉體之SEM分析
4.1.2 生物活性玻璃樣品Span 85粉末之SEM分析
4.1.3 生物活性玻璃樣品PEG粉末之SEM分析
4.1.4 生物活性玻璃樣品P123粉末之SEM分析
4.1.5 生物活性玻璃樣品之EDS分析
4.1.6 生物活性玻璃樣品粉末之FTIR分析
4.1.7 生物活性玻璃樣品浸泡SBF溶液後之XRD分析
4.1.8 生物活性玻璃樣品之BET分析
4.1.9 生物活性玻璃粉樣品之重量百分率圖
4.1.10 生物活性玻璃樣品之細胞貼附測試 (CCK-8 assay)
4.2 靜電噴塗於發泡鈦基材之表面分析
4.2.1 空白鈦基材之SEM圖
4.2.2 BG – Ti之SEM圖分析
4.2.3 P123 – Ti之SEM圖分析
4.2.4 生物活性玻璃靜電噴霧於鈦基材上之FTIR分析
4.2.5 生物活性玻璃靜電噴霧於鈦基材上之XRD分析
4.2.6 鈦基材之細胞貼附測試(CCK-8 assay)
第五章 結論
第六章 未來展望
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