臺灣博碩士論文加值系統

近幾年發展離子感測器已有許多的進展，這些離子感測器主要是
應用於測量人體的電解液、血液、汗水、尿素…等其相關離子濃度量
測，藉由所提供的訊息來了解身體的狀況。傳統之離子感測器之參考
電極主要是以可逆反應的電解質來穩定其電位，再藉由感測電極對應
該參考電極之相對電位差來判別離子濃度，如 3.5M HCl 填充液於
Ag/AgCl 參考電極等。但由於該溶液的關係致使感測器難以做到微
型化之地步，近年技術發展已逐漸採用固態導電離子薄膜取代原先填
充溶液來逐步實現感測器之微縮。本研究發展以噴墨式列印機來製備
出軟性離子感測器所需要的各種薄膜，實現了可大量且快速之生產製
程。此外所提出噴墨式印刷技術，可成功地將感測器微縮到 100µm
之尺寸並成功實現陣列感測器，而所製備出的工作電極可擁有
45.3mV/decade 的感測靈敏度，此外藉由本噴墨印刷技術製備出的薄
膜將可適用於人體內鈉離子濃度，偵測上限可達 186mM 以上，將來
可透過此技術來實現軟性多重離子感測器的整合。

In recent years, the development of solid-state ionic sensors has been with lots of
engineering progress. These ionic sensors have been extensively used to measure
the body's electrolyte, blood, sweat, urine to provide corresponding physiology
information to monitoring the body status. Conventional reference electrodes of these
ion sensors must be filled with a saturated solution, i.e. 3.5M HCl for Ag/AgCl
reference electrode, to keep its potential stable, so the working electrode of the
sensors can detect the ionic concentration based on its potential change referred to the
reference electrode. However, to hermetically encapsulate the filling solution with the
reference electrode is very difficult for the sensor miniaturization. Nowadays
several solid-state ion-conductive films instead of the solution have been developed
for the purpose. In this thesis, a flexible inkjet printed sodium sensor has been
successfully developed using in-lab. inks. Meanwhile, the corresponding printing
technology has revealed the characteristics of rapid and easy manufacture and
facilitated the miniaturization of the sensor down to 100μm in size with a sensitivity
of 45.3mV / decade. Experimental results also show the developed ion-conductive
membrane can enhance the upper detection limit of the sodium sensor up to 186mM,
which is a typical sodium concentration inside the human body. In the future it is our
belief that the ink-jet printing technology can easily advance the integration of
multiple ion sensors on a flexible substrate for various biomedical applications.

摘要…………………………………………………………………………………………I
Abstract……………………………………………………………………………II
內容………………………………………………………………………………………III
圖標題…………………………………………………………………………………IV
表標題…………………………………………………………………………………V
第一章 介紹………………………………………………………………………1
1.1.鈉離子對身體影響…………………………………………………1
1.2.離子感測器歷史………………………………………………………2
1.3.文獻回顧……………………………………………………………………4
1.4.實驗動機……………………………………………………………………6
第二章 設計與分析……………………………………………………10
2.1.原理……………………………………………………………………………10
2.2.實驗介紹……………………………………………………………………13
2.2.1.墨水限制………………………………………………………………15
2.2.2.金屬導線保護……………………………………………………17
2.2.3.實驗前量測…………………………………………………………18
第三章 製程與實驗………………………………………………………20
3.1.實驗準備……………………………………………………………………20
3.2.製程步驟……………………………………………………………………21
3.3.墨水黏滯係數測量…………………………………………………23
第四章 結論與討論………………………………………………………25
第五章 結論與未來發展……………………………………………38
參考資料………………………………………………………………………………40

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