臺灣博碩士論文加值系統

This study was to evaluate the effects of reduced masticatory muscle function on the maxillofacial suture bone growth of growing rats. Botulinum Neurotoxin type A (BTX-A) was injected as the method of reduction masticatory muscle force and further evaluation of the growing of the sutures.

This study was to evaluate the effects of reduced masticatory muscle function on the maxillofacial suture bone growth of growing rats. Botulinum Neurotoxin type A (BTX-A) was injected as the method of reduction masticatory muscle force and further evaluation of the growing of the sutures.

Contents
Table of contents I
Table caption III
Figures caption IV
Chinese abstract V
English abstract VIII

INTRODUCTION 1
1.1 GENERAL BACKGROUND 1
1.2 RESEARCH RATIONALE 3
1.3 RESEARCH PURPOSE 3
1.4 RESEARCH HYPOTHESIS 3
LITERATURE REVIEW 4
2.1 EFFECT OF MASTICATORY MUSCLE FUNCTION CHANGE ON MAXILLOFACIAL STRUCTURE GROWTH 4
2.2 BOTULINUM TOXIN 6
MATERIAL AND METHODS 9
3.1 MATERIAL 9
3.2 METHODS 10
RESULTS 14
4.1 BODY WEIGHT CHANGE 14
4.2 MUSCLE WEIGHT CHANGE 14
4.3 DENTAL ARCH MEASUREMENTS 15
4.4 BONE MINERAL DENSITY MEASUREMENTS 15
4.5 SUTURAL BONE APPOSITION RATE MEASUREMENT 16
DISCUSSION 19
5.1 BODY WEIGHT CHANGE 19
5.2 MUSCLE WEIGHT CHANGE 19
5.3 DENTAL ARCH MEASUREMENTS 20
5.4 BONE MINERAL DENSITY MEASUREMENTS 21
5.5 SUTURAL BONE APPOSITION RATE MEASUREMENT 22
CONCLUSION 24
FIGURES AND TABLES 25
REFERENCE 32

Table captions

Table 1. Mean body weight change (g). 27
Table 2. Masseter muscle and temporalis muscle weight (g). 28
Table 3. Dental arch measurements (mm). 29
Table 4. Bone mineral density of maxillofacial sutures (g/cm3). 30
Table 5. Suture bone apposition rate (μm). 31

Figure captions

Figure 1. Arch size measurements. 25
Figure 2. Bone mineral density. 26

1.Moss ML, Rankow RM. The role of the functional matrix in mandibular growth. Angle Orthod. 1968;38(2):95-103.
2.Kiliaridis S, Mejersjo C, Thilander B. Muscle function and craniofacial morphology: a clinical study in patients with myotonic dystrophy. Eur J Orthod. 1989;11(2):131-8.
3.Proffit WR, Fields HW, Nixon WL. Occlusal forces in normal- and long-face adults. J Dent Res. 1983;62(5):566-70.
4.Proffit WR, Fields HW. Occlusal forces in normal- and long-face children. J Dent Res. 1983;62(5):571-4.
5.Kiliaridis S, Engstrom C, Thilander B. The relationship between masticatory function and craniofacial morphology. I. A cephalometric longitudinal analysis in the growing rat fed a soft diet. Eur J Orthod. 1985;7(4):273-83.
6.Kiliaridis S, Engstrom C, Thilander B. Histochemical analysis of masticatory muscle in the growing rat after prolonged alteration in the consistency of the diet. Arch Oral Biol. 1988;33(3):187-93.
7.Rauch F, Hamdy R. Effect of a single botulinum toxin injection on bone development in growing rabbits. J Musculoskelet Neuronal Interact. 2006;6(3):264-8.
8.Katsaros C, Kiliaridis S, Berg R. Functional influence on sutural growth. A morphometric study in the anterior facial skeleton of the growing rat. Eur J Orthod. 1994;16(5):353-60.
9.Katsaros C, Berg R, Kiliaridis S. Influence of masticatory muscle function on transverse skull dimensions in the growing rat. J Orofac Orthop. 2002;63(1):5-13.
10.Katsaros C, Zissis A, Bresin A, Kiliaridis S. Functional influence on sutural bone apposition in the growing rat. Am J Orthod Dentofacial Orthop. 2006;129(3):352-7.
11.Sun Z, Lee E, Herring SW. Cranial sutures and bones: growth and fusion in relation to masticatory strain. Anat Rec A Discov Mol Cell Evol Biol. 2004;276(2):150-61.
12.Ulgen M, Baran S, Kaya H, Karadede I. The influence of the masticatory hypofunction on the craniofacial growth and development in rats. Am J Orthod Dentofacial Orthop. 1997;111(2):189-98.
13.Maxwell LC, Carlson DS, McNamara JA, Jr., Faulkner JA. Adaptation of the masseter and temporalis muscles following alteration in length, with or without surgical detachment. Anat Rec. 1981;200(2):127-37.
14.Navarro M, Delgado E, Monje F. Changes in mandibular rotation after muscular resection. Experimental study in rats. Am J Orthod Dentofacial Orthop. 1995;108(4):367-79.
15.Carter GM, Harkness EM. Alterations to mandibular form following motor denervation of the masseter muscle. An experimental study in the rat. J Anat. 1995;186 ( Pt 3):541-8.
16.Phillips C, Shapiro PA, Luschei ES. Morphologic alterations in Macaca mulatta following destruction of the motor nucleus of the trigeminal nerve. Am J Orthod. 1982;81(4):292-8.
17.Gardner DE, Luschei ES, Joondeph DR. Alterations in the facial skeleton of the guinea pig following a lesion of the trigeminal motor nucleus. Am J Orthod. 1980;78(1):66-80.
18.Jankovic J, Brin MF. Therapeutic Uses of Botulinum Toxin. New England Journal of Medicine. 1991;324(17):1186-94.
19.Nayyar P, Kumar P, Nayyar PV, Singh A. BOTOX: Broadening the Horizon of Dentistry. J Clin Diagn Res. 2014;8(12):ZE25-9.
20.Tsai CY, Chiu WC, Liao YH, Tsai CM. Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle. Am J Orthod Dentofacial Orthop. 2009;135(2):142 e1-6; discussion -3.
21.Tsai CY, Lin YC, Su B, Yang LY, Chiu WC. Masseter muscle fibre changes following reduction of masticatory function. Int J Oral Maxillofac Surg. 2012;41(3):394-9.
22.Tsai CY, Lei YY, Yang LY, Chiu WC. Changes of masseter muscle activity following injection of botulinum toxin type A in adult rats. Orthod Craniofac Res. 2015;18(4):202-11.
23.Watt DG, Williams CH. The effects of the physical consistency of food on the growth and development of the mandible and the maxilla of the rat. Am J Orthod. 1951;37(12):895-928.
24.Bouvier M, Hylander WL. The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats. Am J Anat. 1984;170(1):117-26.
25.Dorfl J. Migration of tendinous insertions. I. Cause and mechanism. J Anat. 1980;131(Pt 1):179-95.
26.Dorfl J. Migration of tendinous insertions. II. Experimental modifications. J Anat. 1980;131(Pt 2):229-37.
27.Proffit WR. Functional Matrix Theory of Growth. Contemporary Orthodontics. 3rd ed2000. p. 45-8.
28.Kiliaridis S, Bresin A, Holm J, Strid KG. Effects of masticatory muscle function on bone mass in the mandible of the growing rat. Acta Anat (Basel). 1996;155(3):200-5.
29.Warner SE, Sanford DA, Becker BA, Bain SD, Srinivasan S, Gross TS. Botox induced muscle paralysis rapidly degrades bone. Bone. 2006;38(2):257-64.
30.Waltimo A, Nystrom M, Kononen M. Bite force and dentofacial morphology in men with severe dental attrition. Scand J Dent Res. 1994;102(2):92-6.
31.Porter JD, Strebeck S, Capra NF. Botulinum-induced changes in monkey eyelid muscle. Comparison with changes seen in extraocular muscle. Arch Ophthalmol. 1991;109(3):396-404.
32.Aoki KR. A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice. Toxicon. 2001;39(12):1815-20.
33.Brin MF. Botulinum toxin: chemistry, pharmacology, toxicity, and immunology. Muscle Nerve Suppl. 1997;6:S146-68.
34.Spencer RF, McNeer KW. Botulinum toxin paralysis of adult monkey extraocular muscle. Structural alterations in orbital, singly innervated muscle fibers. Arch Ophthalmol. 1987;105(12):1703-11.
35.Ma J, Elsaidi GA, Smith TL, Walker FO, Tan KH, Martin E, et al. Time course of recovery of juvenile skeletal muscle after botulinum toxin A injection: an animal model study. Am J Phys Med Rehabil. 2004;83(10):774-80; quiz 81-3.
36.Dressler D, Saberi FA, Barbosa ER. Botulinum toxin: mechanisms of action. Arq Neuropsiquiatr. 2005;63(1):180-5.
37.Borodic GE, Ferrante R, Pearce LB, Smith K. Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections. Mov Disord. 1994;9(1):31-9.
38.Langer JC, Birnbaum EE, Schmidt RE. Histology and function of the internal anal sphincter after injection of botulinum toxin. J Surg Res. 1997;73(2):113-6.
39.Bianchi ML, Mazzanti A, Galbiati E, Saraifoger S, Dubini A, Cornelio F, et al. Bone mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporos Int. 2003;14(9):761-7.
40.Chappard D, Chennebault A, Moreau M, Legrand E, Audran M, Basle MF. Texture analysis of X-ray radiographs is a more reliable descriptor of bone loss than mineral content in a rat model of localized disuse induced by the Clostridium botulinum toxin. Bone. 2001;28(1):72-9.
41.Yamamoto S. The effects of food consistency on maxillary growth in rats. Eur J Orthod. 1996;18(6):601-15.
42.Shimizu Y, Ishida T, Hosomichi J, Kaneko S, Hatano K, Ono T. Soft diet causes greater alveolar osteopenia in the mandible than in the maxilla. Arch Oral Biol. 2013;58(8):907-11.
43.Tsai CY, Huang RY, Lee CM, Hsiao WT, Yang LY. Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats. J Oral Maxillofac Surg. 2010;68(5):1081-7.
44.Moon YM, Kim YJ, Kim MK, Kim SG, Kweon H, Kim TW. Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation. Maxillofac Plast Reconstr Surg. 2015;37(1):46.
45.Miyazaki M, Yonemitsu I, Takei M, Kure-Hattori I, Ono T. The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats. Arch Oral Biol. 2016;63:22-31.
46.Tamut T, Pooran C, Pratap SB, Arvind T, Jitendra R, Dayal SR. Effect of bone mineral density on masticatory performance and efficiency. Gerodontology. 2012;29(2):e83-7.