臺灣博碩士論文加值系統

本研究中以篩選澎湖地區具有抗躁鬱及助眠之天然素材作為樣本。樣品以不同方法處理包括粉碎、榨油及樣本分別通過大氣電漿0、5、10min之發芽，並探討樣品之功效性成分，包括色胺酸(Tryptophan)、酪胺酸(Tyrosine)、γ-胺基丁酸(γ-aminobutyric acid；GABA)、血清素(Serotonin)、麩胺酸(Glutamic acid)，另一方面試驗抗氧化能力，包括總酚含量、總類黃酮含量、清除DPPH自由基能力及清除ABTS自由基及抑制血管收縮素轉化酶(angiotensin converting enzyme,ACE)能力。結果顯示，利用高效液相層析方法分析樣本功效性成分，榨油處理方法含量皆高於粉碎處理，電漿5min效果較佳；抗氧化分析方面，榨油處理及電漿處理在總酚含量、總類黃酮含量、清除DPPH自由基、清除ABTS自由基具有較佳的抗氧化能力；抑制血管收縮轉化酶的抑制活性中，電漿5min具有較佳的抑制能力。本研究的成果對於澎湖地區農產品之應用及加工方面可以提供有用的資訊，以發展當地的農業特產。

Sample was treatment with different methods ,including crush process, defatted and sample was prepared by 0 minute, 5minute, 10 minute plasma processing with germination. To investigate the effectiveness of component of sample, Tryptophan, Tyrosine, γ-aminobutyric acid(GABA), Serotonin, Glutamic acid. On the other hand, sample were examined antioxidant capacity, total phenolic compounds, flavonoid content, scavenging effects of 1,1-diphenyl-2-picylhydrazyl (DPPH) radicals, ABTS free radical （2,2 –azino-bis[3-ethlbenzthiazoline-6-sulphonic acid]）scavenging ability and inhibited angiotensin converting enzyme (ACEi) capacity was also examined. The result were showed that the effectiveness of component of sample used high performance liquid chromatography( HPLC) analysis , defatted crush the effectiveness of component content more than process, plasma processing with germination in 5 minute had a good effect. In the antioxidant capacity, defatted and plasma processing are the best effect in total phenolic compounds, flavonoid content, scavenging effects of 1,1-diphenyl-2-picylhydrazyl (DPPH) radicals, ABTS free radical （2,2 –azino-bis[3-ethlbenzthiazoline-6-sulphonic acid]）scavenging ability .The result of ACEi , cessing with germination in 5 minute has a nice inhabitation capability.The results of this study for Penghu can offer useful information for the development of local agricultural produce.

目錄
謝誌..................................................................................................................I
中文摘要...............................................................................................................III
Abstract..............................................................................................................IV
目錄...................................................................................................................V
表次...................................................................................................................VIII
圖次...................................................................................................................IX
第一章文獻整理..........................................................................................................1
1.1南瓜子..............................................................................................................1
1.2電漿(Plasma)介紹.....................................................................................................2
1.3功效性成分...........................................................................................................6
1.3.1γ-胺基丁酸（γ-aminobutyric acid, GABA).............................................................................6
1.3.2 麩胺酸(Glutamic acid).............................................................................................9
1.3.3血清素(Serotonin)..................................................................................................10
1.3.4色胺酸(Tryptophan).................................................................................................13
1.3.5 酪胺酸(Tyrosine)..................................................................................................16
1.4憂鬱症(Depression)之定義..............................................................................................16
1.4.1躁鬱症(Bipolar disorder)...........................................................................................18
1.5 自由基..............................................................................................................19
1.5.1自由基（free radicals）的定義.......................................................................................19
1.5.2活性氧的定義 .......................................................................................................20
1.5.3自由基與活性氧來源..................................................................................................20
1.5.4氧化壓力的形成......................................................................................................21
1.5.5抗氧化防禦能力......................................................................................................22
1.6高血壓...............................................................................................................27
1.6.1高血壓簡介.........................................................................................................27
1.6.2高血壓的分類.......................................................................................................29
1.6.3血管收縮素轉化酶(ACE)與高血壓的關係..................................................................................29
實驗大綱................................................................................................................31
不同機能性素材...........................................................................................................31
第二章、探討素材不同處理及不同發芽條件之功效性成分分析之比較..................................................................32
2.1前言.................................................................................................................32
2.2材料與方法............................................................................................................33
2.2.1實驗儀器............................................................................................................33
2.2.2實驗藥品............................................................................................................33
2.2.3藥品配製............................................................................................................34
2.2.3.1.機能性成分萃取...................................................................................................34
2.2.3.2HPLC標準品配置....................................................................................................34
2.2.3.3HPLC溶液.........................................................................................................34
2.2.3.4 GABA、色胺酸、酪胺酸、麩胺酸分離條件：.............................................................................34
2.2.3.5 Serotonin分離條件：..............................................................................................35
2.2.4樣品製備...........................................................................................................35
2.2.5機能性成分處理......................................................................................................35
2.2.5.1種子不同處理方法之機能性成分比較....................................................................................35
2.2.5.2不同處理條件之發芽南瓜子機能性成分比較...............................................................................36
2.2.6功效性成分分析......................................................................................................37
2.3統計分析.............................................................................................................40
2.4結果與討論...........................................................................................................40
一、功效性成分...........................................................................................................40
第三章 探討素材之抗氧化能力與ACE抑制效果...................................................................................44
前言...................................................................................................................44
3.1材料方法.............................................................................................................45
3.1.1實驗儀器...........................................................................................................45
3.2實驗藥品.............................................................................................................45
3.3藥品配置.............................................................................................................45
3.3.1 DPPH配製.........................................................................................................45
3.3.2 ABTS配置.........................................................................................................45
3.3.3 ACE..............................................................................................................46
3.4抗氧化分析...........................................................................................................46
3.4.1總酚..............................................................................................................46
3.4.2總類黃酮...........................................................................................................46
3.4.3自由基清除能力測定(DPPH)............................................................................................46
3.4.4清除(2,2’-azinobis[3-ethylbenzothiaziline-6-sulfonate]）(ABTS).....................................................47
3.5血管收縮素(ACE)抑制能力................................................................................................ 48
3.6統計分析..............................................................................................................49
3.7結果與討論............................................................................................................49
一、抗氧化分析...........................................................................................................49
1.樣本之總酚.............................................................................................................49
2.樣本之自由基清除能力(DPPH)..............................................................................................50
3.樣本之總類黃酮.........................................................................................................51
4.樣本之清除 ABTS 自由基能力測定..........................................................................................51
二、血管收縮素(ACE)抑制能力...............................................................................................52
結論....................................................................................................................54
參考文獻.................................................................................................................55

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