(34.231.21.123) 您好!臺灣時間:2019/11/15 20:17
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
本論文永久網址: 
line
研究生:蔡智揚
研究生(外文):Chi-yang Tsai
論文名稱:從性別、年齡動態網路研究疾病併發症
論文名稱(外文):Research disease complication from gender and age dynamic disease network
指導教授:吳立青
學位類別:碩士
校院名稱:國立中央大學
系所名稱:系統生物與生物資訊研究所
學門:生命科學學門
學類:生物訊息學類
論文出版年:2015
畢業學年度:103
語文別:英文
論文頁數:36
中文關鍵詞:疾病網路動態網路偏度檢定因果關係
相關次數:
  • 被引用被引用:1
  • 點閱點閱:104
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:10
  • 收藏至我的研究室書目清單書目收藏:0
  此研究是從性別、年齡的疾病動態網路研究疾病併發症,每個疾病發生可能會隨著年紀的增加或者性別的影響而有所不同,我們利用這動態的網路圖去了解在每個年齡層的男女生分別會有甚麼併發症的出現。而人之所以會生病不光只是某個病的病發,有可能因為本身自己有得過甚麼病而影響另一個病的出現。所以利用McNemar's test觀察兩疾病間是否有關係,以及skewness test觀察兩疾病間的方向性。
  而男生要注意生殖器的清潔,這將會影響自己在未來會不會得更多關於生殖泌尿系統的疾病。隨著年紀的增加,男生在中年期會有攝護腺增生的疾病出現,而月經的問題會一直困擾著女性,直到老年期之後問題才會有所改善,但卻會有停經之後的問題存在。

This research is to look into complications through dynamic disease network of gender and age, every occurrence of disease may be affected by the differentials of age or gender. Use this dynamic network to show varied complications among all age within each gender. An emerge of a certain disease may be more than a complication of another disease, previously gotten diseases may lead to its emergence. Therefore, we applied McNemar's test to observe correlations between each disease, and skewness test to obtain theirdirection.
The cleaning of male genital organ requires attention, it has impacts upon the occurrence of genital organs related diseases in the future. As age increases, male may have benign prostatic hyperplasia related diseases at mid ages. While menstruated issues have always been a concern of female's, not until old ages will these problems be solved, yet elders have to deal with amenorrhea.

Chinese Abstract i
English Abstract ii
Table of Contents iv
List of figures vi
List of tables vii
Chapter 1 Introduction 1
1-1 Background 1
1-2 Motivation 2
Chapter 2 Material and methods 2
2-1 Material 2
2-1-1 Medical record 2
2-1-2 ICD-9-CM codes 3
2-2 Methods 4
2-2-1Hypothesis 4
2-2-2 McNemar's test 4
2-2-3 Skewness test 6
2-2-4 Odd ratio 6
2-3 Data processing 7
Chapter 3 Results 10
3-1 Medical division 10
3-2 Age 11
3-3 Gender 12
3-4 Focus on disease 13
3-5 Case study: genitourinary system 15
Chapter 4 Discussion 22
References 23

1. Yancik R, Ries LAG. Cancer in the aged: an epidemiologic perspective on treatment issues. Cancer 1991; 68 (Suppl): 2502–10.
2. Elston, R.C., J.M. Olson, and L. Palmer, Biostatistical genetics and genetic epidemiology. Wiley reference series in biostatistics. 2002, Chichester,England ;: New York, NY Wiley. xxiv, 831 p.
3. Fleiss, J.L., B.A. Levin, and M.C. Paik, Statistical methods for rates andproportions. 3rd ed. Wiley series in probability and statistics. 2003,Hoboken, N.J.: J. Wiley. xxvii, 760 p.
4. Vanunu, O., et al., Associating Genes and Protein Complexes with Disease via Network Propagation. PLoS Computational Biology, 2010. 6(1): p.e1000641
5. Goh, K.-1., et al., The human disease network. PNAS, 2007. 104(21): p.8685-8690.
6. Buck, C.J., 2001 ICD-9-CM, volumes 1, 2, and 3. 2003.
7. OSVOLL, P.O. and T. WOLDBaK, Distribution and skewness of occupational exposure sets of measurements in the Norwegian industry. Elsevier Science Ltd, 1999. 43(6): p.421-428.
8. Kraemer, H.C., Reconsidering the odds ratio as a measure of 2x2 association in a population. Stat Med, 2004. 23(2): p.257-70
9. Knapp, R.G. and M.C. Miller, Clinical epidemiology and biostatistics. National medical series for independent study. 1992, Malvern, Pa; Baltimore London : Harwal Pub. Co; Williams &Wilkins.Xi, 435p.
10. Wassertheil-Smoller, S., Biostatistics and epidemiology : a primer for health and biomedical professionals. 3rd ed. 2004, New York: Springer-Verlag. Xvi, 243p.
11. Oliva, R., Novials, A., Sanchez, M., Villa, M., Ingelmo, M., Recasens, M., Ascaso, C., Bruguera, M., Gomis, R. The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2. Endocrine 24: 111-114, 2004.
12. Douglas, A. S., et al. (1991). Composition of Seasonality of Disease. Sage journals 36 no. 3: 76-82.
13. Yildirim, M. A., et al. (2007). "Drug-target network." Nat Biotechnol 25(10): 1119-1126.
14. Carl R, Tom SC, Mark WJ, et al.: Diabetic Retinopathy. In: AAO, ed. Retina and Vitreous. San Francisco, American Academy of Ophthalmology, 2007:99-119.

連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔