臺灣博碩士論文加值系統

　　(一)二苯妥因(Diphenylhydantoin)為目前常用的抗痙攀劑(Anticonvulsant)。本研究以類似於二苯妥因之基本構造之硫代乙內醯(thiohydantoin)為出發物進行氮及硫上的烷基化反應(alkylation)，合成具有鎮靜及抗痙攀的效果，並降低副作用，在本研究總共合成了16個新化合物。
　　(二)丁香油中丁香酚之核磁共振光譜定量分析法
　　丁香油(Clove Oil)主要的成分為丁香酚，其含量79∼95%，因各地所產的主含量有異，需要尋找一個準確、快速而方便的定量方法。
　　氫核磁共振光譜定量分析法，以乙醯苯為內標準，碳13核磁共振光譜定量分析法以氯仿為內標準，並且加入0.1M Cr(acac)3當作緩和劑以節省時間，將此結果與氣相層析分析結果908%(W/W)，標準偏差0.7%和化學方法分析結果89.6%(W/W)，標準偏差1.2%比較，氫核磁共振光譜定量分析的結果90.4%，標準偏差0.3%，時間20分鐘碳13核磁共振光譜定量分析結果含量90.5%，標準偏差0.7％，時間2-3小時，氣相層析儀和氫核磁共振光譜定量分析都是迅速、精確的方法。

　　(1)Diphenylhydantoin has been used as anticonvulsant rug for many years, but it has many side effects.
　　In order for a systematical investigation the corelation between anticonvulsive activity and structure, ixteen new compounds have been synthesized. In hope, the nticonvulsive effects of the new compounds will be improved.
　　Derivatives of 5,5-diphenyl-2-thiohydantoin(A) (R1,%) (yield), mpoc): 1(propyl, H,155-156); 2 (isopropyl, 88.2, 142-143);3 (amy1, H,75.2, 200-201); 4 (methy1, propy1, 5,3, 91-92); 5 (methy1, isopropy1, 79.3, 165-166); 6 (methyl, 11y1, 79.8, 198-199); 7 (methy1, buty1, 85.0, 93-94); 8 (methy1 my1, 74.0. 195-196); 9 (methy1, isoamy1, 73.9, 81-82); 10 isoamy1, methy1, 79.2, 154-155).
　　Derivatives of 5,5-Di-p-toly1-2-thioh-dantoin (B) R1,R2,%, mpoC); 11 (isopropy1,H,89.8, 158-159); 12 (buty1, 82.8, 100-101); 13 (amy1, H,76.4, 129-139); 14 (isoamy1, H,2.7, 121-122); 15 (methy1, ethy1, 865.4, 134-135); 16 (methy1, soamy1, 83.2, 106-107).
　　(2)A procedure utilizing NMR spectrometry in the quantitative analysis of eugenol in clove oil is described. The 1H-NMR spectrum is determined with acetophenone as internal standard and the 13C-NMR spectrum is determined with chloroform and o.IM of cr (acac)3 as relaxation reagent. The contents of eugenol are compared to the results obtained from G.C. (90.8%, s.d. 0.7%) and from chemical method (89.6% s. d. 1.2%).
　　The result obtained from 1H-NMR method is 90.4% (s.d.0.3%) and from 13C-NMR method is 90.5% (s.d.0.7%). The time required for the 1H-NMR method is about 20 minutes. For the 13C-NMR method is about 2-3 hours.
　　Apparently, G.C. and 1H-HMR methods prove to be rapid and accurate.