臺灣博碩士論文加值系統

為了探討Furo[2,3-b]quinolin-4-one衍生物的生理活性,以合成的
方法合成了F. N. Lahey 和 M. Mc Camish 所發表 Acrophyllidine 的
結構化合物,所合成的產物其光譜數據與原文獻 Acrophyllidine 的敘述
相符合,因此,這生物鹼的的原始結構是正確的.另外也合成一系列的衍生
物,以供藥理之篩選。
對合成所得的化合物做藥理活性評估，包括肥大細胞去顆粒化作用，
中性白血球超過氧化物形成作用及抗血小板凝集作用等試驗。在這些試
驗中發現化合物 11 [ ethyl 2-( 3'-hydroxyanilino )-4-oxo-4,5-
dihydrofuran-3-carboxylate ] 是最有希望做為新抗發炎藥的結構原形。

In order to examine the biologic activities of Furo[2,3-b]-
quinolin-4-one derivatives , a synthesic approach to the
structure reported for Acrophyllidine by F. N. Lahey and M.
Mc.Camish was carried out . The spectral data of the syntheic
product were identical with those described previouly for
Acrophyllidine,thus, the original structure of this natural
alkaloid should be correct.
The synthetic compounds were evaluated its activity by mast
cell degranulation test, neutrophil degranulation test, neutro-
phil superoxide formation test and antiplatelet aggregation test
Among those tested compound 11 [Ethyl 2-(3'-hydroxyanilino)-4-
oxo-4,5-dihydrofuran-3-carboxylate] was the most promising agent
which could provide a novel structural prototype to antiinfla-
mmatory agents.