臺灣博碩士論文加值系統

近來本研究室所合成之 4,8-Dihydrobenzo[1,2-b:4,5-b']dithio-
phene-4,8-diones 對 KB cell，HCT-8，MCF，P-388 與 L-1210 等多種
cell lines 呈現極佳的細胞致毒活性。
為了探討並尋找 4,8-Dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-
diones 與 4,8-Dihydrobenzo[1,2-b:4,5-b']dithiophene-4,8-diones 兩
類衍生物之構效關係(SAR)，合成了一系列的 Methyl-4,8-dihydrobenzo
[1,2-b:5,4-b']dithiophene-4,8-dione 及其衍生物。此等化合物之結構
分別以化學及光譜等方法所確認。
所合成之產物，其藥理活性篩選之測試尚在進行當中;然而本所往昔所
合成之生物等價異構物具有之良好活性，或許可望亦有樂觀的結果。

Recently, a series of 4,8-dihydrobenzo[1,2-b:4,5-b']dithio-
phene-4,8-diones were synthesized and exhibited excellent cyto-
toxity for such cell lines as KB cell, HCT-8, MCF, P-388 and
L-1210 and so on.
In order to search for the SAR between 4,8-dihydrobenzo[1,2-
b:5,4-b']dithiophene-4,8-diones and 4,8-dihydrobenzo[1,2-b:4,5-
b']dithiophene-4,8-diones, the methyl-4,8-dihydrobenzo[1,2-b:5,4-
b']dithiophene-4,8-dione derivatives were synthesized. The struc-
tures of these compounds were fully identified chemically and
spectrally.
The pharmacological screening tests of these synthetic com-
pounds are still in progress; however, their bioisosteric com-
pounds have been shown significant activity, we expect the
results.