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研究生:梁楊鴻
研究生(外文):Liang,Yang-Hung
論文名稱:鉛對小白鼠嗜中性白血球功能之行影響
論文名稱(外文):Effects of Lead Acetate on the Functions of Mouse Peritoneal
指導教授:蕭水銀蕭水銀引用關係
指導教授(外文):Shoei-Yn Lin-Shiou
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:毒理學研究所
學門:醫藥衛生學門
學類:其他醫藥衛生學類
論文種類:學術論文
論文出版年:1993
畢業學年度:81
語文別:中文
論文頁數:70
中文關鍵詞:
外文關鍵詞:neutrophilpkCNADPH oxidase.
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  本研究目的在於試管內及小白鼠體內試驗醏酸鉛(Pb acetate)對腹
腔中性白血球(PMN)功能之影響,結果發現鉛(10-250μM)對 fMLP 促
進PMN Superoxide 產生之作用有明顯抑制。另外,醏酸鉛( 1500 ppm)
於飲水中餵小白鼠六星期,結果明顯增加 fMLP 促進 PMN Superoxide 之
產生,此作用與其增加 protei kinase C 活性及抑制 protein
phosphatase 活化有一致作用,此發現與前人認為 PMN 之 NADPH
oxidase 活化必須經內protein phosphorylation 之觀念一致,因此鉛對
動物體內第一道防禦細胞(PMN)之功能確實有影響。

The purpose of this study was aimed at the investigation of the
possible action mechanisms of Pb accetate on the superoxide
generation of mouse peritoneal neutrophils (PMN). The in-vitro
study, Pb at low concentration (1μM) significantly enhanced
PMA-induced superoxide generation but at high concentration
(10-250μM) inhibited fMLP-action. Although phosphatase
inhibitors (Okadaic acid and microcystine) as well as
cytochalesin B augmented superoxide generation, Pb (3.5μM) did
not show any interaction with them.  The in-vivo study, Pb
acetate (1500 ppm in drinking water) admini- stration for a
short period of either 2 weeks or 6 weeks, significantly
enhanced superoxide generation, coupled with increased PKC and
decreased phosphatase activities of the treated mouse
peritoneal PMN. This result agrees with the current working
hypothesis of the important role of protein phosphorylation in
the activation of NADPH oxidase. The reduced harvest of
peritoneal PMN from the Pb treated mice was evidently related
to the decreased chemotactic and migration ability of PMN which
was suspected to be due to the release of tumor necrosis factor
from PMN induced by Pb. Zn acetate was proofed in this study as
an antidote fo Pb acetate in vivo.

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