本篇報告是利用神經性發炎引發血漿外滲的特性，來研究大鼠單側迷走神
經切除，經0,1,3,7及14天後，對於辣椒素及物質P誘發支氣管神經性發炎
影響之時程研究。取約三個月大的大鼠，以手術破壞位於頸總動脈的左、
或右側迷走神經，經過0,1,3,7及14天等不同的時間後，再以股靜脈注射
辣椒素或物質P，誘發呼吸道神經性發炎，並以單星藍當追蹤染劑，標定
Whole mount 標本中發炎組織部位的小靜脈，然後經顯微拍照製成相片，
以點數計數分式作形態計量分析；另以伊氏藍當染劑，並以 formamide萃
取染劑，於 620 nm 波長下測吸光度，以便量化發炎程度。另外以
glycol methacrylate 包埋支氣管，作切片、PAS 染色，作組織病理學研
究。實驗結果顯示：在單星藍標識血管之形態計量分析及伊氏藍標定血漿
之生化分析中，在單側迷走神經切除經0,1,3,7及14天後，以辣椒素刺激
引發支氣管之神經性發炎，對手術同側的肺葉支氣管之發炎反應而言，分
別有減小之趨勢；而以物質 P 所引發之血漿外滲，在左、右肺葉支氣管
則無明顯的差異。此外，由切片觀察可知：杯狀細胞在切除迷走神經當天
，有去顆粒現象出現，而未手術側的主支氣管有較多的杯狀細胞出現明顯
的去顆粒現象。故切除大白鼠單側的迷走神經，可以選擇性的減低肺葉支
氣管神經性發炎，尤其是在左內側次級支氣管與右第三次級支氣管。

The present paper was designed to study the effect of
unilateral vagotomy on plasma extravasation in the lobar
bronchi of rats. Sprague - Dawley rats of 3 months of age were
subjected to left- or right-side vagotomy at level of common
carotid artery. The rats were allowed to survive for 0,1,3,7
and 14 days and neuro- genic inflammation in respiratory tract
was provoked by an intravenous injection of capsaicin, 90 ug/kg
or substance P, 3 ug/kg. The magnitude of neurogenic
inflammation was expressed as area percentage of Monastral blue-
labeled blood vessels of total mucosal surface area evaluated
in lobar bronchial whole mount by sterological point counting.
Besides, spectrophotometer was used to calculate the
concentration of the Evans blue. Finally, bron- chial tissues
blocks were embeded with glycol methacrylate and stained with
Alcian blue-Periodic acid Schiff reagent for histopathological
study. The degree in neurogenic inflammation induced by
capsaicin tended to decrease at the first few days after
vagotomy. Besides, the magnitude of the plasma extravasa- tion
in lobar bronchi of vagotomized side was smaller than that of
the unoperated side. In addition, on vagotomy side of lobar
bronchi,goblet cells didn't degranulate and intercellular
spaces were not dilated. These were not observed on the
unoperated side. While induced with substance P,the magnitude
of the neurogenic inflammation were not significantly
difference between trachea and lobar bronchi.It was suggested
that unilateral vagotomy could selectively inhibit neurogenic
inflammation in the ipsilateral lobar bronchi.