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The current study was designed to investigate the effect of
excipients on the dissolution stability of naproxen capsules.
Twenty formulations were stored in four different circumstances
(25℃ 27%RH, 25℃ 97%RH, 55℃ 27%RH and 55℃ 97%RH) for one
month. Some formulations contained soluble excipents, showed
very large change in dissolution profile after storage in 55℃
and 97%RH for one month. Formulations contained mannitol and
dibasic calcium phosphate showed less change because mannitol
and dibasic calcium phosphate are not hydroscopic. Formulations
contained starch, microcrystalline cellulose, and
methylcellulose 4000 cps also showed less difference in
dissolution after this storage because of their disintegrant
properties. In conclusion, considering dissolution stability of
the drug, we should choose excipients with nonhydroscopic or
disintegrant properties. In the other study, zinc sulfadiazine
cream was administered to the injured and uninjured ears of six
rabbits by a cross-over experimental design. We could conclude
that zinc sulfadiazine will become zinc and sulfadiazine after
they enter bodies, and the absorption of zinc sulfadiazine is
related to whether the skin is injured or not.
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