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研究生:余文雯
研究生(外文):Wen Wen Yu
論文名稱:不同處理之精白米在有或無外源性膽固醇下對大白鼠脂質代謝的影響
論文名稱(外文):The different treatment of polished rice and with or without exogenous cholesterol influence on lipid metabolism in rats
指導教授:謝明哲;鄭心嫻
指導教授(外文):Ming Jer Shieh;Hsing-Hsien Cheng
學位類別:碩士
校院名稱:台北醫學院
系所名稱:藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:1994
畢業學年度:82
語文別:中文
論文頁數:4
中文關鍵詞:難消化澱粉膽固醇抗生素脂質代謝大白鼠
外文關鍵詞:RiceResistant starchCholesterolAntibioticsLipid metabolismRats
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本研究的目的是探討生米、烹煮米及儲存米三種之不同處理的精白米中難
消化澱粉在有或無添加外源性膽固醇下,對大白鼠脂質代謝的影響,並探
討添加抗生素抑制大白鼠腸中之發酵作用是否會影響大白鼠脂質的代謝。
實驗Ⅰ是將雄性Wistar隨機分成八組,分別餵予添加或不添加1%膽固醇的
玉米澱粉、生米、烹煮米及儲存米飼料。實驗Ⅱ將大白鼠分成四組,添加
或不添加抗生素及添加或不添加膽固醇的儲存米飼料。實驗進行四週後,
分析血清三酸甘油酯(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇 (HDL-
C) 及低密度脂蛋白膽固醇(LDL-C) ,肝臟之三酸甘油酯及總膽固醇,以
及糞便難消化澱粉、總中性固醇與總膽酸含量。實驗Ⅰ結果顯示,在添加
膽固醇情形下,烹煮米組及儲存米組均可抑制血清LDL-C 濃度、肝臟 TC
含量的上升 (p﹤0.05),可增加糞便總中性固醇每日排出量 (p﹤
0.05)。糞便中難消化澱粉含量為烹煮米組及儲存米組大於生米組。在無
添加膽固醇情形下,烹煮米組及儲存米組可降低血清LDL-C 的濃度。血
清 TG、HDL-C 濃度,肝臟TC、TG含量及糞便排出總中性固醇與總膽酸,
各組間無顯著差異(p>0.05) 。實驗Ⅱ結果顯示,儲存米組添加抗生素,
使血清 LDL-C 濃度、肝臟中 TC 含量上升(p﹤0.05) ,糞便中難消化澱
粉含量明顯增加(p﹤0.05) 。由以上結果得知,在添加膽固醇下,烹煮米
及儲存米抑制大白鼠體內TC、TG含量上升的效果比生米好,在無添加膽固
醇下效果比較不明顯。儲存米組添加抗生素抑制大白鼠腸中之發酵作用後
,儲存米抑制大白鼠體內TC、TG含量上升的效果降低。

The purpose of this study was to investigate resistant
starch in the diffferent treatment of polished rice and
with or without exogenous cholesterol influence on lipid
metabolism in rats and investigate whether or not the
fermentation in hind-gut of rats inhibited by antibiotics
added would be influence on lipid metabolism in rats. In
experiment Ⅰ, male wistar rats were randomly divided into
eight groups. The eight groups include corn starch diets(+C,
-C), raw rice diets (+R, -R), cooked rice diets (+P,-P) and
cook-stored rice diets(+S, -S) and with or without added 1%
cholesterol. In experimentⅡ, male wistar rats were randomly
divided into four groups. The four groups included cook-
stored rice diet with ( +SA, -SA ) or without (+S,-S) anti-
biotics and with or without added 1% cholesterol. Rats were
sacrificed affter four-week feeding, and artery blood, liver
and feces were collected. Analytical items included serum
triglyceride (TG), total cholesterol (TC), HDL-cholesterol
(HDL-C), LDL-cholesterol (LDL-C), liver triglyceride and
total cholesterol, fecal neutral steroids and bile acids.
The result of experiment Ⅰ show that +P and +S had lower
serum LDL-C level, liver TC content than +C ( P<0.05 ). +P
and +S had higher fecal neutral steroids content than +R (
P<0.05). +P and +S had higher fecal resistant starch content
than +R (P<0.05 ). -P and -S had lower serum LDL-C level
than -C. Serum TG and HDL-C, liver TC, TG and fecal neutral
steroids, bile acids were no significant different between
-C, -R, -P and -S. The result of experimentⅡ show that cook
-stored rice diet with antibiotics had higher serum LDL-C
level and liver TC content than cook-stored diet without
antibiotics. Cook-stored rice diet with antibiotics had
higher resistant starch content than Cook-stored rice diet
without antibiotics(P<0.05).

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