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研究生:李純青
研究生(外文):Lee Chun Ching
論文名稱:加味小柴胡湯對慢性C型肝炎之療效評估
論文名稱(外文):Assessement of the effect Supplemented Minor Bupleurum Decoction (jia wei xiao chai hu tang)in the treatment ofchronic Hepatitis C
指導教授:林昭庚林昭庚引用關係
指導教授(外文):Jaung-Geng Lin
學位類別:碩士
校院名稱:中國醫藥學院
系所名稱:中國醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:1995
畢業學年度:83
語文別:中文
論文頁數:70
中文關鍵詞:慢性C型肝炎加味小柴胡湯干擾素多聚合鋂鏈反應
外文關鍵詞:Chronic hepatitis cJia wei xiao chai hu tangInterferonePCR
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慢性C型肝炎由於預後較差,易形成肝硬化及肝癌,故需積極謀求治療之法。現行最有效之方法為干擾素治療,然療效並不佳,且費用昂貴,具有副作用。因而本研究以加味小柴胡湯治療慢性 C 型肝炎,並評估ALT、AST、HCV RNA、HCV Ab 及臨床症狀,且比較其副作用及價格,以了解取代干擾素治療之可能性。
本研究從中國醫藥學院附設醫院肝膽科門診病人中篩選合乎「慢性 C型肝炎」診斷標準之志願者作為研究對象。其中實驗組十例,給予加味小柴胡湯六個月治療;對照組十二例,注射干擾素治療六個月後進行比較。經 Wilcoxon Rank Sum Test 及 Oddsratio 等統計分析後顯示:加味小柴胡湯能改善慢性 C 型肝炎臨床症狀,未出現注射干擾素後之副作用,價格便宜且能降低 ALT、AST 值。然在 ALT、 AST 降至正常範圍比例上及清除 HCV RNA 之效果上不如干擾素治療,因而加味小柴胡湯不能有效取代干擾素治療。由於本研究尚屬初報,雖初步顯示不能有效取代干擾素之治療,但在臨床上亦有其治療作用。故適當加入專一性抗病毒藥物,以增強其清除 HCV RNA 的功能,將是一值得發展的方向,有進一步研究的必要,以開創中醫藥治療慢性C型肝炎之新途徑。

For years, it has been of much interest and value to many identify methodology for curing chronical C hepatitis, for this disease is likely to turn into cirrhosis or hepatoma due to low expectation of curability. Of all known medication for chronical hepatitis C, the injection of interferone has been shown to be the most effective. The outcome, however, is still not satisfactory. Besides, it is costly and has side effects. This study seeks the curing power of "jia wei xiao chai hu Tang" on chronical C type hepatitis. This study also assesses the level of ALT, AST, HCV RNA, HCV Ab, and the clinic symptom, and compares the side effects and costs in order to identify the possibility of a substitute to interferone. The test group for this study was selected from the volunteered patients, who were most qualified, for China Medical College Hospital. Ten patients as the test group were given " jai wei xiao chai hu Tang" for six months. Another twelve patients as the control group were injected interferone for the same period. The results, analyzed through Wilcoxon Signed Rank Test and Odds ratio, show that "jai wei xiao Chai hu Tang" is able to improve clinical symptom of chronical C hepatitis, and the side effects do not appear in the medication. Besides, it reduces the level of ALT and AST, and it costs less. However, the effectiveness in the reduction of the level of ALT and AST to normal range and the effect of clearing-up of HCV RNA is not as powerful as using interferone. This preliminary report shows that although (jia wei xiao chai hu tang) cannot substitute interferon, it does nevertheless have it clinical effect.if it is to be developed, agents that address the virus and eliminate HCV RNA function must be incorporated into it. Further research is necessary if a new Chinese medical approach to the treatment of chronic Hepatitis C is to be created

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