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研究生:陳文秀
研究生(外文):Wen-Shiow Chen
論文名稱:中西藥合併治療葛雷佛斯病(Graves'Disease)之臨床療效評估
論文名稱(外文):An Evaluation of the Clinical Efficacy of Chinese-Western Integrated Treatment of Graves' Disease
指導教授:陳榮洲陳榮洲引用關係
指導教授(外文):Jung-Chou Chen
學位類別:碩士
校院名稱:中國醫藥學院
系所名稱:中國醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:1995
畢業學年度:83
語文別:中文
論文頁數:36
中文關鍵詞:甲狀腺機能亢進葛雷佛斯病天王補心丹丹梔逍遙散
外文關鍵詞:HyperthyroidismGraves' diseaseDan Zhi Xiao Yao SanTian Wang Bu Xin Dan
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葛雷佛斯病( Graves' Disease )是造成甲狀腺機能亢進最常見的原因,而甲狀腺機能亢進乃是由於過多的血中游離甲狀腺荷爾蒙造成的綜合症候群,臨床病案甚多。由於症候複雜,復發率高,故受其困擾者為數不少。
本研究之目的即運用中醫辨證論治模式,配合少量西藥,把中西醫之長處集合在一起尋求治療學上的進一步突破。本研究分兩組,其一為中藥加西藥治療實驗組,另一為西藥治療對照組,定期評估其甲狀腺功能及 TSH receptor Ab(TRAb)。研究對象中實驗組病人來源,以民國82年7月至民國84年3月間在中國醫藥學院附設醫院中醫內科甲狀腺特別門診患者為研究對象,對照組病人則以西醫內科甲狀腺特別門診的患者為比較對象。其中實驗組有31例,其辨證分型及治療模式為:肝鬱化火型有15例,治方為丹梔逍遙散;氣陰兩虛型有16例,治方為天王補心丹。三個月為一療程,總共三個療程,經過治療之後,比較實驗組與對照組的治療結果,前者的 TRAb 血中濃度出現較明顯的降低,並呈現統計學上的差異 (p<0.05),所以顯示中藥加西藥比單純使用西藥者更有效地降低血中 TRAb 之濃度。

Graves' disease is the most commonly observed from of hyperthyroidism, a well-recorded syndrome caused by excessive free circulating thyroid hormones. The complexity of signs (symptoms) and hign rate of recurrence create numerous difficulties. It this study, the effectiveness of treatment combining the advantages of Chinese medicine based on traditional Chinese diagnosis with Western medical therapy was compared with simple Western medical treatment. The study divided subjects into two groups, a study group given Chinese combined with Western medical medication, and a control group give only Western medical therapy (Methimazole). Thyroid function and TSH receptor Ab (TRAb) were regularly assessed. The study study group subjects were outpatients who visited the Thyroid Unit of the Department of Internal Chinese Medicine of China Medical Hospital between July 1993 and March 1994. The subjects of the control group were outpatients visiting the corresponding unit of the Department of Internal Western Medicine over the same period. The subject group comprised 31 patients, 15 of whom were classified as "depressed liver transforming into fire" (gan yu hua huo) and treated with Dan Zhi Xiao YaoSan (Moutan and Gardenia Free Wanderer Decoction), and 16 of whom were classified as "dual vacuity of qi and yin" (qi yin liang xu) and treated with Tian Wang Bu Xin Dan (Celestial Emperor Heart-Supplementing Elixir). Each patient was given three month courses of treatment. After the treatment, the TRAb of the studyy group compared with that of the control group showed more obvious reduction, and the statistical difference (p<0.05) existed. Therefore, the results showed that the Chinese medical treatment combined with Western medical treated was more effective than simple Western medical treatment in reducing TRAb

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