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研究生:羅崇誠
研究生(外文):Lo.Chung-Cherng
論文名稱:犬實驗以Warfarin誘導中毒和Vit.K1治療之研究
論文名稱(外文):Studies on the experimentally induced warfarin poisoning and therapy with vitamin K1 in dogs
指導教授:曾秋隆曾秋隆引用關係
指導教授(外文):Chan Chauo Long
學位類別:碩士
校院名稱:國立中興大學
系所名稱:獸醫學系
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:1995
畢業學年度:83
語文別:中文
論文頁數:97
中文關鍵詞:華福林中毒抗凝血劑華福林可邁丁
外文關鍵詞:warfarin poisoninganticoagulantwarfarinCoumarin
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 本論文目的在犬隻以華福林(warfarin)殺鼠劑誘導急慢性中毒,和其部
份犬隻對維生素K1治療反應在臨床學、血液學、血液化學和止血障礙之研
究。 warfarin誘導犬隻主要的臨床症狀包括血痢便、粘膜蒼白、皮膚紫
斑、流鼻血、發燒、牙齦和鞏膜出血。死亡病例犬每天最高平均體溫有比
恢復犬要高。warfarin誘導期間,所有誘導犬隻的紅血球數、血紅素量與
血容比值皆有下降。死亡病犬白血球總數高,相對地,恢復期病犬則較低
。在誘導早期血小板數下降不明顯,根據本實驗,給予warfarin期間或總
劑量越多,血小板下降越明顯。在warfarin誘導慢性中毒犬隻,麩胺酸丙
酮酸轉氨(ALT) 其值呈現暫時性升高,而天門冬酸轉氨(AST) 值呈現
持續性稍高值,然而血中尿素氮(BUN) 和鹼性燐(ALP)無明顯變化。以
最高warfarin 劑量誘導急性中毒犬隻,有明顯較高肝腎功能血清生化測
試值。總血清蛋白質顯著性降低,相對照於纖維素原值呈現高值,於幾乎
所有末期warfarin誘導犬隻,除了急性中毒犬隻低纖維素原值外。在止血
障礙測試方面,以warfarin 誘導中毒犬隻於第3天內,凝血原時(PT)和
部份形成血栓質時間(APTT)有顯著性延長,無維生素K1處理犬隻,在本實
驗中於warfarin停止誘導後,顯示出至少抑制維生素K1依靠因子6∼9天。
除此外,死亡病例犬隻在病理學上發現,可出血在身體各部份為特徵,尤
其是胃腸道和肌肉出血及多處血腫。而死亡病例犬隻,組織學病變上可發
現肝小葉出血和退行性變化。另一方面,死亡病犬尿液分析呈現蛋白尿、
酮尿和潛血反應。在本實驗warfarin 單一致死劑量是每公斤體重100-150
mg,然而急性的warfarin中毒,能夠在warfarin誘導3天後成功地治療,
以每公斤體重 5mg維生素K1每天單次劑量連續6天皮下注射。
The purposes of this research were designed to observe the
clinical, hematology, blood-chemistry and hemostatic disorders
with warfarin anticoagulant induced acute and chronic poisoning
as well as partial their response to vitamin K1 therapy in
dogs. The major clinical signs were observed in warfarin
induced dogs including bloody diarrhea, mucous membrane pallor,
purpur of the skin, epistaxis, fever, gingival and scleral
hemorrhage. The daily highest average body temperature of the
succumbed dogs had higher than that of the during the warfarin
induced period. The WBC counts were high in the succumbed dogs,
on the contrary, the lukocyte counts lower than in the
convalescence stage. Platelet was not apparently decreased with
warfarin inducing as early period, according to thes
experiment, the more durations or dosage of feeding warfarin
were given, the more platelet counts deccreasing were noted.
The values of ALT were tentative elevated, but AST presented
persistently with mild high values, whereas BUN and ALP values
were not apparently changed with warfarin induced chronic
poisoning in dogs. In hemostatic disorders testing, values of
PT and APTT were remarkable prolonged in warfarin induced
poisoning dogs within the third day. Besides, the pathological
findings of the succumbed cases were characterized by bleeding
from any body parts, and above all, the gastrointestinal tract
and muscle haemorrhage as well as multiple haematoma. The
histopathological findings of the succumbed cases were
presemted haemorrgage and degeneration changed in the liver
lobules. On the other hand, urinalysis of the succumbed dogs
were presented with proteinuria, ketonuria and occult blood
positive reaction.
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