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研究生:莊峻毅
論文名稱:使君子果實及印度人莧之鞣質與相關化合物之研究
論文名稱(外文):Studies on the Tannins and Related Compounds from Quisqualis indica Linn. and Acalypha indica Linn.
指導教授:徐鳳麟徐鳳麟引用關係
學位類別:碩士
校院名稱:台北醫學大學
系所名稱:藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:1995
畢業學年度:83
語文別:中文
論文頁數:129
中文關鍵詞:君子果實印度人莧
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近年來,由於單寧化學的發展,導致其新的生物活性的發現,使得單寧在醫療用途上倍受注目。因此,本論文以天然藥物資源之開發為目的,對使君子之果實及印度人莧進行化學研究,探索其所含之單寧及其相關的化合物。
 使君子為使君子科植物,原產於熱帶的印度及東南亞,種子在民間曾用作驅虫及治療消化性障礙。經由各種管柱層析,縱使君子之果實純化出七個化合物,其結構分別確認為protocatechuic aldehyde (1)、protocatuic acid (2)、gallic acid (3)、brevifolin carboxylic acid (4)、1-O-galloyl-β-D-glucose (5)、2, 3-hexahydroxydiphenoyl-D-glucose (6)及castalagin (7)。其中castalagin為主成份。
 印度人莧屬於大戟科,為分佈於亞洲及非洲的熱帶植物,根據文獻記載,其含抗生素及具催吐作用之生物鹼。本實驗從乾燥的印度人莧純化得十二個化合物,其結構分別確認為quercetin-3-O-glucoside (8)、rutin (9)、1-O-galloyl-β-D-glucose (5)、1, 2, 3, 6, -tetra-O-galloyl-β-D-glucose (10)、corilagin (11)、geraniin (12)、acetonylgeraniin A (13)、euphormisin M2 (14)、repandusinic acid A (15)、chubulagic acid (16)、potassium brevifolin carbosylate (17)及acaindinin (18)。其中corilagin及genaniin為主要成份,而potassium brevifolin carboxylate 及acaindinin為首次從植物分離出,文獻尚未記載之化合物。


Recent development in tannin chemistry and the discovery of new biological activities have drawn attentions in the investigation of tannins as medical agents. Therefore, a chemical investigation of tannins and related compounds in the fruit of Quisqualis indica and the dried herb of Acalypha indica was undertaken.
 Quisqualis indica Linn. (Combretaceae), which is originated from tropic India and southest Asia, and its fruit used as folk medicine for anthelmintic and digestive disorders. By means of various column chromatography, seven compounds (1~7) were isolated and purified. The structure of these compounds were elucidated as protocatechuic aldehyde (1), protocatecuic acid (2), gallic acid (3), brecifolin carboxylic acid (4), 1-O-galloyl-β-D-glucose (5), 2, 3-hexahydroxydiphenoyl-D-glucose (6) and castalagin (7). Among them, castalagin (7) was the major component.
 Acalypha indica Linn. (Euphorbiaceae) is a common tropic plant distributed over Asia and Africa. According to the literatures, it contains antibiotic agents and the emetic alkaloids. From the dried herb, twelve compounds (5 and 8~18) were obtained and their structures were elucidated as quercetin -3-O-glucoside (8), rutin (9), 1-O-galloyl-β-D-glucose (5), 1,2,3,6-tetra-O-galloyl-β-D-glucose (10), corilagin (11), geraniin (12), acetonylgeraniin A (13), euphormisin M2 (14), repandusinic acid A (15), chebulagic acid (16), potassium brecifolin carboxylate (17) and acaindinin (18). Among them, corilagin and geraniin were the major components. Potassium brevifolin carboxylate (17) and acaindinin (18) were isolated for the first time from the plant source.

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