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研究生:莊亞欣
研究生(外文):Juang, Ya-Hsin
論文名稱:1-苯基內桂木亞烯基乙酸化之Poly(HEMA)的製備及性質研究
論文名稱(外文):Preparation and characterization ofα-phenylcinnamylideneacetylated poly(HEMA)
指導教授:王盈錦
指導教授(外文):Wang, Yng-Jinn
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:醫學工程研究所
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:1996
畢業學年度:84
語文別:中文
論文頁數:81
中文關鍵詞:醫學工程桂木亞烯基乙
外文關鍵詞:MEDICAL-ENGINEERING
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  • 被引用被引用:2
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本研究利用1-苯基肉桂木亞烯基乙酸(α-phenylcinnamylideneacetic acid)與HEMA反應,形成一感光性單體(pcaEMA)﹔以pcaEMA(15%mol)與HEMA(85%mo1)於AIBN起始下做溶液聚合反應,以製備出共聚物。而感光性單體及共聚物,均以IR、1H-NMR圖譜鑑定其化學結構。根據"Fneman-Ross"與"Mayo-Lewis"等方法計算出兩種單體的反應性比,發現HEMA(r1=1.2)比pcaEMA(r2=0.8)高且為無規則共聚型高分子結構。
以高壓水銀燈照射高分子材料時,會使高分子側鏈基團產生[2+2]環化架橋反應,在照光35分鐘後可達60%的光交聯轉化率,且最大含膠量為65%。利用微差掃描卡計與偏光顯微鏡觀察此共聚物的熱性質與微結構,均發現有似結晶區產生。此外,以圓環法測試結果發現此共聚物具有良好的血液相容性。將高分子製成薄膜來包覆藥物,於不同的照光程度下,可以調節藥物釋放速度﹔當照光時間增長時,p-nitrophenol與flurbiprofen的釋放速率均有明顯降低 ,此外flurbiprofen在釋放上較符合"HiguchiModel"。
A photodimerizable compound, 2(α-phenylcinnamylideneacyloxy) ethyl methacrylate(pcaEMA), was synthesized and identified by IR and 1H-NMR spectra analyses. The pcaEMA monomer (15%w) was then polymerized with 85%w of 2-hydroxyethyl methacrylate (HEMA) to obtain a photosensitive copolymer which contains 12% pca-EMA and 88% HEMA. The difference of HEMA content in the copolymer from that in the original feed is attributed to the higher reactivity ratio of HEMA (n=1.2) as compared to t5hat of pcaEMA (r2=0.7). The copolymer has the average molecular weights of 9.65x104 (Mw) and 4.55x104(Mn) with intrinsic viscosity of about 18.2 cc/gm. It displays a maximal light absorption at 331nm as compared to 326nm observed for the monomer.
Light irradiation on the polymeric material induces photodimerization between the pcaEMAs as indicated by the gradual disappearance of light absorption at 331nm. The gel content of the polymeric film increases by increasing the light irradiation period and reaches a maximal level of 65% after 30 minutes of exposure. The dried film of this copolymer exihibits different domain structure before and after light exposure at 220℃. Results of the Chandler loop test predicts that this copolymer is resistant to blood coagulation. Furthermore, light-induced photodimerization can be used to regulate the release rate of drugs dispersed in this polymer film. Flurbiprofen and p-nitrophenol were entrapped inside the polymeric film and their releases were investigated. The release rates of both two chemicals are reduced by longer light exposure. Of these two entrapped chemicals, only the release of flurbiprofen follows the prediction of Higuchi model but at a slower rate than that of the p-nitrophenol.



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