厚朴酚 ( magnolol ) 為木蘭科（Magnoliaceae）植物厚朴Magnolia
officinalis REHD. et WILS.之主要活性成分之一，本研究係針對厚朴酚
(magnolol) 解熱降溫作用及其機轉進行探討。實驗結果顯示：厚朴酚
（25, 50, 100 mg/kg）在室溫下（22+1℃）腹腔給予正常大鼠可引起一
具劑量依存性之降溫作用，其降溫作用乃由于降低大鼠之新陳代謝率及增
加足趾皮膚之溫度所致。利用微透析法對麻醉大鼠腦內 (下視丘) 單胺濃
度進行測定，發現厚朴酚可明顯降低麻醉大鼠下視丘epinephrine (Epi)
、norepinephrine (NE)、dopamine (DA)及5-hydroxytryptamine (5-HT)
之濃度。其次，厚朴酚之降溫作用，會因6-hydroxydopamine (6-OHDA；
dopamine 之 neurotoxin；200?慊/rat, i.c.v.) 破壞腦中 dopamine 神
經系統所抑制，或因5,7-hydroxytryptamine (5,7-DHT；5-HT之
neurotoxin；200?慊/ rat, i.c.v.) 破壞腦中 serotonin 神經系統而減
弱；進一步研究發現厚朴酚之降溫作用雖然不會被 L-dopa
(dopaminergic system 之活性增強劑；200 mg/kg, i.p.) 加
benserazide (dopa decarboxylase inhibitor；50 mg/kg, i.p.) 所抑
制；但可被 pindolol (5-HT1A antagonist；10 mg/kg, i.p. ) 及 DOI
（5-HT2 agonist；5?慊/rat, i.c.v., 1 mg/kg, i.p.） 所拮抗，或為
8-OH-DPAT (5-HT1A agonist；0.05 mg/kg, s.c.) 及 ketanserin
(5-HT2 antagonist；0.5 mg/kg, i.p.）所加強。自大鼠腦腔中注入一種
致熱原interleukin-1??(被認為可提升下視丘的5-HT濃度)可引起發燒反
應。厚朴酚可以有效地抑制此類熱原性發燒，而且其退熱作用約略與
aspirin相當。綜合以上結果，顯示厚朴酚具明顯之解熱降溫作用，為厚
朴的主要解熱成分之一，其解熱降溫作用之機轉主要是經由作用於下視丘
的五-羥色胺或多巴胺神經系統，引發新陳代謝熱產生減少與周邊血管擴
張(增加熱散失)，而導致解熱降溫作用。

Magnolol is one of the active constituents isolated from
Magnolia officinalis. The present study was investigated the
antipyretic and hypothermic effects of magnolol and its action
mechanism.In unanesthetized rats, magnolol （25-100 mg/kg）
intraperitoneally caused a dose-related fall in colonic
temperature at room temperature (22+1C). It also significantly
decreased the metabolic heat production and increased the paw-
skin temperature via cutaneous vasodilation.On the other hand ,
magnolol significantly attenuated the interlenkin-1?? induced
fever in the unanessthetized rats. Moreover, magnolol caused a
decrease in the hypothalamic epinephrine, norepinephrine,
dopamine and serotonin levels, and an increase in the
hypothalamic 5-HIAA levels with microdialysis -high performance
liquid chromatography methodFurthermore, magnolol-induced
hypothermia was attenuated by intracerebroventricular
administration of 6-OHDA or 5,7-DHT. This effect was also
antagonized by pindolol or DOI, and potentiated by 8-OH-DPAT or
ketanserin. But this effect was not antagonized by L-dopa plus
benserazide.From these results, we found that magnolol possessed
the antipyretic and hypothermic activities, its effects might be
due to the decrease in the metabolic heat production and
cutaneous vasodilation, also the decrease in the hypothalamic
monoamine release.