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Digital image processing techniques have been widely and successfullyapplied to many medical images. Not only is medical image processing able to enhance critical symptoms on medical images associated with some medical diseases for assisting clinical diagnosis, but it can also possibly lead to a fully automated disease diagnosis system for use by the doctors. Among many medical images, retinal (or fundus) images provide enormous information about diabetes, which is the leading cause of visual impairment and blindness. The associated retinal disease is known as diabetic retinopathy, and a specific pathology called venous beading, provides a good indication for the degree ofthe disease. In this thesis, we aim to develop automated diagnosis system for venous beading. Our work consists of two main phases. In the preprocessing phase, we develop a new method, both effective and efficient, for extracting blood vessels of retinal images. The method is based on the concept of Gaussian match filters, with immediate improvement in computation time. The extracted blood vessels are then used for diagnosing or discriminating the disease in the second phase. The discriminating phase adopts the approach of Shape-Cognitron neural networks for learning and discriminating beaded veins from normal veins. Experiment results are given and discussed, and show great reliability and promise of the approach.
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