臺灣博碩士論文加值系統

中文摘要 生物活性材料不僅擁有高度的生物相容性( biocompatibility
),其凝固時泥狀物的 pH 值接近人體,植入人體後可與骨骼組織形成鍵結
，不引起毒性，不刺激組織,而且兼具引導骨骼向內生長的能(
osteoconductivity )等優點； CPC 骨水泥具有脆性(stiffer ),不易成
形,低破壞韌性( toughness )等缺點。本研究選擇本實驗室自行製造的
CPC ( calcium phosphate cement ,俗稱骨水泥)合成氫氧基磷灰石( HA
)，改變溶液之成分藉調整溶液濃度及 pH 值來改變CPC在水中硬化成型(
setting )的性質及硬化時(setting time ),並加入添加劑改善 CPC 的操
作性質。 本實驗的CPC 可在水溶液中的環境中硬化成形,可依需要調整硬
化時間,對於所使用溶液的濃度, pH 值及使用 CPC 粉末的粒徑大小所造
成的影響也加討論。

Abstrate CPC has generated considerable interest field of
calcium phosphate phosphate biomaterials because it
posesses self-hardening cement properties and forms
the mainly end product hydroxyapatite,HA, the
putative mineral in teeth and bones.Because the HA was formed
in a n aqueous environment it is more similar to the biological
apatites than is the HA formed in high temperature proess.As a
consequence ,CPC was formed to be highly ostesconductive.While
CPC does appear to have several advantages over
presently used calcium phosphate biomaterials,one of
the apparent shortcomings is the relatively long
setting time of approximately 30 min and the other is
the decay of the cement when the cement paste is in contact with
blood.This studt is to improve the properties of CPC by chaning
the liquid phase of CPCincluding solution
concentration and pH.The results show that the
setting time was reduced from 30 to 1.7 min and the
setting time was variable.When the cement paste is contact
with distrilled water,it can set without decaying.