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研究生:吳文玲
研究生(外文):Wu, Wen Lin
論文名稱:烏腳病盛行地區居民缺血性心臟病與血清中微量營養素及砷甲基化代謝能力之相關性研究
論文名稱(外文):A Study on the Association of Ischemic Heart Disease with Serum Micronutrients and Arsenic Methylation Capability among Residents in Blackfoot Disease Hyperendemic Area
指導教授:薛玉梅薛玉梅引用關係
指導教授(外文):Hsueh Yu Mei
學位類別:碩士
校院名稱:台北醫學院
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:1997
畢業學年度:85
語文別:中文
論文頁數:72
中文關鍵詞:缺血性心臟病砷物種微量營養素
外文關鍵詞:ischemic heart diseasearsenic speciesmicronutrients
相關次數:
  • 被引用被引用:1
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The objective of this study is to elucidate the association
among ischemic heart disease,chronic arsenic exposure indices,
serum micronutrients(vitaminA, vitamin E, lycopene, α-carotene,
β-carotene), urinary arsenic species(AsIII,DMA, MMA and AsV)
and other risk factors. 74 prevalence cases of ischemic heart
disease and 193 age-sex-matched healthy controls were selected
from a study cohort of residents lived in three villages where
blackfoot disease was hyperendemic. Urinary arsenic species were
isolated by high performance liquid chromatography.(HPLC) and
determined by automic absorption spectrometry(AAS). Serum
micronutrients were determined by Htomic absorption
spectrometry. There was no significant difference between
urinary arsenic species and ischemic heart disease except total
arsenic level. A significant dose-response relationship was
observed between ischemic heart disease and drinking high-
arsenic artesian well water.The relation was boarderline
significant after adjustment for age,sex,α-caroteneor β-
carotene, total cholesterol level, body mass index(BMI) and
hypertension. There was a negtive dose-response relationship
between α-carotene or β-caroteneand ischemic heart diseas. The
relation on β-carotene was also significant and α-carotene was
boraderline significant after adjustment for age, sex,
drinkinghigh-arsenic artesian well water, total cholesterol, BNI
and hypertension. Otherrisk factors, except hypertention, such
as serum triglyceride, cholesterol, high density lipoprotein,
low density lipoprotein, apolipoprotein A1, apolipoprotein B
concentration, smoking, alcohol drinking, and liver function
indices, had no significant association with ischemic heart
diseas.
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