臺灣博碩士論文加值系統

中文摘要

在中藥標準方中，治療胃潰瘍的方劑很多，四君子湯是「補脾祚臐v的代
表，具有抑制胃酸的效果。而衛生署公佈消導劑的標準方丹w中散係脾胃
虛寒與氣鬱所引起胃痛及腹痛的主要方劑；此兩方是刈慦v療消化性潰瘍
的常用方劑。Fordtran法是現今唯一用來測量體本臚予M能力的測定方法
，由於胃的正常生理現象，除了有胃酸分泌 外，同時進行著胃液的排空
，人工胃的模型就是以Fordtran的方法夾}，模擬胃的實際生理狀況，減
少影響因子的漏失，以評量中藥方齒b體外的制酸效果。本論文除建立兩
種人工胃之模型外，同時測定忖G方劑在體外生理性制酸作用及物理性促
進鹼性分泌的效果。本實聽H水為空白組，磷酸鋁凝膠為正對照組，在靜
態滴定法的制酸作用 中，我們用Fordtran法改良以人工胃液滴定，並以
氫離子毫莫耳表巨蹍蠔蘆G，結果顯示：安中散、四君子湯均呈現弱的制
酸作用，且尼Y反應完成無持續性，而其制酸機制是中和作用，安中散略
優於四坐l湯。在生理性動態的人工胃制酸作用中，安中散、四君子湯同
樣妓{微弱的制酸作用。能使pH1.2的人工胃液分別提升至pH1.53、
pH1.46，制酸的時間分別為117、94分鐘，制酸機制均呈現無緩衝的中和
作用。在進行物理性促進碳酸氫離子鹼性分泌作用的實驗時，妣抳P空白
組水作比較，其各提高了43.66%、28.17%由此一實驗結果“畯怚i知安中
散、四君子湯除了有弱的制酸作用外又有胃黏膜的保襲@用。

關鍵詞：消化性潰瘍、人工胃模型、中藥方劑、四君子湯、安中散?

Abstract

There are many formulas for the treatment of gastric ulcer in
the "Standarized Traditional Chinese Medicine Formulas".
Among them, Si- Jun-Zi-Tang S.J.Z.T. is the representative
one for gastric ulcer and An- Chong-San A.C.S. is the major
formula for stomach and abdominal pain. These two formulas
are commonly used by herbal medical doctors to treat gastric
ulcer.

The classical Fordtran test method until now the only one
employed to evaluate antacid products, does not evaluate the
duration of antacid action since it is only a quantitative
method to determine Acid NeutralizinCapacity. We have tried to
approach pysiological conditions, by constructing a
model of an "Artificial Stomach" possessing some of the
featured of a normal functioning stomach. This model was
designed to account for some of the parameters lacking in
conventional in vitro antacidevaluation. The antacid activity
and effect on gastric bicarbonate secretioof S.J.Z.T. and A.C.S.
were assessed with three different conditions our experiments
have found that:

1. Fordtran's method experiment without hog stomach and without
secretory and emptying flux: neutralization reaction was very
fast and complete. without sustained reaction. both drugs
exhibited weak antacid activity. A.C.S. was better than S.J.
Z.T. on antacid activity. 2. Experiment without hog
stomach but with secretory and emptying flux Increased the
pH of artificial gastric fluid from pH1.2 to pH1.53 and
pH1.46 respectively for A.C.S. and S.J.Z.T.Duration of antacid
activity were 117minutes and 94mimutes respectively for A.C.S.
and S.J.Z.T.

These findings indicate that the mechanism of antacid activity
of S.J.Z.T. and A.C.S. were the same, namely neutralization;
no buffer capacity was found.

3.Experiment with hog stomach but without secretory and emptying
flux using water as blank and aluminium phosphate gel as
cortrol, the antacid

activity of both drugs were found partly from their promoting
effect on gastric bicarbonate secretion by surface epithelial
cell. compared with blank the pH rose 43.66%、28.17% and this
effect was significant. The results of this study
suggested that besides weak antacid activity.A.C.S. and
S.J.Z.T. also possess the protective action on gastric mucosa.

Keywords: Peptic ulcer, Artificial Stomach, Traditional Chinese
Medicine Formulas, Si-Jun-Zi-Tang,(S.J.Z.T.) An-
Chong-San(A.C.S.).