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研究生:胡健民
研究生(外文):Hu, Jian-Min
論文名稱:Structure-solubilityrelationshipsamonginclusioncomplexationofhydroxypropyl--cyclodextrinwithbicyclicdrugs
指導教授:鄭慧文鄭慧文引用關係陳朝洋
指導教授(外文):Zheng, Hui-WenChen, Zhao-Yang
學位類別:碩士
校院名稱:台北醫學院
系所名稱:藥學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
畢業學年度:85
語文別:中文
論文頁數:87
中文關鍵詞:包覆錯合氫氧丙基--環糊精58-二氫氧基-14-酮類衍生物(6+6環)類衍生物(6+5環)對位-氫氧基苯甲酸酯纇衍生物藥物學
外文關鍵詞:complexation58-dihydroxy-14-naphthoquinone derivatives (6+6 ring structure)indole derivatives (6+5 ring structure)p-hydroxybenzoic acid estersPHARMACOLOGY
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The complexation of hydroxypropyl--cyclodextrin with bicyclic
compounds was studied. 5,8-Dihydroxy-1,4-naphthoquinone
derivatives(6+6 ring structure) and indole derivatives (6+5 ring
structure) were used as the model chemicals and the solubility
increment was employed as an indicator to monitor the
complexation progress. The solubility experiments revealed that
the position and 3-dimensional structure of the substituents
provided more impact on the solubility increment than the
polarity and chain length did. This result indicated that both
the position and 3-dimensional structure were the major
determinants affecting the complexation among the factors
studied. The control study with monocyclic compounds, using p-
hydroxybenzoic acid esters as the model chemicals, showed
opposite results. These results suggested that complexation of
hydroxypropyl--cyclodextrin with monocyclic compounds had a
different complexation mechanism with the bicyclic compounds.

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