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研究生:劉克武
研究生(外文):Liu, kou-wu
論文名稱:經低壓電漿誘導接枝聚合Methacryloxyethylphosphate於PE表面
論文名稱(外文):Surface Characterization and Platelet Adhesion Studies of PE grafted with Metharyloxyethyl phosphate by Plasma-induced Grafted Polymerization
指導教授:林睿哲
指導教授(外文):Jui-Che Lin
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:1998
畢業學年度:86
語文別:中文
論文頁數:72
中文關鍵詞:低壓電漿誘導接枝法血液相容性
外文關鍵詞:MOEPplasma-induced graft polymerizationMOEPblood comatibility
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中文摘要
由於物質表面性質為影響血液相容性的重要因素,因此本研究利用低壓電
漿誘導接枝聚合法(Plasma-Induced Graft polymerization),嘗試將含
有磷酸官能基的Methacryloxyethyl phosphate(MOEP)接枝在PE膜表面上
,觀察其血液相容性的改善程度。 在低壓電漿系統中,改
變氧氣壓力(100、300、500mtorr)、電漿處理時間(1、5、10min)及電漿
功率(5、25、50watts),活化PE膜表面。並以DPPH method定量電漿系統
活化後之PE膜表面上的過氧化物(peroxide groups),發現在氧氣壓力越
低、處理時間越短,電漿功率越大,過氧化物產生量越多。因而選擇了
virgin PE、電漿條件500mtorr、25watts、10mins,及電漿條件100mtorr
、25watts、5mins三種不同條件,以UV照光各15min、2hr、4hr及8hr進
行1wt% MOEP單體溶液(加入0.01wt%之riboflavin,並經氮氣bubbling三
十分鐘以上)聚合反應。最後經由靜態接觸角、ATR-FTIR、ESCA分析得知
UV照光時間越長、電漿活化後之PE膜表面的過氧化物量越多,其MOEP接枝
量越多。 在血小板吸附的情形中,只經
由電漿活化後的PE膜上,血小板不僅大量吸附且有被活化的現象。在MOEP
接枝後,隨著UV照光時間的增長,血小板吸附量有增加的趨勢,但在4hr
及8hr條件中,血小板吸附沒有明顯的增加,且活化的程度不若只經由電
漿活化後的PE膜。造成血小板吸附的原因可能在於磷酸官能基的電負性,
亦或是磷酸官能基本身的化學結構所導致。
【關鍵詞】電漿誘導接枝聚合法、MOEP、血液相容性

Abstract
It is believed that the blood compatibility of artificial
material are greatly influenced by the material's surface
properties. Henceforth, plasma-induced graft polymerization
technique is employed to modify polyethylene surface properties
with an aim to improve its blood compatibility.
Methacryloxyethyl phosphate(MOEP) is used as the monomer in this
study in order to incorporate phosphate functionalities onto PE
surface. Oxygen plasma
is used to active the substrate with the formation of surface
peroxide groups. Oxygen pressure, duration of plasma and RF
input power are varied throughout the study. It was found that
the amount of surface peroxide group, determined by DPPH method,
increases with oxygen pressure and RF input power , and
decreases with duration of plasma. Then, the virgin PE and
plasma-activated PE(500mtorr、25watts、10mins and 100mtorr、25
watts、5mins) were chosen for further MOEP polymerization
reaction by 15min、2hr、4hr、8hr of UV irradiation.(0.01 wt%
riboflavin was added into monomer solution , and nitrogen were
bubbling for 30mins.) After polymerization, static contact
angle, ATR-FTIR& ESCA analysis indicate the amount of grafted-
MOEP increases with UV irradiation and the amount of surface
peroxide groups. In vitro
platelet adhesion studies have shown plasma-activated PE
exhibited high level of platelet adhesion and activation. After
MOEP was grafted onto PE surface, the number of adherent
platelet increased slightly with the duration of UV irradiation.
There were no significant change in the number of adherent
platelet between 4 and 8 hours of UV irradiation. Furthermore,
it was also found that the degree of platelet activation in
MOEP-grafted PE was less than the plasma-activated PE. It seems
that negative charge characteristic of phosphate functional
group or its chemical structure plays some important roles for
platelet adhesion and activation.
【key words】plasma-induced graft polymerization、MOEP、blood
compatibility

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