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研究生:洪瑞聰
研究生(外文):Hong, Rai-Chong
論文名稱:明膠作為保護膠體製備微粒膠囊之研究
論文名稱(外文):Use gelatin as protective collid to prepare microcapsules
指導教授:蔡三元
指導教授(外文):Tsay Sun-Yuan
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:1998
畢業學年度:86
語文別:中文
論文頁數:83
中文關鍵詞:微粒包覆保護膠體
外文關鍵詞:microencapsuleprotective collid
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本研究是採用O/W型乳化溶劑揮發法,來製備具緩釋效果之微粒膠囊
。為改善乳化安定劑不易移除之困擾,選擇明膠作為保護膠體。而微膠囊
的核質藥物則選定阿斯匹靈,並以乙基纖維素作為高分子殼質。就七種實
驗變因:明膠濃度、攪拌速率、不同高分子溶劑成份比、乙基纖維素黏度
、預先添加非溶劑、藥物與殼質比及分散介質再使用等,來製備微粒膠囊
,並就所製備之微粒膠囊來探討其產率、粒徑分佈、藥物含量、藥物溶出
速率、電子顯微鏡分析及釋放動力學模式等特性。由實驗結果得知:產率
在明膠濃度1 ﹪以上即不再明顯提高,而選擇適當的轉速及明膠水溶液濃
度、降低乙基纖維素之黏度,可獲得較高之產率。提高攪拌速率,可使平
均粒徑降低。而增加藥物與殼質比、分散介質再使用、不預先添加非溶劑
,可增加其負載效果,添加非溶劑、降低乙基纖維素黏度及分散介質再利
用,會使藥物溶出速率增快。以SEM照片觀察微膠囊之表面形態,發現有
些表面有皺摺及大孔洞,其表面愈平滑,其釋放愈緩慢;反之,皺摺及孔
洞愈多,則釋放速率愈快。對於其釋放之動力模式,實驗中所製備之微膠
囊,以Higuchi動力模式最為符合。

The O/W emulsion solvent evaporation method was used to prepare
controlled release formation of drugs in this report. We
selected gelatin as emulsion agent. The microcapsules was
form by polymer solution(Ethylcellulose) containing drug
(Aspirin).
There were seven variables, including the gelatin concentration,
the stirred speed, the ratio of polymer solvents, the viscosity
of Ethylcellulose,the addition of non-solvent in polymer
solution, the ratio of drug to shell and the re-use of
dispersion medium to prepads were investigated. The yield of
microcapsules, the particle sizes distribution, the drug
content, therelease rate, SEM and the release kinetics were
studied. The results indicated that the yield no longer
increased when the concentration of gelatinmore than 1%. The
average particle size was increased by decrease the stirred
speed.Increasethe ratio of drug to shell, not addition non-
solvent in polymer solution and re-use of dispersion medium
increased the drug content. Addition non-solvent in polymer
solution, decreasing the viscosity of Ethylcellulose and re-use
of dispersion medium increased the release rate. We observed the
surface character of microcapsule by SEM, and found that
the release rate reduced withthe fine surface structure. The
release rate behavior of microcapsules is more conform to fit
the Higuchi release model.

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