|
Purposes in this study are to prepare controlled release
microspheresby spray drying technique. PLGA is chosen as the
polymeric matrix because of its excellent biocompatibility. 5-Fu
is a multipurpose anticanceragant. The results show that the
spray drying technique can prepare microspheres with diameter
under 10um(average diameter is 2um). Theyield of spray drying
process can reach 60% and drug content of microspheres approach
approximately to 9%, and the drug recovery is approach
approximately 90%. In vitro dissolution studies show that drug
released from microsphereslast over 24hr(85:15 PLGA even reach
155hr). The results indicate that spray drying method was more
efficient than emulsification solvent diffusion method.Methanol,
methylene chloride and chloroform were used as mixed solvents
toprepare microspheres. The microspheres were almost spherical
with someaggregation, but the morphology is different. FTIR
spectra imply that nochemical interaction occurs between 5-Fu
and PLGA. In vitro degradation studies show the hydrolyses of
85:15 PLGA do not occur within 30 day,but 65:35 PLGA and 50:50
PLGA degrade within 30 day.
|