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研究生:陳立言
研究生(外文):Chen, Li-Yen
論文名稱:聚乙烯-乙烯醇薄膜結構控制並對控制釋放及生物適應性之影響
論文名稱(外文):Structure control of membranes and its effects on controlled release and biocompatibility for poly(ethylene-co-vinyl alcohol)
指導教授:陳劉旺陳劉旺引用關係---
指導教授(外文):Chen Leo-Wang
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:化學工程學系研究所
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:1998
畢業學年度:86
語文別:中文
論文頁數:92
中文關鍵詞:聚乙烯-乙烯醇高分子薄膜結構控制控制釋放生物適應性
外文關鍵詞:poly(ethylene-vinyl alcohol)polymeric membranestructure controlcontrolled releasebiocompatibility
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本研究選擇乙烯-乙烯醇共聚合物(EVAL copolymer),以已知之薄膜成膜機構為基礎,利
用不同製程製備出非對稱性薄膜與顆粒型結構薄膜,配合光學顯微鏡觀察與光穿透實驗,
探討薄膜之成膜機構,並以溶解度參數與擴散係數來解釋醇類非溶劑與孔隙度之關聯。又
將該薄膜應用於藥物釋放上的探討,研究中,選擇不同親疏水性藥物溶於不同之醇類溶劑
與共溶劑,並探討薄膜-藥物-溶劑間三者相互間引力之影響,並以一預測值(Predicted v
alue, Pr)來解釋,結果發現:Pr值的確能夠準確評估藥物溶於不同溶劑中透過薄膜之釋放
大小。最後,製備不同表面形態的薄膜應用於血液中單核球細胞的培養,評估EVAL之生物
適應性,結果發現: 細胞的貼附量與細胞激素的釋放量的大小關係,以兩階段的方式來進
行單核球細胞貼附在薄膜表面,然後再活化釋放出細胞激素的重要步驟。在相同高分子製
備的薄膜,不同的表面結構:薄膜表面越平滑,細胞激素釋放量會越多,表示較易引起發
炎反應。薄膜表面為顆粒形結構時,細胞激素釋放量較少,生物適合性越好。而以不同高
分子材料所製備的薄膜,在相似表面結構上,細胞激素的釋放量會隨著薄膜親水性的性質
愈明顯而有減少的趨勢。

In this work, the effect of different nonsolvent in the membrane formation o
n the structure of asymmetric and particulate EVAL (poly(ethylene vinyl alcoho
l)) membranes was systematically investigated. In the experiments of light tra
nsmission and optical observation were used to study the mechanism of membrane
formation, and the relations of alcohol coagulations and porosity were explai
ned by solubility parameter and diffusion coefficient.
The application of membranes to controlled release is another focus in this
study. The effect of polar solvents and polar cosolvent mixtures on the transp
ort properties of different hydrophilic and hydrophobic drugs in EVAL membrane
s were studied. It was found that the drug flux through EVAL membrane is stron
gly dependent on the predicted value(Pr), which can caculate by the interactio
n force of membrane-drug- solvent.
In addition, in vitro cell culture techniques to evaluate the effect of diff
erence membranes with various structure of surface on monocyte activation and
interleukin-1 (iL-1) generation. It was found that the relations of monocyte a
ttachment and cytokine release were processed by two-step mechanisms. The fist
step is physicochemical adsorption andtivation. The results indicate that rou
ghness surface displayed better affinity for monocyte than glossy surface on t
he same terial, and hydrophilic surfaces displayed better affinity for monocyt
e than hydrophobic surfaces on the same structure. Consequently, the surface s
tructure should be suitably selected according to the purpose for which the ma
terial is to be used. So, by changing conditions of membrane formation, we can
evaluate the membranes for biomedical material.

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