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研究生:戴嘉言
研究生(外文):Chia-Yen DAI
論文名稱:南台灣C型肝炎高盛行地區G型肝炎盛行率及其臨床特徵之研究
論文名稱(外文):The prevalence and clinical significance of hepatitis G virus infection in a hepatitis C hyperendemic area in southern Taiwan
指導教授:張文宇
指導教授(外文):Wen-Yu Chang
學位類別:碩士
校院名稱:高雄醫學院
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:1999
畢業學年度:87
語文別:英文
論文頁數:66
中文關鍵詞:G型肝炎病毒C型肝炎病毒高盛行地區G型肝炎外套蛋白第二區抗體 (Anti-E2抗體)
外文關鍵詞:Hepatitis G virusHepatitis C virusHyperendemic areaanti-E2 antibody
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背景與目的:在台灣地區,C型肝炎病毒感染是除了B型肝炎病毒以外,引起慢性肝炎及肝細胞癌之最重要病因。近年來,南台灣地區發現有許多C型肝炎高盛行地區。馬沙溝社區位於台南縣將軍鄉,地處台灣西南沿海地區亦是其中之一。G型肝炎病毒於1995年和1996年被研究人員分離出來。雖然G型肝炎病毒被認為可能導致人類肝炎,但其臨床上扮演之角色及對肝細胞之破壞作用至今仍無定論。為了探討G型肝炎病毒在C型肝炎高盛行地區之感染狀況、臨床上扮演之角色、影響病毒清除之可能因子和C型,G型及B型肝炎病毒感染之間可能之相互關聯,特別針對馬沙溝居民進行此研究。
材料與方法:共有200位馬沙溝的居民 (男性有84位,女性有116位)之血清檢體接受了各項檢查,包括轉胺 (Alanine aminotransferase, ALT )、B型肝炎表面抗原 (HBsAg)、C型肝炎抗體 (Anti-HCV)、G型肝炎外套蛋白第二區抗體 (Anti-E2抗體)及C型和G型肝炎病毒核醣核酸(HCV RNA , HGV RNA)等。此外,本研究亦對來自高雄捐血中心400例設籍於南部七縣市之自願捐血者的血清進行HGV RNA及Anti-E2檢測,以作為研究之對照組。統計分析採用包括卡方檢定 (chi-square test)、費歇恰當檢定 (Fisher's exact test) 或t 檢定 (t test) 及逐步複迴歸分析 (stepwise multiple regression method)。計算部份是以 BMDP統計軟體進行。
結果:與自願捐血者比較,無論是HGV RNA或 Anti-E2抗體之陽性率,或是G型肝炎病毒暴露之盛行率,馬沙溝居民比自願捐血者均明顯偏高 (三項分別為17%與3.3%、25.5%與7.5%、39.5%與10.3%, p<0.05)。若比較兩組之Anti-E2抗體之血清轉換率 (rate of seroconversion),馬沙溝居民與捐血者之間並無統計學上之明顯差異。將馬沙溝居民分為有G型肝炎病毒暴露及無G型肝炎病毒暴露兩組,再就性別和年齡、轉胺及B型肝炎表面抗原等變項對兩組進行統計分析時,我們發現兩組並無明顯差異。依C型肝炎病毒暴露變項進行統計分析時,結果發現C型肝炎病毒暴露組之G型肝炎病毒暴露盛行率比無C型肝炎病毒暴露組明顯較高 (45.8%與24.2%,p=0.005)。G型肝炎暴露病毒後,男性比起女性有較高之Anti-E2抗體之血清轉換率 (71.0%與47.9%,p=0.04),而且性別為唯一與Anti-E2抗體血清轉換有關之因子。 然而性別引起之Anti-E2血清轉換率差異,在G型肝炎病毒暴露之捐血者的研究中卻未能觀察到。在馬沙溝地區血清ALT值與性別、年齡、G型肝炎病毒暴露、Anti-E2抗體之血清轉換、B型肝炎表面抗原狀態等變項無明顯相關,而HCV RNA陽性者之血清ALT值異常率比HCV RNA陰性者明顯較高 (34.9%與7.0%,p<0.001),且HCV RNA陽性與否為唯一與ALT值升高有關之因子。
結論:馬沙溝地區除了是個B型肝炎及C型肝炎病毒感染之高盛行區外,同時也是G型肝炎病毒感染之高盛行區。G型肝炎與C型肝炎病毒感染之間有密切關係而與B型肝炎帶原狀態無關。C型肝炎高盛行區居民之ALT值不受G型及B型肝炎病毒影響且ALT值異常主要是因為C型肝炎病毒感染的緣故。G型肝炎病毒之清除率不受C型肝炎病毒感染影響,至於男性比女性有較高之Anti-E2抗體之血清轉換率的原因則需作更進一步的研究及探討。

HCV is the second cause of chronic hepatitis and hepatocellular carcinoma in Taiwan . To shed light on the status and clinical characteristics of the HGV infection in the HCV hyperendemic area, we studied the presence of HGV viremia and anti-E2 antibodies, the relation of HGV infection to the clinical characteristics, the factors influencing the seroconversion of anti-E2 antibodies and possible association of hepatitis B, C and G viruses among residents of Mashagou where is a highly endemic area for HCV located in the southwestern coastal area of Taiwan.as an HCV hyperendemic area model. Materials and Methods: Serum of two hundred residents of Mashagou were tested for alanine aminotransferase (ALT), HBsAg, second-generation HCV antibody (anti-HCV), HCV RNA and HGV RNA by nested RT-PCR using 5'untranslated region (5'UTR)-specific primers, and anti-E2 antibody by an enzyme linked immunosorbent assay. The prevalence of serum HGV RNA and anti-E2 antibodies were also investigated in 400 consecutive volunteer blood donors. Statistical analyses: Frequency was compared between groups using the chi-square test or Fisher's exact test, and group means were compared using the t test. Stepwise logistic regression method was used to analyze the study data. Results: The prevalence of HGV viremia, anti-E2 and HGV exposure among residents of Mashagou were significantly higher than those among volunteer blood donors (17.0% vs. 3.3%, 25.5% vs. 7.5% and 39.5% vs. 10.3%, respectively; all p<0.001). The prevalence of HGV exposure was significantly higher in individuals exposed to HCV than in those without HCV exposure (45.8% vs. 24.1%, respectively; p=0.005). None of sex, age, ALT levels, marker of chronic HBV infection and HCV genotype distribution was related to the exposure of HGV. The rate of anti-E2 seroconversion in Mashagou patients exposed to HGV (57.0%) was similar to that of blood donor (68.3%). Male had significant higher rate of anti-E2 seroconversion than female did (71.0% vs. 47.9%; p=0.04) in Mashagou rather than blood donors (male: 71.0%; female: 60.0%). None of age, ALT levels, markers of chronic HBV infection and HCV exposure was related to anti-E2 seroconversion. There was no difference of serum ALT levels between HGV viremic and non-viremic individuals in each group by the status of HBsAg and HCV RNA.The mean ALT level was significantly higher in those positive for HCV RNA with or without other viral markers (HBsAg and HGV RNA) than in those negative for HCV RNA. Based on multiple logistic regression analyses, significant factors associated ALT elevation was HCV RNA with odds ratio and 95% confidence interval of 6.96 and 2.60-18.7. Conclusions: In HCV hyperendemic area of Taiwan, HGV infection is closed associated with HCV infection. With minimal pathogenic-effect of HGV infection after exposure of HGV, HCV rather than HGV played the most important clinical hepatopathic role. HGV had lower persistent infection rate than HCV and there was no influence on the recovery from HGV infection by HCV infection. The reasons for the higher seroconversion rate in male than female in HCV endemic area can not be provided and need further evaluation.

壹:中文摘要 1
貳:英文摘要 3
參:中文論文全文
第一章 前言及文獻回顧 5
G型肝炎病毒及G型肝炎
C型肝炎病毒及C型肝炎
研究目的
第二章 材料與方法 10
對象
C型及G型肝炎病毒RNA之萃取
C型肝炎病毒HCV RNA之檢測
G型肝炎病毒HGV RNA之檢測
G型肝炎外套蛋白第二區抗體(Anti-E2)之檢測
第三章 結果 19
B型肝炎及C型肝炎標記
G型肝炎病毒及Anti-E2抗體
血清轉胺(ALT)值
第四章 討論 34
G型肝炎病毒與C型肝炎
G型肝炎病毒與B型肝炎
G型肝炎之臨床特徵
血清ALT值之影響因子
Anti-E2抗體
第五章 結論 38
第六章 參考文獻 39
肆:英文論文全文 46

1. Simons JN, Leary TP, Dawson GJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, Desai SM, Mushahwar IK. Isolation of novel virus-like sequences associated with human hepatitis. Nature Medicine 1995;1:564-569.
2. Linnen J, Wages J, Zhang-Keck ZY, Fry KE, Krzysztof Z, Krawczynski KZ, Alter M, Hadziyannis, Karayiannis P, Fung K, Nakatsuji Y, Shih JWK, Young L, Piatak M, Hoover C, Fernandez J, Chen S, Zou JC, Morris T, Hyams KC, Ismay S, Lifson JD, Hess G, Foung SKH, Thomas H, Bradley D, Margolis H, Kim JP. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science 1996;271:505-508.
3. Deinhardt F, Holmes A W, Capps R B, Popper H. Studies on the transmission of human viral hepatitis to marmoset monkeys. Transmission of disease, serial passage and description of liver lesions. J Exp Med 1967;125:673-687
4. Simons J N, Pilot-Matias, Leary T P. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci USA 1995;92:3401-3405
5. Zuckerman A J. Alphabet of hepatitis viruses. Lancet 1996;347:558-559
6. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ., Erker JC, Chalmers ML, Schlauder GG, Dawson GJ, Desai SM., IK Mushahwar. Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A-E hepatitis. J Med Virol 1996;48:60-67.
7. Erker J C, Simons J N, Muerhoff A S. Nucleotide sequence of a GB virus C isolate from a patient with non A-E hepatitis. J Gen Virol 1996;77:2713-2720
8. Yoshiba M, Okamoto H, Mishiro S. Detection of the GBV-C hepatitis virus genome in serum from patients with fulminant hepatitis of unknown etiology. Lancet 1995;346:1131-1132.
9. Tucker T J, Louw S J, Robson S C, Isaacs S, Kirsch R. High prevalence of GBV-c hepatitis G virus in a rural South African population. J Med Virol 1997;53:225-228
10. Dawson G J, Schluader G G, Pilot-Martias T J. prevalence studies of GB virus C infection using reverse transcriptase-polymerase chain reaction. J Med Virol 1996;50:97-103
11. Saiz J C, Ampurdanes S, Olmedo E. Hepatitis G virus infection in chronic hepatitis C: frequency, features and response to interferon therapy. J Hepatol 1997;26:787-93
12. Herringlake S, Osterkaamp S, Trautwein C. Association between fulminant hepatic failure and a strain of GBV virus C. Lancet 1996;348:1626-1629
13. Jarvis L M, Davidson F, Hanley J P, Yap P L, Ludlan C A, Simmonds P. Infection with hepatitis G virus among recipients of plasma products. Lancet 1996;348:1352-1355
14. Brown K E, Wong S, Buu M, Binh T V, Be T V, Young N S. High prevalence of GB virus C/hepatitis G virus in healthy persons in Ho Chi Minh city, Vietnam. J infect Dis 1997;175:450-453
15. Raengsakulrach B, Ong-Aj-Yooth L, Thaipraser T. High prevalence of hepatitis G viremia among kidney transplant patients in Thailand. J Med Virol 1997;53:162-166
16. Masuko K, Mitsui T, Iwano K, Yamazaki C, Okuda K, Meguro T, Murayama N, etla:Infection with hepatitis Gbvirus C in patients on maintainance hemodialysis. N Engl. J. Med. 1996;334:1485-1490
17. Schlueter V, Schmolke S, Stark K, Hess G, Ofenloch-Haehnle B, Engel AM. Reverse transcription -PCR detection of hepatitis G virus. J. Clin. Microb. 1996;74:2260-2264
18. Fiordalisi G, Bettinardi A, Zanella I, Stelleni R, Paranonfo G, Cadeo Ghprimi D. Parenternal and sexual exposure transmission of GB virus C and hepatitis C virus among human immuno-deficiency virus-positive patients. J. Infect Dis. 1997;175:1025-1026
19. Gonzalez-Perez M A, Norder H, Bergstorm A, Lopez E, Visona K A, Magnius L O. High prevalence of GB virus C strains genetically related to strains of Asian origin in Nicaraguan hemophiliacs. J Med Virol 1997;52:149-155
20. Stark K, Bienzle U, Hess G, Engel A M, Hegenscheid B, Schlueter V. Detection of hepatitis G virus genome among injecting drug users, homosexual and bisexual men, and blood donors. J infect Dis 1996;174:1320-123
21. Masuko K, Mitsui T, Iwano K. Infection with hepatitis GB virus C in patients on maintaince hemodialysis. N Engl J Med 1996;334:1485-1490
22. De Lamballerie X, Charrell R N, Dussol B. Hepatitis GB virus C in patients on hemodialysis. N Engl J Med 1996;334:1549
23. Alter MJ, Gallagher M, Morris TT, Moyer LA, Meeks EL, Krawcaynski K, Kim JP, Margolis HS. Acute non-A-E hepatitis in the United States and the role of hepatitis G Virus infection. N Engl J Med 1997;336:741-746.
24. Alter HJ, Nakatsuji Y, Melpolder J, Wages J, Wesley R, Shih JWK. W-K, Kim JP. The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N Engl J Med 1997;336:747-754.
25. Yashina T L, Favorov M O, Khudyakov Y E. Detection of hepatitis G virus (HGV) RNA: clinical characteristics of acute HGV infection. J infect Dis 1997;175:1302-1307
26. Francesconi R, Giostra F, Ballardini G. Clinical implications of GBV-C/HGV infection in patients with "HCV-related" chronic hepatitis. J Hepatol 1997;26:1165-1172
27. Fried MW, khudyakov YE, Smallwood Ga, et al. Hepatitis G Virus coinfection in liver transplantation recipients with chronic hepatitis C and non-viral chronic liver disease. Hepatology 1997;25:1271-1275
28. Cotler S, Gretch D R, Bronner M P. Hepatitis G virus co-infection does not alter the course recurrent hepatitis C virus infection in liver transplantation recipients. Hepatology 1997;26:432-436
29. Sallie R, Shaw J, Mutimer D. GBV-C virus and fulminant hepatic failure. Lancet 1996;347:68
30. Haydon G H, Jarvis L M, Simpson K J, Hayes P C, Simmonds P. The clinical significance of the detection of hepatitis GBV-C RNA in the serum of patients with fulminant, presumed viral, hepatitis. J Viral Hepat 1997;4:45-49
31. Heringlake S, Osterkamp S, Trautwein C, Tillmann HL, Boker K, Muerhoff S, Mushahwar IK, Hunsmann G, Manns MP. Association between fulminant hepatic failure and a strain of GBV virus C. Lancet 1996;348:1626-1629.
32. Tagger A, Donato F, Ribero ML, Chiesa R, Tomasoni V, Portera G, Gelatti U, Albertini A, Fasola M, Nardi G, the Brescia HCC study. A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma. Hepatology 1997;26:1653-1657.
33. Tacke M, Kiyosawa K, Stark K, Schlueter V, Ofenloch-Haehnle B, Hess G, Engel AM. Detection of antibodies to a putative hepatitis G virus envelope protein. Lancet 1997;349:318-320.
34. Choo QL, Kuo G, Weiner AJ. Isolation of a cDNA clone derived from a blood-born non-A, non-B viral hepatitis genone. Science 1989; 244:359-362
35. Hosoda K, Omata M, Yokosuka O, Kato N, Ohto M. Non-A, non-B chronic hepatitis is chronic hepatitis C: a sensitive assay for detection of hepatitis C virus RNA in the liver. Hepatology 1992;15:777-781
36. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the USA 87:6547-6549
37. Chuang WL, Chang WY, Lu SN, Lin ZY, Chen SC, Hsieh MY, Wang LY, You SL, Chen CJ. The role of hepatitis C virus in chronic hepatitis B virus infection. Gastroenterol Jpn 1993;28(Suppl 5):23-27.
38. Lu SN, Chue PY, Chen HC, Wu MH, Chen IL, Huang JF, Wang JH, Peng CF, Shih CH, You SL, Lu CF, Chen CJ, Chang WY. Different viral aetiology of hepatocellular carcinoma between two hepatitis B and C endemic townships in Taiwan.J Gastroenterol Hepatol, 1997;12:7,547-550
39. Chang SJ, Chen HC, Ying J, Lu CF, Ko YC. Risk factors of hepatitis C virus infection in a Taiwanese aboriginal community. Kaohsiung J Med Sci 1996;12:241-247.
40. Jing-Hong Wang, Sheng-Nan Lu, Jung-Chou Wu, Jee-Fu Huang, Ming-Lung Yu, Shinn-Cherng Chen and Wan-Long Chuang. A hyperendemic community of hepatitis B virus and hepatitis C virus infection in Taiwan. Transactions of The Royal Society of Tropical Medicine and Hygiene 1999; 93:1-2.
41. Wang CS, Chang TT, Chou P. Differences in risk factors for being either a hepatitis B carrier of anti-hepatitis c+ in a hepatoma-hyperendemic area in rural Taiwan. J Clin Epidemiol 1998;51:733-738.
42. Chen DS, WangJT, Chen PJ, Wan TH,Sung JL:Hepatitis C virus infection in Taiwan. Gastroenterol Jpn 1991;26:S164-S166.
43. Chang WY, Chen CJ, Lu SN, You SL, Chuang WL, Chen SC, Su WP, Wang LY, Hsieh MY, Wu MM, Tai TY. Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus. J Gastroenterol Hepatology. 1992;7:455-458
44. Yu, M.L., Chuang, W.L., Chen, S.C., et al. 1996b. Treatment of chronic hepatitis C with interferon-alpha: a preliminary report. Kaohsiung J. Med. Sci. 1996;12, 581-589.
45. Mukaide M, Mizokami M, Orito E , Ohba KI , Nakano T,, Ueda R, Hikiji K, Iino S, Shapiro S, Lahat N, Park YM , Kim BS, Oyunsuren T, Rezieg M, Mohammed N. Ahdal A, Johnson Lau YN. Three different GB virus C/hepatitis G virus genotypes Phylogenetic analysis and a genotyping assay based on restriction fragment length polymorphism. FEBS Letters 1997;407:51-58.
46. Wang JT, Chen PJ, Liu DP, Sheu JC, Wang TH, Chen DS. Prevalence and infectivity of hepatitis G virus and its strain variant,the GB agent, in volunteer blood donors in Taiwan. Transfusion 1998;38:290-295.
47. Kane M. Progress on the control of hepatitis B infection through immunisation. Gut 1993;34(suppl):S10-S12
48. Chen DS. Viral hepatitis in East Asia. Jourmal of the Formosan Medical Association 1996;19(1): 6-12.
49. Alter M, Master E.The epidemiology of viral hepatitis in the United State. Gastroenterol. Clin. North Am. 1994;23:437
50. Hsu SC, Change MH, Ni YH. Horizontal transmission of hepatitis B virus in children. J. Ped. Nutr. 1993;16:66
51. Hurie MJ, Mast EE, Davis JP. Horizontal transmission of hepatitis B virus infection to United State born children of Hmong refugees. Pediatrics 1992; 89:269
52. Huey-Ling Chen, Mei-Hwei Chang, Yen-Hsuan Ni, Hong-Yuan Hsu, Jia-Horng Kao, Pei-Jer Chen. Hepatits G virus infection in normal and prospectively followed posttransfusion children. Pediatric Research 1997;42:784-787
53. Birgit Kallinowski, Rezvon Ahmadi, Stefani Seipp, Jurgen Bommer, Wolfgang Stremmel. Clinical impact of GB-C virus in hemodialysis patients. Nephrol. Dial. Transplant. 1998;13:93-98
54. Kazuhiko Koike, Kiyomi Yasuda, Hinoshi Yotsuyanagi, Kyoji Morita, Kunihiko Hino. Dominant Replication of either virus in dual infection with hepatitis viruses B and C. Journal of Medical virology. 1995;45:236-239
55. Sheen IS,Liaw YF, Chu CM, Pao CC. Roleof hepatitis C virus infection in spontaneous hepatitis B surface antigen clearance during chronic hepatitis B virus infection J Infect Dis 1992;105:831-834
56. Patrizia Pontisso, Maria Grazia Ruvoletto, Giovanna Fattorich. Clinical and Virological profiles in patients with multiple hepatits virus infections. Gastroenterol 1993;105:1529-1533
57. Alfredo Alberti, Patrizia Pontisso, Liliana Chemello, Giovanna Fattovich, Luisa Benvegnu, Fabio Belussi, Maria Stella De Mitri. The interaction between hepatitis B virus and hepatitis C virus in acute and chronic liver disease. J. of Hepatol 1995;22(supl 1):38-41
58. Shinjiro Sato, Shigetoshi Fujiyama, Motohiko Tanaka, Kunio Yanasaki, Izumi Kuramoto, Shin-ichi Kawano, Tatsuo Sato, Kyosuke Mizuno, Saneo Nonaka. Coinfection of hepatitis C virus in patients with chronic hepatitis B infection J Hepatolol. 1994;21:159-166
59. Ross RS, Viazov S, Schmitt U, Schmolke S, Tacke M., Ofenloch-Haehnle B, Holtmann M, Muller N, Da Villa G, Yoshida C.F, Oliveira J.M, Szabo A, Paladi N, Kruppenbacher J.P, Philipp Th., Roggendorf M . Distinct prevalence of antibodies to the E2 protein of GB virus C/hepatitis G virus in different parts of the world. J Med Virol. 1998;54:103-106.
60. Dille. B. J., T. K. Surowy, R. A. Gutierrez, P. F. Coleman, M. F. Knigge, R. J. Carrick, R. D.Aach, F. B. Holinger, C. E. Stevens, L. H. Barbosa, G. J. Nemo, J. W. Mosley, G. J. Dawson, I.K. Mushahwor. An ELISA for detection of antibodies to the E2 protein of GB virus C. J Infect Dis. 1996;225:293-299.
61. Pilot-Matias, T. J., R.J. Carrick, P.F. Coleman, T.P. Leary, Y.K. Surowy, J.N. Simons, A.S. Muerholf, S.L. Buijk, M.L. Chalmers, G.J. Dawson, S.M. Desai, I.K. Mushahwar. Expression of the GB virus C E2 glycoprotein using the Semliki Forest virus vector system and its utility as a serologic marker. Virology 1996;225:282-292
62. Eiji Tanaka, Michael Tache, Masakazu Kobayashi, Yoshiyuki Nakatsuji, Kendo Kiyosa, Susaanne Schmolke, Alfed m. Engel, Georg Hess, Harvey Alter. Past and present Hepatitis G virus infections in Area where hepatitis C is highly endemic and those where it is not endemic. J. Clin. micro. 1998;36:110-114
63. Yun-Fan Liaw. Role of hepatitis C virus in dula and triple hepatitis virus infection. Hepatol 1995;22:1101-1108
64. Liaw YF, Tsai SL, Chang JJ, Sheen IS, Chien RN, Lin DY, Chu CM. Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing chronic hepatitis. Gastroenterology 1994;106:1048-1053
65. Aach R.D., C.E. Stevens, F.B. Hollinger, J.W. Mosley, D.A. Peterson, P.E. Tayler, R.G. Johnson, L.H. Barbosa, G.J. Nemo. Hepatitis C virus infection in post-transfusion hepatitis: an analysis with first- and second-generation assars. N. Engl. J. Med. 1991;325:1325-1329.
66. Alter H.J.,R.H. Purcell, J.W. Shih, J.C. Melolder, M. Houghton, Q.L. Choo, G.Kuo. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 1989;321:1494-1500
67. Tanaka, E., K. Kiyosawa, Y. Nakatsuji, Y. Inoue, T.Miyamura, J. Chiba, S. Furuta. Clinical significance of antibodies to nonstructural and core protein of hepatitis C virus in posttransfusion hepatitis patients during long-term follow-up. J. Med. Virol. 1993;39:318-324

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