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研究生:陳建達
研究生(外文):Chien-Ta Chen
論文名稱:南丹參根部之成分研究
論文名稱(外文):The constituents of the roots of Salvia bowleyana Dunn
指導教授:吳天賞吳天賞引用關係
指導教授(外文):Tian-shung Wu
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學系
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:1999
畢業學年度:87
語文別:中文
論文頁數:174
中文關鍵詞:南丹參
外文關鍵詞:Salvia bowleyana
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中文摘要
自中國大陸採得南丹參(Salvia bowleyana)根部5.4 Kg,陰乾切碎後,以甲醇熱迴流萃取,再以丙酮與水7比3的混合溶劑熱迴流萃取,經減壓濃縮去除溶劑,分別以氯仿、正丁醇和水進行分配萃取,各分配層以管柱層析、薄層層析及再結晶方式分離共得到47個化合物,其中41個經光譜分析及化學方法或與文獻比對後確定其結構式,分別為:tanshinone Ⅰ, dihydrotanshinone Ⅰ,tanshinone ⅡA, 1,2-dihydrotanshinquinone, tanshinone ⅡB, nortanshinone, cryptotanshinone, hydroxytanshinone ⅡA, danshexinkun B, dihydroisotanshinone Ⅰ, (-)-danshexinkun A, sugiol, dehydrosugiol, montbretol, 6α-hydroxy-7-oxo-ferruginol, ferruginol, denshenspiroketallactone, salvialide A, cryptoacetalide, epicryptoacetalide, vanillin, aurantiamide acetate, β-sitosterol, β-sitosterone, physcion, catemarin, erythroglaucin, ω-hydroxyemodin, salviaquinone A, salviaquinone B, salviaquinone C, salviaquinone D, salviaquinone E, salviaquinone F, 2-acetyl-3-methoxyfuran, methyl rosemarinate, salvibowlein A, salvibowlein B, salvibowlein C, SA-15, 2α,3β,19α-hydroxyurs-12-en-28-oic acid;其中salvalide A, salviaquinone A, salviaquinone B, salviaquinone C, salviaquinone D, salviaquinone E, salviaquinone F, salvibowlein A, salvibowlein B, salvibowlein C為天然界首次分離之新化合物。
Abstract:
The root of Salvia bowleyana was collected from China. It was extracted with the MeOH (x8), then Me2CO-H2O (7:3) (x3) and concentrated to give the deep brown syrup. The crude extract was partitioned between H2O and CHCl3, and then with n-BuOH. Each fraction was subjected to chromatography and gave thirty one known compounds: tanshinone Ⅰ, dihydrotanshinone Ⅰ, tanshinone ⅡA, 1, 2-dihydrotanshinquinone, tanshinone ⅡB, nortanshinone, cryptotanshinone, hydroxytanshinone ⅡA, danshexinkun B, dihydroisotanshinone Ⅰ, (-)-danshexinkun A, sugiol, dehydrosugiol, montbretol, 6α-hydroxy-7-oxo-ferruginol, ferruginol, denshenspiroketallactone, cryptoacetalide, epicryptoacetalide, vanillin, aurantiamide acetate, β-sitosterol, β-sitosterone, physcion, catemarin, erythroglaucin, ω-hydroxyemodin, 2-acetyl-3-methoxyfuran, methyl rosemarinate, SA-15, 2α, 3β, 19α-hydroxyurs-12-en-28-oic acid, together with ten new compounds: salvialide A, salviaquinone A, salviaquinone B, salviaquinone C, salviaquinone D, salviaquinone E, salviaquinone F, salvibowlein A, salvibowlein B, salvibowlein C. Their structures were determined by spectral analysis and chemical transformation.
目錄
謝誌………………..…………………………………………………………Ⅰ
英文摘要………………………………………………………………………Ⅱ
中文摘要………………………………………………………………………Ⅲ
第一章 緒論
第一節 植物形態………………………………………………………………1
第二節 藥理與藥效回顧及研究動機…………………………………………1
第三節 丹參屬植物之成分回顧………………………………………………3
第二章 南丹參根部成分之抽取及分離……………………………………52
第三章 化合物之構造研究
第一節 Tanshinone Ⅰ (1) 之構造決定…………………………………62
第二節 Dihydrotanshinone Ⅰ (2) 之構造決定…………………………64
第三節 Tanshinone ⅡA (3) 之構造決定…………………………………66
第四節 Danshexinkun B (9) 之構造決定…………………………………68
第五節 (-)-Danshexinkun A (11) 之構造決定…………………………70
第六節 Denshenspiroketallactone (17) 之構造決定…………………73
第七節 Salvialide A (18) 之構造決定…………………………………77
第八節 Physcion (25) 之構造決定………………………………………81
第九節 Erythroglaucin (27) 之構造決定………………………………85
第十節 Salviaquinone A (29) 之構造決定………………………………87
第十一節Salviaquinone B (30) 之構造決定……………………………89
第十二節Salviaquinone C (31) 之構造決定……………………………94
第十三節Salviaquinone D (34) 之構造決定……………………………100
第十四節Salviaquinone E (35) 之構造決定……………………………104
第十五節Salviaquinone F (36) 之構造決定……………………………106
第十六節Methyl rosmarinate (38) 之構造決定………………………109
第十七節Salvibowlein A (39) 之構造決定……………………………111
第十八節Salvibowlein B (40) 之構造決定……………………………113
第十九節Salvibowlein C (41) 之構造決定……………………………117
第二十節SA-15 (42) 之構造決定…………………………………………121
第二十一節 其他化合物之構造研究………………………………………124
第四章 結論…………………………………………………………………125
第五章 實驗部分
第一節 本實驗所使用之儀器………………………………………………127
第二節 萃取與分離…………………………………………………………128
第三節 甲基化反應…………………………………………………………130
第四節 光譜數據……………………………………………………………131
參考文獻……………………………………………………………………152
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