|
Reference: 1. Small, D. H. 1998. The role of the Alzheimer's Disease: Does the normal function of APP explain the topography of neurodegeneration? Neurochemical Research, 23(5): 795-806. 2. Price, D. L., S. S. Sisodia and D. R. Borchelt. 1998. Genetic neurodegenerative diseases: the human illness and transgenic model. Science, 282(6): 1079-1083. 3. Masters, C. L., G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald, and K. Beyreuther. 1985. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. USA, 82: 4245-4249. 4. Buxbaum,J. D., E. K. Choi, Y. Luo, C. Lilliehook, A. C. Crowley, D. E. Merriam and W. Wasco. 1998. Calsenilin: A calcium-binding protein that interacts with the presenilin and erqulates the level of a presenilin fragment. Nature Medicine, 4(10):1177-1181. 5. Yan, S. D., S. F. Yan, C. J. Fu,M. Chen, P. Kuppusamy, M. A. Smith, G. Perry, G. C. Godmman, P. Nawroth and J. L. Zweier. 1995. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloidβ-peptide. Nature Medicine,1(70):693-699. 6. Shi du Yan, Xi Chen, Jin Fu, Ming Chen, Huaijie Zhe, R, Alex, T. Slattery, Z. Lei, M. Nagashina, J. Morser, A. Migheli, P. Nawroth, D. Stern and A. M. Schmidt. 1996. RAGE and amyloid-βpeptide neurotoxicity in Alzheimer's disease. Nature, 382: 685-691. 7. Joseph El Khoury, S. E. Hickman, C. A. Thomas, L. Cao, S. C. Silverstein and J. D. Loike. 1996. Scavenger receptor-mediated adhesion of microglial toβ-amyloid fibrils. Nature,382:716-719. 8.Lucia Meda M. A. Cassatella, G. I. Szendrei, L. O. Jr, P. Baron, M. Villalba, D. Ferrari and F. Rossi. 1995. Activation of microglial cells byβ-amyloid protein and interferon-γ. Nature, 374: 647-650. 9.Mark P. Mattson. 1997. Cellular actions of b-amyloid precusor protein and it's souble and fibrillogenic derivatives. Physiological Reviews. 77(4): 1081-1132. 10. Yoshikai, S., H. Sasaki, K. Doh-ura, H. Furuya, and Y. Sakaki. 1990. Genomic organization of the human amyloid beta-protein precursor gene. Gene, 87: 257-263. 11. Golde, T. E., S. Estus, M. Usiak, L. H. Younkin, and S. G. Younkin. 1990. Expression of b amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron, 4: 253-267. 12. Golde, T. E., S. Estus, L. H. Younkin, D. J. Selkoe, and S. G. Younkin.1992. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science, 255: 728-730. 13.Haass, C., M. G. Schlossmacher, A. Y. Hung, C. Vigo-Pelfrey, A. Mellon, B. L. Ostaszewski, I. Lieberburg, E. H. Koo, D. Schenk, D. B. Teplow, and D. L. Selkoe. 1992. Amyloid b-peptide is Produced by cultured cells during normal metabolism. Nature, 359: 322-325. 14.Estus, S., T. E. Golde, T. Kunishita, D. Blades, D. Lowery, M. Eisen, M. Usiak, X. Qu, T. Tabira, B. D. Greenberg, and S. G. Younkin. 1992. Potentially amyloidogenic, carboxy-terminal derivatives of the amyloid protein precursor. Science, 255: 726-728. 15. Araki, W., N. Kitaguchi, Y. Tokushima, K. Ishii, H. Aratake, S. Shimohama, S. Nakamura, and J. Kimura. 1991. Trophic effect of b-amyloid precursor protein on cerebral cortical neurons in cluture. Biochem. Biophys. Res. Commun., 181: 265-271. 16. Mattson, M. P., B. Ceng, A. Culwell, F. Esch, I. Lieberburg, and R. E. Rydel. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of b-amyloid precursor protein. Neuron, 10: 243-254. 17. Jung, S. S., J. Nalbantoglu, and N. R. Cashman. 1996. Alzheimer's b-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: a flow cytometric study. J. Neurosci. Res., 46: 336-348. 18. Jin, L., H. Ninomiya, J. Roch, D. Schubert, E. Masliah, D. Otero, and T. Saitoh. 1994. Peptides containing the RERMS sequence of Amyloid b/A4 protein precursor bind cell surface and promote Neurite extension. J. Neurosci., 14: 5461-5470. 19. Furukawa, K., B. Sopher, R. E. Rydel, J G. Begley, G. M. Martin, and M. P. Mattson. 1996. Increased activity-regulating and neuroprotective efficacy of a-secretase-derived secreted APP is conferred by a C-terminal heparin-binding domain. J. Neurochem., 14: 1882-1896. 20. Kibbey, M, M. Jucker, S. Week, R. Neve, W. Van Nostrand, and H. Kleinman. 1993. b-Amyloid precursor protein binds to the Neurite-promoting IKVAV site of laminin. Proc. Natl. Acad. Sci. USA., 90: 10150-10153. 21. Barger, S. W., R. Fiscus, P. Ruth, F. Hofmann, and M. P. Mattson. 1995. Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of b amyloid precursor. J. Neurochem., 64: 2087-2096. 22. Barger, S. W., and M. P. Mattson. 1995. Secreted form of the Alzheimer's amyloid precursor protein stimulates a membrane- Associated guanylate cyclase. Biochem. J., 311: 45-47. 23. Furukqwa, K., S. Barger, E. Blalock, and M. Mattson. 1996. Activation of K+ channels and suppression of neuronal activity by secreted b-amyloid precursor protein. Nature, 379: 74-78. 24. Furukawa, K., and M. P. Mattson. Secreted APPa suppresses NMDA currents in hippocampal neurons: involvenment of cyclic GMP. Neuroscience. In press. 25. Barger, S. W., and M. P. Mattson. 1995. Induction of neuroprotective k b-dependent transcription by secreted forms of the Alzheimer's b-amyloid precursor. Mol. Brain Res., 40: 116-126. 26. Barger, S. W., D. Horster, K. Furukawa, Y. Goodman, J. Krieglstein, and M. P. Mattson. 1995. TNFa and TNFb protect hippocampal neurons against amyloid b-peptide toxicity: evidence for involvement of a k b-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc. Natl. Acad. Sci. USA., 92: 9328- 9332. 27. Bruce, A. J., W. Boling, M. S. Kindy, J. Peschon, P. J. Kraemer, M. K. Carpenter, F. W. Holtsberg, and M. P. Mattson. 1996. Altered neuronal and microglial responses to brain injury in mice lacking TNF receptors. Nature Med., 2: 788-794. 28. Nishmoto, I., T. Okamato, Y. Matsuura, S. Takahashi, T. Oka Mato, Y. Murayama, and E. Ogata. 1993. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go. Nature, 362: 75-79. 29. Smith-Swintosky, V. L., S. Zimmer, J. W. Fenton II, and M. P. Mattson. 1995. Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation- induced injury. J. Neurosci., 15: 5840-5850. 30. Smith-Swintosky, V. L., S. Zimmer, J. W. Fenton II, and M. P. Mattson. 1995. Opposing actions of thrombin and protease nexin-1 on amyloid b-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons. J. Neurochem., 65: 1415-1418. 31. Small, D., V. Nurcombe, G. Reed, H. Clarris, R. Moir, K. Beyreuther, and C. Masters. 1994. A heparin-binding domain in the amyloid precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J. Neurosci., 14: 2117-2127. 32. Ghiso, J., A. Rostagno, J. E. Gardella, L. Liem, P. D. Gorevic, and B. Frangione. 1992. A 109 amino acid C-terminal fragment of Alzheimer's disease amyloid precursor protein contains a sequence, RHDS, that promotes cell adhesion. Biochem. J., 288: 1053-1059. 33.Beher, D., L. Hesse, C. L. Masters, and G. Multhaup. 1996. Regulation of amyloid protein precursor ( APP ) binding to collagen and mapping of the binding sites on APP and collagen type I. J. Biol. Chem., 271: 1613-1620. 34. Ninomiya, H., J. Roch, and T. Saitoh. 1994. Secreted form of amyloid b/A4 protein precursor ( APP ) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity. J. Neurochem., 63: 495-500. 35. Roch, J., E. Masliah, A. Roch-lLevecq, M. Sundsmo, D. Otero, S. Veinberg, and T. Saitoh. 1994. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid b/A4 protein precursor. Proc. Natl. Acad. Sci. USA., 91: 7450-7454. 36. Ninomiya, H., J. Roch, M. Sundsmo, D. Otero, and T. Saitoh. 1993. Amino acid sequence RERMS represents the active domain of amyloid b/A4 protein precursor that promotes fibroblast growth. J. Cell Biol., 121: 879-886. 37.Van Broeckhoven C. J. Haan, E. Bakker, Harely JA, Van hul W, MD. Power and I. Lieberburn. 1990. Amyloid b protein precursor gene and hereitary cerebral hemorrhage with amyloidosis (Dutch). Science, 248 : 1120-1122. 38.Levy E and IJ. Fernandez-madrid. 1990. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrage, Dutch type. Science, 248 : 1124-1126. 39.Goate A. M-C. Chartier-Harlin, M. Mullan, J. Brown, and F. Crawford. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature, 349 : 704-706. 40.Hendricks L., CM. Van Duijn, P. Cras, M. Cruts and W. Van Hul.1992. Presenile dementia and cerebal haemorrhage linked to a mutation at condon 692 of the b-Amyloid precursor protein gene. Nature Genet, 1 : 218-221. 41.Shen J., RT. Bronson, DF. Chen, W. Xia, DJ. Selkoe and S. Tonegegawa. 1997. Skeletal and CNS defects in presenilin-1deficient mice. Cell, 89 : 629-639. 42.Lemere CA, F. Lopera, KS. Kosik, Cl. Lendon and J. Dssa. 1996. The E280A presenilin 1 Alzheimer mutation produces increased Ab42 deposition and severe cerebellar pathology. Nature Medicine, 2 : 1146-1150. 43.Perez-Tur J, S. Forelich, G. Prihar, R. Crook and m. Baker. 1995. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport, 7 : 297-301. 44.Levy- Lahad E, W. Wasco, P. Poorkaj, DM. Romano and J. Oshima. 1995.Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science,269 : 973-977. 45.Levy- Lahad E, EM. Wijsman, E. Nemens, L. Anderson and KAB. Goddard. 1995. A familial Alzheimer's disease locus on chromosome 1. Science 269 : 970-973. 46.Rogaev EI., R. Sherrington, EA. Rogaeva, G. Levesque and M. Ikeda. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376 : 775-778. 47. Zheng H, Jiang M-H, Trumbauer ME, Sirinathsinghji DJS, Hopkins R, et al. 1995. b-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell, 81: 525-531. 48. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. 1997. Skeletal and CNS defects in presenilin-l-deficient mice. Cell, 89: 629-639. 49. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, et al. 1995. An adverse property of a familial ALS-linked SOD l mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron., 14: 1105-1116. 50. Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegon M, et al. 1992. Deposition of b/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA., 89: 857-861. 51. Neve RL, Kammesheidt A, Hohmann CF. 1992. Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc. Natl. Acad. Sci. USA., 89: 3448-3452. 52. Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, et al. 1992. Cholinergic agonists and interleukin l regulate processing and secretino of the Alzheimer b/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA., 89: 10075-10078. 53. Hsiao K, Chapman P, Nilsen S, Eckman C, Hargaya Y, et al. 1996. Correlative memory deficients, Ab elevation and amyloid plaques in Transgenic mice. Science, 274: 99-102. 54. LaFerla FM, Tinkle BT, Bieberich CJ, Hauden-schild CC, Jay G. 1995. The Alzheimer's Ab peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet., 9: 21-30. 55.Price D. L. and S. S. Sisodia. 1998. Mutant genes in familial Alzheimer's disease and transgenic models. Ann. Rev. Neurosci. 21 : 479-505. 56.Barger, S. W. and A. D. Harman. 1997. Microglial activation by Alzheimer amyloid precusor protein and modulation by apolipoprotein E. Nature, 388 : 878-881. 57. Gerrd Multhaup, A. Schlicksupp, L. Hesse, D. Beher, T. Ruppert, C. L. Masters and K. Beyreuther. 1996. The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper (I). Science. 271 ; 1406-1409. 58. Holcomb , L., M. N. Gordon, E. Mcgowan, X. Yu, et al. 1998. Accelerated Alzheimer-type phenotype in transgenic mice canying both mutant amyloid precusor protein and presenilin 1 transgene. Nature Medicine, 4( 1 ): 97-100. 59. Wanggai , M., I. Imafuku, S. Takeuchi, I. Kanazawa, F. Dyama, Y. Udagawa, M. kanabata, and H. Okazawa. 1997. Presenilin 1 binds to amyloid precursor protein directly. Biochemical and Biophysical Research communication, 239: 480-482. 60. Thinakaran, G., J. B. Regard, C. M. L. Bouton, C. L. Harris, D. L. Price, D. R. Borchelt, and S. S. Sisodia. 1998. Stable association of Presenilin derivatives and absence of presenilin interaction with APP. Neurobilogy of Disease, 4: 438-453. 61. Pradier, L., N. Carpentier, L. Delalonde, N. Clavel, M. D. Bock, L. Buee, L. Mercken, B.Tocque and C. Czech. 1999. Mapping the APP/Presenilin ( PS ) binding domains : The hydrophilic N- terminus of PS2 is sufficient for interaction with APP and displace APP/PS1 interaction. Neurobiology of Disease, 6: 43-55. 62. Li J., M. Xu, H. Zhou, J. Ma and H. Potter. 1997. Alzheimer Presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell, 90: 917-927. 63. Suzuki , T., M. Oishi, D. R. Marshak, A. J. Czernik, A. C. Nairn and P. Greengard. 1994. Cell cycle-dependent regulation of the phosphorylation and metabolism of Alzheimer amyloid precursor protein. The EMBO Journal, 13( 5 ): 1114-1122. 64. Behl, C., J. B. Daris, R. Lesley and D. Schubert. 1994. Hydrogen peroxide mediates amyloid-b protein toxicity. Cell, 77: 817-827. 65. Evan G. and T. Littlewood. 1998. A matter of life and cell death. Science, 281: 1317-1321. 66. Roperch, J. P., V. Alvaro, S. Prieur, M. Tuynder, M. Nemanui, F. Lethrosne, L.Piouffre, M. C. Gendron, D. IsraeLi, J. Dausset, M. Oren, R. Amson and A. Telerman. 1998. Inhibition of presenilin 1 expression is promoted by P53 and P21WAF-1 and results in apoptosis and tumor suppression. Nature Medicine, 4( 7 ): 835- 838. 67.J. Sambrook, E. F. Fritsch and T. Manitatis.1989. Molecular cloning. Cold spring harbor laboratory press. 68.Daniel M. B., M. D. Rozycki and S. J. Edelstein. 1996. Protein Methods. Second edition. A John Wiley & Sons. INC.. Publication. New York. 69.R. I. Freshney. 1994. Cell culture of animal cells. Willey-Liss. New York. 70.Hansen M. B., S. E. Nielsen and K. Berg. 1989. Re-examination and futher development of a precise and rapid dye method for measuring cell growth/cell kill. Journal of Immunological Methods, 119 : 203-210. 71.Howard M. Shapiro. 1995. Practical flow cytometry. WILEY- LISS. New York. 72.Furukawa K. et al. 1996. Activation of K+ channels and supression of neuronal activity by secreted beta-amyloid-precusor protein. Nature, 379(6560):74-78. 73.Grnat SM et al. 1999. Mitochondrial abnormalities in neuroectodermal cell stably expressing human amyloid precursor protein. Neuroreport. 10(1):41-46. 74.Yihai Cao, W. J. Richard, D. Davidson, J. Schaller, D. Marti, S. Sohndel, S. G. McCance, S. O. Michael, L. Miguel and J. Folkman. 1996. Kingle domains of human Angiostatin.J.B.C. 271:29461-29467. 75.Yihai Cao, Andrew Chen, Seong Soo A. An J. W. Richard, D. Davidson, Yumei Cao and M. Linas.1997. Kingle 5 of plasminogen is a novel inhibitor of endotheial. 1997, 272:22924-22938. 76.Shin Hisahara, Shin ichi Shoji, Hideyuki Okano and Masayuki Miura. 1997. ICE/CED-3 familuy executes Oligodendrocyte apoptosis by tumor nucrosis factor. Journal of neurochemistry, 69:10-20. 77.Christopher, D.B. et al. 1999. RGD peptides indues apoptosis by direct caspase-3 activation. Nature, 397:534-539. 78.Antoni Matilla, B. T. Koshy, C. J. Cummings, T. Isobe, H. T. Orr and H. Y. Zoghbi. 1997. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Nature, 389:974-978.
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