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研究生:李珍珍
研究生(外文):Lee Chen Chen
論文名稱:多環芳香烴引起ECV304細胞外鈣離子內流及一氧化氮生成作用
論文名稱(外文):Polycyclic aromatic hydrocarbons induce extracellular calcium influx and nitric oxide formation in ECV304 cells
指導教授:康照洲康照洲引用關係
指導教授(外文):Kang Jaw Jou
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:毒理學研究所
學門:醫藥衛生學門
學類:其他醫藥衛生學類
論文種類:學術論文
論文出版年:1999
畢業學年度:87
語文別:中文
論文頁數:93
中文關鍵詞:多環芳香烴內皮細胞鈣離子一氧化氮
外文關鍵詞:polycyclic aromatic hydrocarbonsendothelialsCa2+NO
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多環芳香烴類為廣泛存在環境污染物不論在水、土壤、沈澱物及植物的表面及城市、鄉村都可偵測到其存在。雖然已有許多報導指出多環芳香烴類對於人體健康的危害例如致癌及免疫毒性但對於其在心血管功能可能產生的影響仍然不是十分明朗。之前,我們實驗室證實數種多環芳香烴類在老鼠胸主動脈上會透過活化內皮細胞內一氧化氮合成而引起一種需內皮細胞存在下才有的血管放鬆作用 ;而最近我們也發現多環芳香烴類在老鼠胸主動脈所造成cGMP上升是需要細胞外鈣離子存在的。因此,為了進一步探討多環芳香烴類在內皮細胞上的直接作用,我們利用人類臍靜脈轉型細胞株(ECV304)來做進一步的實驗。
我們發現多環芳香烴類包括acenaphthene, acenaphthylene, naphthalene,fluorene,fluoranthene都會隨濃度的增加而引起ECV304細胞內鈣離子濃度上升及一氧化氮產生量隨之增加。而外加細胞外鈣離子螯合劑EGTA可抑制多環芳香烴類所引起細胞內鈣離子濃度上升及一氧化氮產生增加的情形;此外,我們利用許多不同鈣離子通道抑制劑來進一步瞭解多環芳香烴類所引起細胞內鈣離子濃度上升由那一個通道進入,由結果得知只有Ni2+ (nonselective calcium channel blocker)及SKF96365 (receptor operator calcium channel blocker)才可抑制而其他如verapamil,dilitiazem (voltage dependent calcium channel blocker),amiloride (Na+-Ca2+ exchange blocker)都沒有抑制作用。而我們也用了細胞色素P450抑制劑econazole,miconazole (P4501A 抑制劑),SKF 525A (nonselective P450抑制劑)去釐清多環芳香烴類所引起細胞內鈣離子濃度上升及一氧化氮產生增加的情形是否需透過細胞色素P450代謝,結果也顯示沒有抑制現象。因此,由本實驗結果所得結論為環境污染物多環芳香烴類可透過細胞外鈣離子內流而活化內皮細胞上的一氧化氮合成而釋放一氧化氮。
Polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants which have been detected in surface waters, sediment, soils, plants, and both rural and urban air. Although numerous studies have examined the deleterious health effects of PAHs, their role in the development of cardiovascular disorders remains controversial. Previously, we have shown that several PAHs induced vasorelaxation through activation nitric oxide (NO) synthase in endothelium of rat aorta. In the preliminary study, we have seen that the cGMP contents of rat aorta were elevated upon addition of PAHs in an extracellular calcium dependent manner. The direct effects of PAHs on endothelium were further investigated by using the transformed human endothelial cell, ECV304.
We have found that PAHs, including acenaphthene, acenaphthylene, naphthalene, fluorene, fluoranthene, dose dependently induced the increase of [Ca2+]i and NO formation in ECV304 cells. The increase of [Ca2+]i and NO formation induced by PAHs were inhibited when the extracellular calcium was chelated by EGTA. However, higher concentration of PAHs induced a minor raise of [Ca2+]i even in the absence of extracellular calcium. We have also found that the PAHs induced [Ca2+]i increase and NO formation were inhibited by Ni2+ (nonselective calcium channel blocker) and SKF96365 (receptor-operated calcium channel blocker), but not by the verapamil, diltiazem (voltage-dependent calcium channel blockers) and amiloride (Na+-Ca2+ exchange blocker). In addition, we have found that the effects of PAHs on ECV304 cells were not inhibited by econazole, miconazole (P450 1A inhibitors) and SKF 525A (nonselective P450 inhibitor). The results from this study suggested that PAHs could induce influx of extracellular calcium which further activate the NO synthase of endothelial cell and hence NO formation.
圖目錄
Fig.1 The structure of PAHs which were listed by U.S. EPA of heavy effect on health...............................................................................3
Fig.2 Role of endothelial P2-purinergic receptors in the interaction between platelets and a lesion of the arterial wall.........................8
Fig.3 Endothelium-derived vasoactive substances .................................9
Fig.4 Schematic representation of the interations that NO can undergo and the effects of NO both as a physiological messenger and a cytotoxic agent ............................................................................13
Fig.5 Cytotoxic effect of PAHs in ECV304 cells .................................78
Fig.6 Effect of ATP on [Ca2+]i changes in ECV304 cells ......................79
Fig.7 Naphthalene induced increase of [Ca2+]i in ECV304 cells ..........80
Fig.8 Effect of naphthalene on [Ca2+]i change in ECV304 cells ...........81
Fig.9 Effect of acenaphthylene on [Ca2+]i changes in ECV304 cells ....82
Fig.10 Effect of acenaphthene on [Ca2+]i changes in ECV304 cells .....83
Fig.11 Effect of fluorene on [Ca2+]i changes in ECV304 cells ..............84
Fig.12 The dose-dependent effect of fluoranthene on 45Ca2+-uptake in ECV304 cells ..............................................................................85
Fig.13 The induction of NO production by naphthalene in ECV304 cells .............................................................................................86
Fig.14 The induction of NO production by acenaphthylene in ECV304 cells .............................................................................................87
Fig.15 The induction of NO production by acenaphthene in ECV304 cells .............................................................................................88
Fig.16 The induction of NO production by fluoranthene in ECV304 cells .............................................................................................89
Fig.17 The induction of NO production by fluorene in ECV304 cells .90
Fig.18 The effect of calcium blockers, and P450 inhibitors on 45Ca2+-uptake induced by fluoranthene in ECV304 cells.....................
表目錄
Table.1 Summary of the characteristics and properties of the different isoforms of nitric oxide synthase(NOS)...............................10
Table.2 Factors affecting the effect of PAHs on the induction of cyclic GMP formation in rat aorta ......................................................23
Table.3 The effect of calcium channel blockers and P450 inhibitors on increases of intracellular calcium induced by PAHs in ECV304 cells............................................................................................92
Table.4 The effect of calcium channel blockers and P450 inhibitor on increase of NO production upon treated by PAHs in ECV304 cells............................................................................................93
Albert, R.E., Nishizumi, M., and Burns, F.J. Effect of carcinogens on atherosclerosis in the chicken aorta. Proc. Am. Assoc. Cancer Res. 1975 16, 25.
Albert, R.E., Vanderlaan, F.J., Burns, F.J. and Nishizumi, M. Effect of carcinogens on chicken atherosclerosis. Cancer Res. 1977 37, 2232.
Almers, W., and Neher, E. The Ca signal from fura-2 loaded mast cells depends strongly on the method of dye-loading. Federation of European Biochemical Societies. 1985 192 (1) 13-18.
Arfstenm, D.P., Schaeffer, D.J., and Mulveny, D.C. The effect of near ultraviolet radiation on the toxic effects of polycyclic aromatic hydrocarbons in animals and plants: review. Ecotoxicol. Environ. Safety 1996 33, 1-24.
Arnal, J.F., Warin, L., and Michel, J.B. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 1992 90, 647-652.
Babich, H., Sardana, M.K., and Borenfreund, E. Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line. Cell Biol. Toxicol. 1988 4, 295-309.
Baroni, C.D., Scelsi, R., Scelsi, M., Soravito, G., Ruco, L., and Uccini, S. T and B immunodepression during 7,12-dimethylbenz[a]anthracene (DMBA) carcinogenesis in mice. Adv. Exp. Med. Biol. 1975 66, 501-506.
Barzu, T., Molho, P., Tobelem, G., Petitou, M., and Caen, J. Binding and endocytosis of heparin by human endothelial cells in culture. Biochim. Biophys. Acta. 1985 845, 196.
Battegay, E.J., Raines, E.W., Seifert, R.D., and Ross, R. TGF-βinduces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 1990 63, 515-524.
Beach, A.C., and Harmon, H.J. Additive effects and potential inhibitory mechanism of some common aromatic polutants on in vitro mitochondrial respiration. J. Biochem. Toxicol. 1992 7, 155-161.
Bernard, K.L., and Brigham, K.L. Acute respiratory distress in adults. Cardiol. Ser. 1984 7, 5.
Bjorseth, A., and Ramdahl, T. Handbook of polycyclic aromatic hydrocarbons, Marcel Dekker, New York, P. 1.
Bock, K.W., Van, Ackeren, G., Lorch, F., and Birke, F.W. Metabolism of naphthalene to naphthalene dihydrodiol glucuronide in isolated hepatocytes and in liver microsomes. Biochem. Pharmacol. 1976 25, 2351-2356.
Borneff, J., Selenka, F., Kunte, H., and Maximomos, A. The synthesis of 3,4-benzopyrene and other polycyclic aromatic hydrocarbons in plants. Environ. Res. 1968 2, 22-29.
Boulanger, C.M., and Luster, T.F. Release of endothelin from the porcine aorta. J. Clin. Invest. 1990 85, 587-590.
Boulanger, C.M., Tanner, F.C., Bea, M.L., Hahn, A.W., Werner, A., and LUster, T.F. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Cir. Res. 1992 70, 1191-1197.
Bradford, M.M. A rapid and sensitive method for the quantiation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976 72, 248-254.
Breemen C. Role of calcium in the activation of endothelial cells. J. Cardiovasc. Pharmacol. 1988 12 (suppl. 5) S119-123.
Bregestovski, P., Bakhramov, A., Davilov, S., Moldobaeva, A., Takeda, K. Histamine-induced inward currents in cultured endothelial cells from human umbilical vein. Br. J. Pharmacol. 1988 95, 429-436.
Brigham, K.L., Bowers, R.E., and Haynes, J. Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ. Res. 1979 45, 292.
Brigham, K.L., Begley, G., Hutchison, A., Loyd, J., Lucht, W., Meyrick, B., Newman, J., Niedermeyer, M., Ogletree, J., and Snapper, J. Septicemia and lung injury 1983 8, 719.
Bryson, S.E., and Rodger, I.W. Effects of phosphodiesterase inhibitor on normal and chemically-skinned isolated airway smooth muscle. Br. J. Pharmacol. 1987 92, 673-681.
Burchiel, S.W., Hadley, W.M., Barton, S.L., Fincher, R.H., Lauer, L.D., and Dean, J.H. Persistent suppression of humoral immunity produced by 7,12-dimethylbenz[a]anthracene in B6C3F1 mice: Correlation with changes in spleen cell surface markers detected by flow cytometry. Int. J. Immunopharmacol. 1988 10, 369-376.
Burchiel, S.W., Davis, D.P., Gomez, M.P. Montano, R.M., Barton, S.L., and Seamer, L.C. Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz[a]anthracene. Toxicol. Appl. Pharmacol. 1990 105, 434-442.
Burnstock, G. Neurotransmitters and trophic factors in the autonomic nevous system. J. Physiol. 1981 313, 1.
Buonarati, M., Morin, D., Plopper, C., and Buckpitt, A. Glutathione depletion and cytotoxicity by naphthalene 1,2 oxide in isolated hepatocytes. Chem-Biol. Interact. 1989 71, 147-165.
Busby, W.F.Jr., Garner, R.C., Chow, F.L., Martin, C.N., Stevens, E.K., Newbernw, P.M., and Wogan, G.N. 6-Nitrochrysene is a potent tumorigen in newborn mice. Carcinogenesis. 1985 6, 801-803.
Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D., and Mitchell, J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 1987 47, 936-942.
Castellot, J.J. Jr., Beeler, D.L., Rosenberg, R.D., and Karnovsky, M.J. Structure determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells. J. Cell. Physiol. 1984 120, 315-320.
Chae Y.H., Delclos, K.B., Blaydes, B., and El-Bayoumy, K. Metabolism and DNA binding of the environmental colon carcinogen 6-nitrochrysene in rats. Cancer Res. 1996 56, 2052-2058.
Clapham, D. Intracellular calcium. Replenishing the stores. Nature (London) 1995 375, 634-635.
Cohen, R.A., Shepherd, J.T., and Vanhoutte, P.M. Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets. Science 1983 221, 273-274.
Colden-Stanfield, M., Schilling, W.P., Ritchie, A.K., Eskin, S.G., Navarro, L.T., and Kunze, D.L. Bradykinin-induced increases in cytosolic calcium and ionic currents in bovine aortic endothelial cells. Circ. Res. 1987 61, 632-640.
Conny, A.H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons:G. H. A. clowes memorial lecture. Cancer Res. 1982 42, 4875-4917.
Dawson, J.P., Thayer, W.W., and Desforges, J.F. Acute hemolytic anaemia in the new-born infant due to naphthalene poisoning: report of two cases, with investigations into the mechanism of the disease. Blood 1958 13, 1113-1125.
Davila, R.D., Davis, D.P., Capmbell, K., Cambier, J.C., Zigmond, L.A., and Burchiel, S.W. Role of alteration in Ca2+-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health. 1995 45, 101-126.
Demaurex, N., Lew, D.P., and Krause, K.H. Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells. J. Biol. Chem. 1992 267 (4) 2318-2324.
De Mey, J.G., and Vanhoutte, P.M. Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium. Circ. Res. 1982 51, 439-447.
Dean, J.H., Ward, E.C., Murray, M., Lauer, L.D., and House, R.V. Mechanisms of dimethylbenzanthracene-induced immunotoxicity. Clin. Physiol. Biochem. 1985 3, 98-110.
Diamond, L., and Gelboin, H.V. Alpha-naphthoflavone : an inhibitor of hydrocarbon cytotoxicity and micosomal hydroxylase. Science 1969 166, 1023-1026.
El-bayoumy, K., Shiue, G.H., and Hecht, S.S. Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice. Carcinogenesis. 1989 10, 369-372.
Esbenshade, A.M., Newman, J.H., Lams, P.M., Jolles, H., and Brigham, K.L. Respiratory failure after endotoxin infusion into sheep: lung fluid balance. J.Appl. Physiol. 1982 53, 967.
Escargueil-Blanc, I., Andrieu-Abadie, N., Caspar-Bauguil, S., Brossmert, R., Levade, T., Negre-Salvayre, A., and Salvayre, R. Apoptosis and activation of sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. J. Biol. Chem. 1998 273(42), 27389-27395.
Fein, A., Payne, R., Corson, D.W., Berridge, M.J., and Irvine, R.F. Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate. Nature 1984 311, 157-160.
Freay A., John A., Adams, D.J., Ryan, U.S., and Van Breeman C. Bradykinin and inositol 1,4,5-triphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells. Pflunger Arch. 1988 65, 2221-2227.
Forrester, T. and Lind, A.R. Adenosine triphosphate in the venous effuent and its relationship to exercise. Federation Proceeding. 1969 28, 1280.
Furchgott, R.F. and Zawadzki, J.V. The obligatory role of endothelium cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 1980 288, 373-376.
Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P.A. Adenosine diiphosphate in red cells as a factor in the adhesiveness of human blood platelet. Nature (London) 1961 192, 531.
Garg, U.C., and Hassid, A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 1989 83, 1774-1777.
Glushkov A.N., Anosova T.P., Anosov M.P., Nebesnaia N.G., Zheleznova L.I., and Kurilov K.S. New approaches in evaluating the antitumor immune response in breast cancer. Voprosy Onkologii 1996 42, 33- 36.
Graber, M., and Pastroiza-Munoz, E. Regulation of cell pH by K+/H+ antiport in renal epithelial cells. J. Physiol. 1993 265, F773-F783.
Graier, W.F., Schmidt, K., and Kulkovetz, W.R. Is the bradykinin-induced Ca2+ influx and the formation of endothelium-derived relaxation factor mediated by a G protein. Eur. J. Pharmacol. 1992 225, 43-49.
Graier, W.F., Simecek, S., and Sturek, M. Cytochrome P450 mono-oxygenase-regulated signalling of Ca2+ entry in human and bovine endothelial cells. J. Physiol. 1995 482 (2) 259-274.
Grynkiewicz, G., Poenie, M., and Tsiec, R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985 260 6, 3440-3450.
Hahn, A.W., Resink. T.J., Scott-Burden, T., Powell, J., Dohi, Y., and Buster, F.R. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function. Cell. Regul. 1990 1, 649-659.
Hardin, J.A., Hinoshita, F., and Sherr, D.H. Mechanisms by which benzo[a]pyrene, an environmental carcinogen, suppresses B cell lymphopoiesis. Toxicol. Appl. Pharmacol. 1992 117, 155-164.
Harrison, D.G., Freiman, P.C., Armstrong M.L., Marcus, M.L., and Heistad, D.D. Alterations of vascular reactivity in atherosclerosis. Circ. Res. 1987 61, 1174-1180.
Hirano, S.I., Agata, N., Hara, Y., Iguchi, H., Shirai, M., Tone, H., and Urakawa, N. A possible mechanism of endothelium-dependent relaxation induced by pirarubicin and carbachol in rat isolated aorta. J. Pharm. Pharmacol. 1992 44, 244-249.
Hobel, B.G., Kostner, G.M., and Graier, W.F. Activation of microsomal cytochrome P450 mono-oxygenase by Ca2+ store depletion and its contribution to entry in porcine aortic endothelial cells. Br. J. Pharmacol. 1997 121, 1579-1588.
Hughes, A.D., and Schachter, M. Mutiple pathways for entry of calcium and other divalent cations in a vascular smooth muscle cell line (A7r5). Cell Calcium. 1994 15(4), 317-30.
Hutter J.F., Piper, H. M., and Spieeckermann, P.G. Myocardial fatty acid oxidation: evidence for an albumin-receptor-mediated membrance transfer of fatty acid. Basic Res. Cardiol. 1984 79, 294.
Ignarro, L.J. Endothelium-derived nitric oxide : actions and properties. FASEB J. 1989 3, 31-36.
Imaida, K., Uneyama, C., Ogasawara, H., Hayashi, S., Fukuhara, K., Miyata, N., and Takahashi, M. Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Cancer Res. 1992 52, 1542-1545.
Isabelle, E.-B., Andrieu-Abadie, N., Caspar-Bauguil, S., Brossmer, R., Levade, T., Negre-Salvayre, A., and Salvayre, R. Apoptosis and activation of the Sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. J. Biol. Chem. 1998 16, 27389-27395.
Jeng, Y.J., and Peng, F.C. Chemical analysis and identification of motorcyclic exhaust particles. The Twelth Joint Annual Conference of Biomedical Sciences 1997 P149.
Jesen, B.S., Strobaek, D., Christophersen, P., Jorgensen, T.D., Hansen, C., Silahtaroglu, A., Oleasn, S.P., and Ahring, P.K. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. Am. J. Physio. 1998 275(3 Pt 1), C848-856.
Joannides, R., Haefeli, W.E., Linder, L., Richard, V., Bakkli, E.H., Thuillez, C., and LUscher, T.F. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo. Circulation. 1995 91, 1314-1319.
Johns, A., Lategan, T.W., Lodge, N.J., Ryan, U.S., van Breeman, C., and Adams, D.J. Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells. Tissue Cell 1987 19, 733-745.
Johns, A., Freaz, A.D., Adams, D.J., Lategan, T.W., Ryan, U.S., and van Breeman, C. Role of calcium in the activation of endothelial cells. J. Cardiovasc. Pharmacol. 1988 12, 5119-5123.
Kang, J.J., and Cheng, Y.W. Polycyclic aromatic hydrocarbons-induced vasorelaxation through activation of nitric oxide synthase in endothelium of rat aorta. Toxicol.Lett. 1997 93, 39-45.
Kataoka, M., and Tavassli, M. Ceruloplasmin receptors in liver cell suspensions are limited to the endothelium. Exp. Cell Res. 1984 155, 232.
King, G.L., and Johnson S.M. Receptor-mediated transport of insulin across endothelial cells Science 1985 227,1582.
Konar, N.R., Roy, H.K., and De, M.N. Naphthalene poisoning. Indian. Med. Gaz. 1939 74, 723-725.
Koch, H.R., Doldi, K., and Hockwin, O. Naphthalene cataract development. Doc. Ophthal. 1976 3, 323-332.
Koch, B.D., Faurot, G.F., Kopanitsa, M.V., and Swinney, A.P. Pharnacology of a Ca2+-influx pathway activated by emptying the intracellular Ca2+ store in HL-60 cells: evidence that a cytochrome P450 is not involved. Biochem. J. 1994 302, 187-190.
Kuno M., and Gardner, P. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes. Nature 1987 326, 301-305.
Kuster, C.F., and Luster, T.F. Different mechanisms if endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 1995 25, 194-200.
Lakritz, J., Chang, A., Weir, A., Nishio, S., Hyde, D., Philpot, R., Buckpitt, A., and Plopper, C. Cellular and metabolic basis of clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. Ⅰ: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenase in mice exposed to multiple doses of naphthalene. J. Pharmacol. Exp. Therapeu. 1996 278, 1408-1418.
Lansman, J.B. Hallam T.J., and Rink T.J. Single stretch-activated ion channels in vascular endothelial cells as mechanotransducer. Nature 1987 325, 811-813.
Lariviere, R., Thibault, G., and Schiffrin, E.L. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension 1993 21, 294-300.
Lawrie, A.M., Zolle, O., and Slimpson, W.M. Modulation of mitochondria Ca2+ in ECV304 endothelial cells by agents which elevate cAMP. Cell Calcium 1997 22(4), 229-234.
Lerman, A., Edward, B.S., Hallett, J.W., Heublein, D.M., Sandberg, S.M., and Burnett, J.J. Circulation and tissue endothelin immunoreactivity in advanced atherosclerosis. N. Engl. J. Med. 1991 325, 997-1001.
Lincoln, J., Hoyle, C.H.V., and Burnstock, G. Nitric oxide in health and disease. Cambridge University Press 1997.
Lomax, R.B., Herreo, C.J., Garcia-Palmero, E., Garcia, A.G., and Montiel, C. Capacitative Ca2+ entry into Xenopus oocytes is sensitive to omega-conotoxins GVIA, MVIIA, and MVIIC. 1998 23(4), 229-239.
Long C.J., and Stone T.W. The release of endothelium-derived relaxant factor is calcium dependent. Blood Vessels. 1985 22, 205-208.
Lowry, D.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951 193, 265-275.
Lubek, B.M. Kubow, D., Basu, P.K., and Wells, P.G. Cataractogenicity and bioactivation of naphthalene derivatives on lens culture and in vivo. Lens Eye Toxicol. Res. 1989 6, 203-209.
Luckhoff, A., and Clapham, D.M. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 1992 355, 356-358.
Luckoff A., Poul U., Mulsch A., and Busse R. Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells. Br. J. Pharmacol. 1988 95, 189-196.
Luscher, T.F. (Ed.) The endothelium in cardiovascular disease. Springer-Verlag Berlin Heidelberg Press 1995.
Luscher, T.F., and Vanhoutte, P.M. The endothelium: modulator of cardiovascular function. CRC Press, Boca Raton 1990.
Luscher, T.F, Boulanger, C.M., Dohi, Y., and Yang, Z.H. Endothelium-derived contracting factors. Hypertension. 1992 19, 117-130.
Luscher, T.F., Vanhoutte, P.M., and Schiffrin, E.L. Antihypertensive treatment normalizes decreased endothelium-dependent relaxation in rat with salt-induced hypertension. Hypertension 1987 9[Suppl Ⅲ], 193-197.
Marshall S. Handbook of Toxic and Hazardous Chemical and Carcinogenes. 1991 third edition. Park Ridge, N.J., U.S.A.
Margulies, K.B. Hildebrand F.J. Lerman, A., Perrela M.A., and Burnett J.J. Increased endothelin in experimental heart failure. Circulation 1990 82, 2226-2230.
Mason, M.J., Mayer, B., and Hymel, L.J. Inhibition of Ca2+ transport pathway in thymic lymphocytes by econazole. Am. J. Physio. 1993 264(3 Pt 1), C654-662.
Matthews, G., Neher, E., and Penner, R.. Second messenger-activated calcium influx in rat peritoneal mast cells. J. Physiol. 1989 418, 105-130.
McCulloch, A.I., Bottrill, F.E., Randall, M.D., and Hiley, C.R. Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol. 1997 120, 1431-1438.
McQueen, C.A., and Willams, G.M. Cytotoxicity of xenobiotics in adult rat hepatocytes in primary culture. Fundam. Appl. Toxicol. 1982 2, 139-144.
Merritt, J.E., Armstrong, W.P., Benham, C.D., Hallam, T.J., Jacob, R., Jaxa-Chamiec, A., Leigh, B.K., Mccarthy, S.A., Moores, K.E., and Rink, T.J. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J. 1990 271, 515-522.
Meryrick, B. Pathology of adult respiratory distress syndrome. Crit. Care Chin. 1986 2, 405.
Miller, R.C., Schoeffter, P., and Stoclet, J.C. Insensitivity of calcium-dependent endothelial stimulation in rat isolated aorta to the calcium entry blocker flunarizine. Br. J. Pharmacol. 1985 22, 205-208.
Minor, R.Jr., Myers, P.R., Guerra, R.Jr., Bate, J.N., and Harrison, D.G. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest 1990 86, 2109-2116.
Moncada, S., and Vane, V.R. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin. Pharmacol. Rev. 1979 30, 293-331.
Montero, M., Garcia-Sancho J., and Alvarez, J. Comparative effects of cytochrome P-450 inhibitors on Ca2+ and Mn2+ entry induced by agonists or by emptying the Ca2+ stores of human neutrophils. BBA 1993 1177(2), 127-133.
Moreau, P., Takase, H., KUng, C.F., van Rouijen M.M., Schaffner, T., and LUscher T.F. Structure and function of the rat basilar artary during chronic nitric oxide synthase inhibition. Strock. 1995 26 (10), 1922-1928.
Moritoki, H., Hisayama, T., Takeuchi, S., Kondoh, W., Inoue, S., and Kida, K. Inhibiton by SK&F 96365 of NO-mediated relaxation induced by Ca2+-ATPase inhibitors in rat thoracic aorta. Br. J. Pharmacol. 1996 117, 1544-1548.
Mozhaveya, G.N., Naumov, A.P., and Kuryshev, Y.A. Variety of Ca2+-permeable channel in human carcinoma A431 cells. J. Membrane Biol. 1991 124, 113-126.
Mumford, R.S., Chapman, R.S., Harris, D.B., He, X.Z., Cao, Y.L., and Li, X.M. Indoor air expose to coal and wood combustion emission associated with a high lung cancer rate in Xuan Wei, China. Environment International. 1989 15, 315-320.
Nava, E., Noll, G., and LUscher, T.F. Increased cardiac activity of nitric oxide synthase in spontaneous hypertension. Circulation 1995 91, 2310-2313.
Navab, M., Hough, G.P., Berliner, J.A., Frank, J.A., Fogelman, A.M., Haberland, M.E., and Edwards, P.A. Rabbit beta-migrating very low density lipoprotein increased endothelial macromolecular transport without altering electrical resistance. J. Clin. Invest. 1986 73, 1121.
Nebert,D.W., and Gonzalez, F.J. P450 genes: Structure, evolution and regulation. Ann. Rev. Biochem. 1987 56, 945-993.
Olesen, S.P., Clapham, D.E., and Davies, P.F. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature 1988 331, 168-160.
Okada, T., Shimizu, S., Wakamori, M., Maeda, M., Maeda, A., Kurosaki, T., Takada, N., Imoto, K., and Mori, Y. Molecular cloning and function characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J. Biol. Chem. 1998 273 (17) 10279-10287.
Parekh, A.B., Fleig, A., and Penner, R. The store-operated calcium current ICRAC: nonlinear activation by InsP3 and dissociation from calcium release. Cell 1997 89, 973-980.
Parkinson, A. Biotransformation of xenobiotics. In Casarett and Doull’s toxicity:the basic science. (5th ed.) 1996, 113-186, McGraw Hill-press, Inc., New York, U.S.A.
Pearson, J.D., Carleton, S.J., and Gordon, J.L. Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth muscle cells in culture. Biochem. J. 1980 190, 421.
Philipp, S., Cavalie, A., Freichel, M., Wissenbach, S.Z., Trost, C., Marquart, A., Murakami, M., and Flockerzi, V. A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. The EMBO J. 1996 15 22, 6166-6171.
Pott, P. Chirugical Observation Relative to the Cataract Reprint in National Cancer Inst. Monogr. 1983 10, 7-13.
Putney, J.W., Jr. A model for receptor-regulated calcium entry. Cell Calcium 1986 7, 1-12.
Putney, J.W., Jr. Capacitative calcium entry revisted. Cell calcium 1990 11, 611-624.
Radomski, M.W., Palmer, R.M., and Mocada, S. Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelet. Br. J. Pharmacol. 1987 92, 181-187.
Randriamampita, C., and Tsien, R. Emptying of intracellular Ca2+ store releases a novel small messenger that stimulates Ca2+ influx. Nature 1993 364 (36) 809-814.
Ranganathan, R., Malicki, D.M., and Zuker, C.S. Signal transduction in Drosophila photoreceptors. 1995 Annu. Rev. Neurosci. 18, 283-317.
Rees, D.D., Palmer, R.M.J., and Moncada, S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA 1989 86, 3375-3378.
Revis, N.W., Bull, R., Laurie, D., and Schiller, C.A. The effectiveness of chemical carcinogens to induce atherosclerosis in the white carneau pigeon. Toxicology 1984 32, 215-227.
Richard, V., Tanner, F.C., Tschudi, M., and Luscher, T.F. Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries. Am. J. Physiol. 1990 259, H1433-H1439.
Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993 362, 801-809.
Ross, P., De Swart, R., Addison, R., Van Loveren, H., Vos, J., and Osterhaus, A. Contaminant-induced immunotoxicity in harbour seals : wildlife at risk? Toxicology. 1996 112, 157-169.
Rubanyi, G.M., Romero, J.C., and Vanhoutte, P.M. Floe-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 1986 250, H1145-1149.
Russell, P., Yamada, T., Xu, G.T., Garland, D., and Zigler, J.S. Effects of naphthalene metabolites on cultures cell from eye lens. Free Radic. Biol. Med 1991 10, 255-261.
Ryan, J., and Smith, U. Metabolism of adenosine 5’-monophosphate during circulation through the lungs. Trans. Assoc. Am. Physicians. 1971 84, 271.
Ryu. D.Y., Levi, P.E., and Hodgson, E. The regulation of hepatic CYP1A isoenzymes by piperonyl butoxide and acenaphthylene in the mouse. Chemico-Biological Internations. 1997 105(1), 53-63.
Schaeffer, V., Mpanza, Z., and Thakker, D. Novel stereoselectivity of rat liver cytochromes P450 in the metabolism (1S, 2S)-dihydrodiols and (1R, 2R)-dihydrodiols of naphthalene to diol epoxides. Fed. Proc. 1987 46, 865.
Scheepers P.T.J., and Bos R.P. Combustion of diesel fuel from a toxicological perspective. Int. Arch. Environ. Health. 1992 64, 163-177.
Schilling, W.P., Cabello, O.A., and Rajan, L. Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca2+-influx pathway. Biochem. J. 1992 284, 521-530.
Schirmer, K., Dixon. D.G., Greenbery, N.C., and Bols, N.C. Ability of 16 priority polycyclic aromatic hydrocarbons to be directly cytotoxic to a cell line from the rainbow trout gill. Toxicology 1998 127, 129-141.
Schwarz, G., Droogmans, G., and Nilius, B. Multiple effects of SK&F 96365 on ionic currents and intracellular calcium in human endothelial cells. Cell Calcium 1994 15, 45-54.
Sewer, M.B., and Morgan, E.T. Down-regulation of the expression of three major rat liver cytochrome P450s by endotoxin in vivo occurs independently of nitric oxide production. J. Pharmacol. Exp. Ther. 1998 287, 352-358.
Shimokawa, H., Flavhan, N.A., and Vanhoutte, P.M. Natural course of the impairment of endothelium-dependent relaxation after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein. Circ. Res. 1989 65, 740-753.
Shimokawa, H., and Vanhoutte, P.M. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ. Res. 1989 64, 900-914.
Shuttleworth, K.L., and Cerniglia, C.E. Environmental aspects of PAHs biodegradation. Appl. Biochem. Biotech. 1995 54, 291-302.
Stegeman, J.J., Hahn, M.E., Weisbrod, R., Woodin, B.R., Joy, J.S., Najibi, S., and Cohen, R.A. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol. Pharmacol. 1995 47, 296-306.
Stegeman, J.J., Miller, M.R., and Hilton, D.E. Cytochrome P4501A1 induction and localization in endothelium of vertebrate(Teleost)heart. Mol. Pharmacol. 1989 36, 723-729.
Steinberg, S.F., Bilezikian, J.P., and Al-Awqati, Q. Fura-2 fluorescence is localized to mitochondria in endothelial cells. Am. J. Physiol. 1987 253, C744-C747.
Stewart, D.J., Langleben, D., Cernacek, P., and Cianflone, K. Endothelin release is inhibited by coculture endothelial cells with cells of vascular media. Am. J. Physiol. 1990 259, H1928-H1932.
Struble, V,G., and Harmon. H.J. Molecular basis for inhibition of mitochondrial respiration by naphthalene. Bull. Environ. Contam. Toxicol. 1983 31, 644-648.
Taddei, S., Virdis A., Mattei, P., and Salverri A. Vasodiation to acetylcholine in primary and secondary hypertension. Hypertension 1993 21, 929-933.
Takeda, K., Schini, V., and Stoeckel, H. Voltage-activated potassium, but not calcium currents, in cultured bovine aortic endothelial cells. Pflugers Arch. 1987 410, 385-393.
Tanner, F.C., Noll, G., Boulanger, C.M., and Luscher, T.F. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation. 1991 83, 2012-2020.
Tavassoli, M., Kishimoto, T., and Kataoka, M. Liver endothelium mediates the hepatocytes uptake of ceruloplasmin. J. Cell Biol. 1986 102, 1298.
Taylor, C.J.S.O., and Russell. H. Blackwater fever and naphthalene poisoning. W. African Med. J. 1932 5, 48-49.
Thastrup, O., Cullen, P.J., Drobak, B.K., Hanley, M.R., and Dawson, A.P. Thapsigargin, a tumor promotor, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase. Proc. Natl. Acad. Sci. USA 1990 87, 2466-2470.
Tingle, M.D., Pirmohamed, M., Templeton, E., Wilson, A.S., Madden, S., Kitteringham, N.R., and Park, B.K. An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene and human liver microsomes. Biochem. Pharmacol. 1993 46 (9), 1529-1538.
Tosun, M., Paul, R.J., and Rapoport, R.M. Role of extracellular Ca2+ influx via L-type and non-L-type Ca2+ channels in thromboxane A2 receptor-mediated contraction in rat aorta. J. Pharmacol. Exp. Ther. 1998 284 (3) 921-928.
Tomar, R.S., Lim, S., and Gill, S.S. The effects of epoxidized xenobiotics on mitogen responsiveness and antibody-producing ability of murine spleen cells in vitro. Int. J. Immunopharmacol. 1991 13, 57-65.
Trams, E. G., Kaufmann, H., and Burnstock, G. A proposal for the role of ecto-enzymes and adenylates in traumatic shock. J. Theor. Biol. 1980 87, 609.
Tschudi, M., Richard, V., and LUscher T.F. Important of endothelium-derived nitric oxide in porcine coronary resistance arteries. Am. J. Physiol. 1991 260, H13-H20.
Vanhoutte, P.M. Vascular physiology: the end of quest? [news]. Nature 1987 327, 459-460.
Varanasi U., and Stein, J.E. Disposition of xenobiotic chemicals and metabolites in marine organism. 1991 90, 93-100.
Verma, D.K. Polycyclic aromatic hydrocarbons (PAHs): a possible cause of lung cancer mortality among nickle/copper smelter and refinery workers. Am. Ind. Hyg. J. 1992 53, 317-324.
Villalobos, C., Fonter, R., and Peace, F.L. Inhibition of voltage-gated Ca2+ entry into GH3 and chromaffin cells by imidazole antimycotic and other cytochtome P450 blockers. FASEB J. 1992 6, 2742-2747.
Vos, J.G., Moore, J.A., and Zinkl, J.G. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57B1/6 mice. Toxicol. Appl. Pharmacol. 1974 29, 229-241.
Vosta, J.G., and Fratantoni, J.C. Econazole inhibits thapsigargin-induced platelet calcium influx by mechanisms other than cytochrome P450 inhibition. Biochem. J. 1993 295, 525-529.
Vuchetich, P.J., Bagchi, D., Bagchi, M., Hassoun, E.A., Tang, L., and Stohs, J. Naphthalene-induced oxidative stress in rats and the protective effects of vitamin E succinate. Free Radic. Biol. Med. 1996 21 5, 577-590.
Wagner, O.F., Christ G., Wojta, J., Vierhapper, H., Parzer, S., Nowotny, P.J., Schneider, B., WaldhaUal, W., and Binder, B.R. Polar secretion of endothelin-1 by culture endothelial cells. J. Biol. Chem. 1992 267, 16066-16068.
Ward, E.C., Murray, M.J., Lauer, L.D., House, R.V., Iron, R., and Dean, J.H. Immunosuppression following 7.12-dimethyl-benzo[a]anthrancene exposure in B6C3F1 mice. 1. Effects on humoral immunity and host resistance. Toxicol. Appl. Pharmocol. 1984 75, 299-308.
Warren J.B. (Ed.) The endothelium: an introduction to current research. Wiley-Liss, Inc., Publication 1990.
White D.G., and Martin W. Differential control and calcium-dependence of production of endothelium-derived relaxing factor and prostacyclin by pig arotic endothelial cells. Br. J. Pharmcol. 1989 97, 683-690.
Whorton, A.R., Simonds, D.B., and Plantadosi, C.A. Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. Am. J. Physiol. 1997 272, L1161-l1166.
Winkler, H. The composition of adrenal chromaffin granules: an assessment of controversial results. Neuroscience 1976 65, 1.
Wright, C.E., Rees, D.D., and Moncada, S. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc. Res. 1992 26, 48-57.
Wolf, O. Cancer among chemical workers of a naphthalene cleaning plant. Dtsch. Gesund. Heitsm.1976 31, 996-999.
Wolf, O. Carcinoma of the larynx in naphthalene workers. Z. Gesamte Hyg. 1978 24, 737-739.
Wolfgang, F., Graier, S.S., and Michael, S. Cytochrome P450 mono-oxygenase-regulated signaling of Ca2+ entry in human and bovine endothelial cells. J. Physiol. 1995 482, 259-274.
Wood, S.C., and Holsapple, M.P. Effects of 7.12-dimethyl-benzo[a]anthrancene on the superantigen toxic shock syndrome toxin (Tsst-1)-induced proliferation and antibody by engagement of membrance IgM. Eur. J. Biochem, 1993 213, 455-459.
Yamaguchi, K., Near, R., Shneider, A., Gui, H., Ju, S.T., and Sherr, D.H. Fluoranthene-induced apoptosis in Murine T cell Hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol. Pharmacol. 1996 139, 144-152.
Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Yazaki, Y., Goto, K., and Masaki, T. A novel potent vascular endothelial cells. Nature 1988 332, 411-415.
Yang, H.Y. Namkung, M.J. Nelson, W.L., and Juchau, M.R. Phase Ⅱbiotransformation of carcinogens/atherogens in cultured aortic tissues and cells. Ⅰ. Sulfation of 3-hydroxy-benzo[a]pyrene. Drug Metabolism & Disposition. 1986 14(3), 287-292.
Yang, Z., Richard, V., Von Segesser, L., Bauer, E., Stulz, P., Turina, M., and Luscher, T.F. Threshold concentrations of endothein-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm? Circulation 1990 82, 188-195.
Yang, Z., Stulz, P., Von, S.L., Bauer, E., Turina, M., and Luscher, T.F. Different interactions of platelets with arterial and venous coronary bypass vessels. Lancet 1991 337, 939-943.
Yokokawa, K., Kohno, M., Yasunari, K., Murakawa, K., and Takeda, T. Endothelin-3 regulates endothelin-1 production in culture human endothelial cells. Hypertension 1991 18, 304-315.
Zedeck, M.S. Polycyclic aromatic hydrocarbons. A review. J. Environ. Pathol. Toxicol. 1980 3, 537-567.
Zeiher, A.M., Drexler, H., Saurbier, B., and Just, H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age , atherosclerosis, hypercholesterolemia, and hypertension. J. Clin. Invest. 1993 92, 652-662.
Zhang, H.E., Weir, B.K.A., Macdonald, R.L., Marton, L.S., Solenski, N.J., Kwan, A-L., and Lee, K.S. Mechanisms of [Ca2+]i elevation induced by erythrocyte components in endothelial cells. J. Pharmacol. Exp. Ther. 1996 277 (3) 1501-1509.
Zinkham, W.H., and Childs. B. A defect of glutathione metabolism in erythrocytes from patients with a naphthalene-induced hemolytic anemia. Pediatries. 1958. 22, 461-471.
Zuelzer, W.W., and Apt, L. Acute hemolytic anemia due to naphthalene poisoning. J. Am. Med. Assoc. 1949 141, 185-190.
陳瑞明 6-硝基稠二奈之細胞色素P450誘導作用及毒理性質1998,博士論文,國立臺灣大學毒理所。
蕭欣杰 室內環境固相多環芳香烴特性之研究 1997,碩士論文,國立臺灣大學公共衛生學研究所。
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