臺灣博碩士論文加值系統

人們對於中國天然藥草在化妝品上的應用，有很大的興趣。在中國醫藥書籍上，有許多的藥材記錄為具有抗老化的效果。由於自由基的生成與老化有關，因此我們選擇一些被記載為可使用於抗老化的藥材。分別用水、水和丙二醇(1:1)混合液萃取後，測定這些萃取液對超氧自由基生成之清除效果。
結果顯示，這些使用於抗老化中的藥材，以黨參、白芷、杜仲、女貞子之水萃取液，玉竹、生地黃、白朮、澤瀉、桃仁、雞血藤、薏苡仁之水和丙二醇混合液萃取的萃取液，具有較高的超氧自由基清除效果。可見，傳統中藥材可能具有抗老化的效果。

The application of Chinese herbs for anti-aging had been
recorded in the Chinese medical books. The usage of herbs as the ingredients in the cosmetics become to an interesting topic. Because aging related with the free radical formation. Some herbs have been noted as the anti-aging are the candidates for studying on the scavenge superoxide anion radacal effect. The extracts of the herbs are obtained by using the solvents of water, the mixtures of water and propylene glycol(1:1).
Our study demonstrates high scavenge effect of free radical formation in some extracts indicates that those herbs have the potential and could be applied in the cosmetics formulations. These includes extracts of Angelicae Dahuricae Radix, Ligustri Fructus,Eucommiae Cortex and Codonopsitis Radix with water, the extract of Rehmanniae Radix et Rhizoma, Alismatis Rhizoma, Coicis Semen, PersicaeSemen,Atractyloidis Rhizoma,Polygonati Officinalis Rhizoma and Millettiae Caulis with the mixed solvent of water and propylene glycol(1:1).

目錄
中文摘要…………………………………………………………………1
英文摘要…………………………………………………………………2
壹.緒論………………………………………………………………….3
一.自由基之簡介…………………………………………………..3
1-1什麼是自由基?……………………………………………..3
1-2體內的自由基種類..……………………………………….4
1-3一氧化氮自由基…………………………………………….5
1-3-1簡介…………………………………………………..5
1-3-2一氧化氮與神經系統功能…………………………..6
1-3-3一氧化氮與免疫系統功能…………………………..7
1-3-4過量的一氧化氮產生疾病…………………………..8
1-4氧氣自由基………………………………………………….9
1-4-1氧氣自由基的形成…………………………………..9
1-4-2氧氣自由基的破壞性……………………………….11
二.自由基與疾病的關係…………………………………………13
2-1缺血性腦細胞傷害………………………………………..13
2-1-1腦缺血時自由基的失控……………….…………..13
2-1-2自由基在腦缺血的病理作用.……………………..14
2-1-3動物實驗的證據.…………………………………..15
2-2發炎及風溼性關節炎.…………………………………….17
2-2-1發炎………………………………………………….17
2-2-2風溼性關節炎……………………………………….17
2-3癌症……………….……………………………………….18
三.超氧歧化與中藥之研究…….…………………………….19
3-1簡介………………….…………………………………….19
3-2提高內源性SOD活性……….…………………………….19
3-3抗衰老中藥的類SOD活性作用………….……………….23
3-4結語………….…………………………………………….25
四.抗氧化劑之簡介…….……………………………………….26
4-1抗氧化酵素………………….…………………………….26
4-1-1 SOD(superoxide dismutase)……………………..26
4-1-2 Glutathione peroxidase………………………….28
4-1-3 Catalase…………………………………………….29
4-2 微量元素………………………………………………….30
4-3 抗氧化維他命…………………………………………….31
4-3-1 維他命A…………………………………………….31
4-3-2 β胡蘿蔔素………………….………………………32
4-3-3 維他命E…………………………………………….33
4-3-4 維他命C…………………………………………….35
貳.實驗………………………………………………………………….37
一.藥品………………………………………………………….37
二.儀器………………………………………………………….39
三.試劑配製…………………………………………………….40
四.實驗方法…………………………………………………….41
參.結果………………………………….………………………………46
肆.討論…………………….……………………………………………97 伍.結論…………………………………………….……………………98 陸.參考資料……………………………………….……………………99
柒.附錄…………………….……………………….…………………105

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