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研究生:蕭富榮
研究生(外文):Fu-Jung Hsiao
論文名稱:測量組織受熱後的血量與血量的變化以判斷燒傷程度
論文名稱(外文):Heated blood flow and blood volume measurement to determine the burn depth
指導教授:蔡正倫蔡正倫引用關係
指導教授(外文):Cheng-Lun Tsai
學位類別:碩士
校院名稱:中原大學
系所名稱:醫學工程學系
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2000
畢業學年度:88
語文別:中文
論文頁數:50
中文關鍵詞:燒傷程度加熱式光學探頭血量量測Nth order weighting 訊號處理方法
外文關鍵詞:burn depthheating optical probeblood volumeNth order weighting method
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於燒傷的治療,以手術與植皮的方式,已逐漸普遍。相對的,燒傷程度診斷的準確性,將更加重要。然而,燒傷程度的判斷卻仍是一大難題。一般外科醫師,多半由其外觀與感覺功能,判斷燒傷程度,仍有許多誤判的發生。將組織略為加熱並以雷射都卜勒血流計,量測組織內血流變化,以判斷燒傷程度,經實驗證明,具有較高的準確性。本研究,將獲得加熱前後,受測組織血量的變化,是否也能預測燒傷程度。
具有加熱式光學探頭的血量量測系統,將近紅外光源打入受測組織中,量測具有組織受熱後,血量變化的反射光訊號。於不同的量測部位,加熱前後,頻譜強度變化百分率,介於263%-1688%。以量測組織受熱後,血流與血量變化的方法,將可獲得組織燒傷後,組織中血管功能的情形。
研究中並初步架構了Doppler 訊號量測系統,於米漿與豬血的溶液中,轉速值的提高,造成頻寬的增加與較高的高頻成分。並以Nth order weighting的訊號處理方法,高轉速所造成的高頻成分,更加的明顯。

With the widespread practice of excision and grafting, the accuracy of burn depth determination becomes more and more important. However, it remains an unsolved problem in clinical practice. The most commonly used method for estimating the burn depth of skin is based on appearance and sensory function. This method is found to be very unreliable. By slightly heating the wounded skin and measuring the change in blood flow with Laser Doppler flowmeter has been shown to be more accurate in determining the burn depth. In this study, the comparison between the changes in blood flow of microcirculation and blood volume in heated tissue is proposed. The purpose is to find whether the change in blood volume with tissue heating can also be used for determining the skin burn depth.
An heating optical probe and measurement system as designed and built to carry the measurement of the change in blood volume. A near-infrared LED (940nm) projected light into skin tissue, and the reflected light was detected. The reflected light contains information of blood volume variation with tissue heating. Measurement was performed on different positions in human subjects. The spectral power intensity ratio before and after heating ranges from 263% to 1688%. The result shows that it is a promising method for detecting the condition of capillary and small vessel in skin tissue after skin burn.
A prototype of laser Doppler flowmeter was also built to carry out measurement on phantom and whole blood. The results also showed that higher flow rate would cause broader signal bandwidth. Using higher order weighting method, the differences of high-frequency component become more obvious.

目錄
摘要………………………………………………………………………I
英文摘要………………………………………………………………...II
致謝……………………………………………………………………..III
目錄……………………………………………………………………..IV
圖索引…………………………………………………………………..VI
表索引……………………………………………………………….….IX
第一章 簡介……………………………………………………………..1
1.1 燒傷臨床表徵……………………………………………...1
1.2 判斷燒傷程度的方法技術………………………………...2
1.3 雷射都卜勒流速計的發展背景…………………………...3
1.4 photoplethymograpghy(PPG)血量計的發展背景………....4
1.5 研究目的…………………………………………………...5
第二章 基本原理與方法………………………………………………..6
2.1 皮膚的光學特性…………………………………………...6
2.2 皮膚溫度調節機制………………………………………...6
2.3 photoplethymography 原理………………………………6
2.4 Doppler 原理……………………………………………..7
2.5 血流計算公式…………………………………………….9
第三章 研究方法………………………………………………………12
3.1 In vivo 血量變化量測系統(PPG)……………………..12
3.1.1 光學探頭(PPG)……………………………………….12
3.1.2 檢測、整流、放大與濾波線路…………………………16
3.1.3 訊號擷取與分析………………………………………17
3.2 Doppler 訊號量測系統(LDF)……………………….18
3.2.1 流體模型………………………………………………18
3.2.2 檢測、放大與濾波線路………………………………..20
3.2.3 訊號擷取與分析………………………………………21
第四章 結果與討論……………………………………………………22
4.1 Doppler 頻譜分析………………………………………22
4.1.1 米漿Doppler 頻譜分析………………………………22
4.1.2 豬血Doppler 頻譜分析………………………………29
4.2 加熱前後皮膚血量量測………………………………...37
4.2.1 加熱前後血量量測時域分析…………………………37
4.2.2 加熱前後血量量測頻域分析…………………………40
第五章 結論與未來展望………………………………………………47
第六章 參考文獻………………………………………………………48

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