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研究生:馮毓屏
研究生(外文):Feng Yu-Ping
論文名稱:台灣原住民痛風家庭複雜分離分析
論文名稱(外文):Complex Segregation Analysis of Aborigines Gouty Families in Taiwan
指導教授:葛應欽葛應欽引用關係
指導教授(外文):ko Ying-Chin
學位類別:碩士
校院名稱:高雄醫學大學
系所名稱:醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2000
畢業學年度:88
語文別:中文
論文頁數:63
中文關鍵詞:原住民痛風家庭分離分析
外文關鍵詞:aboriginesgoutfamilysegregation analysis
相關次數:
  • 被引用被引用:1
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  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:5
利用分離分析找出痛風家庭的遺傳模式。從三民鄉的布農族,尖石鄉的泰雅族,阿里山鄉的鄒族,牡丹鄉的排灣族,採挨家挨戶的方式對痛風家庭做問卷訪視,痛風的個案是經過專業醫師診斷出來的。研究一共包含了64個原住民痛風家庭,945個個案。利用遺傳流行病學統計軟體S.A.G.E. (Release 2.2) 中的REGTL (version 3.0) 程式來分析這945個個案。有關大人的痛風病史,是由個案自己陳述,而小孩的痛風病史是由雙親代答。分析中使用性別及年齡做調整,結果發現有單一體染色體基因座的模式最適合解釋這些痛風家庭。非孟德爾遺傳模式 (散發模式以及環境模式)具有統計學上顯著意義 (p<0.05),所以非「親代-子代」的遺傳模式假說會被拒絕,不能用來解釋這些原住民痛風家庭。但是,如果把痛風家庭分成,早期發病家庭以及晚期發病家庭兩類加以分析,孟德爾遺傳和環境模式的假說都會被拒絕。所以研究結果可以顯示台灣原住民痛風在家庭之傳遞受到遺傳的影響,並且有主要基因的作用。
Complex segregation analyses were conducted on families of gout probands to delineate the mode of the inheritance. The probands were ascertained from the persons we had visited by door to door and the gout disease had been identified by a practical doctor. The analyses were based on data from 64 aboriginal families with 945 individuals living in Taiwan, and were performed by using the REGTL (Release 2.2) program of the SAGE (version 3.0) package. The gout information of adults was provided by themselves and that of children was from their parents. We used sex and age to adjust covariates. A single locus model fitted the data well, but none of the Mendelian models (recessive, dominant, and arbitrary) could be distinguished. The no-parent-offspring-transmission hypothesis was rejected. However, when we split the data into early-onset and late-onset, both Mendelian and environmental hypotheses relatively were rejected.
第一章、 緒論
第一節、 研究背景及動機…………………………………6
第二章、 文獻探討
第一節、 痛風………………………………………………8
第二節、 原住民的情形…………………………………..11
第三節、 痛風的危險因子……………………………..…12
第四節、 痛風的遺傳………………………….……….…13
第五節、 分離分析…………………………….………….15
第三章、 材料與方法
第一節、 研究族群…………………………………..……22
第二節、 變項的定義………………………………..……24
第三節、 統計分析………………………………..………25
第四節、 五種遺傳模式的虛無假設………………..……27
第四章、 結果
第一節、 痛風個案分布………………………………...30
第二節、 四族原住民分離分析………………………...30
第三節、 30歲以前發病家族分離分析………………..31
第四節、 30歲以後發病家族分離分析………………..32
第五節、 40歲以前發病家族分離分析………………..32
第六節、 三種基因型的機率…………………………...33
第五章、討論………………………………………………...34
◎ 參考文獻………………………………………………….39
* 表一、四族原住民個案的分布…………………………54
* 表二、痛風個案分布……………………………………55
* 表三、發病時期分布……………………………………56
* 表四、原住民痛風家族分離分析結果…………………57
* 表五、30歲以前發病家族分離分析結果…..………….58
* 表六、30歲以後發病家族分離分析結果…..………….59
* 表七、40歲以前發病家族分離分析結果…………..….60
* 附件一、1997年美國風濕病學會所發表之痛風診斷基準
………………………………………………………………..61
* 附件二、分離分析研究和流行病學研究比較………....62
* 圖一:痛風家庭(編號9018)三種基因型的機率……....63
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