臺灣博碩士論文加值系統

在本研究中我們利用McMurry的合成方法以Ti-Zn為反應試劑，且以泰母芬（Tamoxifen）為骨架，改變苯環上之取代基與烷基修飾其結構，而製備1-（4-胺苯基）-1,2-二苯基-1-丁烯；1-（4-胺苯基）-1,2-二苯基-1-丙烯；1-（4-胺苯基）,1-（4-氟苯基）-2-苯基-1-丁烯以及1-（4-胺苯基）,1-（4-氟苯基）-2-苯基-1-丙烯，及在碘的摧化下與丙酮反應，製備含新型二甲基喏（dimethyl quinoline）取代基之1-（2,4-二甲基喏林）-1,2-二苯基-1-丁烯；1-（2,4-二甲基喏林）-1,2-二苯基-1-丙烯；1-（2,4-二甲基喏林）-1-（4-氟苯基）-2-苯基-1-丁烯及1-（2,4-二甲基喏林）-1-（4-氟苯基）-2-苯基-1-丙烯，並將這些合成之產物做抗癌活性及藥理活性之評估。

The Tamoxifen skeleton with various substituents were prepared by using a McMurry's method with titanium-zinc system as coupling reagent. In this work,1-(4-aminophenyl)-1,2-diphenyl-1-butene;1-(4-ami-nophenyl)-1,2-diphenyl-1-propene;1-(4-aminophenyl),
1-(4-flurophenyl)-2-phenyl-1-propene;1-(4-aminophenyl),1- (4-flurophenyl)-2-phenyl-1-butene were synthesized under this conditions.
Above results were reacted with a doubly nucleophilic reagent, acetone and anilines with the presence of iodine as a catalysis, to yield 1-(2,4- dimeythylquinoline)-1,2-diphenyl-1-propene;1-(2,4-dimeythylquinoline)-1,2-diphenyl-1-butene.
All the compounds have prepared for cytotoxic test, anticancer activity, and pharmacological activity.

目錄
1. 摘要…………………….……….……I
2. Abstract……………….………………II
3. 緒論………………….……….……….1
4. 結果與討論………………………….20
5. 結論…………………………….……35
6. 儀器與藥品…………………….……36
7. 實驗步驟……………….……………39
8. 參考文獻………………………….…51

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