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研究生:韓之強
研究生(外文):Chi-Chiang Han
論文名稱:生物組織內光子動態擴散的量測與模擬
論文名稱(外文):Measurement and Simulation of the Dynamic of Phanton Diffusion in Biological Tissue
指導教授:蔡正倫蔡正倫引用關係
指導教授(外文):Cheng-Lun Tsai
學位類別:碩士
校院名稱:中原大學
系所名稱:醫學工程研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
論文頁數:71
中文關鍵詞:蒙地卡羅模擬光動態擴散光學係數低同調光干涉
外文關鍵詞:Optical coefficientDynamic migration of photon
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光動力治療、雷射都卜勒及血氧濃度檢測等生醫光學的應用,都需掌握生物組織的光學特性與光學參數(包括吸收係數、散射係數、非均向散射係數),才能準確預估光線進入組織後的能量分佈範圍與光線經過的部位深度。本研究使用低同調光干涉的原理來量測光在生物組織內散射及動態擴散情形,藉以瞭解光在組織內分佈的範圍與光的擴散路徑。
此量測的基本架構為馬克詹德(Mach-Zender)干涉儀,光源使用波長650nm的雷射二極體工作在閥值以下,干涉影像以12位元的數位攝影機拍攝再以電腦作影像的分析處理。研究中也使用蒙地卡羅方法來模擬光在組織內的動態擴散情形,並製作組織假體來當作測試樣本,用來與蒙地卡羅模擬的結果做比較以為數學模型修正的依據。
研究的結果顯示低同調干涉影像可以顯示光在組織內擴散行進的情形,所拍攝到的影像除了有尚保持著同調性的斑點影像外,還有已無同調性的擴散光影像。比較假體實驗與模擬結果發現光源射入點至組織樣本表面的距離及組織樣本的散射係數,皆對所測得光在組織內擴散行進的方向與範圍有相當大的影響。在肌肉組織的量測上,發現近場的光分佈會受到紋理組織角度的影響。脂肪加熱的實驗也證明溫度是影響光分佈的因素。
Most applications of biomedical optics, such as photodynamic therapy, laser Doppler flowmetry, and pulse oximetry require some knowledge of optical characteristics and coefficients of biological tissues in order to predict the light energy distribution and penetration depth in tissues. The most typical optical coefficients are optical absorption, scattering, and anisotropy coefficients. In this study, a low coherent interferometer system was used to detect the dynamic migration of photon in biological tissues. This measurement would be helpful in understanding how photons propagate in biological tissues.
The basic structure of the measurement system is a Mach-Zender interferometer. A diode laser with wavelength of 650nm working below threshold was used as the light source. The interference image was captured by a CCD camera with 12-bits of resolution. The images were further processed and analyzed in a personal computer. Monte Carlo model was also used in this study to simulate the dynamic migration of photon. Comparison of the results of measurement on tissue phantom can be used to verify the simulation results and to help modifying the model.
The results show that the system can acquire the dynamic migration of photons. Before processing, the light distribution image included the coherent speckle image and the noncoherent diffusive image. By comparing the results of phantom experiment and simulation, the distance from the injecting site to the measuring surface and the scattering coefficient of sample have great influence on the speckle image. The measurement on muscle tissue showed the light distribution at near field would be influence by the direction of muscle fibers. The results on heated fat tissue showed that temperature is a major factor that affected light propagation in fat tissue.
摘 要……...………………………………………………………………I
Abstract………..………………………………………………………….II
致 謝…………………..……..………………………………………….III
目 錄……………………………………………………………….……IV
圖索引………………………………………………………...…………..VI
表索引…………..…………………………………………………..…..VIII
第一章緒論
1.1 研究背景…………………………………………………………...1
1.2 重要文獻…………………………………………………………...3
1.3 研究目的與重要性………………………………………………...4
1.4 論文架構…………………………………………………………...5
第二章背景知識與理論
2.1 皮膚、脂肪與肌肉組織……………………………………………6
2.2 光學參數的影響……………………………………………………8
2.3 光干涉及基本干涉儀………………………………………………10
2.4 光脈衝延遲反應……………………………………………………13
2.5 同調干涉與低同調干涉……………………………………………14
2.6 低同調光干涉影像…………………………………………………16
2.7 動態平衡的低同調光靜態分佈影像………………………………17
第三章實驗設計與方法
3.1 實驗設計……………………………………………………………18
3.2 實驗方法……………………………………………………………19
3.3 研究設備與材料……………………………………………………20
3.4 假體樣本的重要性及製作…………………………………………21
3.5 組織樣本的處理與樣本夾具………………………………………23
3.6 低同調光干涉量測系統的架設……………………………………24
3.6.1 光靜態分佈影像的拍攝……………..……………………...26
3.6.2 光動態擴散影像的擷取系統……..………………………...27
3.6.3 低同調光干涉影像的分析………………..………………...28
3.7 光動態擴散影像的模擬……………………………………………30
3.7.1 蒙地卡羅模型與程式流程………………………….………31
第四章結果與討論
4.1 低同調干涉影像的驗證……………………………………………36
4.2 低同調干涉影像的分析……………………………………………38
4.3 組織樣本散射光的組成……………………………………………40
4.4 干涉斑點移動的現象與強化………………………………………41
4.5 組織假體的量測……………………………………………………43
4.5.1 拍攝光行經不同散射層及在行進中受阻的現象….………52
4.6 生理組織的量測……………………………………………………55
4.7 非同調光動態擴散模擬的結果……………………………………63
4.7.1 斑點光動態模擬的結果…………………………….………66
4.8 遭遇之問題與可能解決的方法……………………………………68
第五章結論與未來展望…………………………………………………...69
第六章參考文獻…………………………………………………………...70
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