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研究生:江志明
研究生(外文):Chiang Chih Ming
論文名稱:利用磁振造影計算心肌質量與心臟功能之研究
論文名稱(外文):Myocardial Mass and Heart Function Calculating Study by Magnetic Resonance Imaging
指導教授:劉英明李三剛李三剛引用關係
學位類別:碩士
校院名稱:國立中興大學
系所名稱:生命科學院碩士在職專班
學門:生命科學學門
學類:生物學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
論文頁數:77
中文關鍵詞:MRImyocardial massheart function
外文關鍵詞:磁振造影心肌質量心臟功能
相關次數:
  • 被引用被引用:2
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本研究是希望利用磁振造影系統對心臟掃瞄技術的成熟與及其
所能取得高解析度之解剖結構影像,進行完全無侵入性、高準確度
的左心室質量、心室容積、心搏出量和心射出率等心臟功能之電腦
計算評量。首先利用不同大小重量的八顆豬心臟進行體外模擬掃瞄,接著用貓建立動物體內(in vivo)體外(in vitro)之磁振造影心肌質量掃瞄計算評估校正實驗模式。然後進行電腦影像之幾何結構作評量計算值之準確度估算;以同人多次重複驗證(intra-observation)及多人次重複驗證(inter— observation),證明磁振造影影像對心肌質量與心臟功能評估之可靠性;豬心體外實驗重複測試之計算值有很好的相關性,相關係數為R2=0.99。而貓左心室實稱重10公克,實驗計算平均值為10.75±1.3公克。最後再進行二十位健康心臟男性自願者(21歲至26歲,平均23歲)之心臟掃瞄取像,並進行與動物實驗模式相同之驗証後,所得之計算值與文獻報告上所記錄的數值相近。經由本研究之探討所獲成果之心得將可提供給日後臨床心臟醫學影像診斷之實際應用。
Magnetic resonance imaging (MRI) has been considered as an ideal and noninvasive techniques for imaging and diagnosing of myo- cardial and heart functions owing to the good soft tissue contrast and nature flow phenomenon, especially in the dilated and hyper -trophic cardiomyopathy. MRI is very suitable for the diagnosis and quantification of ventricular volume, stroke volume, ejection fraction, and myocardial mass. After the advancement of higher technique on the machine. MRI has been increasing dramatically on the utility of study. The pilot study including pigs heart for in vitro imaging, and then followed with an in vivo and in vitro imaging study of cat heart. The clinical study included the heart MRI data from 20 healthy young man (age 23- 26 years). This study demonstrated that there is a good calculated from MR imags obtained from the in vivo and in vitro studies. The correlation of in vitro study (LV only ,n=8, R =0.99) and in vivo studies(LV mass 10g, imaging mean 10.75±1.3g) was excellent as well as the inter and intra-observer variance. There is a good result of the myocardial mass and heart function calculation studied by MRI.
目 錄
審查簽名頁------------------------------------------Ⅰ
授權書----------------------------------------------Ⅱ
封面內頁--------------------------------------------01
目錄------------------------------------------------02
中文摘要--------------------------------------------05
英文摘要--------------------------------------------06
誌謝------------------------------------------------07
圖目錄----------------------------------------------08
表目錄----------------------------------------------12
第一章‧前言
一、 研究背景與目的-----------------------------13
二、 研究內容--------------------------------------15
第二章‧文獻探討
(一)、磁振造影原理-------------------------18
(二)、磁振造影心肌質量與心臟功能計算流程---28
(三)、心臟磁振造影技術分析-----------------29
1. 自旋回訊脈衝序列之暗血造影技術
(Black blood imaging with spin-echo
sequences) ---------------------------29
2. 梯度回訊脈衝序列之明血造影技術
(Bright blood imaging with gradient-
echo sequences) ----------------------30
3. 自旋回訊多切片(位)∕多相次影像
(Multi-slice / Multi-phase image with
spin echoes) -------------------------31
4. 輪轉式多切片(位)造影
(Rotating multi-slice imaging) ---------34
5. 梯度磁場回訊連續取像
(Cine with gradient echo) --------------35
6. 多切片(位)連續取像技術
(Multi-slices Cine techniques) ---------36
(四)、心肌質量計算-------------------------37
(五)、心臟功能計算-------------------------40
第三章、材料與方法
一、 研究設備-----------------------------------42
二、 研究材料-----------------------------------46
三、 研究方法
(一)、磁振造影心肌質量與心臟功能計算掃瞄技術
---------------------------------48
(二)、動物體外(in vitro)心臟模擬掃瞄----49
(三)、動物體內(in vivo)及體外心臟掃瞄---51
(四)、人體心臟掃瞄------------------------------54
(五)、磁振造影心臟影像之擷取與描繪評量模式------57
第四章、 研究結果與分析
一、體外心肌質量模擬掃瞄影像計算與分析---------61
二、動物活體掃描與體外掃模擬掃描結果之分析-----66
三、人體內掃描心肌質量和心臟功能之評估---------69
第五章‧討論與未來研究發展--------------------------71
第六章‧結論----------------------------------------73
參考文獻--------------------------------------------74
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