|
Ahmed, N.N., Grimes, H.L., Bellacosa, A., Chan, T.O. and Tsichlis, P.N. (1997) Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci U S A, 94, 3627-3632. Alessi, D.R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. and Hemmings, B.A. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. Embo J, 15, 6541-6551. Alessi, D.R. and Cohen, P. (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev, 8, 55-62. Altomare, D.A., Guo, K., Cheng, J.Q., Sonoda, G., Walsh, K. and Testa, J.R. (1995) Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene, 11, 1055-1060. Andjelkovic, M., Jakubowicz, T., Cron, P., Ming, X.F., Han, J.W. and Hemmings, B.A. (1996) Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/ PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci U S A, 93, 5699-5704. Andjelkovic, M., Suidan, H.S., Meier, R., Frech, M., Alessi, D.R. and Hemmings, B.A. (1998) Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells. Eur J Biochem, 251, 195-200. Aquilina, G., Biondo, R., Dogliotti, E., Meuth, M. and Bignami, M. (1992) Expression of the endogenous O6-methylguanine-DNA- methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions. Cancer Res, 52, 6471-6475. Ariza, R.R., Keyse, S.M., Moggs, J.G. and Wood, R.D. (1996) Reversible protein phosphorylation modulates nucleotide excision repair of damaged DNA by human cell extracts. Nucleic Acids Res, 24, 433-440. Barrows, L.R. and Magee, P.N. (1982) Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis, 3, 349-351. Bellacosa, A., Testa, J.R., Staal, S.P. and Tsichlis, P.N. (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science, 254, 274-277. Beranek, D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat Res, 231, 11-30. Beranek, D.T., Weis, C.C. and Swenson, D.H. (1980) A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography. Carcinogenesis, 1, 595-606. Blume-Jensen, P., Janknecht, R. and Hunter, T. (1998) The kit receptor promotes cell survival via activation of PI3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol, 8, 779-782. Bodell, W.J. (1990) Molecular dosimetry for sister-chromatid exchange induction and cytotoxicity by monofunctional and bifunctional alkylating agents. Mutat Res, 233, 203-210. Borkhardt, A., Repp, R., Haas, O.A., Leis, T., Harbott, J., Kreuder, J., Hammermann, J., Henn, T. and Lampert, F. (1997) Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). Oncogene, 14, 195-202. Branch, P., Aquilina, G., Bignami, M. and Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature, 362, 652-654. Brodbeck, D., Cron, P. and Hemmings, B.A. (1999) A human protein kinase B γ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem, 274, 9133-9136. Bronner, C.E., Baker, S.M., Morrison, P.T., Warren, G., Smith, L.G., Lescoe, M.K., Kane, M., Earabino, C., Lipford, J., Lindblom, A. and et al. (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature, 368, 258-261. Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J. and Greenberg, M.E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96, 857-868. Burgering, B.M. and Coffer, P.J. (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature, 376, 599-602. Cantley, L.C. and Neel, B.G. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A, 96, 4240-4245. Cardone, M.H., Roy, N., Stennicke, H.R., Salvesen, G.S., Franke, T.F., Stanbridge, E., Frisch, S. and Reed, J.C. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science, 282, 1318-1321. Chan, T.O., Rittenhouse, S.E. and Tsichlis, P.N. (1999) AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem, 68, 965-1014. Chu, Z.L., McKinsey, T.A., Liu, L., Gentry, J.J., Malim, M.H. and Ballard, D.W. (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc Natl Acad Sci U S A, 94, 10057-10062. Coffer, P.J., Jin, J. and Woodgett, J.R. (1998a) Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J, 335, 1-13. Coffer, P.J., Schweizer, R.C., Dubois, G.R., Maikoe, T., Lammers, J.W. and Koenderman, L. (1998b) Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5. Blood, 91, 2547-2557. Coffer, P.J. and Woodgett, J.R. (1991) Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem, 201, 475-481. Cohen, P., Holmes, C.F. and Tsukitani, Y. (1990) Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci, 15, 98-102. Datta, S.R., Brunet, A. and Greenberg, M.E. (1999) Cellular survival: a play in three Akts. Genes Dev, 13, 2905-2927. Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. and Greenberg, M.E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231-241. Davis, R.J., Bennicelli, J.L., Macina, R.A., Nycum, L.M., Biegel, J.A. and Barr, F.G. (1995) Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. Hum Mol Genet, 4, 2355-2362. Demple, B. and Karran, P. (1983) Death of an enzyme: suicide repair of DNA. TIBS, April, 137-139. Denhardt, D.T. (1996) Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J, 318, 729-747. Deprez, J., Vertommen, D., Alessi, D.R., Hue, L. and Rider, M.H. (1997) Phosphorylation and activation of heart 6-phosphofructo- 2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem, 272, 17269-17275. Deshmukh, M. and Johnson, E.M., Jr. (1998) Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c. Neuron, 21, 695-705. Diehl, J.A., Cheng, M., Roussel, M.F. and Sherr, C.J. (1998) Glycogen synthase kinase-3 β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev, 12, 3499-3511. Dimmeler, S. and Zeiher, A.M. (2000) Akt takes center stage in angiogenesis signaling. Circ Res, 86, 4-5. Dolan, M.E., Pegg, A.E., Dumenco, L.L., Moschel, R.C. and Gerson, S.L. (1991) Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzyl- guanine and O6-methylguanine. Carcinogenesis, 12, 2305-2309. Dosch, J. and Kaina, B. (1996) Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability. Oncogene, 13, 1927-1935. Dumenco, L.L., Allay, E., Norton, K. and Gerson, S.L. (1993) The prevention of thymic lymphomas in transgenic mice by human O6- alkylguanine-DNA alkyltransferase. Science, 259, 219-222. Ellison, K.S., Dogliotti, E., Connors, T.D., Basu, A.K. and Essigmann, J.M. (1989) Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase. Proc Natl Acad Sci U S A, 86, 8620-8624. Erickson, L.C. (1991) The role of O6-methylguanine DNA methyl- transferase (MGMT) in drug resistance and strategies for its inhibition. Semin Cancer Biol, 2, 257-265. Franke, T.F., Tartof, K.D. and Tsichlis, P.N. (1994) The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Oncogene, 9, 141-148. Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R. and Tsichlis, P.N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81, 727-736. Gajewski, T.F. and Thompson, C.B. (1996) Apoptosis meets signal transduction: elimination of a BAD influence. Cell, 87, 589-592. Gerson, S.L., Trey, J.E., Miller, K. and Berger, N.A. (1986) Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis, 7, 745-749. Gingras, A.C., Kennedy, S.G., O'Leary, M.A., Sonenberg, N. and Hay, N. (1998) 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev, 12, 502-513. Green, D.R. and Reed, J.C. (1998) Mitochondria and apoptosis. Science, 281, 1309-1312. Greulich, H. and Erikson, R.L. (1998) An analysis of Mek1 signaling in cell proliferation and transformation. J Biol Chem, 273, 13280-13288. Griffin, S., Branch, P., Xu, Y.Z. and Karran, P. (1994) DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. Biochemistry, 33, 4787-4793. Grombacher, T. and Kaina, B. (1995) Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation. Biochim Biophys Acta, 1270, 63-72. Gupta, A., Rosenberger, S.F. and Bowden, G.T. (1999) Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis, 20, 2063-2073. Gupta, S., Barrett, T., Whitmarsh, A.J., Cavanagh, J., Sluss, H.K., Derijard, B. and Davis, R.J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. Embo J, 15, 2760-2770. Harris, L.C., von Wronski, M.A., Venable, C.C., Remack, J.S., Howell, S.R. and Brent, T.P. (1996) Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts. Carcinogenesis, 17, 219-224. Hayakawa, H., Koike, G. and Sekiguchi, M. (1990) Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. J Mol Biol, 213, 739-747. Hickman, M.J. and Samson, L.D. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc Natl Acad Sci U S A, 96, 10764-10769. Holmes, J., Jr., Clark, S. and Modrich, P. (1990) Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc Natl Acad Sci U S A, 87, 5837-5841. Ibuki, Y. and Goto, R. (2000) Suppression of apoptosis by UVB irradiation: survival signaling via PI3-kinase/Akt pathway. Biochem Biophys Res Commun, 279, 872-878. Jones, P.F., Jakubowicz, T., Pitossi, F.J., Maurer, F. and Hemmings, B.A. (1991) Molecular cloning and identification of a serine/ threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A, 88, 4171-4175. Kaina, B., Fritz, G., Mitra, S. and Coquerelle, T. (1991) Transfection and expression of human O6-methylguanine-DNA methyl- transferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis, 12, 1857-1867. Kaina, B., Ziouta, A., Ochs, K. and Coquerelle, T. (1997) Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation- tolerant mismatch repair compromised cells: facts and models. Mutat Res, 381, 227-241. Kandel, E.S. and Hay, N. (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res, 253, 210-229. Karran, P. (1985) Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair. Proc Natl Acad Sci U S A, 82, 5285-5289. Karran, P. and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays, 16, 833-839. Kawate, H., Ihara, K., Kohda, K., Sakumi, K. and Sekiguchi, M. (1995) Mouse methyltransferase for repair of O6-methylguanine and O4- methylthymine in DNA. Carcinogenesis, 16, 1595-1602. Kolbus, A., Herr, I., Schreiber, M., Debatin, K.M., Wagner, E.F. and Angel, P. (2000) c-Jun-dependent CD95-L expression is a rate- limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol, 20, 575-582. Konishi, H., Matsuzaki, H., Tanaka, M., Ono, Y., Tokunaga, C., Kuroda, S. and Kikkawa, U. (1996) Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A, 93, 7639-7643. Kupriyanova, T.A. and Kandror, K.V. (1999) Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin. J Biol Chem, 274, 1458-1464. Larson, K., Sahm, J., Shenkar, R. and Strauss, B. (1985) Methylation-induced blocks to in vitro DNA replication. Mutat Res, 150, 77-84. Laval, F. (1990) Induction of proteins involved in the repair of alkylated bases in mammalian cells by DNA-damaging agents. Mutat Res, 233, 211-218. Lawley, P.D. (1995) Alkylation of DNA and its aftermath. Bioessays, 17, 561-568. Lawley, P.D. and Thatcher, C.J. (1970) Methylation of deoxyribonucleic acid in cultured mammalian cells by N- methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. Biochem J, 116, 693-707. Leevers, S.J., Vanhaesebroeck, B. and Waterfield, M.D. (1999) Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol, 11, 219-225. Lefebvre, P., Zak, P. and Laval, F. (1993) Induction of O6-methylguanine-DNA-methyltransferase and N3-methyladenine -DNA-glycosylase in human cells exposed to DNA-damaging agents. DNA Cell Biol, 12, 233-241. Lemmon, M.A., Ferguson, K.M. and Schlessinger, J. (1996) PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell, 85, 621-624. Li, Y.S., Shyy, J.Y., Li, S., Lee, J., Su, B., Karin, M. and Chien, S. (1996) The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol, 16, 5947-5954. Liu, Z.G., Baskaran, R., Lea-Chou, E.T., Wood, L.D., Chen, Y., Karin, M. and Wang, J.Y. (1996) Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature, 384, 273-276. Loechler, E.L., Green, C.L. and Essigmann, J.M. (1984) In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. Proc Natl Acad Sci U S A, 81, 6271-6275. Lutz, W.K. (1990) Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis. Mutat Res, 238, 287-295. Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci, 22, 355-358. Mathison, B.H., Taylor, M.L. and Bogdanffy, M.S. (1995) Dimethyl sulfate uptake and methylation of DNA in rat respiratory tissues following acute inhalation. Fundam Appl Toxicol, 28, 255-263. May, M.J. and Ghosh, S. (1997) Rel/NF-κB and IκB proteins: an overview. Semin Cancer Biol, 8, 63-73. Mazure, N.M., Chen, E.Y., Laderoute, K.R. and Giaccia, A.J. (1997) Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood, 90, 3322-3331. Medema, R.H., Kops, G.J., Bos, J.L. and Burgering, B.M. (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature, 404, 782-787. Meikrantz, W., Bergom, M.A., Memisoglu, A. and Samson, L. (1998) O6-alkylguanine DNA lesions trigger apoptosis. Carcinogenesis, 19, 369-372. Mercurio, F. and Manning, A.M. (1999) Multiple signals converging on NF-κB. Curr Opin Cell Biol, 11, 226-232. Michell, B.J., Griffiths, J.E., Mitchelhill, K.I., Rodriguez-Crespo, I., Tiganis, T., Bozinovski, S., de Montellano, P.R., Kemp, B.E. and Pearson, R.B. (1999) The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol, 9, 845-848. Millward, T.A., Zolnierowicz, S. and Hemmings, B.A. (1999) Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci, 24, 186-191. Modrich, P. (1994) Mismatch repair, genetic stability, and cancer. Science, 266, 1959-1960. Morimoto, K., Dolan, M.E., Scicchitano, D. and Pegg, A.E. (1985) Repair of O6-propylguanine and O6-butylguanine in DNA by O6- alkylguanine-DNA alkyltransferases from rat liver and E. coli. Carcinogenesis, 6, 1027-1031. Muslin, A.J., Tanner, J.W., Allen, P.M. and Shaw, A.S. (1996) Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell, 84, 889-897. Nakatsu, Y., Hattori, K., Hayakawa, H., Shimizu, K. and Sekiguchi, M. (1993) Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase. Mutat Res, 293, 119-132. Nakatsuru, Y., Matsukuma, S., Nemoto, N., Sugano, H., Sekiguchi, M. and Ishikawa, T. (1993) O6-methylguanine-DNA methyl- transferase protects against nitrosamine-induced hepato- carcinogenesis. Proc Natl Acad Sci U S A, 90, 6468-6472. Nehme, A., Baskaran, R., Aebi, S., Fink, D., Nebel, S., Cenni, B., Wang, J.Y., Howell, S.B. and Christen, R.D. (1997) Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin. Cancer Res, 57, 3253-3257. Newbold, R.F., Warren, W., Medcalf, A.S. and Amos, J. (1980) Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification. Nature, 283, 596-599. Ochs, K. and Kaina, B. (2000) Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res, 60, 5815-5824. Ottilie, S., Diaz, J.L., Horne, W., Chang, J., Wang, Y., Wilson, G., Chang, S., Weeks, S., Fritz, L.C. and Oltersdorf, T. (1997) Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J Biol Chem, 272, 30866-30872. Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M. and Donner, D.B. (1999) NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401, 82-85. Pandey, P., Avraham, S., Kumar, S., Nakazawa, A., Place, A., Ghanem, L., Rana, A., Kumar, V., Majumder, P.K., Avraham, H., Davis, R.J. and Kharbanda, S. (1999) Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. J Biol Chem, 274, 10140-10144. Parra, M., Lluis, F., Miralles, F., Caelles, C. and Munoz-Canoves, P. (2000) The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG. Blood, 96, 1415-1424. Paulovich, A.G., Toczyski, D.P. and Hartwell, L.H. (1997) When checkpoints fail. Cell, 88, 315-321. Pegg, A. E. (1983) Alkylation and subsequent repair of DNA after exposure to dimethylnitrosamine and related carcinogens. Rev. Biochem. Toxical., 5, 83-133. Pegg, A.E. (1990a) Mammalian O6-alkylguanine-DNA alkyl- transferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res, 50, 6119-6129. Pegg, A.E. (1990b) Properties of mammalian O6-alkylguanine-DNA transferases. Mutat Res, 233, 165-175. Potapova, O., Haghighi, A., Bost, F., Liu, C., Birrer, M.J., Gjerset, R. and Mercola, D. (1997) The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem, 272, 14041-14044. Potter, P.M., Wilkinson, M.C., Fitton, J., Carr, F.J., Brennand, J., Cooper, D.P. and Margison, G.P. (1987) Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyl- transferase gene of E. coli. Nucleic Acids Res, 15, 9177-9193. Pugazhenthi, S., Nesterova, A., Sable, C., Heidenreich, K.A., Boxer, L.M., Heasley, L.E. and Reusch, J.E. (2000) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element- binding protein. J Biol Chem, 275, 10761-10766. Rasouli-Nia, A., Sibghat, U., Mirzayans, R., Paterson, M.C. and Day, R.S., 3rd. (1994) On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line. Mutat Res, 314, 99-113. Rebeck, G.W. and Samson, L. (1991) Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase. J Bacteriol, 173, 2068-2076. Robbins, D.J., Cheng, M., Zhen, E., Vanderbilt, C.A., Feig, L.A. and Cobb, M.H. (1992) Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A, 89, 6924-6928. Romashkova, J.A. and Makarov, S.S. (1999) NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature, 401, 86-90. Rydberg, B., Spurr, N. and Karran, P. (1990) cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. J Biol Chem, 265, 9563-9569. Sassanfar, M., Dosanjh, M.K., Essigmann, J.M. and Samson, L. (1991) Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases. J Biol Chem, 266, 2767-2771. Sato, S., Fujita, N. and Tsuruo, T. (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci U S A, 97, 10832-10837. Shaw, G. (1996) The pleckstrin homology domain: an intriguing multifunctional protein module. Bioessays, 18, 35-46. Sibghat, U. and Day, R.S., 3rd. (1992) Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells. Biochemistry, 31, 7998-8008. Sibghat, U. and Day, R.S., 3rd. (1995) Site specificity of incisions at G:T and O6-methylguanine:T base mismatches in DNA by human cell-free extracts. Biochemistry, 34, 6869-6875. Simili, M., Pellerano, P., Tavosanis, G., Arena, G., Bonatti, S. and Abbondandolo, A. (1995) The induction of aneuploidy by alkylated purines: effects on early and late cell cycle events. Mutagenesis, 10, 105-111. Sizemore, N., Leung, S. and Stark, G.R. (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol Cell Biol, 19, 4798-4805. Songyang, Z., Baltimore, D., Cantley, L.C., Kaplan, D.R. and Franke, T.F. (1997) Interleukin 3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci U S A, 94, 11345-11350. Srivenugopal, K.S., Mullapudi, S.R., Shou, J., Hazra, T.K. and Ali-Osman, F. (2000) Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. Cancer Res, 60, 282-287. Staal, S.P. and Hartley, J.W. (1988) Thymic lymphoma induction by the AKT8 murine retrovirus. J Exp Med, 167, 1259-1264. Sublett, J.E., Jeon, I.S. and Shapiro, D.N. (1995) The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. Oncogene, 11, 545-552. Swenson, D.H. and Lawley, P.D. (1978) Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N- nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3'-5')thymidine. Biochem J, 171, 575-587. Tanno, S., Mitsuuchi, Y., Altomare, D.A., Xiao, G.H. and Testa, J.R. (2001) AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res, 61, 589-593. Tano, K., Shiota, S., Collier, J., Foote, R.S. and Mitra, S. (1990) Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine. Proc Natl Acad Sci U S A, 87, 686-690. Thornberry, N.A. and Lazebnik, Y. (1998) Caspases: enemies within. Science, 281, 1312-1316. Tonks, N.K. and Myers, M.P. (1999) Structural assets of a tumor suppressor. Science, 286, 2096-2097. van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. and Angel, P. (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. Embo J, 14, 1798-1811. Vanhaesebroeck, B. and Alessi, D.R. (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J, 346 Pt 3, 561-576. Voigt, J.M. and Topal, M.D. (1995) O6-methylguanine-induced replication blocks. Carcinogenesis, 16, 1775-1782. Wan, Y.S., Wang, Z.Q., Shao, Y., Voorhees, J.J. and Fisher, G.J. (2001) Ultraviolet irradiation activates PI3-kinase/AKT survival pathway via EGF receptors in human skin in vivo. Int J Oncol, 18, 461-466. Waterston, R., Martin, C., Craxton, M., Huynh, C., Coulson, A., Hillier, L., Durbin, R., Green, P., Shownkeen, R., Halloran, N. and et al. (1992) A survey of expressed genes in Caenorhabditis elegans. Nat Genet, 1, 114-123. Wen, Y., Hu, M.C., Makino, K., Spohn, B., Bartholomeusz, G., Yan, D.H. and Hung, M.C. (2000) HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res, 60, 6841-6845. Wilhelm, D., Bender, K., Knebel, A. and Angel, P. (1997) The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol, 17, 4792-4800. Woodgett, J.R. (1994) Regulation and functions of the glycogen synthase kinase-3 subfamily. Semin Cancer Biol, 5, 269-275. Xiao, W. and Fontanie, T. (1995) Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant: its effects on both exogenous and endogenous DNA alkylation damage. Mutat Res, 336, 133-142. Xiao, W. and Samson, L. (1993) In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc Natl Acad Sci U S A, 90, 2117-2121. Yaffe, M.B., Rittinger, K., Volinia, S., Caron, P.R., Aitken, A., Leffers, H., Gamblin, S.J., Smerdon, S.J. and Cantley, L.C. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-971. Yang, J.L., Lee, P.C., Lin, S.R. and Lin, J.G. (1994) Comparison of mutation spectra induced by N-ethyl-N-nitrosourea in the hprt gene of Mer+ and Mer- diploid human fibroblasts. Carcinogenesis, 15, 939-945. Yarosh, D.B. (1985) The role of O6-methylguanine-DNA methyl- transferase in cell survival, mutagenesis and carcinogenesis. Mutat Res, 145, 1-16. Yuasa, T., Ohno, S., Kehrl, J.H. and Kyriakis, J.M. (1998) Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J Biol Chem, 273, 22681-22692. Zaidi, N.H., Pretlow, T.P., O'Riordan, M.A., Dumenco, L.L., Allay, E. and Gerson, S.L. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456. Zak, P., Kleibl, K. and Laval, F. (1994) Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methyl- guanine-DNA methyltransferases. J Biol Chem, 269, 730-733. Zha, J., Harada, H., Osipov, K., Jockel, J., Waksman, G. and Korsmeyer, S.J. (1997) BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem, 272, 24101-24104. Zhang, H., Richards, B., Wilson, T., Lloyd, M., Cranston, A., Thorburn, A., Fishel, R. and Meuth, M. (1999) Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res, 59, 3021-3027. Zhou, B.P., Hu, M.C., Miller, S.A., Yu, Z., Xia, W., Lin, S.Y. and Hung, M.C. (2000) HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathway. J Biol Chem, 275, 8027-8031. Zhou, B.P., Liao, Y., Xia, W., Spohn, B., Lee, M.H. and Hung, M.C. (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol, 3, 245-252. Zimmermann, S. and Moelling, K. (1999) Phosphorylation and regulation of Raf by Akt (protein kinase B). Science, 286, 1741-1744. Zong, W.X., Edelstein, L.C., Chen, C., Bash, J. and Gelinas, C. (1999) The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis. Genes Dev, 13, 382-387.
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