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研究生:賴郁君
論文名稱:缺氧前處理對大鼠膀胱過度膨脹後的氧化性傷害
論文名稱(外文):The oxidative injury of urinary bladder after overdistention in hypoxia preconditioning rats
指導教授:陳朝峰陳朝峰引用關係鄭劍廷
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:生理學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
中文關鍵詞:膀胱過度膨脹氧化性傷害缺氧前處理
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中 文 摘 要
膀胱過度膨脹造成的氧化性傷害可能會造成膀胱收縮功能不良。缺氧預適應對於器官的缺血性傷害具有保護作用,然而,這樣的保護效果能否應用在膀胱過度膨脹/緩解所造成的氧化傷害目前尚未被提出報告。我們將大鼠分成海平面對照組(sea level group, SL)和長期缺氧組(high altitude group, HA,即將大鼠放置在模擬高度5,500 m的低壓低氧太空艙中,每天15小時,歷經四週)。我們輸入生理食鹽水將大鼠的膀胱分別過度膨脹一小時及兩小時(1 ml/100克體重)而後緩解。使用多功能記錄器來測量此過程對兩組大鼠膀胱收縮壓的影響,並以超低感度的化學冷光儀來測定血液及活體膀胱表面自由基釋出量的變化。結果顯示SL鼠和HA鼠在遭受膀胱過度膨脹/緩解後,膀胱收縮壓皆顯著下降;然而,在過度膨脹緩解後120分鐘時,HA鼠的膀胱收縮壓恢復情形較SL良好。在自由基的釋出量方面,膀胱過度膨脹/緩解會增加SL鼠血液以及膀胱表面的自由基釋放量,在過度膨脹緩解後的5分鐘,自由基的釋放量達到最高峰;在HA鼠膀胱過度膨脹/緩解過程,自由基的釋放量亦有增加的現象,然而,HA鼠自由基的釋放量和SL鼠相比呈現明顯的減少。我們另測量SL鼠和HA鼠膀胱中抗氧化酵素Cu/Zn SOD及熱休克蛋白70(Heat shock protein, HSP 70)的含量變化。結果發現HA鼠的Cu/Zn SOD和HSP 70的表現量比SL鼠者更為明顯。因此,我們推測HA鼠膀胱中Cu/Zn SOD及HSP 70的增加可能和膀胱過度膨脹/緩解之傷害過程的保護作用有關。
Abstract
Oxidative stress resulting from bladder overdistension and relief (OD/RE) may produce micturition dysfunction. Hypoxia adaptation produced protection against ischemic insults in some organs. Whether this benefit extends to ameliorate OD/RE induced bladder damage is not yet defined. We compared rats kept at sea level(SL)and chronically hypoxia rats(high altitude; HA, induced by exposure to an altitude chamber at 5,500 m for 15 days/day). The bladders of SL rats and HA rats were subjected to 1-h or 2-h of saline overdistension (1 ml/100 gw body weight) and followed by relief. We analyzed bladder function by transcystometrogram and determined the amount of reactive oxygen species (ROS) from the whole blood in vitro and bladder surface in vivo by a chemiluminescence method. Results showed that OD/RE reduced the bladder intravesical pressure in SL and HA rats. However, the functional recovery of urinary bladder 2-hr after relief from bladder overdistention was significantly better in HA rats than in SL rats. In addition, ROS release from the blood samples and the bladder surface was increased in SL rats. The enhanced ROS release reached the peak 5 min after bladder relief. ROS release in HA rats was also increased, but less than that of the SL rats. The expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) and heat shock protein 70 (HSP70) was upregulated in the hypoxia adapted bladder. Our results suggest that the increased Cu/Zn SOD and HSP 70 might be related to the acquisition of bladder protection against OD/RE.
目 錄

誌謝……………………………………………………………………… i
圖次………………………………………………………………….. ...iv
中文摘要……………………………………………………...………...vi
英文摘要……………………………………………...……………….viii
文獻回顧
一、急性膀胱過度膨脹…………………………….……..……..1
二、生物體內的自由基……………………………………...…..4
三、生物體內的抗氧化系統…………………….…………..…..8
四、氧化傷害……………………………… ………………...…11
五、缺氧………………………………………… …………...…15
六、長期低氧對自由基和抗氧化酵素的影響……..18
七、熱休克蛋白質……………………………………… …...…20
實驗動機與目的…………………………………………………...…..23
材料與方法
一、實驗動物的準備……………………………………… ...…25
二、各類插管………………………………………………………25
三、儀器設備………………………………………………………26
四、實驗藥品及來源………………………………………………27
五、一般手術過程…………………………………………………29
六、實驗過程………………………………………………………29
七、膀胱收縮壓的測量………………………………………… 30
八、膀胱血液動力學的測量………………………………………30
九、血液中O2.-的偵測…………………………………… …..31
十、動物活體膀胱內O2.-產生的偵測………………………… 32
十一、西方墨點法……………………………………………………33
十二、資料處理及統計方法………………………………………..36
實驗結果
一、膀胱過度膨脹/緩解對膀胱收縮壓的影響………………… 37
二、膀胱過度膨脹/緩解對膀胱內自由基釋出量的影響……… 38
三、在SL鼠和HA鼠膀胱中抗氧化酵素及HSP 70表現量的比較……………………………………………………… 41
討論………………………………………………………………… …..58
結論……………………………………………………………………… 67
參考文獻…………………………………………………………… …..68
附錄 生物醫學年會摘要………………………...……………………84
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