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研究生:陳蕾詩
研究生(外文):Lei-Shih Chen
論文名稱:空氣污染物與學童尿液中氧化壓力標記8-hydroxy-2'-deoxyguanosine之相關研究
論文名稱(外文):Urinary 8-hydroxy-2'-deoxyguanosine expression in primary school children exposed to ambient pollutants
指導教授:鄭尊仁鄭尊仁引用關係
指導教授(外文):Tsun-Jen Cheng
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:職業醫學與工業衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文出版年:2001
畢業學年度:89
語文別:中文
論文頁數:88
中文關鍵詞:臭氧氮氧化物一氧化氮二氧化氮氣懸微粒8-hydroxy-2’-deoxyguanosine
外文關鍵詞:ozonenitrogen oxidesnitric oxidenitrogen dioxideparticulate matter8-hydroxy-2’-deoxyguanosine
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兒童是空氣污染物健康效應的易感性族群。流行病學的研究指出臭氧、氮氧化物與氣懸微粒與學童呼吸道相關的症狀和疾病有關;體外試驗 (in vitro) 的研究也指出臭氧、氮氧化物與氣懸微粒會導致肺部細胞氧化傷害的產生。8-hydroxy-2’-deoxyguanosine (8-OHdG) 是常見的氧化壓力指標,因此本研究嘗試利用8-OHdG來探討人體內臭氧、氮氧化物與氣懸微粒與其之相關性。
本研究收集2000年九天與2001年春季七天18名古亭國小五年級學童早上的尿液,並讓學童的家長填寫問卷,問卷內容包含基本資料與其他可能影響氧化壓力之因素,再利用酵素連結免疫吸附試劑法(competitive enzyme-linked immunosorbent assay,ELISA) 來分析尿液中8-OHdG的濃度。臭氧、氮氧化物與PM10濃度取自該國小頂樓之環保署監測站的監測資料,PM2.5和PM1的濃度則利用架設該校頂樓的高流量三道採樣器 (trichotomous sampler) 24小時採樣分析結果。最後調整潛在干擾因子,探討8-OHdG濃度與臭氧、氮氧化物以及氣懸微粒之相關性。
本研究發現,不管是以秋季、春季或兩季合併的結果來看,學童尿液中8-OHdG濃度與兩天前白天八小時平均的氮氧化物、一氧化氮和二氧化氮濃度均具有統計上的相關性 (ps< 0.05)。然而,臭氧與氣懸微粒與尿液中8-OHdG濃度並無相關性,潛在變因與尿液中8-OHdG濃度也無相關。本研究的結論是尿液中的8-OHdG或許是一個對低濃度氮氧化物具有高敏感性的指標;此外,環境中一氧化氮也許在DNA的氧化傷害上扮演一個重要的角色。

Children are considered as a susceptible group for advert health effects induced by air pollutants. Many epidemiological studies have reported that ozone, nitrogen oxides, particulate matter are responsible for increased respiratory symptoms and diseases in school children. Cellular oxidative damage has also been linked to ozone, nitrogen oxides or particulate matter exposure. As 8-hydroxy-2’-deoxyguanosine (8-OHdG) is a useful marker for oxidative stress, this study investigated the relationship between the level of 8-OHdG in school children and the levels of ambient ozone, nitrogen oxides and particulate matter in school children.
Eighteen children were included in this study and morning urines were collected for nine days in Fall 2000 and seven days in Spring 2001. The children’s parents completed questionnaires including basic data and potential confounders related to oxidative stress. Urinary 8-OHdG level was determined using competitive enzyme-linked immunosorbent assay (ELISA). Data on environmental ozone, nitrogen oxides and PM10 were obtained from Environmental Protection Administration air quality monitoring station which was located in the campus. Also, PM2.5 and PM1 concentrations were determined from trichotomous sampler which collected particles for 24 hour for 16 days. We used linear mix-effected model to determine the association between air pollutants and urinary 8-OHdG after adjusting the potential confounders.
The study revealed that urinary 8-OHdG level was associated with the concentration of 8-hour nitrogen oxides, nitric oxide and nitrogen dioxide two days earlier (ps< 0.05), but not for the concentration of ozone and particular matter. However, no statistical significance between potential confounders and urinary 8-OHdG was found.
We concluded that urinary 8-OHdG may be a sensitive marker related to nitrogen oxides. Besides, ambient nitric oxide may play an important role on oxidative damage.

摘要1
ABSTRACT3
目錄5
第一章 前言7
第一節 空氣污染現況7
第二節 空氣污染流行病學研究7
第三節 空氣污染與氧化壓力相關研究8
第四節 氧化壓力指標8-HYDROXY-2’-DEOXYGUANOSINE9
第五節 研究目的9
第六節 研究假說10
第二章 文獻探討11
第一節空氣污染流行病學研究11
第二節空氣污染與氧化壓力相關研究14
第三節氧化壓力指標8-HYDROXY-2’-DEOXYGUANOSINE20
第三章:材料與方法26
第一節 研究對象與問卷收集26
第二節 尿液收集27
第三節 尿液之8-HYDROXY-2’-DEOXYGUANOSINE分析28
第四節 大氣中污染物的濃度29
第五節 統計分析30
第四章 結果32
第五章 討論37

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