跳到主要內容

臺灣博碩士論文加值系統

(34.204.169.230) 您好!臺灣時間:2024/03/03 07:58
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:歐再富
研究生(外文):Tzay-Fuh Ou
論文名稱:對於上腭咀嚼性黏膜潛變行為的評估
論文名稱(外文):evaluation of creep behavior on maxillary masticatory mucosa
指導教授:王若松王若松引用關係
指導教授(外文):Juo-Song Wang
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:臨床牙醫學研究所
學門:醫藥衛生學門
學類:牙醫學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
中文關鍵詞:口腔黏膜黏彈性質
外文關鍵詞:oral mucosavisco-elastic properties
相關次數:
  • 被引用被引用:1
  • 點閱點閱:131
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
中文摘要
對於口腔黏膜受力後之生物力學反應,以往學者曾涉及動物實驗以及少數的人體測試,但若要使用於有限元素分析,資料還是不完整。所以本次研究的目的是希望經由機械式的方法,直接針對人體口腔的硬顎黏膜進行受力試驗﹝潛變試驗﹞,取得應力、應變與時間的關係曲線,並評估黏膜變化的邏輯性以及分析其影響的主要因素。
實驗中選取十二個自願者﹝六男及六女,其平均年齡為26.50±2.47歲﹞,其上顎硬顎的黏膜平均厚度為2.83±0.45㎜,利用一施力儀器﹝5㎏﹞及位移偵測器﹝2.6㎜﹞的組合裝置,藉著自凝式樹脂製作的咬合板經由水門汀固定黏著於牙齒上;在試驗過程中進行200及400公克/平方公分兩種不同力量的施力,每一個力量皆包含兩次30秒的持續性施力,中間插入20次0.5Hz的循環性施力,然後紀錄黏膜沉降、施力大小與時間的變化。
結果中,首先黏膜組織在受力時有反應延遲的現象,反應遲緩之平均時間,在200公克/平方公分為 0.0355秒而400公克/平方公分為0.0324秒,統計上則沒有明顯的差異〈P>0.05〉。其次,持續施力下大致呈現二階段位移變化,第一階段時間較短為力量達到定力前之位移變化,第二階段則代表達定力後的組織潛變。
持續性施力的第一階段,在位移變化量百分比中,第二次持續性施力會比第一次大約二至三倍;400公克/平方公分的位移變化量會比200公克/平方公分大;而在曲線斜率方面,第一次與第二次持續性施力之間,在400公克/平方公分有較明顯的趨勢〈第二次大於第一次持續性施力〉,400公克/平方公分的斜率〈0.6至1.0〉比200公克/平方公分〈0.4至0.8〉有較大的斜率。在統計學上,選用位移百分比當作應變數的預估能力〈57.18%〉是較高的,而且在黏膜厚度、持續性施力次數、施力速率及施力大小方面有顯著的影響力〈P<0.05〉。
持續性施力的第二階段,在位移變化量百分比中,就第二階段位移量在總位移量中所佔的比例來看,第二次持續性施力的比例則有明顯降低,約比第一次減少一至二倍;而在曲線斜率方面,第二次持續性施力約比第一次小了一倍,當施力增加時,斜率也有增加的傾向。在統計學上,選用斜率來當作應變數的預估能力〈43.89%〉是較高的,而且在持續性施力次數及施力大小方面有顯著的影響力〈P<0.05〉。
至於在兩次持續性施力間的循環性施力,對於力量的增加,第一階段位移斜率則有些微位移增加的趨勢;在波峰連線的斜率方面,則大致呈現正向的斜率,而且比持續性施力的第二階段的斜率約大二至三倍。
最後,在實驗中發現口腔黏膜在受力後,確實反映出黏彈物質的力學變化,其位移變化經分析後,呈現二階段反應。第一階段以位移百分比的變化較具代表性,而第二階段則以斜率變化較有解釋能力;其中,持續性施力次數及施力大小對於以上兩個階段都有顯著的影響。
Abstract
Researchers had attempted to perform experiments on living subjects mostly animal to observe the biomechanical response of oral mucosa under loading. However, the results were still limited if applied on finite element analysis. The purpose of this study was to investigate the displacement responses of hard palate mucosa under constant and cyclic loads.
Twelve volunteers included 6 females and 6 males with mean age of 26.50 were enrolled in this study. The mean mucosa thickness in loading sites was 2.83±0.45mm. By means of acrylic resin splints and zinc phosphate cement, an assembly of loading device and displacement measurement transducer was attached to the maxillary dentition. Two different loading forces, 200 and 400 g/cm2 respectively, were applied to mucosa. Each loading trial included two persistent loadings for 30 seconds, which was interrupted by a series of 20 cyclic loading at the frequency of 0.5Hz. The changes in mucosal displacement and the loading force in the time domain were recorded.
In results, the oral mucosa showed the delay response when loading, and the mean delay was 0.0355 seconds and 0.0324 seconds under the 200 g/cm2 and 400 g/cm2 loading forces respectively. However, there was no statistically significant difference (p>0.05). Under persistent loading forces, the mucosa generally showed two-phased displacement. The first phase represented the instantaneous mucosal displacement before the force getting stable, and the second phase showed the mucosal displacement under persistent loading (creep).
In the first phase of persistent loading, the results of displacement percentage showed that the second persistent loading was 2-3 times greater than the first one. The 400 g/cm2 loading force showed greater displacement percentage than that of 200 g/cm2. With regards to the slope of the displacement curve, the 400 g/cm2 loading force showed clear tendency that the second persistent loading was greater than the first one. The slope of the displacement curve under the 400 g/cm2 loading force (0.6-1.0) was greater than that of 200 g/cm2 (0.4-0.8). In statistical analysis, the displacement percentage of dependent variable showed highest predictability (57.18%) in regression model. Significant contribution was also found in independent variables including mucosal thickness, times of persistent loading, loading rates, and loading forces (p<0.05).
In the second phase of persistent loading, with regards to the displacement ratio, the second phase of the second persistent loading was approximately 1-2 times lower than that of first loading. In the displacement slope of the second phase, the first persistent loading force was about double of the second one. And as the loading force increased, the displacement slope also had a tendency to increase. In regression analysis, the predictability of displacement slope was higher (43.89%), and significant independent variables were also found in times of persistent loading and loading forces (p<0.05).
For cyclic loading between the persistent loadings, the slope of the first phase displacement showed increasing tendency as the force increased. The slope of all the displacement peaks was generally positive, which was 2-3 times greater than the second phase of the persistent loading force.
In conclusion, the oral mucosa showed the visco-elastic properties under the persistent loading, and two phases of the displacement was noted. The displacement percentage showed the best predictability for the first phase and the displacement slope for the second phase. Besides, the times of persistent loading and loading forces showed the significant influence on predictability.
第一章、前言1
第二章、文獻回顧2
2.1生物觀點2
2.1.1咀嚼黏膜(masticatory mucosa)2
2.1.2襯黏膜(lining mucosa)3
2.2機械觀點4
2.3臨床研究5
2.3.1光彈法5
2.3.2機械式模型6
2.4有限元素分析法7
2.5研究目的8
第三章、材料與方法9
3.1測試裝置9
3.2儀器連接9
3.3受測者及受測部位10
3.4潛變試驗10
3.5持續性施力中位移變化的分類11
3.6結果分析11
3.7統計方法12
第四章、實驗結果14
4.1受測者及受測部位14
4.2施力狀況14
4.3受測黏膜位移變化量15
4.3.1持續性施力總位移量百分比15
4.3.2持續性施力第一階段位移量16
4.3.3持續性施力第二階段位移量16
4.4受測黏膜位移變化曲線斜率17
4.4.1第一階段位移變化曲線斜率17
4.4.2第二階段位移變化曲線斜率18
4.5黏膜組織反應之遲緩〈Delay〉19
4.6統計分析結果19
4.6.1第一階段曲線部分19
4.6.2第二階段曲線部分22
4.6.3黏膜反應遲緩的時間部分23
第五章、討論25
5.1施力裝置25
5.2位移偵測器26
5.3施力量測儀器之架設27
5.4受測對象27
5.5黏膜的受力條件28
5.6施力面積及形狀29
5.7黏膜厚度的量測29
5.8黏膜位移量30
5.9黏膜組織受力反應之遲緩31
5.10循環施力後的波峰連線31
5.11統計分析結果32
5.11.1第一階段曲線部分32
5.11.2第二階段曲線部分33
5.12實驗結果疑點34
5.13臨床意義與未來發展35
第六章、結論37
參考文獻39
圖表43
圖一、施力裝置及位移偵測器43
圖二、施力桿之簡圖及施力直徑43
圖三、固定咬合板與牙齒間的磷酸水門汀44
圖四、整個施力量測裝置的連接簡圖44
圖五、施力控制器、記錄器、位移應變訊號處理器、類比數位訊號轉換器及施力激發控制器之實體(由上而下)45
圖六、施力裝置及位移偵測器放置於口腔內的情形46
圖七、量測黏膜厚度之根管擠針及作記號的矽膠片46
圖八、位移百分比之計算方式及斜率示意圖47
圖九、每平方分200公克之施力狀況分布48
圖十、每平方分400公克之施力狀況分布48
圖十一、受測者一在200g的應力、位移與時間的關係圖49
圖十二、受測者一在400g的應力、位移與時間的關係圖49
圖十三、受測者二在200g的應力、位移與時間的關係圖50
圖十四、受測者二在400g的應力、位移與時間的關係圖50
圖十五、受測者三在200g的應力、位移與時間的關係圖51
圖十六、受測者三在400g的應力、位移與時間的關係圖51
圖十七、受測者四在200g的應力、位移與時間的關係圖52
圖十八、受測者四在400g的應力、位移與時間的關係圖52
圖十九、受測者五在200g的應力、位移與時間的關係圖53
圖二十、受測者五在400g的應力、位移與時間的關係圖53
圖二十一、受測者六在200g的應力、位移與時間的關係圖54
圖二十二、受測者六在400g的應力、位移與時間的關係圖54
圖二十三、受測者七在200g的應力、位移與時間的關係圖55
圖二十四、受測者七在400g的應力、位移與時間的關係圖55
圖二十五、受測者八在200g的應力、位移與時間的關係圖56
圖二十六、受測者八在400g的應力、位移與時間的關係圖56
圖二十七、受測者九在200g的應力、位移與時間的關係圖57
圖二十八、受測者九在400g的應力、位移與時間的關係圖57
圖二十九、受測者十在200g的應力、位移與時間的關係圖58
圖三十、受測者十在400g的應力、位移與時間的關係圖58
圖三十一、受測者十一在200g的應力、位移與時間的關係圖59
圖三十二、受測者十一在400g的應力、位移與時間的關係圖59
圖三十三、受測者十二在200g的應力、位移與時間的關係圖60
圖三十四、受測者十二在400g的應力、位移與時間的關係圖60
圖三十五、黏膜在不同力量大小及持續性施力次數的總位移百分比61
圖三十六、黏膜在第一階段的位移百分比61
圖三十七、黏膜在第二階段的位移百分比62
圖三十八、黏膜在每平方分200公克持續性施力及循環性施力第一階段的位移斜率62
圖三十九、黏膜在每平方分400公克持續性施力及循環性施力第一階段的位移斜率63
圖四十、黏膜在不同施力大小及持續性施力次數第一階段的位移斜率比較63
圖四十一、黏膜在不同施力大小及持續性施力次數第二階段的位移斜率比較64
圖四十二、黏膜在不同施力大小下,循環性施力波峰連線斜率之比較64
圖四十三、黏膜在每平方分200公克施力時,反應遲緩的時間分布65
圖四十四、黏膜在每平方分400公克施力時,反應遲緩的時間分布65
表一、受測者之基本資料及黏膜厚度66
表二、第一階段位移斜率之迴歸方程式分析66
表三、第一階段實際位移量之迴歸方程式分析67
表四、第一階段位移量百分比之迴歸方程式分析67
表五、第一階段位移量百分比相對於實際位移量之迴歸方程式分析67
表六、第一階段位移量百分比相對於斜率之迴歸方程式分析68
表七、第二階段位移量百分比之迴歸方程式分析68
表八、第二階段位移斜率之迴歸方程式分析68
表九、第二階段位移斜率相對於位移百分比之迴歸方程式分析69
表十、黏膜在不同力量下反應遲緩之paired-t檢定69
Andersen KL, Mortensen HT, Pendersen EH, Melsen B.: Determination of stress levels and profiles in the periodontal ligament by means of an improved three dimensional finite element model for various types of orthodontic and natural force systems. J Biomed Eng 13:293-303, 1991
Bazirgan M, Bates JF.: Preliminary study of a method of measuring removable partial denture abutment tooth movement in vitro and in vivo. J Prosthet Dent 56:204-7, 1986
Bischoff JE, Arruda EM, Grosh K.:Finite element modeling of human skin using an isotropic, nonlinear elastic constitutive model. J of Biomechanics 33:645-52, 2000
Eger T, Müller H-P, Heinecke A.: Ultrasonic determination of gingival thickness: Subject variation and influence of tooth type and clinical features. J Clin Periodontol 23: 839-45, 1996
Fleisch L, Austin JC.: A histologic study of the response of masticatory and lining mucosa to mechanical loading in the vervet monkey. J Prosthet Dent 39:211, 1978
Gerson SJ, Meyer J.: Metaplastic keratinization in the human buccal mucosa. J Dent Res 43: 536, 1968
Goel VK, Khera SC, Gurusami S and Chen RCS.: Effect of cavity depth on stresses in a restored tooth. J Prosthet Dent 67:174-83, 1992
Hayakawa I, Hirano S, Kobayashi S, Nagao M, Masuhara E.: The creep behavior of denture-supporting tissues and soft lining materials. Int J of Prosthodont 7:339-47, 1994
Igarashi Y, Ogata A, Kuroiwa A, Wang CH.: Stress distribution and abutment tooth mobility of distal-extension removable partial dentures with different retainers: an in vivo study. J of Oral Rehabilitation 26:111-16, 1999
Kratochvil FJ and Caputo AA.: Photoelastic analysis of pressure on teeth and bone supporting removable denture. J Prosthet Dent 46:52-61, 1974
Kratochvil FJ, Thompson WD, Caputo AA.: Photoelastic analysis of stress patterns on teeth and bone with attachment retainers for removable dentures. J Prosthet Dent 46:21-8, 1981
Kydd WL, Daly CH.: The biologic and mechanical effects of stress on oral mucosa. J Prosthet Dent 47:317-29, 1982
Kydd WL, Daly CH, Wheeler JB.: The thickness measurement of masticatory mucosa in vivo. Int Dent J 21:430-41, 1971
Kydd WL, Stroud W, Moffett, BC, and Tamarin A.: The effect of Mechanic stress on oral mucoperiosteum of dogs. Arch Oral Biol 14:921, 1969
Lytle RB.: Management of abused oral tissues in complete denture construction. J Prosthet Dent 7:27, 1957
Lytle RB.: Complete denture construction based on a study of the deformation of the underlying soft tissues. J Prosthet Dent 9:539, 1959
Mercer EH.: Keratin and keratinization: An essay in molecular biology. Oxford, 1961, Pergamon Press.
Müller H-P, Schaller N, Eger T, Heinecke A.: Ultrasonic determination of thickness of masticatory mucosa. A methodologic study. Oral Surg Oral Med Oral Pathol 88:248-53, 1999
Pezzoli M, Rossetto M, and Calderale PM.: Evaluation of load transmission by distal-extension removable partial dentures by using reflection photoelasticity. J Prosthet Dent 56:329-37, 1986
Picton DC, Wills WIR.: Viscoelastic properties of the periodontal ligament and mucous membrane. J Prosthet Dent 40:263, 1978
Rees JS and Jacobsen PH.: Elastic modulus of the periodontal ligament. Biomaterials 18:995-9, 1997
Scapino RP.: Biomechanics of prehensile oral mucosa. J Morphol 122:89, 1967
Watson CJ, Huggett R, Wahab A.: The construction of replica complete dentures for use in measuring pressures at the denture base/mucosal surface interface. Quintessence International 17:237-44, 1986
Schware WD.: Effect of loading on a substitute oral mucosa and underlying bone. Biomaterials 13:1039-42, 1992
Sloan O, Picardo M, Schor SL.: The structure and function of oral mucosa. Dental Update 208-16, 1991
Tucker R.: Surface specializations of mechanically loaded epithelial. Res Vet Sci 9: 381,1968
Wang JL, Parnianpour M, Shirazi-Adl A, Engin AE.: Failure criterion of collagen fiber:Viscoelastic behavior simulated by using load control data. Theoretical and Applied Fracture Mechanics 27:1-12, 1997
Weinans H, Sumner DR, Igloria R, Natarajan RN.: Sensitivity of periprosthetic stress-shielding to load and the bone density-modulus relationship in subject-specific finite element models. J of Biomechanics 33:809-17, 2000
Zarb GA, Bolender CL, Carlsson GE.: Boucher’s Prosthodontic Treatment for Edentulous Patients Eleventh Edition. St. Louis, 1997, Mosby, 8-29
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top