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研究生:劉金華
研究生(外文):Chin-Hua Liu
論文名稱:重鬱症患者飲食型態及魚油補充之改善效果
論文名稱(外文):The Dietary Pattern and Fish Oil Supplement with Patients of Major Depressive Disorder
指導教授:謝明哲謝明哲引用關係黃士懿黃士懿引用關係
指導教授(外文):Ming-Jer ShiehShih-Yi Huang
學位類別:碩士
校院名稱:台北醫學院
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
論文頁數:151
中文關鍵詞:重鬱症飲食調查n-3脂肪酸
外文關鍵詞:n-3 fatty aciddiet surveysmajor depressive disorder
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為探討重鬱症患者之病因與其飲食型態之相關性,以及補充魚油對其症狀之改善效果而從事本實驗研究。本研究係利用各種飲食評估方法,釐清飲食因子與重鬱症之間的相關性,並進一步探討以高劑量的魚油(富含n-3多元不飽和脂肪酸)補充劑來改善重鬱症的臨床效果。實驗期間招募18位重鬱症患者(台北市立萬芳醫院精神科門診,HDRS為44.4±4.4分),以及19位健康受試者(正常組)。分別進行體位測量(身高、體重)、飲食調查(24小時飲食回憶法、三天飲食記錄法及食物頻率問卷法),並抽取禁食血液,檢測血液中基本生化值與紅血球細胞膜脂肪酸組成之分析。
實驗結果發現,重鬱組在用餐不規律性及牛奶攝取頻率明顯高於正常組;石斑魚的攝取頻率則是重鬱組顯著低於正常組(p<0.05)。而且由三天飲食記錄所估算出之膽固醇、亞麻油酸、次亞麻油酸、菸鹼素、灰質及鈉(新鮮食物)等營養素攝取量,在重鬱組皆顯著低於正常組(p<0.05)。另外,對重鬱組患者每天給予魚油補充劑六週(含4.4 g EPA及2.2 g DHA)後,能明顯改善重度重鬱症患者之臨床症狀。
The proposed study is to evaluate the etiology of major depressive disorder especially in dietary pattern, and the effectiveness of fish oil supplementation on clinical improvement. Eighteen major depressive disorder patients were recruited from Department of psychiatry, Taipei Medical University Municipal Wan Fang Hospital, aged from 18 to 65 years. A total of 19 age-sex matched healthy community controls were recruited as controlled subjects. The food frequency questionnaire, twenty four-hour dietary recall and three-day dietary record were used to investigate the differences of nutrients intake between major depressive disorder patients and normal individuals. In dietary frequency questionnaire, the results indicated the dietary pattern of major depressive patients is similar to the normal individual except the drinking milk. According to the three dietary record, the intake of cholesterol, linoleic acid, linolenic acid, niacin, ash and sodium (fresh food) in major depressive patients was significantly less than of normal adults. To compare the dietary nutrients intake, the data from three-day dietary record is more reliable than twenty four-hour dietary recall. The other factors such as age, sex, body mass index and intake of other nutrients showed no significant differences between major depressive disorder patients and normal subjects. Furthermore, the n-3 fatty acids supplementation (4.4 g EPA and 2.2 g DHA) in major depressive patients is significantly improved in HRSD score in 6th week.
頁數
中文摘要……………………………….…………………..….…………..…I
英文摘要…………………………………………………….…………..…..II
致謝……………………………………………………….……………..….III
目錄………………………………………………………………..……...…V
表目錄……………………………………………………...………..…........X
圖目錄…………………………………………………………….……….XIII
附錄目錄…………………………………………………………...……...XIV
縮寫對照表………………………………………………………….……..XV
第一章緒論………………………………….……………………….....1
第二章文獻回顧………………………………………………………..4
第一節重鬱症………………………………………………………...4
壹、重鬱症之定義及分類…………………………………..…4
貳、重鬱症之現況…………………………………………..…5
參、重鬱症之病因…………………………………………..…5
第二節飲食型態與重鬱症的關係………………………...……..….8
第三節營養素與重鬱症的關係……………………………...…..….9
壹、巨量營養素與重鬱症………………………………..…..….9
貳、維生素與重鬱症…………………………………………....10
參、礦物質與重鬱症……………………………………….…...11
第四節膽固醇及脂肪酸與神經生理學的關係………………….…12
壹、膽固醇……………………………………………………....12
貳、脂肪酸……………………………………………………....13
第五節n-3多元不飽和脂肪酸與重鬱症的關係……………….…..18
壹、血液方面…………………………………………...…….…18
貳、飲食方面…………………………………………….…...…19
參、n-3脂肪酸補充劑與情感性疾患之臨床試驗………..…....19
第三章實驗材料與方法………………………………………………21
第一節魚油膠囊的製備………………………………………....….21
第二節研究對象的招募及篩選…………………………………….22
第三節實驗設計…………………………………………………….23
第四節實驗過程…………………………………………………….25
第五節體位測量…………………………………………………….27
第六節飲食評估…………………………………………………….28
第七節精神評估…………………………………………………….30
第八節血液處理…………………………………………………….32
第九節脂肪酸組成分析…………………………………………….33
第十節資料處理………………………………………………..…...34
第四章結果……………………………………………………………35
第一節重鬱組與正常組之特性比較………………………….……35
壹、基本資料…………………………………………….…...…35
貳、疾病、運動及飲食狀況…………………………………....36
第二節重鬱組與正常組之飲食評估……………………………….41
壹、食物頻率問卷………………………………………………41
貳、營養素攝取量評估…………………………………………41
第三節重鬱組與正常組之血液生化值比較……………………….55
第四節重鬱組與正常組紅血球細胞膜脂肪酸組成比較…….…....58
第五節魚油組與安慰劑組基本資料比較………………………….60
第六節魚油組與安慰劑組營養素攝取量比較…………………….62
第七節魚油組與安慰劑組血液生化值比較……………………….80
第八節魚油組與安慰劑組紅血球細胞膜脂肪酸組成比較.………90
第九節魚油組與安慰劑組精神評量比較………………….………94
第五章討論……………………………………………………………96
第一節研究緣起………………………………….…………………96
壹、研究對象的限定……………………………………………96
貳、飲食評估方式的選擇………………………………………97
第二節重鬱症患者之特性……………………………………...…..98
壹、重鬱症患者與正常成人基本資料的比較………………....98
貳、重鬱症患者與正常成人之疾病及飲食狀況的比較………99
第三節重鬱症患者之飲食狀況…………………………………...100
壹、重鬱症患者與正常成人各種食物頻率的比較…………..100
貳、重鬱症患者與正常成人各種營養素攝取量的比較……..101
第四節重鬱症患者之血液生化值評估………………………...…107
壹、重鬱症患者與正常成人之空腹血糖及白蛋白的比較…..107
貳、重鬱症患者與正常成人之白血球及單核球的比較……..108
參、重鬱症患者與正常成人直接型膽紅素之比較…………..108
肆、重鬱症患者與正常成人之天門冬胺酸轉胺酉每 的比較….109
伍、重鬱症患者與正常成人血中鈉及氯離子濃度的比較…..109
陸、重鬱症患者與正常成人凝血功能的比較………………..110
柒、重鬱症患者與正常成人血膽固醇的比較………………..110
第五節重鬱症患者紅血球細胞膜脂肪酸組成評估……………...112
壹、紅血球細胞膜為測量脂肪酸組成之指標………………..112
貳、重鬱症患者與正常成年人之n-3脂肪酸組成的比較…...112
第六節補充魚油之重鬱症患者營養素攝取狀況…………...……114
壹、魚油組及安慰劑組補充前各種營養素攝取量之比較…..114
貳、魚油組補充前後各種營養素攝取量之比較……….…….114
參、安慰劑組補充前後各種營養素攝取量之比較…………..115
肆、魚油組及安慰劑組補充後各種營養素攝取量之比較…..115
第七節補充魚油之重鬱症患者血液生化值評估………………...116
壹、魚油組及安慰劑組補充前血液生化值之比較…………..116
貳、安慰劑對血液生化值之影響……………………………..116
參、魚油補充劑對血液生化值之影響………………………..116
第八節補充魚油患者之紅血球細胞膜脂肪酸組成評估……...…118
第九節魚油補充之改善效果…………………………………...…119
第六章結論與未來展望…………………………………………......120
第一節結論………………………………………………………...120
第二節未來展望………………………………………………...…121
壹、動物模式…………………………………………………..121
貳、人體模式…………………………………………………..121
第七章參考資料……………………………………….………….…123
Adams, P.B., Shery, L., Andrew, S. & Andrew, J.S. (1996) Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipid 31: S167-S176.
Anderson, I.M., Parry-Billings, M., Newsholme, E.A., Fairburn, C.G. & Cowen, P.J. (1990) Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol. Med. 20:785-791.
Anonymous (1982) Vanadium, vitamin C and depression. Nutr. Rev. 40:293-295.
Anonymous (1992) The changing rate of major depression. Cross-national comparisons. Cross-National Collaborative Group. JAMA. 268:3098-3105.
Avdulov, N.A., Eremenko, A.V., Valdman, A.V., Malin, K.M., Bulatova, N.R., Krinskaya, A.V., Lukjanova, L.D., Dudchenko. A.M. & Losev, A.S. (1990) Changes in synaptosomal membranes from cerebral cortex due to psychogenic stress in rats. Annali dell Istituto Superiore di Sanita. 26:31-35.
Avissar, S., Schreiber, G. & Ziskind-Somerfeld research Award (1992) The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol. Psychiat. 31:435-459.
Barbara J.M. & Roy J.M. (1992) The effect of dietary fat on diet selection may involve central serotonin. The American Physiological Society R559-R563.
Barclay, L.L., Gibson, G.E. & Blass, J.P. (1981) The string test: An early behavioral change in thiamine deficiency. Pharma. Biochem. Behav. 14:153-157.
Bartlett, S.J., Wadden, T.A. & Vogt, R.A. (1996) Psychosocial consequences of weight cycling. J. Consult.Clin. Psychol. 64:587-592.
Baumann, P., Perey, M., Laurian, S., Grasset, F., Steck, A. & Gaillard, J.M. (1979) Distribution of tryptophan in erythrocytes, leukocytes and thrombocytes, and its binding to plasma albumin. J. Neural Transm. 15:165S-176S.
Beebe, D.W., Holmbeck, G.N., Albright, J.S., Noga, K. & DeCastro, B. (1995) Identification of "binge-prone" women: an experimentally and psychometrically validated cluster analysis in a college population. Addict. Behav. 20:451-462.
Benton, D. & Donohoe, R.T. (1999) The effects of nutrients on mood. Public Health Nutr. 2:403-409.
Birmaher, B., Rabin, B.S., Garcia, M.R., Jain, U., Whiteside, T.L., Williamson, D.E., al-Shabbout, M., Nelson, B.C., Dahl, R.E. & Ryan, N.D. (1994) Cellular immunity in depressed, conduct disorder, and normal adolescents: role of adverse life events. J. Am. Acad. Child. Adolesc. Psychiat 33:671-678.
Bjerve, K.S., Burbakk, A.M., Foungner, K.J., Johnsen, H., Midjthell, K. & Vik, T. (1993) Omega-3 fatty acid: Essential fatty acids with important biological effects and serum intake. Am. J. Clin. Nutr. 57:801-806.
Blake-Mortimer, J.S., Winefield, A.H. & Chalmers, A.H. (1998) The effect of depression in an animal model on 5''-ectonucleotidase, antibody production, and tissue ascorbate stores. J. Gen. Psychol. 125:129-146.
Blankstein, K.R., Flett, G.L. & Johnston, M.E. (1992) Depression, problem-solving ability, and problem-solving appraisals. J. Clin. Psychol. 48:749-759.
Block, E. & Edwards, D. (1987) Effects of plasma membrane fluidity on serotonin transport by endothelial cells. Am. J. Physiol. 253:C672-C678.
Borkman, M., Storlien, L.H., Pan, D.A., Jenkins, A.B., Chisholm, D.J. & Campbell, L.V. (1993) The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. New Eng. J. Med. 328:238-244.
Bourre, J.M., Dumont, O., Piciotti, M, et al. (1989) Polyunsaturated fatty acids of the n-3 series and nervous system development. In: Galli C, Simopoulos AP, eds. Dietary n-3 and n-6 fatty acids: biological effects and nutritional essentiality. New York: Plenum Publishing, pp:159-175.
Bowlby, J. (1961) Processes of mourning. Int. J. Psychoanal. 42:317.
Brewerton, T.D., Heffernan, M.M. & Rosenthal, N.E. (1986) Psychiatric aspects of the relationship between eating and mood. Nutr. Rev. 5:78S-86S.
Bronsgeest-Schoute, H.C., van Gent, C.M., Luten, J.B. & Ruiter, A. (1981) The effect of various intakes of omega 3 fatty acids on the blood lipid composition in healthy human subjects. Am. J. Clin. Nutr. 34:1752-1757.
Brown, S.L., Salive, M.E., Harris, T.B., Simonsick, E.M., Guralnik, J.M. & Kohout, F.J. (1994) Low cholesterol concentrations and severe depressive symptoms in elderly people. BMJ. 308:1328-1332.
Bruinsma, K.A. & Taren, D.L. (2000) Dieting, essential fatty acid intake, and depression. Nutr. Rev. 58:98-108.
Carmelli, D., Swan, G.E., Kelly-Hayes, M., Wolf, P.A., Reed, T. & Miller, B. (2000) Longitudinal changes in the contribution of genetic and environmental influences to symptoms of depression in older male twins. Psychol.Aging. 15:505-510.
Carrie, I., Guesnet, P., Bourre, J.M. & Frances, H. (2000) Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice. Brit. J. Nutr.. 83:439-447.
Cashore, W.J. (1990) The neurotoxicity of bilirubin. Clin. Perinatol. 17:437-447.
Castell, J.V., Gomez-Lechon, M.J., David, M., Hirano, T., Kishimoto, T. & Heinrich, P.C. (1988) Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS. 232:347-350.
Chang, M.C.J. & Jones, C.R. (1998) Chronic lithium treatment decreases brain phospholipase A(2) activity. Neurochem. Res. 23:887—892.
Christensen, L. & Somers, S. (1994) Adequacy of the dietary intake of depressed individuals. J. Am. Coll. Nutr. 13:597-600.
Cocchi, P., Silenzi, M., Calabri, G. & Salvi, G. (1980) Antidepressant effect of vitamin C. Pediatrics. 65:862-863.
Connor, W.E., Neuringer, M. & Lin, D.S. (1990) Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J. Lipid Res. 31:237-247.
Cowen, P.J. & Charig, E.M. (1987) Neuroendocrine response to intravenous tryptophan in major depression. Arch. Gen. Psychiat. 44:958-966.
Crane, S.B. & Greenwood, C.E. (1987) Dietary fat source influences neuronal mitochondrial monoamine oxidase activity and macronutrient selection in rats. Pharmacol. Biochem. Behav. 27:1-6.
Cummings, P. & Psaty, B.M. (1994) The association between cholesterol and death from injury. Ann. Intern. Med. 120:848-855.
Dantzer, R., Wollman, E., Vitkovic, L. & Yirmiya, R. (1999) Cytokines and depression: fortuitous or causative association? Mole. Psychiat. 4:328-332.
DeLion, S., Chalon, S., Herault, J., Guilloteau, D., Besnard, J. & Durand, G. (1994) Chronic dietary a-linolenic acid deficiency alters dopaminergic and serotonergic neurotransmission in rats. J. Nutr. 124:2466-2476.
Delgado, P.L. (2000) Depression: the case for a monoamine deficiency. J.Clin. Psychiat. 61:7S-11S.
DeMarte, M.L. & Enesco, H.E. (1986) Influence of low tryptophan diet on survival and organ growth in mice. Mechan. Ageing. Develop. 36:161-171.
Dentino, A.N., Pieper, C.F., Rao, M.K., Currie, M.S., Harris, T., Blazer, D.G. & Cohen, H.J. (1999) Association of interleukin-6 and other biologic variables with depression in older people living in the community. J. Am. Geri. Soci. 47:6-11.
Diebold, K. (1976) Investigations of fasting blood glucose in endogenous depressive, schizophrenic, and neurotic patients. Archiv fur Psychiatrie and Nervenkrankheiten. 221:313-320.
DiPietro, L., Anda, R.F., Williamson, D.F. & Stunkard, A.J. (1992) Depressive symptoms and weight change in a national cohort of adults. Internatl. J. Obes.Related Meta. Disor. 16:745-753.
Dubovsky, S.L. & Franks, R.D. (1983) Intracellular calcium ions in affective disorders: a review and an hypothesis. Bio. Psychiat. 18:781-797.
Dubovsky, S.L., Thomas, M., Hijazi, A. & Murphy, J. (1994) Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder. Eur. Arch. Psychiat.Clin. Neuroscience. 243:229-234.
Endres, S., Ghorbani, R., Kelley, V.E., Georgilis, K., Lonnemann, G., van der, Meer, J.W.M., Cannon, J.G., Rogers, T.S., Klempner, M.S., Weber, P.C., Schaefer, E.J., Wolfe, S.M. & Dinarello, C.A. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New Eng. J. Med. 320:265-271.
Endres, S. (1993) Messengers and mediators: interactions among lipids, eicosanoids and cytokines. Am. J. Clin. Nutr. 57:798-800.
Edwards, R., Peet, M., Shay, J. & Horrobin, D. (1998) Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J. Affect. Disord. 48:149-155.
Engelberg, H. (1992) Low cholesterol and suicide. Lancet. 339:727-729.
Espersen, G.T., Grunnet, N., Lervang, H.H., Nielsen, G.L., Thomsen, B.S., Faarvang, K.L., Dyerberg, J. & Ernst, E. (1992) Decreased interleukin-1 b levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin. Rheumatol. 11:393-395.
Evers, C.L. (1987) Dietary intake and symptoms of anorexia nervosa in female university dancers. J. Am. Diet. Asso. 87:66-68.
Farquharson, J., Cockburn, F., Patrick, W.A., Jamieson, E.C. & Logan, R.W. (1992) Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet 340:810-813
Franceschini, G., Calabresi, L., Maderna, P., Galli, C., Gianfranceschi, G. & Sirtori, C.R. (1991) Omega-3 fatty acids selectively raise high-density lipoprotein 2 levels in healthy volunteers. Metabolism: Clin. Exp. 40:1283-1286.
Friedman, E., Hoau-Yan-Wang, Levinson, D., Connell, T.A. & Singh, H. (1993) Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Bio. Psychiat. 33:520-525.
Friend, R., Hatchett, L., Wadhwa, N.K. & Suh, H. (1997) Serum albumin and depression in end-stage renal disease. Adv. Peri. Dial. 13:155-157.
Gallerani, M., Manfredini, R., Caracciolo, S., Scapoli, C., Molinari, S. & Fersini C. (1995) Serum cholesterol concentrations in parasuicide. BMJ. 310:1632-1636.
Garner, C., Feniuk, W. & Brown, P.D. (1993) Serotonin activates Cl- channels in the apical membrane of rat choroid plexus epithelial cells. Eur. J. Pharmacol. 239:31-37.
Gattaz, W.F., Schmitt, A. & Maras, A. (1995) Increased platelet phospholipase A2 activity in schizophrenia. Schizophr. Res. 16:1-6.
Gershenwald, J.E., Fong, Y.M., Fahey, T.J., 3d., Calvano, S.E., Chizzonite, R., Kilian, P.L., Lowry, S.F. & Moldawer, L.L. (1990) Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc. Natl. Acad. Sci.USA. 87:4966-4970.
Glatz, J.F., Soffers, A.E. & Katan, M.B. (1989) Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. Am. J. Clin. Nutr. 49:269-276.
Glueck, C.J., Tieger, M., Kunkel, R., Hamer, T., Tracy, T. & Speirs, J. (1994) Hypocholesterolemia and affective disorders. Am. J. Med Sci. 308:218-225.
Hadigan, C.M., Anderson, E.J., Miller, K.K., Hubbard, J.L., Herzog, D.B., Klibanski, A. & Grinspoon, S.K. (2000) Assessment of macronutrient and micronutrient intake in women with anorexia nervosa. Internatl. J. Eat. Diso. 28:284-292.
Haga, y., Tempero, M.A., Kay, D. & Zetterman, R.K. (1992) Characterization of bilirubin transport system by human peripheral blood mononuclear cells. J. Leucocyte. Biol. 51:2-6.
Hallaq, H., Smith, T.W. & Leaf, A. (1992) Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids. Proc. Natl. Acad. Sci. USA 89:1760-1764.
Haller, J., Weggemans, R.M., Ferry, M. & Guigoz, Y. (1996) Mental health: minimental state examination and geriatric depression score of elderly Europeans in the SENECA study of 1993. Eur. J. Clin. Nutr. 50:S112-S116.
Hamiton, M. (1960) A rating scale for depression. J. Neurol. Neurosurg. Ps. 23:56-62.
Harris, B., Young, J. & Hughes, B. (1984) Appetite and weight change in patients presenting with depressive illness. J. Affect. Disor. 6:331-339.
Harrison, R.W. & Ashton, C.H. (1994) Do cholesterol-lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers. Brit. J. Clin. Pharm. 37:231-236.
Henry, Y., Seve, B., Mounier, A. & Ganier, P. (1996) Growth performance and brain neurotransmitters in pigs as affected by tryptophan, protein, and sex. J. Animal Sci. 74:2700-2710.
Heron, D.S., Shinitzky, M., Hershkowitz, M. & Samuel, D. (1980) Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc. Natl. Acad. Sci. USA. 77:7463-7467.
Hibbeln, J.R. & Salem, N.Jr. (1995) Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am. J. Clin. Nutr. 62:1-9.
Hibbeln, J.R., Umhau, J.C., George, D.T. & Salem, N.Jr. (1997) Do plasma polyunsaturates predict hostility and depression? World Rev. Nutr. Diet. 82:175-186.
Hibbeln, J.R. (1998) Fish consumption and major depression. Lancet 351:1213.
Hibbeln, J.R. Umhau, J.C., George, D.T., Shoaf, S.E., Linnoila, M. & Salem, N.Jr. (2000) Plasma total cholesterol concentrations do not predict cerebrospinal fluid neurotransmitter metabolites: implications for the biophysical role of highly unsaturated fatty acids. Am. J. Clin. Nutr. 71:331S-338S.
Holian, O. & Nelson, R. (1992) Action of long-chain fatty acids on protein kinase C activity: comparison of omega-6 and omega-3 fatty acids. Antican. Res. 12:975-980.
Horney, K. (1967) Feminine psychology, New York, WW Norton & Company.
Horrobin, D.F. (1990) Lowering cholesterol concentrations and mortality. Br. Med. F. 301:554.
Horrobin, D.F. & Bennett, C.N. (1999) Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis possible candidate genes. Prostaglandins Leuko. Essent. Fatty. Acids. 60:217—234.
Jain, S.R. & Jain, M.L. (1973) Investigations on the essential oil of Ocimum basilicum. Planta. Medica. 24:286-289.
Johansson, L.R.K., Solvoll, K., Bjorneboe, G.E. & Drevon, C.A. (1998) Intake of very-long-chain n-3 fatty acids related to social status and lifestyle. Eur. J. Clin. Nutr. 52:716-721.
Kallman, F. (1953) Heredity in health and mental disorder, New York, WW Norton Co.
Kaplan, J.R., Manuck, S.B. & Shively, C. (1991) The effects of fat and cholesterol on social behavior in monkeys. Psychosom. Med. 53:634-642.
Kendler, K. & Eaves, L. (1986) Models for the joint effect of genotype and environment on liability to psychiatric illness. Am. J. Psychiatr. 143:279.
Kendler, K.S., Heath, A., Martin, N.G. & Eaves, L.J. (1986) Symptoms of anxiety and depression in a volunteer twin population. The etiologic role of genetic and environmental factors. Arch. Gen. Psychiat. 43:213-221.
Kerimova, M.G., Akhmedov, I.R., Bagirova, B.A. & Badiagina, O.D. (1985) Importance of correcting the protein, fat and vitamin content of the diets for the work capacity of young people during exams. Vopr Pitan. 6:12-16.
Kim, S. & Ko, S.H. (1989) Theoretical models of causative factors in depression: a review of the literature for nursing. Kanho Hakhoe Chi J. Nurses Acad. Soci. 19:173-190.
Klasing, K.C. (1988) Nutritional aspects of leukocytic cytokines. J. Nutr. 118:1436-1446.
Klerman, G.L. & Weisman, M.M. (1989) Increasing rates of depression. JAMA. 261:2229-2235.
Knapp, H.R. (1990) Polyunsaturates, endogenous eicosanoids, and cardiovascular disease. J. Am. Coll. Nutr. 9:344-351.
Koda, Y., Wada, A., Yanagihara, N., Uezono, Y. & Izumi, F. (1989) Cis-unsaturated fatty acids stimulate catecholamine secretion, tyrosine hydroxylase and protein kinase C in adrenal medullary cells. Neuroscience. 29:495-502.
Koslow, S.H., Stokes, P.E., Mendels, J., Ramsey, A. & Casper, R. (1982) Insulin tolerance test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects. Psychol. Med. 12:45-55.
Kronfol, A., Silva, J., Greden, J., Dembinski, S., Gardner, R. & Carroll, B. (1983) Impaired lymphocyte function in depressive illness. Life Sci. 33:241-247.
Lambert, G., Johansson, M., Agren, H. & Friberg, P. (2000) Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness: evidence in support of the catecholamine hypothesis of mood disorders. Arch. Gen. Psychiat. 57:787-793.
Laustiola, K.E. (1989) Decreased cyclic AMP accumulation in lymphocytes in response to adrenaline and prostacyclin after n-3 polyunsaturated fatty acid supplementation in man. Eur. J. Clin. Pharma. 37:195-197.
Leckman, J.F., Caruso, K.A., Prusoff, B.A., Weissman, M.M., Merikangas, K.R. & Pauls, D.L. (1984) Appetite disturbance and excessive guilt in major depression. Use of family study data to define depressive subtypes. Arch. Gen. Psychiat. 41:839-844.
Lepage, G. & Roy, C.C. (1986) Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27:114-120.
Lesch, K.P. & Beckmann, H. (1990) The serotonin hypothesis of depression. Fortschritte der Neurologie-Psychiatrie. 58:427-438.
Leviel, V. & Naquet, R. (1977) A study of the action of valproic acid on the kindling effect. Epilepsia. 18:229-234.
Levine, R.L., Fredericks, W.R. & Rapoport, S.I. (1982) Entry of bilirubin into the brain due to opening of the blood brain barrier. Pediatrics 69:255-259.
Linnoila, M., Whorton, A.R., Rubinow, D.R., Cowdry, R.W., Ninan, P.T. & Waters, R.N. (1983) CSF prostaglandin levels in depressed and schizophrenic patients. Arch. Gen. Psychiat. 40:405-406.
Maes, M., Vandewoude, M., Scharpe, S., DeClercq, L., Stevens, W., Lepoutre, L. & Schotte, C. (1991a) Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J. Affect. Disorders. 23:25-33.
Maes, M., Bosmans, E., Soy, E., Vandervorst, C., DeJonckheere, C. & Raus, J. (1991b) Depression- related disturbances in mitogen-induced lymphocyte responses and interleukin-1b and soluble interleukin-2 receptor production. Acta Psychiatr Scand. 84: 379—386.
Maes, M. (1993) A review on the acute phase response in major depression. Reviews in the Neurosciences. 4(4): 407-416.
Maes, M., D''Haese, P.C., Scharpe, S., D''Hondt, P., Cosyns, P. & DeBroe, M.E. (1994a) Hypozincemia in depression. J. Affect. Disord. 31:135-140.
Maes, M., Delanghe, J., Meltzer, H.Y., Scharpe, S., D''Hondt, P. & Cosyns, P. (1994b) Lower degree of esterification of serum cholesterol in depression: relevance for depression and suicide research. Acta Psychiatrica Scandinavica. 90:252-258.
Maes, M. & Meltzer, H.Y.M. (1995a) The sorotonin hypothesis of major depression. In: Bloom, FE, Kuper DJ (Eds), Psychopharmacology, the 4th Generation of Progress. Raven Press, New York, p: 933-941.
Maes, M., Wauters, A., Neels, H., Scharpe, S., Van, Gastel, A., D''Hondt, P., Peeters, D., Cosyns, P. & Desnyder, R. (1995b) Total serum protein and serum protein fractions in depression: relationships to depressive symptoms and glucocorticoid activity. J Affect Disord. 34:61-69.
Maes, M., Smith, R., Christophe, A., Cosyns, P., Desnyder, R. & Meltzer, H. (1996) Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl ester and increased C20:4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J Affect Disord. 38: 35-46.
Maes, M., Bosmans, E., DeJongh, R., Kenis, G., Vandoolaeghe, E. & Neels, H. (1997) Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine. 9: 853—858.
Maes, M. & Smith, R.S. (1998) Fatty acids, cytokines, and major depression. Bio. Psychiat. 43:313-314.
Maes, M., Armand, C., Joris, D., Carlo, A., Hugo, N. & Herbert, Y.M. (1999) Lowered omega-3 polyunsaturated fatty acid levels in serum phospholipids and cholesteryl esters of depressed patients. Psychi Res 85:275-291.
Maguire, P.A. & Druse, M.J. (1989) The influence of cholesterol on synaptic fluidity and dopamine uptake. Brain Res. Bull. 22:431-437.
Makrides, M., Gibson, R.A. & Simmer, K. (1993) The effect of dietary fat on the developing brain. J. Paediat.Child Health. 29:409-410.
Makrides, M., Neumann, M.A., Byard, R.W., Simmer, K. & Gibson, R.A. (1994) Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am. J. Clin. Nutr.. 60:189-194.
Manji, H.K. (1992) G proteins: implications for psychiatry. Am. J. Psychiat. 149:746-760.
Mantzioris, E., James, M.J., Gibson, R.A. & Cleland, L.G. (1994) Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am. J. Clin. Nutr. 59:1304-1309.
Mantzioris, E., Cleland, L.G., Gibson, R.A., Neumann, M.A., Demasi, M. & James, M.J. (2000) Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Am. J. Clin. Nutr. 72:42-48.
McLaren, D.S. (1981) Nutrition and its Disorders, 3rd ed. Churchill, Livingstone, Edinburgh.
Meador-Woodrugg, J. & Greden, J. (1988) Effects of psychotropic medications on hypothalamic-pituitary-adrenal regulation. Endocrinol. Metab. Clin. N. Am. 17:225.
Mellor, J.E., Laugharne, J.D.E. & Peet, M. (1996) Omega-3 fatty acid supplementation in schizophrenic patients. Hum Psychopharmacol. 11:39-46.
Meydani, S.N., Endres, S., Woods, M.M., Goldin, B.R., Soo, C., Morrill-Laborde, A., Dinarello, C.A. & Gorbach, S.L. (1991) Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121:547-555.
Morgan, R.E., Palinkas, L.A., Barrett-Connor, E.L. & Wingard, D.L. (1993) Plasma cholesterol and depressive symptoms in older men. Lancet. 341:75-79.
Mueller, P.S., Heninger, G.R. & McDonald, R.K. (1969) Insulin tolerance test in depression. Arch. Gen. Psychiat. 21:587-94.
Muldoon, M.F., Manuck, S.B. & Matthews, K.A. (1990) Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trails. Br. J. Med. 301: 309-314.
Mullen, B.J. & Martin, R.J. (1992) The effect of dietary fat on diet selection may involve central serotonin. Am. J. Physio. 263: R559-R563.
Muller, N., Schiller, P. & Ackenheil, M. (1991) Coincidence of schizophrenia and hyperbilirubinemia. Pharmacosychiat. 24:225-228.
Muller, N., Klages, U. & Gunther, W. (1994) Hepatic encephalopathy presenting as delirium and mania. The possible role of bilirubin. Gen. Hospi. Psychiat. 16:138-140.
Neuringer, M., Connor, W.E., Van, Petten, C. & Barstad, L. (1984) Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest. 73:272-276.
Nieman, D.C., Butterworth, D.E., Nieman, C.N., Lee, K.E. & Lee, R.D. (1992) Comparison of six microcomputer dietary analysis systems with the USDA Nutrient Data Base for Standard Reference. J. Am. Diet. Asso. 92:48-56.
Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:607-614.
Nobbs, B.T. (1974) Pyridoxal phosphate status in clinical depression. Lancet. 1:405-406.
Nowak, G. (1998) Alterations in zinc homeostasis in depression and antidepressant therapy. Polish J. Pharma. 50:1-4.
O''Donnell, R.A. & Miller, A.A. (1991) The effect of lamotrigine upon development of cortical kindled seizures in the rat. Neuropharma. 30:253-258.
Paykel, E.S. (1977) Depression and appetite. J. Psychosom. Res. 21:401-407.
Peet, M., Murphy, B., Shay, J. & Horrobin, D. (1998) Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol. Psychiatry. 43:315-319.
Pekkanen, J., Nissinen, A., Punsar, S. & Karvonen, M.J. (1989) Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. Arch. Intern. Med. 149:1589-1591.
Pepe, S., Bogdanov, K., Hallaq, H., Spurgeon, H., Leaf, A. & Lakatta, E. (1994) Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. Proc. Natl. Acad. Sci. USA. 91:8832-8836.
Perez-Granados, A.M., Vaquero, M.P. & Navarro, M.P. (1995) Iron metabolism in rats consuming oil from fresh or fried sardines. Analyst. 120:899-903.
Post, R.M. & Weiss, S.R.B. (1989) Non-homologus animal models of affective disorders: clinical relevance of sensitization and kindling. In: Koob GF, Ehlers CL, Kupfer DJ, eds. Animal models of depression. Boston: Birkhauser 30-54.
Price, V. & Archbold, J. (1995) Development and application of social learning theory. Br. J. Nur. 4:1263-1268.
Ramsey, T.A., Frazer, A. & Mendels, J. (1979) Plasma and erythrocyte cations in affective illness. Neuropsychobio. 5:1-10.
Richardson, A.J., Easton, T., Gruzelier, J.H. & Puri, B.K. (1999) Laterality changes accompanying symptom remission in schizophrenia following treatment with eicosapentaenoic acid. Internal. J. Psychophysiol. 34:333-339.
Ravindran, A.V., Griffiths, J., Merali, Z., Knott, V.J. & Anisman, H. (1999) Influence of acute tryptophan depletion on mood and immune measures in healthy males. Psychoneuroendocrino. 24:99-113.
Rodriguez Jimenez, J., Rodriguez, J.R. & Gonzalez, M.J. (1998) Indicators of anxiety and depression in subjects with different kinds of diet: vegetarians and omnivores. Boletin - Asociacion Medica de Puerto Rico. 90:58-68.
Ross, B.M., Hudson, C., Erlich, J., Warsh, J.J. & Kish, S.J. (1997) Increased phospholipid breakdown in schizophrenia — Evidence for the involvement of a calcium-independent phospholipase A(2). Arch. Gen. Psychiat. 54:487—494.
Rulka, C.A. & Hamm, M.W. (1988) Dietary fat and the beta-adrenergic-mediated chronotropic response in the rat. J. Nutr. 118:1304-1310.
Salem, N, Yim, H-Y. & Yergey, J.A. (1986) Docosahexaenoic acid: membrane function and metabolism. In: Simopoulos. A.P., Kifer, R.R., Martin R.E. (Eds) Health Effects of Polyunsaturated Fatty Acids in Seafoods. Academic Press, Orlando. pp:263-317.
Salem, N.Jr. (1989) Omega-3 fatty acids: molecular and biochemical aspects. In: Spiller GA, Scala J, eds. New roles for selective nutrients. New York: Alan R Liss Inc: 109-228.
Salem, N. Jr. & Niebylski, C.D. (1995) The nervous system has an absolute molecular species requirement for proper function. Mole. Membra. Bio. 12:131-134.
Schildkraut, J.J. (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am. J. Psychiat. 122:509-522.
Schlesser, M. & Altshuler, K. (1983) The genetics of affective disorder: data, theory, and clinical application. Hosp. Commun. Psychiatr. 34:415.
Schreiber, G., Avissar, S., Danon, A. & Belmaker, R.H. (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol. Psychiat. 29:237-280.
Shimokawa, H. & Vanhoutte, P.M. (1989) Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries. Am. J. Physiol. 256:H968-H973.
Slater, S.J., Kelly, M.B., Taddeo, F.J., HoC., Rubin, E. & Stubbs, C.D. (1994) The modulation of protein kinase C activity by membrane lipid bilayer structure. J. Bio. Chem. 269:4866-4871.
Slater, S.J., Kelly, M.B., Yeager, M.D., Larkin, J., Ho, C. & Stubbs, C.D. (1996) Polyunsaturation in cell membranes and lipid bilayers and its effects on membrane proteins. Lipids. 31:S189-S192.
Smith, G.D., Shipley, M.J., Marmot, M.G. & Patel, C. (1990) Lowering cholesterol concentrations and mortality. Br. Med. F. 301:552.
Smith, R.S. (1991) The macrophage theory of depression. Med. Hypothese. 35:298-306.
Somenzini, G., Tosca, P., Cominelli, F., Zerbi, F. & Biscaldi, G. (1989) Depression and home environment. Giornale Italiano di Medicina del Lavoro. 11:145-148.
Song, C., Dinan, T. & Leonard, B.E. (1994) Changes in immunoglobulin, complement and acute phase protein levels in depressed patients and normal controls. J. Affect. Disord. 30:283-288.
Song, C. & Leonard, B.E. (1995) Interleukin-2-induced changes in behavioural, neurotransmitter, and immunological parameters in the olfactory bulbectomized rat. Neuroimmunomodu. 2:263-273.
Speizer, L.A., Watson, M.J. & Brunton, L.L. (1991). Differential effects of omega-3 fish oils on protein kinase activities in vitro. Am. J. Physiol. 261:E109-E114.
Spratt, M.L. & Denney, D.R. (1991) Immune variables, depression, and plasma cortisol over time in suddenly bereaved parents. J. Neuropsychiat. Clin. Neurosci. 3:299-306.
Stoll, A.L. & Severus, W.E. (1996) Mood stabilizers: shared mechanisms of action at postsynaptic signal-transduction and kindling processes. Harvard Rev. Psychiat. 4:77-89.
Stoll, A.L., Severus, W.E., Freeman, M.P., Rueter, S., Zboyan, H.A., Diamond, E., Cress, K.K. & Marange, L.B. (1999) Omega 3 fatty acids in bipolor disorder: a preliminary double-blind, placebo-controlled trial. Arch. Gen. Psychiatry. 56:407-412.
Stoll, A.L., Locke, C.A., Marangell, L.B. & Severus, W.E. (1999) Omega-3 fatty acids and bipolar disorder: a review. Prostaglandins Leuko. Essent. Fatty Acids. 60:329-337.
Storlien, L., Jenkins, A.B., Chishlom, D.J., Pascoe, W.S., Khouri, S. & Kraegen, E.W. (1991) Influence of dietary fat composition on development of insulin resistance in rat. Diabetes. 40:280-289.
Stubbs, C.D. (1992) The structure and function of docosahexaenoic acid in membranes: In: Sinclair A, Gibson R, eds. Third International Congress on essential fatty acids and eicosanoids, Adelaide, Australia. Champaign, IL: Am. Oil Chem. Soci. 116-121.
Sun, G. & Sun, C. (1979) Effect of chronic ethanol administration on phospholipid acyl groups of synaptic membrane fraction isolated from guinea pig brain. Res. Commun. Chem. Pathol. Pharmacol. 24:405-408.
Szepesi, B. & Freedl, R.A. (1967) Alterations in the activities of several rat liver enzymes at various times after initiation of a high protein regimen. J. Nutr. 93:301-306.
Tamaoki, J., Chiyotani, A., Takemura, H. & Konno, K. (1997) 5-Hydroxytryptamine inhibits Na absorption and stimulates Cl secretion across canine tracheal epithelial sheets. Clin. Exp. Allergy. 27:972-977.
Tarter, R.E., Arria, A.M. & Van, Thiel, D.H. (1991) Hepatic encephalopathy coexistent with alcoholism. Recent. Dev. Alcohol. 9:205-224.
Truchlinski, J. & Grela, E. (1987) Alanine and aspartate transaminase and acid and alkaline phosphatase activities in the blood serum in relation to the protein and energy levels in the pigs'' feeds. Polskie Archiwum Weterynaryjne. 27:129-136.
Tucker, D.M., Penland, J.G., Sandstead, H.H., Milne, D.B., Heck, D.G. & Klevay, L.M. (1990) Nutrition status and brain functioning in aging. Am. J. Clin. Nutr. 52:93-102.
Ustun TB. (2000) Cross-national epidemiology of depression and gender. J. Gender-Specific Med. 3:54-58
Vaddadi, K.S., Courtney, P., Gilleard, C.J., Manku, M.S. & Horrobin, D.F. (1989) A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. Psychiat. Res. 27:313-323.
Virkkunen, M. (1979) Serum cholesterol in antisocial personality. Neuropsychobiol. 5:27-30.
Wardle, J., Armitage, J., Collins, R., Wallendszus, K., Keech, A. & Lawson, A. (1996) Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration. Oxford Cholesterol Study Group. BMJ. 313:75-78.
Weidner, G., Connor, S.L., Hollis, J.F. & Connor, W.E. (1992) Improvements in hostility and depression in relation to dietary change and cholesterol lowering. The Family Heart Study. Ann. Intern. Med. 117:820-823.
Weissman, M.M., Bland, R.C. & Canino, G.J. (1996) Cross-national epidemiology of major depression and bipolor disorder. JAMA. 276:293-299.
Weissmann, M., Merikangas K. & John, K. (1986) Family-genetic studies of psychiatric disorder. Arch. Gen. Psychiatr. 43:1104.
Wells, A.S., Read, N.W., Laugharne, J.D. & Ahluwalia, N.S. (1998) Alterations in mood after changing to a low-fat diet. Br. J. Nutr. 79:23-30.
Winokur, A., Maislin, G., Phillips, J.L. & Amsterdam, J.D. (1988) Insulin resistance after oral glucose tolerance testing in patients with major depression. Am. J. Psychit. 145:325-330.
Wurpel, J.N. & Iyer, S.N. (1994) Calcium channel blockers verapamil and nimodipine inhibit kindling in adult and immature rats. Epilepsia. 35:443-449.
Wurtman, J.J., Brezeinski, A., Wurtman, R.J. & Laferrere, B. (1989) Effect of nutrient intake on premenstrual depression. Am. J. Obst. Gyn. 161:1228-1234.
Yeagle, P.L. (1989) Lipid regulation of cell membrane structure and function. FASEB. J. 3:1833-1842.
Yorek, M., Leeney, E., Dunlap, J. & Ginsberg, B. (1989) Effect of fatty acid composition on insulin and IGF-I binding in retinoblastoma cells. Investigative Ophthalmol.Visual Sci. 30:2087-2092.
Yoshimura, T., Matsui, K., Ito, M., Yunohara, T., Kawasaki, N., Nakamura, T. & Okamura, H. (1987) Effects of highly purified eicosapentaenoic acid on plasma beta thromboglobulin level and vascular reactivity to angiotensin II. Artery. 14:295-303.
Zureik, M., Courbon, D. & Ducimetiere, P. (1996) Serum cholesterol concentration and death from suicide in men: Paris prospective study. BMJ. 313:649-651.
Zidovetski, R. & Lester, D. (1992) The mechanism of action of protein kinase C: a biophysical perspective. Biochim. Biophys. Acta. 1134:261-272.
Zimmer, L., Hembert, S., Durand, G., Breton, P., Guilloteau, D., Besnard, J.C. & Chalon, S. (1998) Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. Neurosci. Lett. 240:177-181.
Zimmer, L., Delion-Vancassel, S., Durand, G., Guilloteau, D., Bodard, S., Besnard, J.C. & Chalon, S. (2000) Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n-3 polyunsaturated fatty acids. Lipid Res. 41:32-40.
Zimmerman, T.W. & Binder, H.J. (1984) Serotonin-induced alteration of colonic electrolyte transport in the rat. Gastroenterol. 88:310-317.
中華民國行政院衛生署(1993)每日營養素建議攝取量。
中華民國行政院衛生署(1998)81-86年國民營養健康狀況變遷調查結果研討會。
中華民國行政院衛生署(2000)民國八十八年台灣地區國民死因統計報告。
孔繁鐘(1999a)DSM Ⅳ 精神疾病的診斷與統計。合計圖書出版社 初版 311-321。
孔繁鐘,孔繁錦(1999b)精神疾病診斷準則手冊。合記圖書出版社 初版 pp:28-31。
台灣地區慢性精神病患復健研討會彙編。(1987) 高雄市立凱旋醫院編印 pp:21-41。
李引玉、郭世音、傅綢妹、楊美賞、邱麗蓮、楊南瑩、高雪芬、黃愛娟、連寶珠、饒雅萍、廖肇安、沈志仁、許敏桃、盧純華、毛家舲(1998)實用精神科護理學。華杏出版股份有限公司 初版 pp:21-33; 213-217; 259-262。
李明濱(1997)醫學的人性面:情緒與疾病。國立台灣大學醫學院 初版 pp:61-66。
邱鈺茹、陳為堅(2000)青少年之生活事件與憂鬱症狀。國立台灣大學公共衛生學院流行病學研究所碩士論文。
韋白克(1995)50種常見疾病的營養療法。和碩科技文化有限公司 初版 111-124。
韋珊(1991)抑鬱症及其治療。淑馨出版社 十一月版 35-46。
陳重助(1999)藥理學十日速成。合記圖書出版社 初版 p:177-184。
黃條來、文榮光、陽明仁、吳淑娟(1999)精神科急性住院病人血中的總膽固醇濃度。台灣精神醫學 13(2): 55-59。
謝明哲(1987)食物份量換算手冊。台北醫學大學保健營養學系、台北醫學大學附設醫院臨床營養室編印。
傅偉光、陳秀瑩、仇志強、陳景川(1998)台灣地區食品營養成分資料庫。行政院衛生署委辦、食品工業發展研究所編印。
鍾信心、周照芳、李引玉、毛家舲、蕭淑貞、蔡欣玲、楊美賞、張宏俊、熊秉荃、連寶珠、黃惠滿、黃珮玲、沈志仁、陳杏佳、饒雅萍、盧純華、徐儷瑜(1992)精神科護理學。華杏出版股份有限公司 第三版 pp:63-67; 149-158。
續光清(1991)食品化學。財團法人徐氏基金會 初版 pp:81。
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1. 殷天爵,「中共大國外交與夥伴關係之研析」。共黨問題研究,25卷3期(1999年3月),頁82-93。
2. 陳一新,「布希政府亞太戰略的構想與部署」。遠景季刊,第2卷第4期(2001年10月),頁1-27。
3. 徐斯儉,「全球化─中國大陸學者的觀點」。中國大陸研究,43卷4期(2000年4月) ,頁1-28。
4. 胡志強,「中共『大國外交』及我國因應之道」。政策月刊,50期(1999年9月),頁29-36。
5. 施子中,「中共推動大國外交與建構夥伴關係之研析」。戰略與國際研究,1卷3期(1999年7月),頁1-42。
6. 張雅君,「上海五國安全合作與中共的角色」。中國大陸研究,44卷4期(2001年4月),頁33-54。
7. 張登及,「中共『大國外交』構思下兩岸關係的發展─思辯模型試擬」。中國事務,第4期(2001年4月),頁131-135。
8. 邱坤玄,「冷戰後中共與朝鮮半島的權力平衡」。中國事務,第4期(2001年4月),頁90-102。
9. 畢英賢,「論中俄戰略協做夥伴關係」。問題與研究,35卷12期(1996年12月),頁19-64。
10. 林宗達,「中俄關係之改善對中共軍事現代化的助力分析」。共黨問題研究,27卷8期(2001年8月),頁58-76。
11. 李登科,「冷戰後中共大國外交策略之研究」。國際關係學報,15期(2000年12月),頁33-67。
12. 吳玲君,「中共APEC策略與腳色的轉變:新現實主義的解析」。問題與研究,40卷3期(2001年5月)。頁1-20。
13. 吳東野,「北約全球化戰略走向對台海情勢發展之意義與影響」。遠景季刊,1卷4期(2000年10月),頁25-57。
14. 何家棟,「二十一世紀中國國家利益與國家安全─兼駁國家主義意識型態」,中國社會科學季刊,2000年春季號(2000年4月),頁103-109。
15. 石之瑜,「論台灣政治的移民性質」。二十一世紀,總68期(2001年12月),頁66-75。