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研究生:蔡孟勳
論文名稱:長期低劑量輻射線照射人體細胞與殘留DNA傷害之研究
論文名稱(外文):Residual DNA damage in human populations with chronic low-dose gamma-irradiation
指導教授:張武修張武修引用關係
學位類別:博士
校院名稱:國立陽明大學
系所名稱:公共衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2001
畢業學年度:89
語文別:中文
中文關鍵詞:輻射線微細胞核P53蛋白輻射屋長期低劑量
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自從民國八十一年八月在北台灣、台北、桃園、基隆一帶發現市民在未受告知的情況下常期居住在較背景值為高的鈷-60污染鋼筋住宅中。初步估計全台灣約有超過200棟建築物、超過1,600戶公寓含有鈷-60污染鋼筋,在民國70年初期建造出來。目前估計總共有超過7,000位居民或學生受到1至15年額外的長期低劑量輻射線暴露。這些居住於輻射屋或輻射教室的居民或學生,曾接受一系列研究評估其所接受的累積暴露劑量,包括每天在家中生活型態的詳細記錄、暴露期間每年在家的時間,以及環境中的放射線劑量的測量。
本論文針對此一受暴露族群進行追蹤研究,希望藉由此特殊的世代研究來探討人體內淋巴球細胞受到長期低劑量輻射照射所產生的DNA傷害。
封面
一、前言                 
二、實驗設計               
三、研究方法               
四、結果                 
五、討論                 
六、參考文獻               
附表                   
附圖                   
Appendix I Follow-up in the micronucleus frequencies and its subsets in human population with chronic low-dose γ-irradiation exposure (Mutation Research, 428, 99-105)
Appendix II Dynamics of changes in micronucleus frequencies in subjects post cessation of chronic low-dose radiation exposure (Mutagenesis, 16, 251-255)
Appendix III Residual DNA damage in lymphocytes of subjects with chronic low-dose radiation exposure
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