臺灣博碩士論文加值系統

自從民國八十一年八月在北台灣、台北、桃園、基隆一帶發現市民在未受告知的情況下常期居住在較背景值為高的鈷-60污染鋼筋住宅中。初步估計全台灣約有超過200棟建築物、超過1,600戶公寓含有鈷-60污染鋼筋，在民國70年初期建造出來。目前估計總共有超過7,000位居民或學生受到1至15年額外的長期低劑量輻射線暴露。這些居住於輻射屋或輻射教室的居民或學生，曾接受一系列研究評估其所接受的累積暴露劑量，包括每天在家中生活型態的詳細記錄、暴露期間每年在家的時間，以及環境中的放射線劑量的測量。
本論文針對此一受暴露族群進行追蹤研究，希望藉由此特殊的世代研究來探討人體內淋巴球細胞受到長期低劑量輻射照射所產生的DNA傷害。

封面
一、前言　　　　　　　　　　　　　　　　　
二、實驗設計　　　　　　　　　　　　　　　
三、研究方法　　　　　　　　　　　　　　　
四、結果　　　　　　　　　　　　　　　　　
五、討論　　　　　　　　　　　　　　　　　
六、參考文獻　　　　　　　　　　　　　　　
附表　　　　　　　　　　　　　　　　　　　
附圖　　　　　　　　　　　　　　　　　　　
Appendix I Follow-up in the micronucleus frequencies and its subsets in human population with chronic low-dose γ-irradiation exposure (Mutation Research, 428, 99-105)
Appendix II Dynamics of changes in micronucleus frequencies in subjects post cessation of chronic low-dose radiation exposure (Mutagenesis, 16, 251-255)
Appendix III Residual DNA damage in lymphocytes of subjects with chronic low-dose radiation exposure

Alberts B, Denis B, Julian L, Martin R, Keith R, James DW. Chapter 16, The cytoskeleton. In: Gavin Borden ed. Molecular biology of the cell. New York & London: Garland Publishing, 1994; 787-862.
Bryant, P.E. (1984) Enzymatic restriction of mammalian cell DNA using PvuII and Bam H1: evidence for the double-strand break origin of chromosomal aberrations, International journal of radiation biology, 46, 52-65.
Cardarelli, J.n., L. Elliott, R. Hornung and W.P. Chang (1997) Proposed model for estimating dose to inhabitants of 60Co contaminated buildings, Health Physics, 72, 351-60.
Chang, W.P. (1993) Spread of Taiwan''s radiation panic, Lancet, 342, 1544.
Chang, W.P., C.C. Chan and J.D. Wang (1997a) 60Co contamination in recycled steel resulting in elevated civilian radiation doses: causes and challenges [see comments], Health Physics, 73, 465-72.
Chang, W.P., W.A. Hsieh, D.P. Chen, Y.P. Lin, J.S. Hwang, J.J. Hwang, M.H. Tsai and B.F. Hwang (1999a) Change in centromeric and acentromeric micronucleus frequencies in human populations after chronic radiation exposure, Mutagenesis, 14, 427-32.
Chang, W.P., B.F. Hwang, D. Wang and J.D. Wang (1997b) Cytogenetic effect of chronic low-dose, low-dose-rate gamma-radiation in residents of irradiated buildings, Lancet, 350, 330-3.
Chang, W.P., J.S. Hwang, M.C. Hung, T.H. Hu, S.D. Lee and B.F. Hwang (1999b) Chronic low-dose gamma-radiation exposure and the alteration of the distribution of lymphocyte subpopulations in residents of radioactive buildings, International Journal of Radiation Biology, 75, 1231-9.
Chang, W.P. and J. Kau (1993) Taiwan: Exposure to high doses of radiation, Lancet, 341, 750.
Chiu, S.M., N.L. Oleinick, L.R. Friedman and P.J. Stambrook (1982) Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation, Biochimica et Biophysica Acta, 699, 15-21.
Demple, B. and L. Harrison (1994) Repair of oxidative damage to DNA: enzymology and biology, Annu. Rev. Biochem., 63, 915-48.
Elledge, S.J. (1996) Cell cycle checkpoints: preventing an identity crisis, Science, 274, 1664-1671.
Haber, J.E. (2000) Partners and pathways repairing a double-strand break, Trends Genet., 16, 259-264.
Khanna, K.K. and M.F. Lavin (1993) Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells, Oncogene, 8, 3307-3312.
Kondrashova, T.V. and T.I. Ivanova (2000) Do quiescent human peripheral lymphocytes repair radiation-induced chromosome damage?, Radiation Reseach, 153, 122-4.
kuerbitz, S.J., B.S. Plunkett, W.V. Walsh and M.B. Kastan (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation, Proc. Natl. Acad. Sci. USA, 89, 7491-7495.
Lindahl, T. (1993) Instability and decay of the primary structure of DNA, Nature, 362, 709-15.
Hsieh, W.A., Lucas, J.N., Hwang, J.J., Chan, C.C. and Chang, W.P. (2001) Biodosimetry using chromosomal translocations measured by FISH in a population chronically exposed to low dose-rate 60Co g-irradiation, International Journal of Radiation Biology, 77, 797-784.
Tsang, N.M., H. Nagasawa, C. Li and J.B. Little (1995) Abrogation of p53 function by transfection of HPV16E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation, Oncogene, 10, 2403-2408.
Unger, C., S. Kress, A. Buchmann and M. Schwarz (1994) Gamma-irradiation-induced micronuclei from mouse hepatoma cells accumulate high levels of the tumor suppressor protein p53, Cancer Research, 54, 3651-5.