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研究生:黃敏偉
研究生(外文):Min-Wei Huang
論文名稱:長程視覺誘發波在精神分裂病患認知功能評估與運用
論文名稱(外文):The Evaluation and Application of Cognitive Function with Visual Long-term Evoked Potentials in Schizophrenic Patients
指導教授:鄭國順鄭國順引用關係
指導教授(外文):Kuo-Sheng Cheng
學位類別:碩士
校院名稱:國立成功大學
系所名稱:醫學工程研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:英文
論文頁數:73
中文關鍵詞:精神分裂病威斯康辛卡片排序測驗長程視覺誘發波
外文關鍵詞:ERPsSchizophreniaWCST
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精神分裂病患者認知功能常有缺損,且缺損愈嚴重者,其預後愈差。常用來評估認知功能的工具有威斯康辛卡片排序測驗(Wisconsin Card Sorting Test,WCST)與其它神經心理組合測驗,而較少用長程視覺誘發波來檢測。故本研究的主要目的:首先建立標準化的刺激,探討長程視覺誘發與認知功能關係,另外,再利用此建立的標準化系統,來探討正常人、不同亞型之精神分裂病患者與治療反應不同的精神分裂病患者(治療反應佳者、對治療部份反應者、及對治療反應差者)認知功能的表現情形,並同時以WCST與神經心理組合測驗檢測受試者,藉以比較彼此在認知功能檢測結果的相關性。
本研究利用20-45歲男女約略相等的正常人40名及年齡、性別配對之精神分裂病患者43名進行長程視覺誘發波與認知功能關係之比較,進行本研究可行性的探討及提供有價值的最新基礎資料,同時,比較其與WCST與神經心理組合測驗檢測認知功能的差異性;所得的資料以SPSS 中文第10.0視窗版進行統計分析。
藉由上述系統化及客觀量化研究的結果,發現在聽覺與視覺誘發波中,N100, N200, P200, P300, P400及 WCST皆能提供有價值的資料來驗證認知功能的理論基礎,同時在臨床上提供較佳療效及癒後評估,及早發現並治療病人,以減輕其認知功能障礙,提高生活品質及節省醫療資源的浪費。
關鍵詞:精神分裂病 威斯康辛卡片排序測驗 長程視覺誘發波
論文目次參考文獻論文頁數異動記錄2002/5/2 11:11 163.28.112.100 90ncku0530 登錄 Cognitive dysfunction is now generally accepted as a symptom of schizophrenia. Neuropsychological testing has been increasingly applied in the study and clinical treatment assessment in psychiatry. The severer cognitive impairment was, the poorer prognosis was. Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries were often introduced to evaluate the cognitive function, rather than Visual Long-term Evoked Potentials. However, the long?latency auditory and visual evoked potentials are seldom used to evaluate cognitive function. The purpose of this study is to discrimination the cognitive function among normal control and treatment schizophrenic patients by image stimulation included Visual Long-term Evoked Potentials. However, the correlation of Visual Long-term Evoked Potentials (VLEP), Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries is prospected to be setup.
Forty-three schizophrenic patients were recruited as the experimental group of this study. Forty normal persons were chosen to compare twenty-five schizophrenia patients with sex and age matched in the study. The study is to evaluate cognitive function as well as comparison correlation among auditory and visual Long-term Evoked Potentials, Wisconsin Card Sorting Test (WCST) and other neuropsychological batteries. Visual event related potentials (ERPs) were studied during an oddball paradigm, to testify whether cognitive slowing in schizophrenic patients exists and to investigate whether cognitive information processing can be influenced by different responses to an oddball task in patients with schizophrenic patients and normal subjects. All the data will be analyzed by use of SPSS 10.0 version.
Compared with auditory and visual ERPs in the schizophrenic subjects, P300 amplitude at Fz, Cz and Pz was significantly different. There were also significantly different N100, N200 and P200 latency at Fz, Cz and Pz between auditory and visual ERPs. Cognitive processing reflected by auditory and visual P300 latency and another visual P400 to rare target stimuli were probably indicator for cognitive function in patients with schizophrenia. In our study, the items of “Total number of errors”, “Perseverative errors”, “Non-perseverative errors” in WCST were correlated with N100, P200, N200, P300 and P400 in schizophrenic patients.
長程視覺誘發波在精神分裂病患
認知功能評估與運用
The Evaluation and Application of Cognitive Function with Visual Long-term Evoked
Potentials in Schizophrenic Patients
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