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研究生:廖振偉
研究生(外文):Chen-Wei Liao
論文名稱:多孔性磷酸鈣鹽之結構與機械性質研究
指導教授:朱建平朱建平引用關係陳瑾惠
指導教授(外文):C. P. JuJ. H. Chern Lin
學位類別:碩士
校院名稱:國立成功大學
系所名稱:材料科學及工程學系碩博士班
學門:工程學門
學類:材料工程學類
論文種類:學術論文
畢業學年度:90
語文別:中文
論文頁數:106
中文關鍵詞:孔隙度磷酸鈣鹽
外文關鍵詞:porouscalcium phosphate ceramics
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摘 要

組織工程是近年來最具開發潛力及競爭力的領域,且引起材料、醫學及生物界的高度興趣,對於人體各部位的缺損重建上帶來莫大的幫助。臨床研究中發現如由膠原為主要鷹架的皮膚再生,在復原期間,可降低傷口的收縮及減少疤痕的形成。
組織工程的主要目的是藉由合成或再生一個完全的器官或組織再將特定的細胞經體外培養後種入鷹架內,期望能慢慢地降解、再吸收和成長。本研究目的便是發展出一個以鈣磷系骨水泥為基質的多孔性鷹架,企圖於骨置換有比原來CPC更快的速度被骨母細胞佔據及吸收,另有Na+、CO32-參與反應取代HA之部分Ca2+和PO43-的位置,形成B-type sodium carbonate hydroxyapatite,是一種更接近人體骨骼組成的礦物質相,故可能有更好的生物相容性與組織反應等。氫氧基磷灰石(HA),其泥狀物pH值接近人體,植入人體後可與骨骼組織形成鍵結,具有高度的生物相容性(biocomptibility)、無細胞毒性(noncytotoxicity)、不刺激組織(inflammatory)、兼引導骨骼向內生長的特性(osteoconductivity)並且結合骨水泥容易塑型以及最後產物有低結晶程度(low-crystallized),利於往組織工程方向發展等優點。
經實驗顯示,想藉由熱處理增加其抗壓強度,必須盡量的減少添加物來降低對基材的影響,並且添加碳酸鈉於CPC中會有抑制HA反應,孔洞的大小、分佈及多寡等諸多因素影響著抗壓強度,呈現敏感性,熱處理至600℃會有相轉變發生。
總 目 錄
摘要 …………………………………………………………….. 3
總目錄 …………………………………………………………….. 4
圖目錄 …………………………………………………………….. 6
表目錄 …………………………………………………………….. 9
第一章 緒論……………………………………………………….. 10
1-1 前言……………………………………………………….. 10
第二章 文獻回顧………………………………………………….. 15
2-1-1 塊狀氫氧基磷灰石及其複合材料簡介………………… 15
2-1-2 塊狀氫氧基磷灰石燒結製程及性質簡介……………. 15
2-1-3 塊狀氫氧基磷灰石與其複合材料…………………….. 17
2-2 理論基礎…………………………………………………. 20
2-2-1 陶瓷複合材料之內應力………………………………….. 20
2-2-2 相變導致之內應力……………………………………….. 22
2-3 添加生物活性玻璃於氫氧基磷灰石之背景…………….. 23
2-4 氫氧基磷灰石的晶體結構……………………………... 24
2-5 組織工程…………………………………………………. 25
2-6 鷹架的設計與材料選擇………………………………... 26
2-7 研究目的…………………………………………………. 27
第三章 實驗方法與步驟………………………………………….. 38
3-1 試片的製備……………………………………………… 38
3-2 硬化時間……………………………………………… 38
3-3 PH值的量測………………………………………….. 38
3-4 企圖取得多孔性試片-scaffold…………………….. 38
3-4-1 浸泡實驗……………………………………………… 38
3-4-2 熱處理實驗…………………………………………… 38
3-5-1 抗壓強度……………………………………………… 39
3-5-2 X光繞射……………………………………………… 40
3-5-3 SEM電子顯微分析...………………………………… 40
3-5-4 孔隙度測試…………………………………………… 40
3-6 毒性測試……………………………………………… 41
3-6-1 細胞解凍步驟………………………………………… 42
3-6-2 細胞培養步驟………………………………………… 43
3-6-3 細胞分盤步驟………………………………………… 43
3-6-4 細胞冷凍步驟………………………………………… 44
3-6-5 注意事項……………………………………………… 44
3-6-6 臨界點乾燥…………………………………………… 44
第四章 實驗結果及分析………………………………………….. 49
4-1 硬化時間測試………………………………………… 49
4-2 SEM顯微分析………………………………………... 49
4-3 抗壓強度的分析……………………………………… 52
4-5 孔隙度的分析………………………………………… 54
第五章 結論……………………………………………………….. 101
第六章 總參考資料……………………………………………….. 102
第六章 總參考資料
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