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研究生:林昌緯
研究生(外文):Chang-Wei Lin
論文名稱:周邊神經生物力學及電學分析於神經義肢應用
論文名稱(外文):Biomechanical and bioelectrical analyses of peripheral nerves with application to neural protheses
指導教授:朱銘祥朱銘祥引用關係林宙晴林宙晴引用關係
指導教授(外文):Ming-Shaung JuChou-Ching K. Lin
學位類別:碩士
校院名稱:國立成功大學
系所名稱:機械工程學系碩博士班
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:79
中文關鍵詞:周邊神經生物力學電學神經義肢神經電極有限元素法
外文關鍵詞:finite elementelectricalneural prosthesesperipheral nerveselectrodesbiomechanical
相關次數:
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  • 下載下載:44
  • 收藏至我的研究室書目清單書目收藏:2
近年來,神經義肢與組織工程為生醫工程的重要領域。環型銬式電極為神經義肢的元件,此電極主要應用於功能性電刺激與神經電位訊號的量測。環型銬式電極植入人體周邊神經所施壓力,有可能導致周邊神經內微管與血管的阻塞,造成神經組織的壞死而失去功能。目前對周邊神經生物力學方面的研究相當有限,因此有需要建立一套生物力學與電學的模型來改善電極的設計與效能。本研究的目的在於周邊神經生物力學與電學分析,由於周邊神經組織為非均質且幾何形狀不規則,因此以有限元素套裝軟體ANSYS進行分析。生物力學分析包括材料特性實驗與模擬,而電學分析則包括肌電訊號對神經電位訊號的干擾與電極的佈置對電刺激空間選擇性的影響。
本研究成果在生物力學分析方面,已完成周邊神經壓縮位移與力量的實驗,並藉以估測周邊神經材料參數的數量級,其楊式係數為41.6kPa。在電學分析方面,當銬式電極全長大於25mm之後,能有效地降低肌電訊號的干擾;並且設計出新的十字型電極佈置能有效地提升傳統侍從向電極的電刺激選擇性,降低橫向電極刺激所需的能量。
Recently, neural prostheses and tissue engineering are important areas in biomedical engineering. In neural prosthesis, spiral cuff electrodes are utilized for functional electrical stimulation and electroneurogram recording. However, the peripheral nerves surrounded by spiral cuff electrodes may be subject to external pressure, which may result in the injury or malfunction of the nerve. Furthermore, the selectivity of FES is an important design factor for spiral cuff electrodes. Therefore, the goal of this thesis is to develop biomechanical and bioelectrical models of peripheral nerves for designing spiral cuff electrodes and for understanding biomechanics of neural tissues. An experimental system was built to measure the mechanical properties and geometric shape of peripheral nerves. It was difficult to study the electric characteristics of peripheral nerves by analytic method, so the finite element method is utilized for analysis and design of electrodes.
From the peripheral nerves testing, biomechanical properties of nerve are estimated. The apparent Young’s modulus of peripheral nerve is 41.6 kPa. For the electrical analyses, the performance of ENG recording may be improved by proper shielding of electromyogram. A novel electrodes may be that can increase the selectivity and decrease the current density is designed based on the bioelectrical analyses.
中文摘要 i
英文摘要 ii
誌謝 iii
目錄 iv
圖目錄 vi
表目錄 ix
符號表 x
第一章 緒論 1
1-1 簡介 1
1-1-1 周邊神經系統 1
1-1-2 周邊神經材料之力學特性 3
1-1-3 周邊神經之電性 4
1-1-4 有限元素法簡介 7
1-2 文獻回顧 8
1-3 研究動機與目的 11
第二章 方法 12
2-1 研究方法概述 12
2-2 周邊神經材料試驗 15
2-2-1 系統架構 15
2-2-2 實驗設備 17
2-2-3 實驗步驟 21
2-3 生物力學分析 23
2-3-1 周邊神經力學模型的建立 23
2-3-2 周邊神經的材料性質 26
2-3-3 生物力學分析的邊界條件與負荷 27
2-3-4 生物力學分析與實驗之比較 27
2-4 電學分析 29
2-4-1 周邊神經電學模型的建立 29
2-4-2 周邊神經的材料性質 34
2-4-3 電學分析的邊界條件與負荷 35
第三章 結果與討論 39
3-1 周邊神經力學實驗結果 39
3-2 有限元素分析的結果 47
3-2-1 收斂分析結果 47
3-2-2 生物力學分析結果 52
3-2-3 銬式電極尺寸與EMG干擾的分析結果 53
3-2-4 電極空間佈置與電刺激選擇性分析結果 55
3-3 討論 64
3-3-1 周邊神經生物力學實驗 64
3-3-2 元素數目收斂性測試 65
3-3-3 生物力學分析 67
3-3-4 環型銬式電極尺寸與EMG干擾 68
3-3-5 電極空間佈置與電刺激的選擇性 68
第四章 結論與建議 70
4-1 結論 70
4-2 建議 71
參考文獻 73
附錄A 76
附錄B 78
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