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研究生(外文):Chun-Yu Chen
論文名稱(外文):Mechanisms of Gastric Mucosal Hemorrhagic Ulceration in Salmonella typhimurium-infected Rats:Protection by Several Drugs
指導教授(外文):Chen-Road Hung
外文關鍵詞:histamineSalmonella typhimuriumgastric hemorrhagic ulcerglutathionefree radical
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沙門氏菌屬是一種常見的致病性菌種。當牠們進入身體之後,將會造成很多臟器的傷害,包括肝臟、腎臟、腸道及其他重要的器官。鼠傷寒桿菌是傷寒桿菌屬的一種,牠們可以感染很多種動物,包含了人類、家禽、家畜、實驗用的動物等等。沙門氏菌屬對於人類器官的影響常常被研究,但是對於胃部方面的研究卻是很少的。因為胃部方面的研究是如此的不足,因此我們對傷寒桿菌屬在胃部方面的影響很感興趣。我們從股靜脈注射1ml 1x109 CFU/ml的鼠傷寒桿菌到雄性的Wistar大白鼠身上。21個小時之後,將老鼠絕食24小時來排空胃部中的食物。胃部迷走神經切除術被施行,接著使用成分為100mM HCl加上54mM NaCl及600mg/L pepsin配製而成的人工胃酸,灌到胃腔中三個小時。潰瘍參數如胃腔中血紅素含量、潰瘍面積、胃酸逆擴散、胃黏膜中的組織胺、脂質過氧化物和麩胺基硫的濃度被測定。我們的結果在受到感染的大白鼠身上呈現出胃酸逆擴散及出血性潰瘍明顯被增加的情形。此外在受感染的大白鼠身上也見到黏膜中脂質過氧化物和組織胺的濃度明顯的增加,以及黏膜中麩胺基硫的濃度明顯的下降。因為自由基和組織胺在當中扮演重要的角色,因此我們假定一些藥物如自由基清除劑、肥大細胞穩定劑和組織胺受體拮抗劑可能在感染期間被使用。我們的研究成果告訴我們上述各類藥物將可改善胃部損傷。
Salmonella species are a common pathogenic bacteria. When they enter into body, they will cause damages of many organs including liver、kidney、intestine and other important organs. Salmonella typhimurim are a kind of Salmonella species, they can infect many kinds of animals including human, poultry, livestock, experimental animals, etc. Effects of Salmonella species are often studied for many organs in human, but studies for stomach are less. Because studies for stomach are not enough, we interest in gastric effects during infection of Salmonella species. 1ml 1x109 CFU/ml Salmonella typhi- murim were injected into male Wistar rats by intravenous from femoral vein. After 21 hours, the animal were deprived of food for 24 hr to empty food from stomach. Gastric vagotomy was performed, followed by irrigation the stomachs for 3hr with a physiological acid containing 100mM HCl plus 54mM NaCl and 600mg/L pepsin. The ulcerogenic parameters including gastric acid back-diffusion, ulcer area, mucosal lipid peroxide (LPO)、glutathione (GSH) and histamine concentrations, and luminal hemoglobin (Hb) contents were determined. Our results show that a marked increase in acid back- diffusion and in hemorrhagic ulceration was found in infected rats. A significant enhancement in mucosal lipid peroxide and histamine concen- tration, and marked decrease in mucosal glutathione levels in infected rats. Because of oxygen radical and histamine played an important role, we hypothesis that several drugs including free radical scavenger, mast cell stabilizer, histamine receptor antagonist may be used during infection. Our results suggest the gastric damages will be improved after treatment of these drugs.
1. Abdullaev F I, Rivera-Luna R, Garcia-Carranca A, Ayala-Fierro F, Espinosa-Aguirre JJ: Cytotoxic effect of three arsenic compounds in HeLa human tumor and bacterial cells. Mutat. Res. 493:31-8, 2001
2. Alican I, Toker F, Arbak S, Yegen BC, Yalcin AS, Oktay S: Gastric lipid peroxidation, glutathione and calcium channel blockers in the stress-induced ulcer model in rats. Pharmacol. Res. 30:123-35, 1994
3. Andersson K, Mattsson H, Larsson H: The role of gastric mucosal histamine in acid secretion and experimentally induced lesions in the rat. Digestion. 46:1-9, 1990
4. al-Moutairy AR, Tariq M: Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers. Digest. Dis. Sci. 41:1165-71, 1996
5. al-Ramadi BK, Al-Dhaheri MH, Mustafa N, Abouhaidar M, Xu D, Liew FY, Lukic ML, Fernandez-Cabezudo MJ: Influence of vector-encoded cytokines on anti-Salmonella immunity: divergent effects of interleukin- 2 and tumor necrosis factor alpha. Infect. Immun. 69:3980-8, 2001
6. Artal MN, Luna JD, Discepola M: A forced choice comfort study of olopatadine hydrochloride 0.1% versus ketotifen fumarate 0.05%. Acta Ophthalmol. Scand. Suppl. (230):64-5, 2000
7. Barbezange C, Humbert F, Rose V, Lalande F, Salvat G: Some safety aspects of salmonella vaccines for poultry: distribution and persistence of three Salmonella typhimurium live vaccines. Avian Dis. 44:968-76, 2000
8. Barja: Ascorbic acid and aging. SubCell. Biochem. 25:157-88, 1996
9. Barrow PA, Page K, Lovell MA: The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis. Vaccine. 19:3432-6, 2001
10. Beaudin BA, Brosnikoff CA, Grimsrud KM, Heffner TM, Rennie RP, Talbot JA: Susceptibility of human isolates of Salmonella typhimurium DT 104 to antimicrobial agents used in human and veterinary medicine. Diagn. Microbiol. Infec. Dis. 42:17-20, 2002
11. Berdy GJ, Spangler DL, Bensch G, Berdy SS, Brusatti RC: A comparison of the relative efficacy and clinical performance of olopatadine hydrochloride 0.1% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the conjunctival antigen challenge model. Clin. Ther. 22:826-33, 2000
12. Beuzon CR, Holden DW: Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo. Microbes Infect. 3:1345-52, 2001
13. Beuzon CR, Unsworth KE, Holden DW: In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to Salmonella enterica serovar Typhimurium virulence. Infect. Immun. 69:7254-61, 2001
14. Boyd D, Peters GA, Cloeckaert A, Boumedine KS, Chaslus-Dancla E, Imberechts H, Mulvey MR: Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J. Bacteriol. 183:5725-32, 2001
15. Bozkaya LA, Ozturk-Urek R, Aydemir T, Tarhan L: Effects of Se, Cu and Se + vitamin E deficiency on the activities of CuZnSOD, GSH-Px, CAT and LPO levels in chicken erythrocytes. Cell Biochem. Funct. . 19:153-7, 2001
16. Brennan P, Holland R, Hall R, Cameron S: An outbreak of Salmonella typhimurium RDNC A045 at a wedding feast in South Australia. Commun. Dis. Intell. 23:101-3, 1999
17. Breyer-Pfaff U, Mey U, Green MD, Tephly TR: Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes. Drug Metabol. Dispos. 28:869-72, 2000
18. Breyer-Pfaff U, Nill K: High-affinity stereoselective reduction of the enantiomers of ketotifen and of ketonic nortriptyline metabolites by aldo-keto reductases from human liver. Biochem. Pharmacol. 59:249-60, 2000
19. Briasoulis E, Karavasilis V, Pavlidis N: Successful rechallenge with taxanes following prophylactic ketotifen in patients who had developed severe hypersensitivity reactions. Ann. Oncol. 11:899, 2000
20. Bullifent HL, Dhaliwal K, Howells AM, Goan K, Griffin K, Lindsay CD, Tunnacliffe A, Titball RW: Stabilisation of Salmonella vaccine vectors by the induction of trehalose biosynthesis. Vaccine. 19:1239-45, 2000
21. Cano DA, Martinez-Moya M, Pucciarelli MG, Groisman EA, Casadesus J, Garcia-Del Portillo F: Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation. Infect. Immun. 69:6463-74, 2001
22. Carlson MC, Tschanz JT, Norton MC, Welsh-Bohmer K, Martin BK, Breitner JC: H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine. Alz. Dis. Assoc. Dis. 16:24-30, 2002
23. Carlson SA, Omary MB, Jones BD: Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells. Life Sci. 70:1415-26, 2002
24. Chiang CH, Wu CP, Perng WC, Yan HC, Yu CP: Use of anti-(tumour necrosis factor-alpha) antibody or 3-deaza-adenosine as additives to promote protection by University of Wisconsin solution in ischaemia/ reperfusion injury. Clin. Sci. 99:215-22, 2000
25. Chong LK, Chess-Williams R, Peachell PT: Pharmacological characterisation of the beta-adrenoceptor expressed by human lung mast cells. Eur. J. Pharmacol. 437:1-7, 2002
26. Chotard C, Ouimet T, Morisset S, Sahm U, Schwartz JC, Trottier S: Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain. J. Neural. Transm. 109:293-306, 2002
27. Chung MH, Kasai H, Nishimura S, Yu BP: Protection of DNA damage by dietary restriction. Free Radic. Biol. Med. 12:523-5, 1992
28. Criss AK, Silva M, Casanova JE, McCormick BA: Regulation of Salmonella-induced neutrophil transmigration by epithelial ADP-ribosylation factor 6. J. Biol. Chem. 276:48431-9, 2001
29. Davies MB, Austin J, Partridge DA: Vitamin C: Its Chemistry and Biochemistry. Royal Society of Chemistry Letchworth, 1994
30. Di Micco B, Metafora S, Colonna G, Carteni M, Ragone R, Macalello MA, Di Micco P, Baroni A, Catalanotti P, Tufano MA: Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis. J. Endotoxin. Res. 7:211-7, 2001
31. Eckmann L, Kagnoff MF: Cytokines in host defense against Salmonella. Microbes Infect. 3:1191-200, 2001
32. Edwards CK 3rd, Myers MJ, Kelley KW, Schook LB: Enhanced macrophage anti-microbial activity following dimethylnitrosamine exposure in vivo is related to augmented production of reactive oxygen metabolites. Immunopharmacol. Immunotoxicol. 13:395-411, 1991
33. Eisenstein TK: Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule. Microbes Infect. 3:1223-31, 2001
34. Enoiu M, Aberkane H, Salazar JF, Leroy P, Groffen J, Siest G, Wellman M: Evidence for the pro-oxidant effect of gamma- glutamyltranspeptidase-related enzyme. Free Radic. Biol. Med. 29:825-33, 2000
35. Ernst RK, Guina T, Miller SI: Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity. Microbes Infect. 3:1327-34, 2001
36. Ferguson GC, Heinemann JA, Kennedy MA: Gene transfer between Salmonella enterica serovar Typhimurium inside epithelial cells. J. Bacteriol. 184:2235-42, 2002
37. Figueroa-Bossi N, Coissac E, Netter P, Bossi L: Unsuspected prophage-like elements in Salmonella typhimurium. Mol. Microbiol. 25:161-73, 1997
38. Freudenberg MA, Merlin T, Gumenscheimer M, Kalis C, Landmann R, Galanos C: Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria. Microbes Infect. 3:1213-22, 2001
39. Friebel A, Ilchmann H, Aepfelbacher M, Ehrbar K, Machleidt W, Hardt WD: SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell. J. Biol. Chem. 276:34035-40, 2001
40. Fujita A, Tashima K, Nishijima M, Takeuchi K: Enhancement of peptone-induced gastric acid secretion in streptozotocin-induced diabetic rats. Jpn. J. Pharmacol. 84:405-11, 2000
41. Galdiero M, Vitiello M, Sanzari E, D'Isanto M, Tortora A, Longanella A, Galdiero S: Porins from Salmonella enterica serovar Typhimurium activate the transcription factors activating protein 1 and NF-kappaB through the Raf-1-mitogen-activated protein kinase cascade. Infect. Immun. 70:558-68, 2002
42. Garcia-del Portillo F: Salmonella intracellular proliferation: where, when and how?. Microbes Infect. 3:1305-11, 2001
43. Garner MJ, Hayward RD, Koronakis V: The Salmonella pathogenicity island 1 secretion system directs cellular cholesterol redistribution during mammalian cell entry and intracellular trafficking. Cell Microbiol. 4:153-65, 2002
44. Garvis SG, Beuzon CR, Holden DW: A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages. Cell Microbiol. 3:731-44, 2001
45. Gieseg SP, Whybrow J, Glubb D, Rait C: Protection of U937 cells from free radical damage by the macrophage synthesized antioxidant 7,8-dihydroneopterin. Free Radic. Res. 35:311-8, 2001
46. Gonzalez MJ, Riordan NH: The paradoxical role of lipid peroxidation on carcinogenesis and tumor growth: a commentary. Med. Hypotheses. 46:503-4, 1996
47. Gorvel JP, Meresse S: Maturation steps of the Salmonella-containing vacuole. Microbes Infect. 3:1299-303, 2001
48. Greenberg LE. Nguyen T. Miller SM. Suspected allopurinol-induced aseptic meningitis. Pharmacotherapy. 21:1007-9, 2001
49. Gross NT, Hultenby K, Mengarelli S, Camner P, Jarstrand C: Lipid peroxidation by alveolar macrophages challenged with Cryptococcus neoformans, Candida albicans or Aspergillus fumigatus. Med. Mycol. 38:443-9, 2000
50. Gruetter CA, Bailey B, Easterling L, Szarek JL: Release of non-mast cell histamine from rat aorta. Life Sci. 70:1709-17, 2002
51. Hansen-Wester I, Stecher B, Hensel M: Type III secretion of Salmonella enterica serovar Typhimurium translocated effectors and SseFG. Infect. Immun. 70:1403-9, 2002
52. Harish MS, Nagur M, Badami S: Antihistaminic and mast cell stabilizing activity of Striga orobanchioides. J. Ethnopharmacol. 76:197-200, 2001
53. Heinrich JM, Bernheiden M, Minigo G, Yang KK, Schutt C, Mannel DN, Jack RS: The essential role of lipopolysaccharide-binding protein in protection of mice against a peritoneal Salmonella infection involves the rapid induction of an inflammatory response. J. Immunol. 167:1624-8, 2001
54. Heithoff DM, Enioutina EY, Daynes RA, Sinsheimer RL, Low DA, Mahan MJ: Salmonella DNA adenine methylase mutants confer cross-protective immunity. Infect. Immun. 69:6725-30, 2001
55. Henningsson R, Alm P, Lundquist I: Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia. Am. J. Physiol.-Cell Physiol. 280:C1242-54, 2001
56. Hirokawa K, Kawasaki H: Changes in glutathione in gastric mucosa of gastric ulcer patients. Res. Commun. Mol. Pathol. 88:163-76, 1995
57. Hofer S, Rescigno M, Granucci F, Citterio S, Francolini M, Ricciardi- Castagnoli P: Differential activation of NF-kappa B subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide. Microbes Infect. 3:259-65, 2001
58. Holzer P, Livingston EH, Guth PH: Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology. 101:416-23, 1991
59. Holzer P, Pabst MA, Lippe IT: Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology. 96:1425-33, 1989
60. Hudson N, Murray FE, Cole AT, Turnbull GM, Lettis S, Hawkey CJ: Ranitidine bismuth citrate and aspirin-induced gastric mucosal injury. Aliment. Pharm. Therap. 7:515-21, 1993
61. Hung C R: Role of histamine in aggravation of gastric acid back-diffusion and vascular permeability in septic rats. Chin. J. Physiol. 44:199-206, 2001
62. Hung CR: Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats. Clin. Exp. Pharmacol. Physiol. 27:306-12, 2000
63. Ibrahim AM, Elhag ER, Mustafa SE: Ketotifen in treatment of uncomplicated falciparum malaria. Saudi Med. J. 21:257-65, 2000
64. Jepson MA, Clark MA: The role of M cells in Salmonella infection. Microbes Infect. 3:1183-90, 2001
65. Joshi M, Misra A: Dry powder inhalation of liposomal Ketotifen fumarate: formulation and characterization. Int. J. Pharm. 223:15-27, 2001
66. Kaiser P, Rothwell L, Galyov EE, Barrow PA, Burnside J, Wigley P: Differential cytokine expression in avian cells in response to invasion by Salmonella typhimurium, Salmonella enteritidis and Salmonella gallinarum. Microbiology. 146 :3217-26, 2000
67. Karmeli F, Eliakim R, Okon E, Rachmilewitz D: Ketotifen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats. Digest. Dis. Sci. 40:1140-6, 1995
68. Kalfayan LH, Farhat D, El-Nakat H, Matar GM, Abdelnoor AM: Immunization of mice against Salmonella typhimurium using different DNA preparations. Immunopharmacol. Immunotoxicol. 23:519-30, 2001
69. Kang HY, Srinivasan J, Curtiss R 3rd: Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar typhimurium vaccine. Infect. Immun. 70:1739-49, 2002
70. Kaufmann SH, Fensterle J, Hess J: The need for a novel generation of vaccines. Immunobiology. 201:272-82, 1999
71. Kerr ME, Bender CM, Monti EJ: An introduction to oxygen free radicals. Heart. Lung. 25:200-9, 1996
72. Korshunov SS, Imlay JA: A potential role for periplasmic superoxide dismutase in blocking the penetration of external superoxide into the cytosol of Gram-negative bacteria. Mol. Microbiol. 43:95-106, 2002
73. Kristal BS, Yu BP: An emerging hypothesis: synergistic induction of aging by free radicals and Maillard reactions. J. Gerontol. 47:B107-14, 1992
74. Kvietys PR, Perry MA, Gaginella TS, Granger DN: Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. Am. J. Physiol. 259:G578-83, 1990
75. Itoh M, Takeuchi T: Role of neutrophil-derived oxygen radicals in ischemic mucosal injury and the mechanism of formation in the rat stomach. Jpn. J. Med. 29:679-80, 1990
76. Labrousse A, Chauvet S, Couillault C, Kurz CL, Ewbank JJ: Caenorhabditis elegans is a model host for Salmonella typhimurium. Curr. Biol. 10:1543-5, 2000
77. Lee AU, Farrell GC: Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury. J. Hepatol. 35:756-64, 2001
78. Levine MM, Tacket CO, Sztein MB: Host-Salmonella interaction: human trials. Microbes Infect. 3:1271-9, 2001
79. Ligumsky M, Sestieri M, Okon E, Ginsburg I: Antioxidants inhibit ethanol-induced gastric injury in the rat. Role of manganese, glycine, and carotene. Scand. J. Gastroenterol. 30:854-60, 1995
80. Lostroh CP, Lee CA: The Salmonella pathogenicity island-1 type III secretion system. Microbes Infect. 3:1281-91, 2001
81. Lu H, Zhang DZ, Hu PJ, Li ZS, Lu XH, Fang XC, Xiao SD: One-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline effectively eradicate Helicobacter pylori: a multicentre, randomized, double-blind study. Aliment. Pharm. Therap. 15:1975-9, 2001
82. Luiz N: Role of Ketotifen in asthma. Indian Pediatr. 36:737, 1999
83. Macfarlane EL, Kwasnicka A, Ochs MM, Hancock RE: PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance. Mol. Microbiol. 34:305-16, 1999
84. Massey RC, Rainey PB, Sheehan BJ, Keane OM, Dorman CJ: Environmentally constrained mutation and adaptive evolution in Salmonella. Curr. Biol. 9:1477-80, 1999
85. McAlindon ME, Muller AF, Filipowicz B, Hawkey CJ: Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers. Gut 38:518-24, 1996
86. Meresse S, Unsworth KE, Habermann A, Griffiths G, Fang F, Martinez-Lorenzo MJ, Waterman SR, Gorvel JP, Holden DW: Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella. Cell Microbiol. 3:567-77, 2001
87. Michael B, Smith JN, Swift S, Heffron F, Ahmer BM: SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities. J. Bacteriol. 183:5733-42, 2001
88. Monack DM, Navarre WW, Falkow S: Salmonella-induced macrophage death: the role of caspase-1 in death and inflammation. Microbes Infect. 3:1201-12, 2001
89. Niedergang F, Sirard JC, Blanc CT, Kraehenbuhl JP: Entry and survival of Salmonella typhimurium in dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors. Proc. Natl. Acad. Sci. U S A 97:14650-5, 2000
90. Niki E: Vitamin C as an antioxidant. World Rev. Nutr. Diet. 64:1-30, 1991
91. Nishikimi M, Yagi K: Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Am. J. Clin. Nutr. 54:1203S-1208S, 1991
92. Norlen P, Bernsand M, Konagaya T, Hakanson R: ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators. Br. J. Pharmacol. 134:1767-77, 2001
93. Norlen P, Lindstrom E, Zhao C, Kitano M, Chen D, Andersson K, Hakanson R: alpha-fluoromethylhistidine depletes histamine from secreting but not from non-secreting rat stomach ECL cells. Eur. J. Pharmacol. 400:1-10, 2000
94. Ostdal H, Bjerrum MJ, Pedersen JA, Andersen HJ: Lactoperoxidase- induced protein oxidation in milk. J. Agr. Food. Chem. 48:3939-44, 2000
95. Palitzsch KD, Morales RE, Kronauge JF, Bynum TE, Szabo S: Effect of histamine on haemorrhagic mucosal lesions is related to vascular permeability in rats: Eur. J. Gastroenterol. Hepatol. 7:447-53, 1995
96. Pascual DW, Hone DM, Hall S, van Ginkel FW, Yamamoto M, Walters N, Fujihashi K, Powell RJ, Wu S, Vancott JL, Kiyono H, McGhee JR: Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect. Immun. 67:6249-56, 1999
97. Peralta C, Xaus C, Bartrons R, Leon OS, Gelpi E, Rosello-Catafau J: Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion. Free Radic. Res. 33:595-605, 2000
98. Perez-Vicente A, Gil-Izquierdo A, Garcia-Viguera C: In vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin C. J. Agr. Food. Chem. 50:2308-12, 2002
99. Prouty AM, Van Velkinburgh JC, Gunn JS: Salmonella enterica serovar typhimurium resistance to bile: identification and characterization of the tolQRA cluster. J. Bacteriol. 184:1270-6, 2002
100. Raetz CR: Regulated covalent modifications of lipid A. J. Endotoxin. Res. 7:73-8, 2001
101. Reynolds CM, Poole LB: Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains. Biochemistry. 40:3912-9, 2001
102. Rönnberg AL, Hakanson R: Improved fluorometric assay of histamine: condensation with o-phthalaldehyde at-20 degreess C. Agents Actions. 4:205-6, 1974
103. Rosenberger CM, Pollard AJ, Finlay BB: Gene array technology to determine host responses to Salmonella. Microbes Infect. 3:1353-60, 2001
104. Rubio A, Downs DM: Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar Typhimurium. J. Bacteriol. 184:2827-32, 2002
105. Rydning A, Lyng O, Adamsen BL, Falkmer S, Sandvik AK, Gronbech JE: Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine. Am. J. Physiol.- Gastrointest. Liver Physiol. 280:G1061-1069, 2001
106. Santana-Rios G, Orner GA, Amantana A, Provost C, Wu SY, Dashwood RH: Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay. Mutat. Res. 495:61-74, 2001
107. Santos RL, Tsolis RM, Zhang S, Ficht TA, Baumler AJ, Adams LG: Salmonella-induced cell death is not required for enteritis in calves. Infect. Immun. 69:4610-7, 2001
108. Santos RL, Zhang S, Tsolis RM, Kingsley RA, Adams LG, Baumler AJ: Animal models of Salmonella infections: enteritis versus typhoid fever. Microbes Infect. 3:1335-44, 2001
109. Schafers RF, Karl I, Mennicke K, Daul AE, Philipp T, Brodde OE: Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers. Br. J. Clin. Pharmacol. 47:59-66, 1999
110. Schuffner A, Morshedi M, Oehninger S: Cryopreservation of fractionated, highly motile human spermatozoa: effect on membrane phosphatidylserine externalization and lipid peroxidation. Hum. Reprod. 16:2148-53, 2001
111. Selvam R, Kalaiselvi P: Studies on calcium oxalate binding proteins: effect of lipid peroxidation. Nephron. 88:163-7, 2001
112. Shay H, Komarov SA, Gruenstein M: Effects of vagotomy in the rat. Archives of Surgery. 59:210-26, 1949
113. Shimada K, Abe T, Zhao Q, Mio M, Kamei C: Effects of histamine and related compounds on the differentiation of HL-60-Eo cells into eosinophils. Method Find. Exp. Clin. Pharmacol. 23:383-8, 2001
114. Shimizu T, Tani T, Hanasawa K, Endo Y, Kodama M: The role of bacterial translocation on neutrophil activation during hemorrhagic shock in rats. Shock. 16:59-63, 2001
115. Slatter DA, Bolton CH, Bailey AJ: The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia. 43:550-7, 2000
116. Soloski MJ, Metcalf ES: The involvement of class Ib molecules in the host response to infection with Salmonella and its relevance to autoimmunity. Microbes Infect. 3:1249-1259, 2001
117. Soma M, Tamaoki T, Kawano H, Ito S, Sakamoto M, Okada Y, Ozaki Y, Kanba S, Hamada Y, Ishihara T, Maeda S: Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease. Biochem. Biophys. Res. Commun. 286:200-5, 2001
118. Stanyer L, Betteridge DJ, Smith CC: An investigation into the mechanisms mediating plasma lipoprotein-potentiated beta-amyloid fibrillogenesis. FEBS Lett. 518:72-8, 2002
119. Steele-Mortimer O, Brumell JH, Knodler LA, Meresse S, Lopez A, Finlay BB: The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells. Cell Microbiol. 4:43-54, 2002
120. Steele-Mortimer O, Meresse S, Gorvel JP, Toh BH, Finlay BB: Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway. Cell Microbiol. 1:33-49, 1999
121. Steinert JR, Wyatt AW, Poston L, JStuart AE, Mekeel HE, Kempter E: Uptake of the neurotransmitter histamine into the eyes of larvae of the barnacle (Balanus amphitrite). Biol. Bull. 202:53-60, 2002
122. Strubelt O, Hoppenkamps R: Relations between gastric glutathione and the ulcerogenic action of non-steroidal anti-inflammatory drugs. Archives Internationales de Pharmacodynamie et de Therapie. 262:268-78, 1983
123. Taira J, Miyagi C, Aniya Y: Dimerumic acid as an antioxidant from the mold, Monascus anka: the inhibition mechanisms against lipid peroxidation and hemeprotein-mediated oxidation. Biochem. Pharmacol. 63:1019-26, 2002
124. Takeuchi K, Niida H, Takinami Y, Okabe S: Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: comparative study with hypertonic NaCl. Jpn. J. Pharmacol. 53:67-74, 1990
125. Talosi G, Nemeth I, Pinter S: Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes. Eur. J. Obstet. Gynecol. Reprod.Biol. 99:25-32, 2001
126. Tashima K, Fujita A, Takeuchi K: Aggravation of ischemia/reperfusion- induced gastric lesions in streptozotocin-diabetic rats. Life Sci. 67:1707-18, 2000
127. Tashima K, Fujita A, Umeda M, Takeuchi K: Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. Life Sci. 67:1639-52, 2000
128. Tedin K, Norel F: Comparison of DeltarelA strains of Escherichia coli and Salmonella enterica serovar Typhimurium suggests a role for ppGpp in attenuation regulation of branched-chain amino acid biosynthesis. J. Bacteriol. 183:6184-96, 2001
129. Tharumaratnam D, Bashford S, Khan SA: Indomethacin induced psychosis. Postgrad. Med. J. 76:736-7, 2000
130. Tomoyasu T, Ohkishi T, Ukyo Y, Tokumitsu A, Takaya A, Suzuki M, Sekiya K, Matsui H, Kutsukake K, Yamamoto T: The ClpXP ATP- dependent protease regulates flagellum synthesis in Salmonella enterica serovar typhimurium. J. Bacteriol. 184:645-53, 2002
131. Tsolis RM, Townsend SM, Miao EA, Miller SI, Ficht TA, Adams LG, Baumler AJ: Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis. Infect. Immun. 67:6385-93, 1999
132. van Diepen A, van der Straaten T, Holland SM, Janssen R, van Dissel JT: A superoxide-hypersusceptible Salmonella enterica serovar Typhimurium mutant is attenuated but regains virulence in p47(phox-/-) mice. Infect. Immun.
133. Vazquez-Torres A, Fang FC: Salmonella evasion of the NADPH phagocyte oxidase. Microbes Infect. 3:1313-20, 2001
134. Velinov H, Mileva M, Nachev C: Influence of acute copper deficiency, cold-restraint stress and the H2 blocker ranitidine on the severity of acute gastric mucosal lesions and lipid peroxidation in rats. Method Find. Exp. Clin. Pharmacol. 23:401-7, 2001
135. Vina J, Gimeno A, Sastre J, Desco C, Asensi M, Pallardo FV, Cuesta A, Ferrero JA, Terada LS, Repine JE: Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol. Iubmb Life. 49:539-44, 2000
136. Warzecha Z, Dembinski A, Brzozowski T, Ceranowicz P, Dembinski M, Stachura J, Konturek SJ: Histamine in stress ulcer prophylaxis in rats. J. Physiol. Pharmacol. 52:407-21, 2001
137. Yanagihara S, Iyoda S, Ohnishi K, Iino T, Kutsukake K: Structure and transcriptional control of the flagellar master operon of Salmonella typhimurium. Genes. Genet. Syst. 74:105-11, 1999
138. Yoshida M, Hirotsu S, Nakahara M, Uchiwa H, Tomita Y: Histamine is involved in ultraviolet B-induced pigmentation of guinea pig skin. J. Invest. Dermatol. 118:255-60, 2002
139. You BY, Wang YH, Kuo ML: Role of reactive oxygen species in cupric 8-quinolinoxide-induced genotoxic effect. Mutat. Res. 491(1-2):45-56, 2001
140. Yrlid U, Svensson M, Hakansson A, Chambers BJ, Ljunggren HG, Wick MJ: In vivo activation of dendritic cells and T cells during Salmonella enterica serovar Typhimurium infection. Infect. Immun. 69:5726-35, 2001
141. Yrlid U, Svensson M, Kirby A, Wick MJ: Antigen-presenting cells and anti-Salmonella immunity. Microbes Infect. 3:1239-48, 2001
142. Yuzurihara M, Ikarashi Y, Ishige A, Sasaki H, Maruyama Y: Anxiolytic-like effect of saiboku-to, an oriental herbal medicine, on histaminergics-induced anxiety in mice. Pharmacol. Biochem. Be. 67:489-95, 2000
143. Zhang Y, Zhang B, Pan R: Protective effect of ischemic preconditioning on liver. Chinese J. Traumatol. 4:123-5, 2001
144. Zhou D, Galan J: Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect. 3: 1293-8, 2001
145. Palitzsch KD, Morales RE, Kronauge JF, Bynum TE, Szabo S: Effect of histamine on haemorrhagic mucosal lesions is related to vascular permeability in rats: studies with histamine, H1-, H2- and H3-agonists and bradykinin. Eur. J. Gastroenterol. Hepatol. 7:447-53, 1995
146. Sahu SC, Washington MC: Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei. Cancer Lett. 58:75-9, 1991
147. Uehara Y, Kawabata Y, Shirahase H, Wada K, Hashizume Y, Morishita S, Numabe A, Iwai J: Oxygen radical scavengers and renal protection by indapamide diuretic in salt-induced hypertension of Dahl strain rats. J. Cardiovas. Pharm. 22 Suppl 6:S42-6, 1993
148. van Lieshout EM, Tiemessen DM, Peters WH, Jansen JB: Effects of nonsteroidal anti-inflammatory drugs on glutathione S-transferases of the rat digestive tract. Carcinogenesis. 18:485-90, 1997
149. Wakulich CA, Tepperman BL: Role of glutathione in nitric oxide-mediated injury to rat gastric mucosal cells. Eur. J. Pharmacol. 319:333-41, 1997
150. Yegen B, Dedeoglu A, Aykac I, Oktay S, Yalcin AS: Effect of cold-restraint stress on glutathione and lipid peroxide levels in the liver and glandular stomach of rats. Pharmacol. Res. 22:45-8, 1990
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