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研究生:陳俊宇
研究生(外文):Chun-Yu Chen
論文名稱:研究鼠傷寒桿菌感染之大白鼠造成的胃部出血性潰瘍的機轉及其防治藥物之探討
論文名稱(外文):Mechanisms of Gastric Mucosal Hemorrhagic Ulceration in Salmonella typhimurium-infected Rats:Protection by Several Drugs
指導教授:洪正路洪正路引用關係
指導教授(外文):Chen-Road Hung
學位類別:碩士
校院名稱:國立成功大學
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:74
中文關鍵詞:組織胺鼠傷寒桿菌胃部出血性潰瘍麩胺基硫自由基脂質過氧化物血管通透性
外文關鍵詞:histamineSalmonella typhimuriumgastric hemorrhagic ulcerglutathionefree radical
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沙門氏菌屬是一種常見的致病性菌種。當牠們進入身體之後,將會造成很多臟器的傷害,包括肝臟、腎臟、腸道及其他重要的器官。鼠傷寒桿菌是傷寒桿菌屬的一種,牠們可以感染很多種動物,包含了人類、家禽、家畜、實驗用的動物等等。沙門氏菌屬對於人類器官的影響常常被研究,但是對於胃部方面的研究卻是很少的。因為胃部方面的研究是如此的不足,因此我們對傷寒桿菌屬在胃部方面的影響很感興趣。我們從股靜脈注射1ml 1x109 CFU/ml的鼠傷寒桿菌到雄性的Wistar大白鼠身上。21個小時之後,將老鼠絕食24小時來排空胃部中的食物。胃部迷走神經切除術被施行,接著使用成分為100mM HCl加上54mM NaCl及600mg/L pepsin配製而成的人工胃酸,灌到胃腔中三個小時。潰瘍參數如胃腔中血紅素含量、潰瘍面積、胃酸逆擴散、胃黏膜中的組織胺、脂質過氧化物和麩胺基硫的濃度被測定。我們的結果在受到感染的大白鼠身上呈現出胃酸逆擴散及出血性潰瘍明顯被增加的情形。此外在受感染的大白鼠身上也見到黏膜中脂質過氧化物和組織胺的濃度明顯的增加,以及黏膜中麩胺基硫的濃度明顯的下降。因為自由基和組織胺在當中扮演重要的角色,因此我們假定一些藥物如自由基清除劑、肥大細胞穩定劑和組織胺受體拮抗劑可能在感染期間被使用。我們的研究成果告訴我們上述各類藥物將可改善胃部損傷。
Salmonella species are a common pathogenic bacteria. When they enter into body, they will cause damages of many organs including liver、kidney、intestine and other important organs. Salmonella typhimurim are a kind of Salmonella species, they can infect many kinds of animals including human, poultry, livestock, experimental animals, etc. Effects of Salmonella species are often studied for many organs in human, but studies for stomach are less. Because studies for stomach are not enough, we interest in gastric effects during infection of Salmonella species. 1ml 1x109 CFU/ml Salmonella typhi- murim were injected into male Wistar rats by intravenous from femoral vein. After 21 hours, the animal were deprived of food for 24 hr to empty food from stomach. Gastric vagotomy was performed, followed by irrigation the stomachs for 3hr with a physiological acid containing 100mM HCl plus 54mM NaCl and 600mg/L pepsin. The ulcerogenic parameters including gastric acid back-diffusion, ulcer area, mucosal lipid peroxide (LPO)、glutathione (GSH) and histamine concentrations, and luminal hemoglobin (Hb) contents were determined. Our results show that a marked increase in acid back- diffusion and in hemorrhagic ulceration was found in infected rats. A significant enhancement in mucosal lipid peroxide and histamine concen- tration, and marked decrease in mucosal glutathione levels in infected rats. Because of oxygen radical and histamine played an important role, we hypothesis that several drugs including free radical scavenger, mast cell stabilizer, histamine receptor antagonist may be used during infection. Our results suggest the gastric damages will be improved after treatment of these drugs.
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中文摘要…………………………………………………1
英文摘要…………………………………………………2
緒論………………………………………………………4
實驗方法與材料…………………………………………10
統計分……………………………………………………20
結…………………………………………………………21
討…………………………………………………………27
結…………………………………………………………32
參考文獻…………………………………………………33
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