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研究生:張憶婷
研究生(外文):I-Ting Chang
論文名稱:積體差動放大器設計完成混成式生物感測器之研究
論文名稱(外文):Study on Integrated Differential Amplifier Circuit for the Hybrid Biosensor Design
指導教授:孫台平
指導教授(外文):Tai-Ping Sun
學位類別:碩士
校院名稱:國立暨南國際大學
系所名稱:電機工程學系
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:81
中文關鍵詞:差動放大器生物感測器離子感測場效電晶體延伸閘極場效電晶體參考電極
外文關鍵詞:differential amplifierbio-sensorion-selective field effect transistor (ISFET)extended-gate field effect transistor (EGFET)reference electrode
相關次數:
  • 被引用被引用:1
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本論文的主要目的是在於以積體差動放大器設計完成一不需參考電極且能克服時漂效應的生物感測器。
在本論文中,我們提出了不同於以往的製作生物感測薄膜之氧化還原方法。藉由此方法製作的感測器薄膜將可減少製程設備花費,又可簡化製作程序以及大量生產,並可結合現有之互補式金氧半標準製程達成微小化的目的。
有鑒於現今的離子感測場效電晶體在量測時需要另外設置一參考電極,造成生物感測器積體化以及微小化的困難,因此我們提出一利用差動放大器的差動特性,有效去除參考電極的新型電路設計架構。在差動放大器的設計部份,我們考量了降低雜訊、減少偏移電壓、提升共模拒斥比等等問題,完成了一穩定且可靠度高之單晶片混成式生物感測器。
The major objective of this thesis is to design an integrated differential amplifier circuit to accomplish a bio-sensor which can get the small time drift voltage without the working electrode.
In this study, we propose the anodic-oxidation system method to fabricate the sensing membrane. By using this anodic-oxidation technology, we can fabricate the sensing membrane with lower cost, simple fabricating processes, and manufacture production on large scale easily. And we can achieve the goal to reduce the sensor’s size with the CMOS IC standard process.
It’s difficult to integrate and miniature the bio-sensors for the needing of working electrodes when we measure the sensing characteristic of the ion selective field effect transistors nowadays. So we propose a whole new circuit structure which can ignore the working electrode by using the properties of the differential amplifier in this thesis. To design the differential amplifier, we consider the methods of decreasing noise, reducing offset voltage, and increasing common-mode rejection ratio. In this study, the hybrid bio-sensor with high stability in a single chip will be accomplished.
中文摘要…………………………………………………………………i
英文摘要…………………………………………………………………ii
誌謝………………………………………………………………………iii
目錄………………………………………………………………………iv
圖目錄……………………………………………………………………vi
表目錄……………………………………………………………………viii
第一章 緒論…………………………………………………………….1
1-1 研究背景……………………………………………………………1
1-2 研究動機與目的……………………………………………………3
1-3 論文架構與研究流程………………………………………………5
第二章 生物感測器之理論分析與探討……………………………….7
2-1 金氧半場效電晶體基本工作原理及有關參數……………….7
2-2 離子感測電晶體基本工作原理及相關理論………………….10
2-3 生物感測器之製作原理……………………………………….16
2-4 延伸閘極場效電晶體之架構與晶片製作…………………….18
第三章 陽極氧化系統製作感測器之研究…………………………….22
3-1 陽極氧化機制………………………………………………….22
3-2 實驗設計……………………………………………………….26
3-2.1 實驗儀器……………………………………………….26
3-2.2 實驗材料……………………………………………….28
3-2.3 實驗步驟……………………………………………….30
3-3 實驗結果與討論…………………….…………………………….35
第四章 積體差動放大器之讀出電路設計…………………………….52
4-1 何以使用差動放大器之優點………………………………….52
4-2 差動放大器之設計考量……………………………………….54
4-2.1 輸入端的選擇………………………………………….54
4-2.2 偏移電壓……………………………………………….56
4-2.3 雜訊…………………………………………………….61
4-2.4 共模拒斥比…………………………………………….64
4-2.5 時漂效應……………………………………………….65
4-3 差動放大器之製作及模擬結果……………………………….67
第五章 生物感測器與前置放大器於單一晶片之實現……………….69
5-1 單一晶片之製作……………………………………………….69
5-2 模擬量測結果………………………………………………….71
第六章 結論與展望…………………………………………………….73
6-1 結論…………………………………………………………….73
6-2 未來展望……………………………………………………….76
參考文獻………………………………………………………………..78
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