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研究生:程以鴻
研究生(外文):CHEN YI HUNG
論文名稱:合成木質板類工作人員暴露甲醛對呼吸系統的影響
論文名稱(外文):The Effect to Wood Based Panels Workers' Lung Function When Exposing to Formaldehyde
指導教授:徐尚為徐尚為引用關係
指導教授(外文):Shang-Wei Hsu
學位類別:碩士
校院名稱:國防醫學院
系所名稱:公共衛生學研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:146
中文關鍵詞:合成木質板甲醛合成木質板工作人員肺功能
外文關鍵詞:wood based panelsformaldehydewood based panels workspulmonary function
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摘 要
瞭解合成木質板類工作人員肺功能情形,及比較木材行工作人員及裝潢工作人員肺功能差異情形。國內目前並沒有對合成木質板類工作人員甲醛暴露對肺功能危害之研究,本研究擬透過對使用合成木質板類現場進行調查,以瞭解合成木質板工作人員甲醛暴露情形,及甲醛對人體肺功能危害情形。另外瞭解國內目前使用木質合成板類在第一線工作場所甲醛釋放情形,並比較木質裝潢與木材行工作場所甲醛釋放濃度。以瞭解其濃度是否有超過勞委會的標準。
本研究設計為橫斷性研究。本研究之研究工具主要包括三大部份:壹、問卷調查。貳、肺功能檢測。參、空氣粉塵、甲醛採樣及分析。利用被動式採樣器至木質裝潢與木材行工作場所採集樣本後,參照CLA2501方法進行檢體處理與分析
結果木材行平均甲醛濃度較木質裝潢工作場所要高,兩者釋放甲醛濃度都有超過勞委會規定的標準(1ppm)。木質裝潢工作人員肺功能較木材行及比較組的人差。在問卷調查自覺症狀方面前者較後二者高。
本研究顯示,國內至目前為止,使用合成木質板類的游離甲醛,仍然偏高。合成木質板從製造業或進口商至第一線工作場所時,甲醛釋放濃度可能已超過法定標準,加上第一線工作場所通風換氣大部份不是很好,使其嚴重影響工作人員的健康。政府應加強工作人員的衛生教育及要求工作場所通風換氣。未來將近一步探討此職業暴露在甲醛中對工作人員健康的影響。本研究証實目前合成木質板類工作人員仍暴露在甲醛中,而且對工作人員的肺功能造成影響,但工作人員對於其可能造成的傷害卻不了解,或不重視。因低甲醛釋放濃度的合成本較昂貴,國內一般民眾較不使用,因此對第一線工作人員及屋主造成傷害。未來將近一步探討國內鼻咽癌患者是否與木質合成板工作有關,以提供政府制訂安全的甲醛釋放濃度標準,進一步維護勞工健康。
關鍵字:合成木質板、甲醛、木質裝潢工作人員、肺功能

Abstract
The aims of this study were 1) to investigate the pulmonary function of wood based panels works,2) to compare the pulmonary function difference between lumber venders and decoration workers, and 3) to establish the relationship between the ambient formaldehyde concentration and the pulmonary function. The aims of this study was to understand the ambient formaldehyde concentration of different wood based panels working environments.
This was a cross sectional study. All the demographic data of workers were collected by a closs-ended questionnaire. The pulmonary function test was performed by. Ambient wood-dust and formaldehyde samples were collected and analyzed according to CLA methods. This was a cross-sectional study. The ambient formaldehyde samples were collected by passive samplers and analyzed .according the CLA 2501 method.
The average ambient formaldehyde concentration of lumber venders working environment was higher than that of decoration workers environment. However, both average concentrations were higher than PEL-TWA The pulmonary function of wood based panels workers were worse than that of control group.
The results of this study showed the ambient formaldehyde concentration of wood base panels working environments was higher than PEL-TWA. Neither the lumber venders working environment nor the decoration workers’ environment were well ventilated. The build-up of formaldehyde concentration might affect the health condition of these workers . A health surveillance study is needed. This study confirmed that wood based panels workers now still expose to high level formaldehyde, and that affect. Most people are reluctant to use the synthetic wood products with low formaldehyde releasing because of the price. Therefore, in a poor ventilated working condition, the build-up of indoor ambient formaldehyde is inevitable. To protect the health condition of these workers, a strict standard in the releasing of formaldehyde for the synthetic wood products is needed.
Key words: wood based panels、formaldehyde、wood based panels works、pulmonary function

目 錄
第一章 緒論………………………………………………………….…1
第一節 問題背景及重要性……………..………………….………1
第二節 文獻探討…………………………………….………………3
第二章 合成木質板甲醛及木屑粉塵暴露情形之評估……..……21
第一節 前言…………...….……………………………...………21
第二節 甲醛及木屑粉塵的特性與塵用………..…………….……22
第三節 研究方法及分析……………….………………...……28
第四節 木質合板作業場所採樣結果….………………….…..30
第三章 合成木質板工作人員暴露甲醛對呼吸系統的影響調查..41
第一節 前言………….…….……………………………..………41
第二節 研究方法流程圖….……….……………………………..42
第三節 研究方法及步驟………………….……………….……..43
第四節 結果……………………………….……………….……..47
第四章 木質裝潢工人暴露甲醛對呼吸系統的影響……………..58
第一節 前言………………………………………………..………58
第二節 研究方法流程圖…….…….……………………………..59
第三節 研究方法及步驟…………………….…………………….60
第四節 結果………………………………………………………..62
第五章 討論…………………………….…….…………………..70
第一節 研究限制……………………………….………………….70
第二節 品質保證及品質管制的重要………….………………….70
第三節 環境採樣……………………………….………………….71
第四節 四組工作人員肺功能工作前的比較….………………….73
第五節 甲醛暴露與呼吸道症狀……………….………………….73
第六節 合成木質板工作人員影響其肺功能因素探討…………..75
第六章 結論與建議…………………………. …......…………77
第一節 結論……………………………………….….……………77
第二節 建議……………………………………….….……………78
第七章 參考文獻……………………………………………………79
表目錄
圖目錄
附錄目錄

Abdel Hameed AA, Khoder MI, Farag SA. Organic dust and gaseous contammants at wood working shops. J of Environ Monitoring 2000 ; 2:73-76.
Akbar-Khanzadeh F , Akbar-Khanzadeh M. Formaldehyde exposure, acute pulmonary response, and exposure control options in a gross anatomy laboratory. Am J of Ind Med 1994;26:61-75.
Akbar-Khanzadeh F, Mlynek JS. Changes in respiratory function after one and three hours of exposure to formaldehyde in non-smoking subjects. Occup Environ Med 1997; 24:296-300.
Alexandersson R, Kolmodin-Hedman B, Hedensterna G. Exposure to formaldehyde: effects on pulmonary function. Arch Environ Health 1982;37:279-84.
B.Gandevia,J.Milne.Occupational asthma and rhinitis due to western red cedar (thuja plicata),with special refeence to bronchial reactivity , Brit.J.Industr.Med.1970;27:235-244.
Borm PJ, Jetten M, Hidayat S,et al. Respiratory symptoms, lung function, and nasal cellularity in Indonesian wood workers: a dose-response analysis. Occup Environ Med 2002 May;59(5):338-44.
Brooks S M,et al. An epidemiologic study of worker exposed to western red cedar and ether wood dust,Chest. 1981;80:30-32.
Brosseau LM, Parker DL, Lazovich D,et al. Designing intervention effective
-ness studies for occupational health and safety: The Minnesota Wood Dust Study. m J Ind Med 2002 Jan;41(1):54-61.
Brosseau LM, Parker D, Lazovich D,et al. Inhalable dust exposures, tasks, and use of ventilation in small woodworking shops: a pilot study. AIHAJ 2001 May-Jun;62(3):322-9.
Burgaz S, Cakmak G, Erdem O,et al. Micronuclei frequencies in exfoliated nasal mucosa cells from pathology and anatomy laboratory workers exposed to formaldehyde. Neoplasma 2001;48(2):144-7.
Chan-Yeung M,et al.A respiratory survey of cedar mill worker,Journal of Occupational Medicine.1978;20:323-332.
Chan-Yeung M,et al.Bronchial reactions to western re cwedar Canadar Med.Association J.Vol.1971;105:56-61.
Chan-Yeung M.Immunologic and nonimmunologic mechanisms in asthma due to westurn red cedar,Journal Allergy Clin .Immunol. 1982 ; 70:32-37.
Conolly RB, Kimbell JS, Janszen DB,et al. Dose response for formaldehyde - induced cytotoxicity in the human respiratory tract.Regul Toxicol Pharmacol 2002 Feb;35(1):32-43.
Dinsdale D, Riley RA, Verschoyle RD. Pulmonary cytochrome P450 in rates exposed to formaldehyde vapor. Environ Sci Technol 1993; 20: 637 -640.
Doig AT.Other lung disease due to dust .Postgrad Med Journal,1949;25:639.
Edling C, Hellquist H, Odkvist L. Occupational exposure to formalde- hyde and histopathological changes in the nasal mucosa. Br J Ind Med 1988; 45:761-765.
Eells JT, McMartin KE, Black K, et al. Formaldehyde poisoning: Rapid metabolism to formic acid. JAMA, J Am Med Assoc 1981;246: 1237 - 1238.
Endo Y, Miyazaki T, Hikita Y,et al. Sampling methods and residential factors affecting formaldehyde concentration in indoor air. Tohoku J Exp Med 2001 Dec;195(4):227-36.
Ferrer A, Maranon F, Casanovas M,et al. Asthma from inhalation of triplochi -ton scleroxylon (Samba) wood dust. J Investig Allergol Clin Immunol 2001; 11(3):199-203.
Ferris BG. Recommended respiratory questionnaire for use with adults and children in epidemiologic research. Epidemiology Standardization Project. Am Rev Respir Dis 1978;118:7-35.
Flyvholm MA, Andersen P. Identification of formaldehyde and formalde- hyde releasers in registered chemical products. Am J of Ind Med 199;24: 533-552.
Friedfeld S, Fraser M, Lancaster D, et al. Field intercomparison of a novel optical sensor for formaldehyde quantification. Geophys Res Lett 2000 Jul 15;27(14):2093-6.
Godish T. Air Quality. 2nd ed. Lewis Publ. Inc.1991.
Hayes RB,Ratgever TW,De Bruyn A,et al.Cancer of the nasal cavity and paranasal si -nuses and formaldehyde exposure .Inst J Cancer1986: 387 -492
Hendrick DJ, Lane DJ. Occupational formalin asthma. Br J Ind Med 1977 ; 34:11-18.
Hildesheim A, Dosemeci M, Chan CC, Occupational exposure to wood, formaldehyde, and solvents and risk of nasopharyngeal carcinoma.
Cancer Epidemiol Biomarkers Prev 2001 Nov;10(11):1145-53.
Hilton J, Dearman RJ, Basketter DA, et al. Experimental assessment of the sensitizing properties of formaldehyde. Food Chem Toxico1996;l 34 : 571-578.
Holmstrom M, Wilhelmsson B, Hellquist H, Histological changes in the nasal mucosa in rates after long-term exposure to formaldehyde and wood dust. Acta Otolaryngol (Stockh) 1989a;108:274-273.
Holmstrom M, Wilhelmsson B, Hellquist H, et al. Histological changes in persons occupationally exposed to formaldehyde alone and in combina- tion with wood dust. Acta Otolaryngol (Stockh) 1989c;107:120-129.
Holmstrom M, Wilhemsson B, Hellquist H. Histological changes on the nasal mucosa in rats after long-term exposure to formaldehyde and wood dust. Acta Otolaryngol (Stockh) 1989a;108:274-283
Holness DL, Nethercott JR. Health status of funeral service workers exposed to formaldehyde. Arc of Environ Health. 1989;44:222-228.
Horvath EP, Anderson H, Pierce WE, et al. Effects of formaldehyde on the mucous memsranes and lung : A study of an industril population. JAMA, J Am Med Assoc1988; 259: 701-707.
Iversen OH. Formaldehyde and skin carcinogenesis. Enciron Int 1986 ; 12 : 541-544.
Johannsen FR, Levinskas GJ, Tegeris AS. Effects of formaldehyde in the rat and dog following oral exposure. Toxicol Lett1986; 30:1-6.
Kamata E, Nakadate M, Uchida O, et al. Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fischer-344 rats. J Toxicol Sci 1997;22:239-254.
Kerns WD, Pavkov KL, Donofrio DJ, et al.. Carcinogenicity of formalde- hyde in rats and mice after long-term inhalation exposure.Cancer Res 1983b 43:4382-4391.
Khoder MI, Shakour AA, Farag SA et al. Indoor and outdoor formalde- hyde concentrations in homes in residential areas in greater cairo J of Environ Monitoring 2000;2:123-126.
Kilburn K, Warshaw R, Boylen CT, et al. Pulmonary and neurobehavior of formaldehyde exposure. Arch Environ Health 1985;40:254-60.
Kim CW, Song JS, Ahn YS,et al. Occupational asthma due to formaldehyde. Yonsei Med J 2001 Aug;42(4):440-5.
Kim WJ, Terada N, Nomura T,et al. Effect of formaldehyde on the expression of adhesion molecules in nasal microvascular endothelial cells: the role of formaldehyde in the pathogenesis of sick building syndrome. Clin Exp Allergy 2002 Feb;32(2):287-95.
Klein RG, Schmezer P, Amelung F,et al. Carcinogenicity assays of wood dust and wood additives in rats exposed by long-term inhalation. Int Arch Occup Environ Health 2001 Mar;74(2):109-18.
Kriebel D, Sama SR, Cocanour Barbara. Rerersible pulmonary response to formaldehyde. Am Rev Respir Dis 1996;148:1509-1515.
Kriebel D, Woskie S, Myers D et al. Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Arch Environ Health 2001;56:11-18.
L.Michaels.Lung changes in woodworkers, Canad.Med Assaciation J.Vol 1967;96:1150-1155,1967.
Laforest L, Luce D, Goldberg P et al. Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: a case-contral study in France. Occup Environ Med 2000;57:767-773.
Lei S, Yu S, Zhao C. Preparation of a ribonucleic acid-(polyamidoamine)- (zirconia-urea-formaldehyde resin) high-performance liquid affinity chromatographic stationary phase. J Chromatogr Sci 2001 Jul;39(7):280-6.
Luce, Gerin M, Berrino F et al. Sources of discrepancies between a job exposure matrix and a case by case expert assessment for occupational exposure to formaldehyde in the British chemical industry: an update. British J of Ind Med 1993;50:827-834.
Maboudou P, Mathieu D, Bachelet H,et al. Detection of oxidative stress. Interest of GC-MS for malondialdehyde and formaldehyde monitoring. Biomed Chromatogr 2002 May;16(3):199-202.
Malaka T, Kodama AM. Respiratory health of plywood workers occu- pationally exposed to formaldehyde. Arc of Environ Health 1990;50: 288-294.
Marks JGJ, Belsito DV, DeLeo VA, et al. North American contact dermatitis group standard tay patch test results(1992 to 1994). Am J Contact Dermatitis 1995;6:160 - 165
Marks TA, Worthy WC, Staples RE.. Influence of formaldehyde and Sonacide (potentiated acid glutaraldehyde)on embryo and fetal develop- ment in mice. Teratology 1980;22:51-58.
Marsh GM, Stone RA, Esmen NA. Mortality Patterns Among Chemical Plant Workers Exposure to formaldehyde and other substances. J of the National Cancer Institute 1994;86:384-388.
Mawatari T, Watanabe T, Takahashi N,et al. Bronchial stump reinforcement in right pneumonectomy with fascia lata and gelatin resorcin formalin (GRF) glue: case report. Ann Thorac Cardiovasc Surg 2001 Jun;7(3):159-61.
Monticello TM, Swenberg JA, Gross EA, et al. Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating population of cells. Cancer Res 1996;56:1012-1022.
Nakano N, Nagashima K. An automatic monitor of formaldehyde in air by a monitoring tape method. J Environ Monit 1999 Jun;1(3):255-8.
Nunn AJ, Craigen AA, Darbyshire JH et al. Six year follow up of lung function in men occupationally exposed to formaldehyde. Bri J of Ind Med 1990;47:747-752.
Ovrebo S, Haugen A, Skaug V. Biotransformation of formaldehyde in cultured human bronchus. Environ Res 2002 May;89(1):38-42.
Overman DO. Absence of embryotoxic effects of formaldehyde after percutaneous exposure in hamsters. Toxicol Lett1985;24:107-110.
Overton JH, Kimbell JS, Miller FJ. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol Sci 2001 Nov;64(1): 122-34.
Owen CM, Beck MH. Occupational allergic contact dermatitis from phenol -formaldehyde resins. Contact Dermatitis 2001 Nov;45(5):294-5.
Pecka I, Wiglusz R, Madeja-Grzyb A,et al. Formaldehyde emissions from wooden products and office furniture. Rocz Panstw Zakl Hig 2001;52 (1) : 49-54.
Posniak M, Koziel E, Jezewska A. Occupational exposure to harmful chemical substances while processing phenol-formaldehyde resins. Int J Occup Saf Ergon 2001;7(3):263-76.
Pross HF, Day JH, Clark RH, et al. Immunological studies of subjects with asthma exposed to formaldehyde and urea-formaldehyde foan insulation(UFFI) off products. J Allergy Clin Immunol 1987;79:797-810..
Riedel F, Hasenauer E, Barth PJ, et al. Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig. Allergy1996;51:94-99.
Rodes CE, Lawless PA, Evans GF et al. The relationship between personal PM exposure for elderly populations and indoor and outdoor concentrations for three retirement center scenarios. J of Exposure Analysis and Environ Ep; 2001;11:103-115.
Rosenberg C, Liukkonen T, Kallas-Tarpila T,et al. Monoterpene and wood dust exposures: work-related symptoms among Finnish sawmill workers. Am J Ind Med 2002 Jan;41(1):38-53.
S. Vedal, et al.Symotoms and pulmonary function in westurn red cedar worker related to duration of employment and dust esposure,Archives of Environmental Heslth.1986;41:179-183.
Schacter EN, Witek TJ, Tosun T, et al. A study of respiratory effects from exposure to 2ppm formaldehyde in health subjects. Arch Environ Health 1986;41:229-39.
Schlunssen V, Schaumburg I, Andersen NT,et al. Nasal patency is related to dust exposure in woodworkers. Occup Environ Med 2002 Jan;59(1):23-9.
Schoenberg JB, Mitchell, CA. Airway disease caused by phenolic (phenolic - formaldehyde) resin exposure. Arch Environ Health 1975; 30:574-77.
Smedje G, Norback D. Incidence of asthma diagnosis and self-reported allergy in relation to the school environment--a four-year follow-up study in schoolchildren. Int J Tuberc Lung Dis 2001 Nov;5(11):1059-66.
Sterling TD, Wenkam JJ. Reanalysis of lung cancer mortality in a national cancer institute study on mortality among industrial workers exposed to formaldehyde. J Occup Med 1988; 30:895-901.
Su YM, Law YP, Lau CK. A survey of pulmonary fumction in cotton textile workers and the effect of smoking. Thorac Med 1994;9(3):136-144.
Swenberg JA, Kerns WD, Mitchell RI, et al. Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formalde- hyde vapor. Cancer Res 1980; 40:3398-3402.
Teng S, Beard K, Pourahmad J et al. The formaldehyde formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes. Chemico-Biological Interactions 2001;130~132:285-296.
Terho EO, Husman K, Kotiman M. Extrinsic allergic alveolitis in a sawmill worker: A case report. 陳艷菁譯. 勞工安全衛生研究季刊 1993;1:81-85.
Til HP,Woutersen VJ, Feron V, et al. Two-year drinking-water study of formaldehyde in rats. Food Chem Toxicol 1989;27:77-87.
Tobe M, Natio K, Kurokawa Y. Chronic toxicity study on formaldehyde administered orally to rats. Toxicology 1989;56:79-86.
Vaughan TL, Stewart PA, Teschke K et al. Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma. Occup Environ Med 2000;57:376-384.
Wilkins CK, Clausen PA, Wolkoff P, Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide. Environ Health Perspect 2001 Sep;109(9):937-41.
Williams PL,Jame PC, Reberts SM. Principles of toxicology:Properties and effects of organic solvents 2000;385-388
Witek TJ, Schachter EN, Tosun T, et al. An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity. Arch Environ Health 1987;42:230-37.
Yang X, Zhang YP, Chen D, et al. Eye irritation caused by formaldehyde as an indoor air pollution--a controlled human exposure experiment. Biomed Environ Sci 2001 Sep;14(3):229-36.
Zhang C, Yu J, Zhai M. Determination of formaldehyde in indoor air by gas chromatography. Se Pu 1998 Jul;16(4):363-4.
NIOSH National Insititute for Occupational Safety and Health. http//www . cdcgov/niosh/homepage.html.
OSHA Workplace environmental exposure level guides. http//www.osha -slc.gov/html/dbsearch.html.
王秋森 粉塵在肺部沉積研究的回顧 勞工安全衛生研究季刊 1994;2:1-10.
尤俊輝 甲醛擴散式採樣器之研究 論文 1994:1-30.
行政院勞工委員會 勞工安全衛生法規暨解釋彙編.1999.441-445.
宋憶青 尿素-酚-甲醛共縮聚合樹脂之反應性及其在木材膠合劑之應用 論文 1999:1-10.
林志銘 以2, 4- dinitrophenylhydrazine 裹附玻璃纖維濾紙及氣相層析儀測定空氣中甲醛之研究 論文 1981:1-37.
許靜儀 農林廢料、酚和甲醛共縮合樹脂木材膠合劑之研究.論文. 1999:1-15.
黃冠仁 室內建材散逸揮發性有機物之研究-黏著劑之揮發性有機物散逸因子 論文 1999:1-35
陳兆梅 工作場所空氣中甲醛採樣策略之探討 論文 1992:1-42.
陳新智 室內木質建材揮發性有機物逸散之研究 論文 2000:1-30.
陳勤仁 合板游離甲醛之研究 論文 1997:1-46.
馮兆康 毛義方 醫院工作人員甲醛暴露危害之研究 勞工安全衛生研究季刊 1997;5:63-72.
蔡詩偉 空氣中甲醛之被動式採樣分析-Pararosaniline 法之研究 論文 1980:1-15.
經濟部統計處 中華民國台灣地區化學工業生產統計月報 1984- 2000.
蘇麗卿 木質板類游離甲醛釋出之研究 論文 1995:1-45.

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