跳到主要內容

臺灣博碩士論文加值系統

(3.238.98.39) 您好!臺灣時間:2022/09/26 10:47
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:邱雅蘭
研究生(外文):Ya-lan Chiu
論文名稱:乳癌細胞中視網酸調控基因RIG1及S100P之研究
論文名稱(外文):Biological analysis of retinoid inducible genes RIG1 and S100P in breast cancer cells
指導教授:姜淑媛
指導教授(外文):Shun-yuan Jiang
學位類別:碩士
校院名稱:國防醫學院
系所名稱:微生物及免疫學研究所
學門:生命科學學門
學類:微生物學類
論文種類:學術論文
論文出版年:2002
畢業學年度:90
語文別:中文
論文頁數:60
中文關鍵詞:全反式維甲酸第二型腫瘤抑制基因鈣離子結合蛋白細胞凋亡細胞移動動情激素乳癌細胞
外文關鍵詞:RIG1S100Pall-trans retinoic acidMCF-7MDA-MB-231 CL10Acalcium binding proteinbreast cancer cellsclassⅡtumor suppressor genes
相關次數:
  • 被引用被引用:2
  • 點閱點閱:554
  • 評分評分:
  • 下載下載:59
  • 收藏至我的研究室書目清單書目收藏:1
中文摘要
RIG1(retinoid-inducible gene 1)及S100P(S100 calcium binding protein P)是自SC-M1胃癌細胞所發現之可被全反式維甲酸(all-trans retinoic acid)所調控的基因。RIG1基因屬於第二型腫瘤抑制基因成員之一,早期研究顯示RIG1會引導癌細胞進行程式性細胞死亡。S100P屬於S100鈣離子結合蛋白家族之成員,此基因表現與乳腺細胞獲得永生之能力(immortalization)及癌細胞轉移有關。本實驗以乳癌細胞為研究模式,分析RIG1與乳癌細胞生長及死亡之關聯性;以及S100P在癌細胞生長及蔓延過程中所扮演的角色。
在RIG1蛋白之研究方面,發現RIG1-myc及RIG1-EGFP融合蛋白之表現可抑制35 % 至57 % 之MCF-7及MDA-MB-231 CL10A乳癌細胞株落之形成,並增加細胞凋亡。以四環黴素(tetracycline)調控系統無法建立可誘導且大量表現之RIG1-myc融合蛋白之細胞株。未來,將繼續朝著分析RIG1轉殖細胞中細胞凋亡相關蛋白,如: Bcl-2 家族及蛋白水解脢(caspases)家族之表現,以了解RIG1誘導細胞凋亡之機制。
在S100P之研究方面,發現S100P大量表現會增加MCF-7細胞之生長速率,但會降低轉殖單株之細胞移動速率。正向(S12, S13)及反向(AS14)S100P轉殖單株對動情激素(17b-estradiol)及全反式維甲酸(all-trans retinoic acid)均有相同之感受性。總結,於乳癌細胞中,RIG1與S100P具有不同之功能。RIG1具有抑制生長及促進細胞凋亡之作用,而S100P具有促進生長但抑制細胞移動之作用。
英文摘要
Retinoid-inducible gene 1 (RIG1) and S100 calcium binding protein P (S100P) were isolated from human gastric cancer cells treated with all-trans retinoic acid. The RIG1 gene belongs to the family of classⅡtumor suppressor genes, and overexpression of the gene leads to growth suppression or cellular apoptosis of several cancer cell lines. The S100P gene belongs to the S100 family and may be associated with cellular immortalization and progression of breast cancer cells. To investigate activities of the RIG1 and S100P genes in breast cancer cells, transient and stable transfection were used in this study.
Activities of colony formation of MCF-7 and MDA-MB-231 CL10A cells were suppressed by 35 % to 57 % in cells transfected with RIG1-myc and RIG1-EGFP expression vectors. While, cellular apoptosis, determined by in situ DNA breakage, was increased by 2.5 % to 10.5 % in cells transiently transfected with the vectors. Cells induced to express the RIG1-myc protein at high levels were not established in MCF-7Tet off cells. Analysis in the alteration of apoptosis-associated proteins and caspases will be helpful to elucidate the mechanism of RIG1 induced apoptosis.
S100P stable transfectants (S12 and S13) had an increase in cellular growth and efficiency of colony formation, compared to that of the antisense transfectant AS14. However, cellular motility of S12 and S13 transfectans was significantly lower than that of AS14 cells. All transfectants remained sensitive to all-trans retinoic acid and required 17b-estradiol for growth.
In conclusion, the RIG1 and S100P genes exhibited different biological activities on breast cancer cells. The RIG1 protein exhibited growth suppression and apoptosis inducing activities. Where as S100P protein enhanced cellular growth. However, the gene inhibited migration of breast cancer cells.
總目錄
目錄-----------------------------------------------------Ⅰ
圖目錄---------------------------------------------------Ⅲ
附錄表---------------------------------------------------Ⅳ
縮寫之專有名詞簡介---------------------------------------Ⅴ
中文摘要-------------------------------------------------Ⅵ
英文摘要-------------------------------------------------Ⅶ
目錄
第一章、 導論--------------------------------------------1
一、 維甲類化合物之作用機轉--------------------------2
二、 維甲類化合物之抑癌機轉--------------------------2
三、 維甲類化合物與其誘導基因------------------------3
四、 細胞凋亡----------------------------------------7
五、 本論文之研究方向--------------------------------9
第二章、 材料與方法--------------------------------------10
一、 質體--------------------------------------------11
二、 大量質體之製備及純化----------------------------12
三、 細胞培養----------------------------------------12
四、 轉染作用----------------------------------------13
五、 建立誘導RIG1表現之穩定細胞株--------------------13
六、 建立S100P表現之單源細胞株-----------------------14
七、 細胞組織學染色法--------------------------------14
八、 蛋白質之粹取------------------------------------15
九、 蛋白濃度測試------------------------------------16
十、 聚丙烯醯胺膠體電泳(SDS-PAGE)及蛋白質轉漬------16
十一、 西方墨點法(western blotting)------------------17
十二、 株落計數(colony formation)--------------------17
十三、 細胞凋亡現象分析(TUNEL assay)-----------------18
十四、 生長曲線測定------------------------------------19
十五、 體外模式分析細胞對E2之反應----------------------19
十六、 動物模式分析細胞對E2之反應----------------------19
十七、 細胞對全反式維甲酸(atRA)之反應測定------------20
十八、 細胞生長能力之分析------------------------------20
十九、 細胞移動能力之分析------------------------------20
第三章、 結果--------------------------------------------22
一、 RIG1部分
(1)RIG1轉殖細胞之確認----------------------------------23
(2)RIG1-EGFP融合蛋白之表現改變MCF-7之細胞型態----------23
(3)RIG1融合蛋白抑制乳癌細胞株落形成之能力--------------23
(4)RIG1融合蛋白抑促進癌細胞進行程式性細胞凋亡----------24
(5)誘導性RIG1蛋白表現細胞株之建立及其表現之調控--------24
二、 S100P部分
(1) S100P轉殖單株之建立與確認-----------------------25
(2) S100P蛋白表現對乳癌細胞生長及株落形成能力之影響-26
(3) S100P轉殖單株對E2生長反應之分析-----------------27
(4) S100P轉殖單株對atRA生長影響之分析---------------28
(5) S100P轉殖單株細胞移動能力之分析-----------------28
第四章、 討論--------------------------------------------29
第五章、 參考文獻----------------------------------------35
圖目錄
圖一、以組織學染色法分析轉染pRIG1-EGFP載體之MCF-7細胞中RIG1-
EGFP融合蛋白之表現。-------------------------------------42
圖二、以組織學染色法分析轉染pRIG1-myc載體之MCF-7細胞中RIG1-myc
融合蛋白之表現。-----------------------------------------43
圖三、MCF-7乳癌細胞表現RIG1-EGFP融合蛋白之細胞型態。-----44
圖四、RIG1融合蛋白的表現對MCF-7WS8及MDA-MB231 CL10A乳癌細胞
株落形成能力之影響。-------------------------------------45
圖五、以TUNEL螢光染色法分析MDA-MB231 CL10A細胞中RIG1-myc融
合蛋白表現引起細胞核酸斷裂之現象。-----------------------46
圖六、利用Tetoff調控系統調控MCF-7乳癌細胞中EGFP蛋白及RIG1-myc
蛋白之表現。---------------------------------------------47
圖七、以細胞組織學染色法分析S100P轉殖單株之S100P蛋白表現。48
圖八、以西方墨點法分析S100P轉殖細胞中S100P蛋白之表現。---49
圖九、S100P轉殖單株生長之分析。--------------------------50
圖十、以結晶紫染色法分析S100P轉殖細胞株落生長情形。------51
圖十一、S100P轉殖單株S12、S13 及AS14株落生長之分析。-----52
圖十二、S100P轉殖單株對E2生長反應之分析。----------------53
圖十三、動物實驗模式中S100P轉殖單株對E2生長反應之分析----54
圖十四、S100P轉殖單株對全反式維甲酸(atRA)生長影響之分析。55
圖十五、S100P轉殖單株細胞移動能力之分析。----------------56
附錄表
附錄一、-------------------------------------------------57
附錄二、-------------------------------------------------58
附錄三、-------------------------------------------------59
附錄四、-------------------------------------------------60
第五章、參考文獻
Akiyama H, Hiraki Y, Noda M, Shigeno C, Ito H, Nakamura T: Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. J Biol Chem. 274: 2192-7;1999.
Adachi H, Preston G, Harvat B, Dawson MI, Jetten AM. Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells. Am J Respir Cell Mol Biol. 18 :323-33, 1998.
Amler LC, Agus DB, LeDuc C, Sapinoso ML, Fox WD, Kern S, Lee D, Wang V, Leysens M, Higgins B, Martin J, Gerald W, Dracopoli N, Cordon-Cardo C, Scher HI, Hampton GM: Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1. Cancer Res. 60: 6134-41, 2000.
Averboukh L, Liang P, Kantoff PW, Pardee AB: Regulation of S100P expression by androgen. Prostate. 29:350-5, 1996.
Becker T, Gerke V, Kube E, Weber K: S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties. Eur J Biochem. 207:541-7, 1992.
Bertram J, Palfner K, Hiddemann W, Kneba M: Elevated expression of S100P, CAPL and MAGE 3 in doxorubicin-resistant cell lines: comparison of mRNA differential display reverse transcription-polymerase chain reaction and subtractive suppressive hybridization for the analysis of differential gene expression Anticancer Drugs 9:311-7, 1998.
Deucher A, Nagpal S, Chandraratna RA, Di Sepio D, Robinson NA, Dashti SR, Eckert RL: The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. Int J Oncol.17:1195-203, 2000.
DiSepio D, Ghosn C, Eckert RL, Deucher A, Robinson N, Duvic M, Chandraratna RA, Nagpal S: Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. Proc Natl Acad Sci. 95:14811-5, 1998.
Douer D, Koeffler HP: Retinoic acid enhances growth of human early erythroid progenitor cells in vitro. J Clin Invest 69:1039-41, 1982.
Duvic M, Helekar B, Schulz C, Cho M, DiSepio D, Hager C, DiMao D, Hazarika P, Jackson B, Breuer-McHam J, Young J, Clayman G, Lippman SM, Chandraratna RA, Robinson NA, Deucher A, Eckert RL, Nagpal S: Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer. Clin Cancer Res 6:3249-59, 2000.
Gottardis MM, Jordan VC: Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res 48:5183-7, 1988.
Granville DJ, Carthy CM, Hunt DWC, McManus BM. Apoptosis: molecular aspects of cell death and dis-ease.Laboratory Investigation 78:893—913, 1998.
Green DR, Reed JC. Mitochondria and apoptosis. Science 281:1309-12, 1998.
Grigorian M, Ambartsumian N, Lykkesfeldt AE, Bastholm L, Elling F, Georgiev G, Lukanidin E: Effect of mts1 (S100A4) expression on the progression of human breast cancer cells. Int J Cancer 67:831-41, 1996.
Gribenko AV, Makhatadze GI Oligomerization and divalent ion binding properties of the S100P protein: a Ca2+/Mg2+-switch model. J Mol Biol 283:679-94, 1998.
Guerreiro Da Silva ID, Hu YF, Russo IH, Ao X, Salicioni AM, Yang X, Russo J: S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo. Int J Oncol 16:231-40, 2000.
Hajnal A, Klemenz R, Schafer R: Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts. Oncogene 9: 479-90, 1994.
Hitomi J. Kimura T. Kusumi E. Nakagawa S. Kuwabara S. Hatakeyama K. Yamaguchi K. Novel S100 proteins in human esophageal epithelial cells: CAAF1 expression is associated with cell growth arrest. Archives of Histology & Cytology. 61:163-78, 1998.
Holt JT, Gopal TV, Moulton AD, Nienhuis AW. Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci USA. 83:4794-8, 1986.
Hsu CA, Rishi AK, Su-Li X, Gerald TM, Dawson MI, Schiffer C, Reichert U, Shroot B, Poirer GC, Fontana JA. Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway. Blood 89:4470-9, 1997.
Huang SL, Shyu RY, Yeh MY, Jiang SY: Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. Mol Cell Endocrinol 159:15-24, 2000.
Huang SL, Shyu RY, Yeh MY, Jiang SY: The retinoid-inducible gene I: effect on apoptosis and mitogen-activated kinase signal pathways. Anticancer Res. 22(2A):799-804, 2002.
Husmann K, Sers C, Fietze E, Mincheva A, Lichter P, Schafer R: Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. Oncogene 17:1305-12, 1998.
Ito H, Akiyama H, Shigeno C, Nakamura T: Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). Cytogenet Cell Genet 93:36-9, 2001.
Jiang SY, Shyu RY, Chen HY, Lee MM, Wu KL, Yeh MY: In vitro and in vivo growth inhibition of SC-M1 gastric cancer cells by retinoic acid. Oncology 53:334-40, 1996.
Jiang SY, Lin DY, Shyu RY, Reichert U, Yeh MY: The RARgamma selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis. Cancer Lett. 137:217-25, 1999.
Koeffler HP, Amatruda TT 3rd. The effect of retinoids on haemopoiesis--clinical and laboratory studies. Ciba Found Symp 113:252-67, 1985.
Koltzscher M, Gerke V: Identification of hydrophobic amino acid residues involved in the formation of S100P homodimers in vivo. Biochemistry 39:9533-9, 2000.
Komatsu K, Kobune-Fujiwara Y, Andoh A, Ishiguro S, Hunai H, Suzuki N, Kameyama M, Murata K, Miyoshi J, Akedo H, Tatsuta M, Nakamura H: Increased expression of S100A6 at the invading fronts of the primary lesion and liver metastasis in patients with colorectal adenocarcinoma. Br J Cancer 83:769-74, 2000.
Li Y. Lin B. Agadir A. Liu R. Dawson MI. Reed JC. Fontana JA. Bost F. Hobbs PD. Zheng Y. Chen GQ. Shroot B. Mercola D. Zhang XK. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Molecular Cellular Biol. 18:4719-31, 1998.
Liu D, Rudland PS, Sibson DR, Platt-Higgins A, Barraclough R: Expression of calcium-binding protein S100A2 in breast lesions. Br J Cancer 83:1473-9, 2000.
McKenna NJ, Lanz RB, O''Malley BW: Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 20:321-44, 1999.
Morriss-Kay G. Retinoic acid and development. Pathobiology 60:264-70, 1992.
Mousses S, Bubendorf L, Wagner U, Hostetter G, Kononen J, Cornelison R, Goldberger N, Elkahloun AG, Willi N, Koivisto P, Ferhle W, Raffeld M, Sauter G, Kallioniemi OP: Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays. Cancer Res 62:1256-60, 2002.
Oridate N, Higuchi M, Suzuki S, Shroot B, Hong WK, Lotan R. Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437). Int J Cancer 70:484-7, 1997.
Rudin CM, Thompson CB. (1997) Apoptosis and disease: regulation and clinical relevance of programmed. cell death. Annual Review Medicine 48:267—81, 1997.
Russo J, Hu YF, Silva ID, Russo IH: Cancer risk related to mammary gland structure and development. Microsc Res Tech 52:204-23, 2001.
Sato N, Hitomi J: S100P expression in human esophageal epithelial cells: Human esophageal epithelial cells sequentially produce different S100 proteins in the process of differentiation. Anat Rec 267:60-69, 2002.
Schwartzman RA, Cidlowski JA: Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr Rev 14:133-51, 1993.
Schafer BW, Heizmann CW: The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 21:134-40, 1996.
Schadendorf D, Kern MA, Artuc M, Pahl HL, Rosenbach T, Fichtner I, Nurnberg W, Stuting S, von Stebut E, Worm M, Makki A, Jurgovsky K, Kolde G, Henz BM. Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo. J Cell Biol 135:1889-98, 1996.
Schonning B, Bevort M, Mikkelsen S, Andresen M, Thomsen P, Leffers H, Norrild B: Human papillomavirus type 16 E7-regulated genes: regulation of S100P and ADP/ATP carrier protein genes identified by differential-display technology. J Gen Virol 81:1009-15, 2000.
Sers C, Emmenegger U, Husmann K, Bucher K, Andres AC, Schafer R: Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors. J Cell Biol 136:935-44, 1997.
Sers C, Husmann K, Nazarenko I, Reich S, Wiechen K, Zhumabayeva B, Adhikari P, Schroder K, Gontarewicz A, Schafer R: The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. Oncogene 21:2829-39, 2002.
Shao ZM, Dawson MI, Li XS, Rishi AK, Sheikh MS, Han QX, Ordonez JV, Shroot B, Fontana JA. p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 11:493-504, 1995.
Sherbet GV, Lakshmi MS: S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Res 18:2415-21, 1998.
Shyu RY, Jiang SY, Huang SL, Chang TC, Wu KL, Roffler SR, Yeh MY: Growth regulation by all-trans-retinoic acid and retinoic acid receptor messenger ribonucleic acids expression in gastric cancer cells. Eur J Cancer 31:237-43, 1995.
Siegrist S, Feral C, Chami M, Solhonne B, Mattei MG, Rajpert-De Meyts E, Guellaen G, Bulle F: hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors. Oncogene 20:5155-63, 2001.
Smith MA, Adamson PC, Balis FM, Feusner J, Aronson L, Murphy RF, Horowitz ME, Reaman G, Hammond GD, Fenton RM, et al. Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer. J Clin Oncol 10:1666-73, 1992.
Sofia Gruvberger, Markus Ringne´r, Yidong Chen, Sujatha Panavally, Lao H. Saal, Åke Borg, Mårten Ferno¨,Carsten Peterson, and Paul S. Meltzer. Estrogen Receptor Status in Breast Cancer Is Associated with Remarkably Distinct. Gene Expression Patterns. Cancer Res 61:5979—5984, 2001.
Su IJ, Cheng AL, Tsai TF, Lay JD. Retinoic acid-induced apoptosis and regression of a refractory Epstein-Barr virus-containing T cell lymphoma expressing multidrug-resistance phenotypes. Br J Haematol 85:826-8, 1993 .
Sun SY, Yue P, Shroot B, Hong WK, Lotan R. Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437. J Cell Physiol 173:279-84, 1997.
Sun SY, Yue P, Wu GS, El-Deiry WS, Shroot B, Hong WK, Lotan R. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. Oncogene 18:2357-65, 1999.
Takase S, Ong DE, Chytil F: Transfer of retinoic acid from its complex with cellular retinoic acid-binding protein to the nucleus. Arch Biochem Biophys 247:328-34, 1986.
Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 281:1312-6, 1998.
吳孟勳. 人類RIG1基因啟動區維甲酸反應序列之鑑定與分析. 國防醫學院生物化學研究所碩士論文2001.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
1. 范麗娟。「深度訪談簡介」。戶外遊憩研究7卷2期(民83年6月),頁25-35。
2. 歐仁和。「臺灣金融產業合併問題解析」。產業論壇2卷2期(民90年1月),頁13-29。
3. 傅雅秀。「資訊尋求的理論與實證研究」。圖書與資訊學刊20期(民86年2月),頁13-27。
4. 溫仁助。「從資訊與資訊需求的定義探討資訊需求和使用的研究方向」。大學圖書館2卷3期(民87年7月),頁58-71。
5. 林麗娟。「質化研究取向與讀者資訊尋求」。資訊傳播與圖書館學4卷1期(民86年9月),頁52-59。
6. 莊太平。「投資者的致勝秘笈-公開發行上市公司財務報告的閱讀及運用」。會計研究月刊107期(民83年8月),頁18-21。
7. 鄒宗佑。「新世紀券商合併願景」。實用稅務月刊304號(民89年4月),頁24-27。
8. 鄒筱涵。「證券商業務員、證券分析人員與會計師事前管理之探討」。證券暨期貨管理18卷10期(民89年10月),頁1-6。
9. 鄭麗敏。「人文學者搜尋資訊行為的探究」。教育資料與圖書館學29卷4期(民81年6月),頁388-410。
10. 蔡瑞修。「投顧事業管理十年回顧與未來方向之建議」。證券市場發展季刊22期(民83年3月),頁109-124。
11. 洪紹陳。「券商合併效應」。元大投資資訊月刊1月號(民89年1月),頁18-22。
12. 張淳淳。「公司圖書館在企業內之處境及其調適之道」。中國圖書館學會會報48期(民80年12月),頁169-178。
13. 張淳淳。「企業競爭資訊之蒐集」。書苑季刊20期(民83年4月),頁48-58。
14. 張漢傑。「股票籌碼對股價的顛覆與平復」。會計研究月刊180期(民89年11月),頁51-55。
15. 張仲岳。「證券分析、價值與市價:分析師獨立批判,投資者決策參考」。會計研究月刊123期(民85年2月),頁37-45。